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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxo4

Z-value: 0.55

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Transcription factors associated with Foxo4

Gene Symbol Gene ID Gene Info
Foxo4
ENSRNOG00000033316 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo4rn6_v1_chrX_+_71155894_711558940.026.6e-01Click!

Activity profile of Foxo4 motif

Sorted Z-values of Foxo4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_168957460 31.45 ENSRNOT00000090745
LOC103694857
hemoglobin subunit beta-2
chr1_+_168945449 31.37 ENSRNOT00000087661
ENSRNOT00000019913
LOC103694855
hemoglobin subunit beta-2-like
chr1_-_168972725 30.29 ENSRNOT00000090422
Hbb
hemoglobin subunit beta
chr4_-_70996395 20.10 ENSRNOT00000021485
Kel
Kell blood group, metallo-endopeptidase
chr3_+_16817051 12.64 ENSRNOT00000071666
AABR07051550.1

chr9_+_67774150 10.41 ENSRNOT00000091060
Icos
inducible T-cell co-stimulator
chr5_-_139921013 9.76 ENSRNOT00000079957
Smap2
small ArfGAP2
chr1_-_216828581 9.56 ENSRNOT00000066943
ENSRNOT00000088856
Tnfrsf26
tumor necrosis factor receptor superfamily, member 26
chr15_-_51834030 6.19 ENSRNOT00000024895
Ccar2
cell cycle and apoptosis regulator 2
chr17_+_76532611 6.14 ENSRNOT00000024099
Camk1d
calcium/calmodulin-dependent protein kinase ID
chrX_+_71342775 6.03 ENSRNOT00000004888
Itgb1bp2
integrin subunit beta 1 binding protein 2
chr1_+_213737788 5.57 ENSRNOT00000020004
Pgghg
protein-glucosylgalactosylhydroxylysine glucosidase
chr20_-_157861 5.45 ENSRNOT00000084461
RT1-CE10
RT1 class I, locus CE10
chr5_-_139933764 5.34 ENSRNOT00000015278
LOC680700
similar to ribosomal protein L10a
chr20_+_5414448 4.86 ENSRNOT00000078972
ENSRNOT00000080900
RT1-A1
RT1 class Ia, locus A1
chrX_+_112555173 4.63 ENSRNOT00000045023
LOC103690888
60S ribosomal protein L10a-like
chr8_+_40009691 4.50 ENSRNOT00000042679
Vsig2
V-set and immunoglobulin domain containing 2
chr5_+_148577332 4.49 ENSRNOT00000016325
Snrnp40
small nuclear ribonucleoprotein U5 subunit 40
chr14_+_88549947 4.44 ENSRNOT00000086177
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr1_+_226252226 4.39 ENSRNOT00000039369
AABR07006258.1

chr10_-_18090932 4.20 ENSRNOT00000064744
ENSRNOT00000006591
Npm1
nucleophosmin 1
chr19_+_9436210 4.13 ENSRNOT00000074845
LOC100910721
60S ribosomal protein L26-like
chr14_+_86652365 4.08 ENSRNOT00000077428
Zmiz2
zinc finger, MIZ-type containing 2
chr6_-_135304422 4.00 ENSRNOT00000010598
Cinp
cyclin-dependent kinase 2-interacting protein
chr7_-_92882068 3.94 ENSRNOT00000037809
Ext1
exostosin glycosyltransferase 1
chr3_+_91870208 3.58 ENSRNOT00000040249
Rpl21
ribosomal protein L21
chr7_-_71139267 3.37 ENSRNOT00000065232
RGD1561812
similar to Retinol dehydrogenase type II (RODH II) (29 k-protein)
chr9_+_42620006 3.21 ENSRNOT00000019966
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr3_-_138116664 3.17 ENSRNOT00000055602
Rrbp1
ribosome binding protein 1
chr1_-_84168044 3.02 ENSRNOT00000084586
ENSRNOT00000028348
Shkbp1
Sh3kbp1 binding protein 1
chr3_+_2877293 2.88 ENSRNOT00000061855
Lcn5
lipocalin 5
chr1_-_80483487 2.82 ENSRNOT00000074418
Gemin7
gem (nuclear organelle) associated protein 7
chr3_+_149144795 2.49 ENSRNOT00000015482
Dnmt3b
DNA methyltransferase 3 beta
chr14_-_1632378 2.36 ENSRNOT00000000080
Dr1
down-regulator of transcription 1
chr3_-_13824870 2.34 ENSRNOT00000066961
Gapvd1
GTPase activating protein and VPS9 domains 1
chr6_+_126623015 2.26 ENSRNOT00000010672
Tmem251
transmembrane protein 251
chr1_-_199320727 2.15 ENSRNOT00000022452
Zfp668
zinc finger protein 668
chr5_-_154363329 2.14 ENSRNOT00000064596
Eloa
elongin A
chr14_+_83510278 2.10 ENSRNOT00000081161
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr14_+_83510640 2.04 ENSRNOT00000089928
ENSRNOT00000082242
ENSRNOT00000025378
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr5_-_148577292 1.98 ENSRNOT00000017156
Zcchc17
zinc finger CCHC-type containing 17
chr5_-_48194251 1.79 ENSRNOT00000081748
ENSRNOT00000065912
Ankrd6
ankyrin repeat domain 6
chr10_+_85744568 1.75 ENSRNOT00000005522
Lasp1
LIM and SH3 protein 1
chr9_+_112360419 1.65 ENSRNOT00000086682
Man2a1
mannosidase, alpha, class 2A, member 1
chr20_-_28263037 1.65 ENSRNOT00000030348
Edar
ectodysplasin-A receptor
chr1_-_82120902 1.54 ENSRNOT00000027684
Erf
Ets2 repressor factor
chr10_-_90049112 1.32 ENSRNOT00000028323
Pyy
peptide YY (mapped)
chr4_+_159622404 1.29 ENSRNOT00000078299
Fgf23
fibroblast growth factor 23
chr10_+_97212432 1.13 ENSRNOT00000088599
Axin2
axin 2
chr7_-_144223429 1.08 ENSRNOT00000020527
Atf7
activating transcription factor 7
chr18_+_66741144 0.91 ENSRNOT00000021161
AABR07032457.1

chr9_+_16427589 0.90 ENSRNOT00000091809
Gltscr1l
GLTSCR1-like
chr20_+_26534535 0.69 ENSRNOT00000000423
Tmem167b
transmembrane protein 167B
chr1_-_82236179 0.59 ENSRNOT00000027845
Cnfn
cornifelin
chr6_+_48452369 0.44 ENSRNOT00000044310
Myt1l
myelin transcription factor 1-like
chr19_+_46733633 0.16 ENSRNOT00000016307
Clec3a
C-type lectin domain family 3, member A
chr4_-_66624912 0.12 ENSRNOT00000064891
Hipk2
homeodomain interacting protein kinase 2
chr3_-_74991168 0.11 ENSRNOT00000049273
Olr550
olfactory receptor 550
chr10_+_93811350 0.03 ENSRNOT00000077280
Tanc2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.3 GO:0010999 regulation of eIF2 alpha phosphorylation by heme(GO:0010999)
4.5 62.8 GO:0015671 oxygen transport(GO:0015671)
3.4 20.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
1.6 4.9 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
1.4 4.2 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407)
1.3 3.9 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.1 3.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.0 6.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.8 2.5 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.7 4.4 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.6 6.2 GO:1901978 positive regulation of cell cycle checkpoint(GO:1901978)
0.6 10.4 GO:0002517 T cell tolerance induction(GO:0002517)
0.4 1.3 GO:1904383 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) response to sodium phosphate(GO:1904383)
0.4 1.1 GO:2000054 regulation of mismatch repair(GO:0032423) regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 1.7 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.2 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 4.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.2 1.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 1.7 GO:0006013 mannose metabolic process(GO:0006013)
0.1 5.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 9.6 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 1.3 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 2.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 6.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 2.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 12.0 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 4.1 GO:0030217 T cell differentiation(GO:0030217)
0.0 0.5 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 10.9 GO:0006412 translation(GO:0006412)
0.0 1.0 GO:0043966 histone H3 acetylation(GO:0043966)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 93.1 GO:0005833 hemoglobin complex(GO:0005833)
2.1 6.2 GO:0044609 DBIRD complex(GO:0044609)
1.5 4.4 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.6 10.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.6 4.2 GO:0001652 granular component(GO:0001652)
0.4 2.8 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.3 2.1 GO:0070449 elongin complex(GO:0070449)
0.2 4.5 GO:0005682 U5 snRNP(GO:0005682)
0.1 2.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 10.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 7.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 2.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 6.0 GO:0030018 Z disc(GO:0030018)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 10.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 30.3 GO:0031720 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
6.3 62.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.7 9.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.7 4.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.6 4.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.5 2.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5 4.2 GO:0030957 Tat protein binding(GO:0030957)
0.3 5.6 GO:0015926 glucosidase activity(GO:0015926)
0.3 1.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 6.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 3.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 6.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 20.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 5.5 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.7 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 3.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.1 4.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 6.0 GO:0005178 integrin binding(GO:0005178)
0.0 12.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 9.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0046790 virion binding(GO:0046790)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 4.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 4.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.1 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 30.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 10.4 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 4.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 4.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 3.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation