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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gli2

Z-value: 0.74

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Transcription factors associated with Gli2

Gene Symbol Gene ID Gene Info
Gli2
ENSRNOG00000007261 GLI family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gli2rn6_v1_chr13_-_35048444_35048444-0.131.8e-02Click!

Activity profile of Gli2 motif

Sorted Z-values of Gli2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_170431073 25.60 ENSRNOT00000024710
Hpx
hemopexin
chr8_+_116332796 21.15 ENSRNOT00000021408
Hyal1
hyaluronoglucosaminidase 1
chr1_-_85220237 17.82 ENSRNOT00000026907
Sycn
syncollin
chr3_+_170354141 16.95 ENSRNOT00000005901
Fam210b
family with sequence similarity 210, member B
chr1_-_256813711 16.85 ENSRNOT00000021055
Rbp4
retinol binding protein 4
chr7_+_54980120 14.82 ENSRNOT00000005690
ENSRNOT00000005773
Kcnc2
potassium voltage-gated channel subfamily C member 2
chr20_-_2652952 14.24 ENSRNOT00000078871
C4a
complement component 4A (Rodgers blood group)
chr7_+_120125633 13.96 ENSRNOT00000012480
Sh3bp1
SH3-domain binding protein 1
chr4_-_78458179 13.34 ENSRNOT00000078473
ENSRNOT00000011327
Tmem176b
transmembrane protein 176B
chr6_-_92643847 12.87 ENSRNOT00000009183
Pygl
glycogen phosphorylase L
chr1_-_146736261 10.45 ENSRNOT00000068167
Fah
fumarylacetoacetate hydrolase
chr17_-_90756048 9.44 ENSRNOT00000085669
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr3_+_61658245 9.44 ENSRNOT00000033511
Hoxd3
homeo box D3
chr8_-_25904564 9.20 ENSRNOT00000082744
ENSRNOT00000064783
Tbx20
T-box 20
chr3_-_123630929 8.57 ENSRNOT00000028855
Siglec1
sialic acid binding Ig like lectin 1
chr8_+_49354115 8.48 ENSRNOT00000032837
Mpzl3
myelin protein zero-like 3
chr2_-_149417212 8.08 ENSRNOT00000018573
Gpr87
G protein-coupled receptor 87
chr17_-_90755852 7.69 ENSRNOT00000003526
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr3_-_83048289 7.48 ENSRNOT00000047571
ENSRNOT00000012806
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
chr10_-_13580821 7.26 ENSRNOT00000009735
Ntn3
netrin 3
chr6_+_12253788 7.19 ENSRNOT00000061675
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr12_+_30165694 7.17 ENSRNOT00000001211
Asl
argininosuccinate lyase
chr5_+_135962911 6.66 ENSRNOT00000087353
Ptch2
patched 2
chr16_+_23668595 6.57 ENSRNOT00000067886
Psd3
pleckstrin and Sec7 domain containing 3
chr7_+_80351774 6.30 ENSRNOT00000081948
Oxr1
oxidation resistance 1
chrX_+_70563570 5.75 ENSRNOT00000003772
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_-_242441247 5.71 ENSRNOT00000068645
Pip5k1b
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chr6_+_58468155 5.69 ENSRNOT00000091263
Etv1
ets variant 1
chr14_+_83341851 5.64 ENSRNOT00000086090
Pisd
phosphatidylserine decarboxylase
chr1_-_281756159 5.53 ENSRNOT00000013170
Prlhr
prolactin releasing hormone receptor
chr4_-_100660140 5.44 ENSRNOT00000020005
Tcf7l1
transcription factor 7 like 1
chr8_-_47529689 5.07 ENSRNOT00000012826
Oaf
out at first homolog
chr8_-_22821397 5.05 ENSRNOT00000045488
Kank2
KN motif and ankyrin repeat domains 2
chr6_+_126170911 4.97 ENSRNOT00000077477
Rin3
Ras and Rab interactor 3
chr4_-_132740938 4.94 ENSRNOT00000007185
Rybp
RING1 and YY1 binding protein
chr8_-_22821223 4.88 ENSRNOT00000014135
Kank2
KN motif and ankyrin repeat domains 2
chr6_+_126170720 4.79 ENSRNOT00000065246
Rin3
Ras and Rab interactor 3
chr2_-_196526886 4.68 ENSRNOT00000077325
Setdb1
SET domain, bifurcated 1
chr9_+_54558202 4.67 ENSRNOT00000068433
Myo1b
myosin Ib
chr2_+_125752130 4.64 ENSRNOT00000038703
Fat4
FAT atypical cadherin 4
chr6_-_51257625 4.61 ENSRNOT00000012004
Hbp1
HMG-box transcription factor 1
chr12_-_44999074 4.40 ENSRNOT00000079177
ENSRNOT00000038293
Vsig10
V-set and immunoglobulin domain containing 10
chr16_-_9430743 4.39 ENSRNOT00000043811
Wdfy4
WDFY family member 4
chr12_+_41385241 4.33 ENSRNOT00000074974
Dtx1
deltex E3 ubiquitin ligase 1
chr2_-_196527127 4.32 ENSRNOT00000028709
Setdb1
SET domain, bifurcated 1
chr4_+_171748273 4.27 ENSRNOT00000009998
Dera
deoxyribose-phosphate aldolase
chr1_+_221099998 4.16 ENSRNOT00000028262
Ltbp3
latent transforming growth factor beta binding protein 3
chr10_+_65448950 4.14 ENSRNOT00000082348
ENSRNOT00000037016
Rab34
RAB34, member RAS oncogene family
chr6_-_7421456 4.05 ENSRNOT00000006725
Zfp36l2
zinc finger protein 36, C3H type-like 2
chrX_+_20216587 3.94 ENSRNOT00000073114
AABR07037412.2
FYVE, RhoGEF and PH domain-containing protein 1
chr1_-_52544450 3.93 ENSRNOT00000043474
Pde10a
phosphodiesterase 10A
chr19_+_52086325 3.83 ENSRNOT00000020341
Necab2
N-terminal EF-hand calcium binding protein 2
chr14_+_60123169 3.81 ENSRNOT00000006610
Sel1l3
SEL1L family member 3
chr1_+_215214853 3.58 ENSRNOT00000071235
ENSRNOT00000080442
LOC103690160
SH3 and multiple ankyrin repeat domains protein 2-like
chr10_+_103934797 3.53 ENSRNOT00000035865
Cdr2l
cerebellar degeneration-related protein 2-like
chr13_+_85580828 3.35 ENSRNOT00000005611
Aldh9a1
aldehyde dehydrogenase 9 family, member A1
chr10_+_58860940 3.28 ENSRNOT00000056551
ENSRNOT00000074523
XAF1
XIAP associated factor-1
chr4_-_82702429 3.25 ENSRNOT00000011069
Hibadh
3-hydroxyisobutyrate dehydrogenase
chr2_+_248249468 3.20 ENSRNOT00000022648
Gbp4
guanylate binding protein 4
chr3_-_11410732 3.18 ENSRNOT00000034930
RGD1561113
similar to Hypothetical UPF0184 protein C9orf16 homolog
chr20_+_5933303 3.07 ENSRNOT00000000617
Mapk14
mitogen activated protein kinase 14
chr1_-_190965115 3.05 ENSRNOT00000023483
AC103221.1

chr7_-_119716238 2.93 ENSRNOT00000075678
Il2rb
interleukin 2 receptor subunit beta
chr2_+_189430041 2.76 ENSRNOT00000023567
ENSRNOT00000023605
Tpm3
tropomyosin 3
chr17_+_56935451 2.70 ENSRNOT00000058966
RGD1564129
similar to hypothetical protein 4930474N05
chr1_+_190964885 2.55 ENSRNOT00000039186
Mettl9
methyltransferase like 9
chr8_-_122841477 2.51 ENSRNOT00000014861
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr1_+_141767940 2.37 ENSRNOT00000064034
Zfp710
zinc finger protein 710
chr10_-_71441389 2.31 ENSRNOT00000003699
Tada2a
transcriptional adaptor 2A
chr10_+_104582955 2.30 ENSRNOT00000009733
Unk
unkempt family zinc finger
chr7_-_11443357 2.27 ENSRNOT00000082126
Zbtb7a
zinc finger and BTB domain containing 7a
chr8_-_59849427 2.20 ENSRNOT00000020332
ENSRNOT00000083900
Nrg4
neuregulin 4
chr4_-_50312608 1.88 ENSRNOT00000010019
Fezf1
Fez family zinc finger 1
chr1_-_214511529 1.85 ENSRNOT00000026390
Chid1
chitinase domain containing 1
chr7_-_2353875 1.80 ENSRNOT00000074873
LOC100911319
zinc finger protein 36, C3H1 type-like 2-like
chr7_+_2718700 1.79 ENSRNOT00000050792
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr4_+_168976859 1.79 ENSRNOT00000068663
Fam234b
family with sequence similarity 234, member B
chr10_-_90265017 1.71 ENSRNOT00000064283
ENSRNOT00000048418
Ubtf
upstream binding transcription factor, RNA polymerase I
chr18_-_28017925 1.66 ENSRNOT00000075420
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chrX_+_53360839 1.65 ENSRNOT00000091467
ENSRNOT00000034372
ENSRNOT00000081061
Dmd
dystrophin
chr10_+_107502695 1.60 ENSRNOT00000038088
Engase
endo-beta-N-acetylglucosaminidase
chr15_-_60056582 1.57 ENSRNOT00000087569
ENSRNOT00000012530
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
chr20_-_4401610 1.55 ENSRNOT00000091468
Ppt2
palmitoyl-protein thioesterase 2
chr10_+_57462447 1.54 ENSRNOT00000041443
Rabep1
rabaptin, RAB GTPase binding effector protein 1
chr9_-_100624638 1.52 ENSRNOT00000051155
Hdlbp
high density lipoprotein binding protein
chr9_-_43022998 1.43 ENSRNOT00000063781
ENSRNOT00000089843
Lman2l
lectin, mannose-binding 2-like
chr9_-_11108741 1.42 ENSRNOT00000072357
Ccdc94
coiled-coil domain containing 94
chr8_-_107380933 1.42 ENSRNOT00000022179
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr5_-_77031120 1.37 ENSRNOT00000022987
Inip
INTS3 and NABP interacting protein
chr9_+_111220858 1.36 ENSRNOT00000076669
Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr17_+_57864244 1.34 ENSRNOT00000089527
LOC102551575
isopentenyl-diphosphate delta-isomerase 2-like
chr1_+_81456984 1.29 ENSRNOT00000027075
Ethe1
ETHE1, persulfide dioxygenase
chr1_-_214074663 1.25 ENSRNOT00000026215
LOC100911881
chitinase domain-containing protein 1-like
chr14_-_83641892 1.18 ENSRNOT00000026032
Limk2
LIM domain kinase 2
chrX_+_73390903 1.08 ENSRNOT00000077002
Zfp449
zinc finger protein 449
chrX_+_28435507 1.02 ENSRNOT00000005615
Prps2
phosphoribosyl pyrophosphate synthetase 2
chrX_+_156863754 0.99 ENSRNOT00000083611
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr2_+_18937458 0.97 ENSRNOT00000022377
Tmem167a
transmembrane protein 167A
chr3_+_112371677 0.94 ENSRNOT00000013316
LOC100912076
HAUS augmin-like complex subunit 2-like
chr2_-_94730978 0.92 ENSRNOT00000087598
Zbtb10
zinc finger and BTB domain containing 10
chr6_+_132702448 0.86 ENSRNOT00000005743
Yy1
YY1 transcription factor
chr7_-_11257977 0.85 ENSRNOT00000027932
Tbxa2r
thromboxane A2 receptor
chr17_+_47241017 0.84 ENSRNOT00000092193
Gpr141
G protein-coupled receptor 141
chr20_+_3555135 0.84 ENSRNOT00000085380
Ddr1
discoidin domain receptor tyrosine kinase 1
chr5_-_59198650 0.84 ENSRNOT00000020958
Olr833
olfactory receptor 833
chr10_-_57671080 0.83 ENSRNOT00000082511
LOC691995
hypothetical protein LOC691995
chr12_+_21721837 0.79 ENSRNOT00000073353
Mepce
methylphosphate capping enzyme
chr7_-_70552897 0.75 ENSRNOT00000080594
Kif5a
kinesin family member 5A
chr19_+_60017746 0.66 ENSRNOT00000042623
Pard3
par-3 family cell polarity regulator
chr3_-_3691972 0.65 ENSRNOT00000061735
Qsox2
quiescin sulfhydryl oxidase 2
chr3_-_165741967 0.64 ENSRNOT00000017063
Zfp64
zinc finger protein 64
chr12_-_17972737 0.58 ENSRNOT00000001783
Fam20c
FAM20C, golgi associated secretory pathway kinase
chr8_+_55279373 0.54 ENSRNOT00000064290
Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
chr19_+_10519493 0.50 ENSRNOT00000030229
Ccdc102a
coiled-coil domain containing 102A
chr6_-_111572949 0.48 ENSRNOT00000016884
RGD1565693
similar to GLE1-like, RNA export mediator isoform 1
chr9_-_15700235 0.47 ENSRNOT00000088713
ENSRNOT00000035907
Trerf1
transcriptional regulating factor 1
chr10_-_56591364 0.43 ENSRNOT00000032481
Elp5
elongator acetyltransferase complex subunit 5
chr17_-_2705123 0.41 ENSRNOT00000024940
Olr1652
olfactory receptor 1652
chr8_+_25246292 0.38 ENSRNOT00000021625
Npsr1
neuropeptide S receptor 1
chr1_-_59347472 0.34 ENSRNOT00000017718
Lnpep
leucyl and cystinyl aminopeptidase
chr17_-_27452314 0.34 ENSRNOT00000018936
Riok1
RIO kinase 1
chr5_+_171441560 0.31 ENSRNOT00000019873
Wrap73
WD repeat containing, antisense to TP73
chr15_+_48327461 0.30 ENSRNOT00000018071
Ints9
integrator complex subunit 9
chr8_-_116532169 0.30 ENSRNOT00000085364
Rbm5
RNA binding motif protein 5
chr4_+_6559545 0.26 ENSRNOT00000067183
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
chrX_+_29157470 0.19 ENSRNOT00000081986
LOC100910245
ribose-phosphate pyrophosphokinase 2-like
chr9_+_26841299 0.18 ENSRNOT00000016664
Il17a
interleukin 17A
chr7_-_9193141 0.17 ENSRNOT00000046955
Olr1061
olfactory receptor 1061
chr1_+_198409360 0.17 ENSRNOT00000013691
ENSRNOT00000091295
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr8_+_32530806 0.12 ENSRNOT00000083659
Nfrkb
nuclear factor related to kappa B binding protein
chr5_-_144341586 0.07 ENSRNOT00000014586
Adprhl2
ADP-ribosylhydrolase like 2
chr19_-_25288335 0.02 ENSRNOT00000050214
Nanos3
nanos C2HC-type zinc finger 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 25.6 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
5.6 16.8 GO:0046865 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
5.3 21.2 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
3.5 13.9 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
3.4 17.1 GO:0030070 insulin processing(GO:0030070)
3.3 13.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
3.3 9.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
3.1 9.2 GO:0060577 visceral motor neuron differentiation(GO:0021524) pulmonary vein morphogenesis(GO:0060577)
2.5 14.8 GO:0021759 globus pallidus development(GO:0021759)
2.4 7.2 GO:0000053 argininosuccinate metabolic process(GO:0000053)
2.4 9.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
2.3 9.0 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
1.7 10.5 GO:0006572 tyrosine catabolic process(GO:0006572)
1.5 4.6 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.4 4.2 GO:1902462 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.4 5.4 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
1.1 3.3 GO:0006574 valine catabolic process(GO:0006574)
0.9 4.3 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.8 7.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.8 7.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.8 3.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.7 8.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.6 2.5 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.6 2.9 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.6 1.7 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.6 3.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.5 1.6 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.5 5.7 GO:0090527 actin filament reorganization(GO:0090527)
0.5 5.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 8.6 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.5 1.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 4.1 GO:0090385 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
0.4 14.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 5.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 1.0 GO:0017198 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.3 2.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 4.9 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.3 1.3 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
0.3 4.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.3 3.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 6.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 0.8 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 1.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 0.9 GO:0034696 response to prostaglandin F(GO:0034696)
0.2 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 3.2 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.2 0.6 GO:0097187 odontoblast differentiation(GO:0071895) dentinogenesis(GO:0097187)
0.2 1.6 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.2 1.9 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.2 1.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 1.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 4.6 GO:0032369 negative regulation of lipid transport(GO:0032369) negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.1 4.3 GO:0045581 negative regulation of T cell differentiation(GO:0045581)
0.1 5.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.7 GO:0003383 apical constriction(GO:0003383)
0.1 1.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.3 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.1 0.8 GO:0040031 snRNA modification(GO:0040031)
0.1 0.4 GO:1903999 negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.1 11.7 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.1 1.6 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 8.5 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0 4.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 4.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.5 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 2.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.0 4.9 GO:0007411 axon guidance(GO:0007411)
0.0 3.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.2 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 1.5 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 2.8 GO:0006936 muscle contraction(GO:0006936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.2 GO:0036117 hyaluranon cable(GO:0036117)
0.8 3.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.4 7.2 GO:0070852 cell body fiber(GO:0070852)
0.4 14.7 GO:0030673 axolemma(GO:0030673)
0.4 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 2.3 GO:0000125 PCAF complex(GO:0000125)
0.4 5.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 1.4 GO:0070876 SOSS complex(GO:0070876)
0.2 9.4 GO:0016235 aggresome(GO:0016235)
0.2 1.0 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 17.8 GO:0030667 secretory granule membrane(GO:0030667)
0.2 25.6 GO:0072562 blood microparticle(GO:0072562)
0.2 4.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 5.8 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.7 GO:0033269 internode region of axon(GO:0033269)
0.1 1.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) filopodium membrane(GO:0031527) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 4.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 5.7 GO:0005884 actin filament(GO:0005884)
0.0 2.3 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 8.9 GO:0005769 early endosome(GO:0005769)
0.0 9.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 20.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.1 GO:0000922 spindle pole(GO:0000922)
0.0 8.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 5.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.9 GO:0005770 late endosome(GO:0005770)
0.0 0.5 GO:0016459 myosin complex(GO:0016459)
0.0 5.7 GO:0030424 axon(GO:0030424)
0.0 2.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 22.0 GO:0005739 mitochondrion(GO:0005739)
0.0 8.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 21.9 GO:0070062 extracellular exosome(GO:0070062)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
3.5 10.5 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
2.8 25.6 GO:0015232 heme transporter activity(GO:0015232)
2.6 13.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.5 7.5 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
1.8 7.2 GO:0016842 amidine-lyase activity(GO:0016842)
1.4 5.6 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.3 16.8 GO:0019841 retinol binding(GO:0019841)
1.1 17.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
1.0 2.9 GO:0004911 interleukin-2 receptor activity(GO:0004911)
1.0 5.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.7 5.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.7 8.1 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.6 13.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 3.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.5 3.3 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.5 5.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.4 2.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.4 3.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273) NFAT protein binding(GO:0051525)
0.3 1.4 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829)
0.3 4.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 1.0 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.3 4.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 1.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3 9.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 6.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 3.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 4.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 3.1 GO:0008061 chitin binding(GO:0008061)
0.2 9.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.6 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 1.7 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.2 3.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 9.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.3 GO:0005112 Notch binding(GO:0005112)
0.2 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 4.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 4.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 2.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.9 GO:0004954 prostanoid receptor activity(GO:0004954)
0.1 14.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 5.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 2.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 4.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 8.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 4.7 GO:0019902 phosphatase binding(GO:0019902)
0.0 1.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.8 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 2.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 6.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 5.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.2 25.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 4.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 4.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 21.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.8 PID E2F PATHWAY E2F transcription factor network
0.1 1.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 3.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.9 ST GA13 PATHWAY G alpha 13 Pathway
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 21.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.0 14.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.6 12.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 0.9 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.4 7.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 3.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.3 14.8 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.2 7.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 7.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 3.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 3.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 4.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 22.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME KINESINS Genes involved in Kinesins