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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata2_Gata1

Z-value: 1.91

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Transcription factors associated with Gata2_Gata1

Gene Symbol Gene ID Gene Info
Gata2
ENSRNOG00000012347 GATA binding protein 2
Gata1
ENSRNOG00000025534 GATA binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata1rn6_v1_chrX_+_15378789_153787890.501.1e-21Click!
Gata2rn6_v1_chr4_+_120133713_1201337130.009.4e-01Click!

Activity profile of Gata2_Gata1 motif

Sorted Z-values of Gata2_Gata1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_119225040 146.91 ENSRNOT00000012365
Bmp10
bone morphogenetic protein 10
chr4_+_57952982 135.57 ENSRNOT00000014465
Cpa1
carboxypeptidase A1
chr1_+_279798187 133.38 ENSRNOT00000024065
Pnlip
pancreatic lipase
chr12_-_46889082 121.41 ENSRNOT00000001525
Pla2g1b
phospholipase A2 group IB
chr14_+_26662965 120.68 ENSRNOT00000002621
Tecrl
trans-2,3-enoyl-CoA reductase-like
chr5_-_155772040 110.46 ENSRNOT00000036788
Cela3b
chymotrypsin-like elastase family, member 3B
chr4_+_70614524 98.01 ENSRNOT00000041100
Prss3
protease, serine 3
chr1_+_72882806 97.34 ENSRNOT00000024640
Tnni3
troponin I3, cardiac type
chr3_+_79940561 94.09 ENSRNOT00000016652
Mybpc3
myosin binding protein C, cardiac
chr6_-_26385761 73.70 ENSRNOT00000073228
Gckr
glucokinase regulator
chr2_+_190073815 66.32 ENSRNOT00000015473
S100a8
S100 calcium binding protein A8
chrX_-_13601069 61.13 ENSRNOT00000004686
Otc
ornithine carbamoyltransferase
chr4_+_70689737 61.03 ENSRNOT00000018852
Prss2
protease, serine, 2
chr1_-_85220237 60.22 ENSRNOT00000026907
Sycn
syncollin
chr8_+_50525091 57.94 ENSRNOT00000074357
Apoa1
apolipoprotein A1
chr9_-_23493081 55.72 ENSRNOT00000072144
Rhag
Rh-associated glycoprotein
chr20_-_2191640 53.26 ENSRNOT00000001016
Trim10
tripartite motif-containing 10
chr13_-_53870428 50.02 ENSRNOT00000000812
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr6_-_47890033 47.14 ENSRNOT00000011290
Colec11
collectin sub-family member 11
chr16_+_10267482 47.01 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chr5_+_133864798 46.57 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr11_-_60679555 46.54 ENSRNOT00000059735
Ccdc80
coiled-coil domain containing 80
chr19_+_27404712 44.37 ENSRNOT00000023657
Mylk3
myosin light chain kinase 3
chr16_+_6970342 44.00 ENSRNOT00000061294
ENSRNOT00000048344
Itih4
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr8_-_48672732 43.71 ENSRNOT00000079275
Hmbs
hydroxymethylbilane synthase
chr4_-_70747226 42.14 ENSRNOT00000044960
LOC102554637
anionic trypsin-2-like
chr10_-_90415070 42.05 ENSRNOT00000055179
Itga2b
integrin subunit alpha 2b
chr19_+_25815207 41.16 ENSRNOT00000003980
Lyl1
LYL1, basic helix-loop-helix family member
chr11_-_44049648 40.82 ENSRNOT00000002257
Cpox
coproporphyrinogen oxidase
chr1_+_199720038 40.75 ENSRNOT00000027297
Ahsp
alpha hemoglobin stabilizing protein
chr8_-_33661049 40.44 ENSRNOT00000068037
Fli1
Fli-1 proto-oncogene, ETS transcription factor
chr8_+_22047697 39.94 ENSRNOT00000067741
Icam4
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr8_-_22974321 39.64 ENSRNOT00000017369
Epor
erythropoietin receptor
chr11_-_64952687 39.35 ENSRNOT00000087892
Popdc2
popeye domain containing 2
chr7_-_143538579 37.70 ENSRNOT00000081518
Krt79
keratin 79
chr7_+_138707426 36.54 ENSRNOT00000037874
Pced1b
PC-esterase domain containing 1B
chr3_-_112985318 36.51 ENSRNOT00000015556
Epb42
erythrocyte membrane protein band 4.2
chr4_+_57855416 35.77 ENSRNOT00000029608
Cpa2
carboxypeptidase A2
chr10_+_70417108 34.47 ENSRNOT00000079325
Slfn4
schlafen 4
chr20_+_34633157 33.41 ENSRNOT00000000469
Pln
phospholamban
chr11_-_35749464 32.63 ENSRNOT00000078818
ENSRNOT00000078425
Erg
ERG, ETS transcription factor
chr20_-_5806097 31.27 ENSRNOT00000000611
Clps
colipase
chr1_+_42121636 30.16 ENSRNOT00000025616
Myct1
myc target 1
chr10_+_70411738 29.96 ENSRNOT00000078046
Slfn4
schlafen 4
chr5_+_153197459 27.37 ENSRNOT00000023187
Rhd
Rh blood group, D antigen
chr5_+_164796185 27.26 ENSRNOT00000010779
Nppb
natriuretic peptide B
chr14_-_86146744 27.24 ENSRNOT00000019335
Myl7
myosin light chain 7
chr4_-_70628470 27.06 ENSRNOT00000029319
Try5
trypsin 5
chr6_-_7961207 26.79 ENSRNOT00000007174
Abcg5
ATP binding cassette subfamily G member 5
chr17_-_84247038 26.39 ENSRNOT00000068553
Nebl
nebulette
chr1_+_142883040 23.90 ENSRNOT00000015898
Alpk3
alpha-kinase 3
chr4_+_51661654 23.11 ENSRNOT00000087359
ENSRNOT00000072470
LOC100909784
leiomodin-2-like
chr11_+_80736576 22.88 ENSRNOT00000047678
Masp1
mannan-binding lectin serine peptidase 1
chr1_-_222272285 22.81 ENSRNOT00000028737
Fermt3
fermitin family member 3
chrX_+_53053609 21.55 ENSRNOT00000058357
Dmd
dystrophin
chr4_-_7342410 20.81 ENSRNOT00000013058
Nos3
nitric oxide synthase 3
chr9_+_52023295 20.39 ENSRNOT00000004956
Col3a1
collagen type III alpha 1 chain
chr15_-_52399074 20.13 ENSRNOT00000018440
Xpo7
exportin 7
chr19_+_55094585 19.87 ENSRNOT00000068452
Zfpm1
zinc finger protein, multitype 1
chr5_+_151776004 19.80 ENSRNOT00000009683
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr16_+_2634603 18.39 ENSRNOT00000019113
Hesx1
HESX homeobox 1
chr9_-_49950093 18.19 ENSRNOT00000023014
Fhl2
four and a half LIM domains 2
chr13_-_61591139 17.88 ENSRNOT00000005324
Rgs18
regulator of G-protein signaling 18
chr3_+_55910177 17.76 ENSRNOT00000009969
Klhl41
kelch-like family member 41
chr17_+_8489266 17.71 ENSRNOT00000016252
Lect2
leukocyte cell-derived chemotaxin 2
chr1_-_275906686 17.60 ENSRNOT00000092170
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_40244081 16.70 ENSRNOT00000030583
Sh2b3
SH2B adaptor protein 3
chr4_-_170932618 16.55 ENSRNOT00000007779
Arhgdib
Rho GDP dissociation inhibitor beta
chr7_+_59326518 16.37 ENSRNOT00000085231
Ptprb
protein tyrosine phosphatase, receptor type, B
chr10_-_104628676 16.08 ENSRNOT00000010466
Unc13d
unc-13 homolog D
chr5_-_76632462 15.76 ENSRNOT00000085109
Susd1
sushi domain containing 1
chr20_-_5076539 15.51 ENSRNOT00000076253
ENSRNOT00000037613
Ly6g6f
lymphocyte antigen 6 complex, locus G6F
chr5_+_25168295 15.23 ENSRNOT00000020245
Fsbp
fibrinogen silencer binding protein
chr17_+_9639330 15.17 ENSRNOT00000018232
Dok3
docking protein 3
chr14_-_21252538 14.43 ENSRNOT00000005003
Ambn
ameloblastin
chr20_+_27954433 14.09 ENSRNOT00000064288
Lims1
LIM zinc finger domain containing 1
chr3_-_148722710 14.05 ENSRNOT00000090919
ENSRNOT00000068592
Plagl2
PLAG1 like zinc finger 2
chr10_+_107455845 13.46 ENSRNOT00000004373
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr1_-_258877045 13.43 ENSRNOT00000071633
Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
chr2_-_198002625 12.83 ENSRNOT00000091888
BC028528
cDNA sequence BC028528
chr4_+_158088505 12.72 ENSRNOT00000026643
Vwf
von Willebrand factor
chr6_-_127653124 12.15 ENSRNOT00000047324
Serpina11
serpin family A member 11
chr5_-_79691258 12.03 ENSRNOT00000072920
Tnfsf8
tumor necrosis factor superfamily member 8
chr6_+_7961413 12.02 ENSRNOT00000007638
ENSRNOT00000061871
Abcg8
ATP binding cassette subfamily G member 8
chr7_+_12144162 11.31 ENSRNOT00000077122
Tcf3
transcription factor 3
chr10_+_108132105 11.29 ENSRNOT00000072534
Cbx2
chromobox 2
chr2_+_227080924 10.99 ENSRNOT00000029871
Fabp2
fatty acid binding protein 2
chr19_-_37916813 10.77 ENSRNOT00000026585
Lcat
lecithin cholesterol acyltransferase
chr7_+_117967818 10.59 ENSRNOT00000073724
LOC100360117
ribosomal protein L8-like
chr16_-_73827488 10.56 ENSRNOT00000064070
Ank1
ankyrin 1
chr15_+_34234755 10.35 ENSRNOT00000059987
Dcaf11
DDB1 and CUL4 associated factor 11
chr16_+_31734944 9.80 ENSRNOT00000059673
Palld
palladin, cytoskeletal associated protein
chr5_+_154522119 9.57 ENSRNOT00000072618
E2f2
E2F transcription factor 2
chr3_+_93909156 8.99 ENSRNOT00000090365
Lmo2
LIM domain only 2
chr3_+_4034921 8.48 ENSRNOT00000026318
Egfl7
EGF-like-domain, multiple 7
chr7_-_70467915 8.08 ENSRNOT00000088995
Slc26a10
solute carrier family 26, member 10
chr17_-_27112820 7.98 ENSRNOT00000018359
Bmp6
bone morphogenetic protein 6
chr3_+_59153280 7.71 ENSRNOT00000002066
Cdca7
cell division cycle associated 7
chr10_+_103874383 7.41 ENSRNOT00000038935
Otop2
otopetrin 2
chr2_-_96668222 7.20 ENSRNOT00000016567
Pkia
cAMP-dependent protein kinase inhibitor alpha
chr3_+_56766475 7.13 ENSRNOT00000078819
Sp5
Sp5 transcription factor
chr6_+_137164535 6.70 ENSRNOT00000018225
Inf2
inverted formin, FH2 and WH2 domain containing
chr20_+_31265483 6.60 ENSRNOT00000079584
ENSRNOT00000000674
Ppa1
pyrophosphatase (inorganic) 1
chr2_-_60657712 6.37 ENSRNOT00000040348
Rai14
retinoic acid induced 14
chr4_-_165541314 6.30 ENSRNOT00000013833
Styk1
serine/threonine/tyrosine kinase 1
chr19_+_37600148 6.27 ENSRNOT00000023853
Ctcf
CCCTC-binding factor
chr1_-_221370322 6.24 ENSRNOT00000028431
Capn1
calpain 1
chr3_+_72447969 5.75 ENSRNOT00000012022
Ssrp1
structure specific recognition protein 1
chr5_-_147584038 5.65 ENSRNOT00000010983
Zbtb8a
zinc finger and BTB domain containing 8a
chr20_-_27657983 5.61 ENSRNOT00000057313
Fam26e
family with sequence similarity 26, member E
chr2_+_208373154 5.53 ENSRNOT00000082943
ENSRNOT00000050538
LOC100911796
adenosine receptor A3-like
chrX_+_83678339 5.46 ENSRNOT00000005997
Apool
apolipoprotein O-like
chr3_-_72447801 5.10 ENSRNOT00000088815
P2rx3
purinergic receptor P2X 3
chr2_-_105047984 4.98 ENSRNOT00000014970
Cpa3
carboxypeptidase A3
chr10_+_83154423 4.85 ENSRNOT00000005939
Fam117a
family with sequence similarity 117, member A
chr7_-_143392777 4.73 ENSRNOT00000086504
ENSRNOT00000038105
Krt72
keratin 72
chr4_+_102290338 4.68 ENSRNOT00000011067
AABR07060992.1

chr10_+_57260680 4.66 ENSRNOT00000035445
Gp1ba
glycoprotein Ib platelet alpha subunit
chr14_-_45165207 4.44 ENSRNOT00000002960
Klf3
Kruppel like factor 3
chr20_+_46428124 4.42 ENSRNOT00000000327
Foxo3
forkhead box O3
chr5_+_33097654 4.26 ENSRNOT00000008087
Cngb3
cyclic nucleotide gated channel beta 3
chr17_+_76008807 3.73 ENSRNOT00000070895
Echdc3
enoyl CoA hydratase domain containing 3
chr5_+_57239086 3.33 ENSRNOT00000060714
Spink4
serine peptidase inhibitor, Kazal type 4
chr3_-_74815509 3.30 ENSRNOT00000045173
Olr499
olfactory receptor 499
chr11_-_78327282 2.59 ENSRNOT00000002636
Tp63
tumor protein p63
chr14_-_18862407 2.53 ENSRNOT00000003823
Cxcl6
C-X-C motif chemokine ligand 6
chr1_+_88451958 2.34 ENSRNOT00000074301
LOC102549115
zinc finger protein 260-like
chr2_-_189602143 2.27 ENSRNOT00000032062
Creb3l4
cAMP responsive element binding protein 3-like 4
chr1_+_243375981 2.20 ENSRNOT00000080689
Kank1
KN motif and ankyrin repeat domains 1
chr16_+_54291251 2.13 ENSRNOT00000079006
Mtus1
microtubule associated tumor suppressor 1
chr11_-_782954 1.95 ENSRNOT00000040065
Epha3
Eph receptor A3
chr1_-_242373764 1.77 ENSRNOT00000076544
Fam122a
family with sequence similarity 122A
chr17_-_44948432 1.77 ENSRNOT00000092195
LOC103690297
putative olfactory receptor 2W6
chr1_+_175445088 1.71 ENSRNOT00000036718
Adm
adrenomedullin
chr1_-_126211439 1.66 ENSRNOT00000014988
Tjp1
tight junction protein 1
chr10_-_102227554 1.56 ENSRNOT00000078035
AC096468.1

chr7_+_71023976 1.29 ENSRNOT00000005679
Tac3
tachykinin 3
chr10_+_83840303 1.28 ENSRNOT00000008481
Gip
gastric inhibitory polypeptide
chr12_+_22274828 1.22 ENSRNOT00000001914
Epo
erythropoietin
chr3_+_159936856 1.14 ENSRNOT00000078703
Hnf4a
hepatocyte nuclear factor 4, alpha
chr7_-_5106708 0.98 ENSRNOT00000046001
Olr892
olfactory receptor 892
chr10_-_42928461 0.86 ENSRNOT00000058619
Fam114a2
family with sequence similarity 114, member A2
chr3_+_76842898 0.78 ENSRNOT00000085537
Olr636
olfactory receptor 636
chr1_+_169636914 0.73 ENSRNOT00000074466
Olr158
olfactory receptor 158
chr1_+_169951913 0.72 ENSRNOT00000040861
Olr189
olfactory receptor 189
chr4_-_155690869 0.67 ENSRNOT00000012216
C3ar1
complement C3a receptor 1
chr7_+_5593735 0.65 ENSRNOT00000042179
Olr917
olfactory receptor 917
chr10_+_61403130 0.62 ENSRNOT00000092490
ENSRNOT00000077649
Ccdc92b
coiled-coil domain containing 92B
chr10_-_39054142 0.59 ENSRNOT00000063772
Rad50
RAD50 double strand break repair protein
chr6_-_7421456 0.53 ENSRNOT00000006725
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr17_-_78561613 0.41 ENSRNOT00000020220
Fam107b
family with sequence similarity 107, member B
chr15_+_33069382 0.33 ENSRNOT00000060193
Mrpl52
mitochondrial ribosomal protein L52
chr14_+_85230648 0.27 ENSRNOT00000089866
Ap1b1
adaptor-related protein complex 1, beta 1 subunit
chr4_+_10748745 0.25 ENSRNOT00000046142
Rsbn1l
round spermatid basic protein 1-like
chr10_-_36502313 0.22 ENSRNOT00000041273
LOC679794
similar to Cytochrome c, somatic
chr2_-_123851854 0.04 ENSRNOT00000023327
Il2
interleukin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata2_Gata1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
40.5 121.4 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
35.8 179.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
19.3 57.9 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
16.6 66.4 GO:0060375 regulation of mast cell differentiation(GO:0060375)
14.8 133.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
14.7 73.7 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) negative regulation of glucokinase activity(GO:0033132) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) negative regulation of hexokinase activity(GO:1903300)
13.1 39.4 GO:0060931 sinoatrial node cell development(GO:0060931)
12.5 50.0 GO:0061113 pancreas morphogenesis(GO:0061113)
12.2 61.1 GO:0006526 arginine biosynthetic process(GO:0006526)
9.9 39.6 GO:1904373 response to kainic acid(GO:1904373)
9.7 38.8 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
9.4 94.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
8.8 26.4 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
8.2 130.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
8.0 55.7 GO:0015670 carbon dioxide transport(GO:0015670)
7.7 84.5 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
7.2 21.5 GO:0021627 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
7.1 120.7 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
6.8 20.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
5.5 16.6 GO:0071461 cellular response to redox state(GO:0071461)
5.4 32.6 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
5.4 16.1 GO:0002432 granuloma formation(GO:0002432)
5.4 21.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
5.2 20.8 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
4.7 66.3 GO:0017014 protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
4.1 41.2 GO:0001955 blood vessel maturation(GO:0001955)
3.9 27.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
3.3 23.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
3.1 18.4 GO:0030916 otic vesicle formation(GO:0030916)
2.7 61.0 GO:0030574 collagen catabolic process(GO:0030574)
2.4 42.8 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
2.3 53.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
2.2 35.0 GO:0020027 hemoglobin metabolic process(GO:0020027)
2.1 40.4 GO:0035855 megakaryocyte development(GO:0035855)
2.1 27.4 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
2.1 22.8 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
2.0 17.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
1.9 22.9 GO:2000258 complement activation, lectin pathway(GO:0001867) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
1.8 10.8 GO:0034370 triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372)
1.8 14.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.6 9.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.5 44.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.5 18.2 GO:0060347 heart trabecula formation(GO:0060347)
1.4 11.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
1.4 12.7 GO:0070417 cellular response to cold(GO:0070417)
1.2 17.8 GO:2000291 regulation of myoblast proliferation(GO:2000291)
1.2 14.0 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
1.0 25.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.9 64.4 GO:0048286 lung alveolus development(GO:0048286)
0.9 46.7 GO:0070527 platelet aggregation(GO:0070527)
0.9 12.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.8 2.5 GO:0070948 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.8 6.3 GO:0010216 maintenance of DNA methylation(GO:0010216) nucleosome positioning(GO:0016584)
0.8 79.8 GO:0008203 cholesterol metabolic process(GO:0008203)
0.7 4.4 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.7 5.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.7 10.6 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.7 90.8 GO:0031638 zymogen activation(GO:0031638)
0.7 7.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.7 2.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.6 6.2 GO:0060056 mammary gland involution(GO:0060056)
0.6 9.8 GO:0003334 keratinocyte development(GO:0003334)
0.6 5.0 GO:0060177 regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.5 2.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 31.3 GO:0032094 response to food(GO:0032094)
0.5 5.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.5 13.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.5 59.3 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.4 1.7 GO:0060529 ectoderm and mesoderm interaction(GO:0007499) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) female genitalia morphogenesis(GO:0048807) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.4 34.9 GO:0030218 erythrocyte differentiation(GO:0030218)
0.4 46.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 5.5 GO:0042407 cristae formation(GO:0042407)
0.3 8.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 1.1 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.3 1.7 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.3 17.1 GO:0006611 protein export from nucleus(GO:0006611)
0.3 1.3 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.2 0.7 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.2 1.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 1.7 GO:0071000 response to magnetism(GO:0071000)
0.2 13.3 GO:0055013 cardiac muscle cell development(GO:0055013)
0.2 6.3 GO:0043304 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.2 17.9 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.2 11.0 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.2 14.4 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.2 19.8 GO:0007219 Notch signaling pathway(GO:0007219)
0.2 10.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 111.4 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.2 16.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.5 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 2.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.1 7.1 GO:0060349 bone morphogenesis(GO:0060349)
0.1 61.7 GO:0006508 proteolysis(GO:0006508)
0.1 2.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 1.1 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.0 GO:0001777 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
24.3 97.3 GO:1990584 cardiac Troponin complex(GO:1990584)
15.7 94.1 GO:0097512 cardiac myofibril(GO:0097512)
12.9 38.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
11.6 57.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
11.1 33.4 GO:0090534 calcium ion-transporting ATPase complex(GO:0090534)
2.8 16.6 GO:0033093 Weibel-Palade body(GO:0033093)
2.3 46.5 GO:0005614 interstitial matrix(GO:0005614)
1.7 20.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.6 46.5 GO:0031430 M band(GO:0031430)
1.6 27.2 GO:0031672 A band(GO:0031672)
1.2 169.1 GO:0030018 Z disc(GO:0030018)
1.2 42.1 GO:0008305 integrin complex(GO:0008305)
1.1 11.0 GO:0045179 apical cortex(GO:0045179)
0.8 5.5 GO:0061617 MICOS complex(GO:0061617)
0.8 11.3 GO:0035102 PRC1 complex(GO:0035102)
0.7 25.9 GO:0002102 podosome(GO:0002102)
0.7 42.4 GO:0045095 keratin filament(GO:0045095)
0.7 60.2 GO:0030667 secretory granule membrane(GO:0030667)
0.7 1006.0 GO:0005615 extracellular space(GO:0005615)
0.5 36.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.5 61.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 51.0 GO:0042383 sarcolemma(GO:0042383)
0.4 10.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 4.7 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.4 19.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 26.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 5.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 50.6 GO:0000793 condensed chromosome(GO:0000793)
0.2 39.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 61.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 9.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 30.9 GO:0005925 focal adhesion(GO:0005925)
0.1 35.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 21.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 16.4 GO:0043235 receptor complex(GO:0043235)
0.1 4.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 6.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 6.4 GO:0001650 fibrillar center(GO:0001650)
0.0 56.2 GO:0005739 mitochondrion(GO:0005739)
0.0 25.2 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 21.7 GO:0016604 nuclear body(GO:0016604)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 2.0 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.3 97.3 GO:0030172 troponin C binding(GO:0030172)
21.0 146.9 GO:0031433 telethonin binding(GO:0031433)
19.3 57.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
14.6 43.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
13.5 121.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
11.1 44.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
11.1 66.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
10.5 73.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
8.6 94.1 GO:0032036 myosin heavy chain binding(GO:0032036)
7.0 42.1 GO:0070051 fibrinogen binding(GO:0070051)
7.0 55.7 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
6.7 133.4 GO:0004806 triglyceride lipase activity(GO:0004806)
6.5 176.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
5.8 40.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
5.8 40.8 GO:0030492 hemoglobin binding(GO:0030492)
5.6 77.8 GO:0042301 phosphate ion binding(GO:0042301)
5.2 20.8 GO:0034618 arginine binding(GO:0034618)
4.8 33.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
3.7 36.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
3.6 14.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
3.3 49.5 GO:0005523 tropomyosin binding(GO:0005523)
2.9 17.6 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
2.8 11.3 GO:0070644 vitamin D response element binding(GO:0070644)
2.5 20.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
2.3 120.7 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
2.2 10.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
2.1 10.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.8 11.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.6 44.0 GO:0005540 hyaluronic acid binding(GO:0005540)
1.6 46.5 GO:0001968 fibronectin binding(GO:0001968)
1.5 134.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.5 20.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.5 319.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.3 6.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
1.2 7.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.1 16.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.1 27.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.1 21.5 GO:0017166 vinculin binding(GO:0017166)
1.0 52.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
1.0 39.4 GO:0030552 cAMP binding(GO:0030552)
0.9 19.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.7 75.5 GO:0005178 integrin binding(GO:0005178)
0.6 5.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.5 4.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 13.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.4 1.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.4 8.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.4 8.5 GO:0005112 Notch binding(GO:0005112)
0.4 15.2 GO:0005158 insulin receptor binding(GO:0005158)
0.3 44.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 29.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 2.3 GO:0035497 cAMP response element binding(GO:0035497)
0.3 12.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 1.7 GO:0071253 connexin binding(GO:0071253)
0.3 6.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 9.0 GO:0070888 E-box binding(GO:0070888)
0.2 2.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 2.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 11.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 16.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 6.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 71.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.6 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 9.6 GO:0001047 core promoter binding(GO:0001047)
0.1 17.9 GO:0005096 GTPase activator activity(GO:0005096)
0.1 41.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.7 GO:0004875 complement receptor activity(GO:0004875)
0.1 6.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 10.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 7.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 18.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 66.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.8 57.6 PID EPO PATHWAY EPO signaling pathway
1.7 44.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.7 121.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
1.5 47.0 PID ALK1 PATHWAY ALK1 signaling events
1.5 42.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
1.4 338.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.2 19.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
1.2 20.8 PID VEGFR1 PATHWAY VEGFR1 specific signals
1.1 59.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 24.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.7 12.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.7 17.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.6 9.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.6 55.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 11.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 37.6 PID CMYB PATHWAY C-MYB transcription factor network
0.4 130.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.4 59.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 14.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 16.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 6.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 8.2 PID ENDOTHELIN PATHWAY Endothelins
0.2 4.3 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 7.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 16.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 121.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
6.8 61.0 REACTOME DEFENSINS Genes involved in Defensins
5.4 272.2 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
5.0 84.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
3.0 54.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
2.9 112.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
2.5 73.7 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
2.1 22.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.7 20.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1.4 51.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.9 17.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.8 14.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.8 39.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8 16.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.6 9.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.5 4.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 11.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 19.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 5.7 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.2 4.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 37.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 19.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 12.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.2 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 5.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks