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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Glis3

Z-value: 0.54

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Transcription factors associated with Glis3

Gene Symbol Gene ID Gene Info
Glis3
ENSRNOG00000014768 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Glis3rn6_v1_chr1_-_246785360_246785360-0.018.4e-01Click!

Activity profile of Glis3 motif

Sorted Z-values of Glis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_65275408 16.22 ENSRNOT00000065137
Hmga2
high mobility group AT-hook 2
chr3_+_61658245 15.61 ENSRNOT00000033511
Hoxd3
homeo box D3
chr7_+_144014173 14.61 ENSRNOT00000019403
Sp1
Sp1 transcription factor
chr4_+_82665094 12.83 ENSRNOT00000078254
AABR07060591.1

chr5_-_151977636 12.43 ENSRNOT00000009173
Arid1a
AT-rich interaction domain 1A
chr5_+_162808646 12.04 ENSRNOT00000021155
Dhrs3
dehydrogenase/reductase 3
chr10_-_13081136 11.70 ENSRNOT00000005718
Kremen2
kringle containing transmembrane protein 2
chr5_+_133620706 10.95 ENSRNOT00000053202
Gm12830
predicted gene 12830
chr1_+_72636959 10.69 ENSRNOT00000023489
Il11
interleukin 11
chrX_-_114232939 10.24 ENSRNOT00000042639
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_-_152247332 8.90 ENSRNOT00000077165
Lin28a
lin-28 homolog A
chr10_+_89181180 8.71 ENSRNOT00000078931
ENSRNOT00000027770
Wnk4
WNK lysine deficient protein kinase 4
chr9_-_92435363 8.61 ENSRNOT00000093735
ENSRNOT00000022822
ENSRNOT00000093245
Trip12
thyroid hormone receptor interactor 12
chr12_+_21721837 7.55 ENSRNOT00000073353
Mepce
methylphosphate capping enzyme
chr16_-_36373546 7.35 ENSRNOT00000079552
Hand2
heart and neural crest derivatives expressed transcript 2
chr14_+_83510278 6.64 ENSRNOT00000081161
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr9_+_25203534 6.57 ENSRNOT00000064584
AABR07066994.1

chr10_+_93415399 6.42 ENSRNOT00000066484
Tlk2
tousled-like kinase 2
chr14_+_91557601 6.37 ENSRNOT00000038733
RGD1309870
hypothetical LOC289778
chr3_-_148312791 6.03 ENSRNOT00000091419
Bcl2l1
Bcl2-like 1
chr1_+_243477493 5.70 ENSRNOT00000021779
ENSRNOT00000085356
Dmrt1
doublesex and mab-3 related transcription factor 1
chr1_+_101012822 5.63 ENSRNOT00000027809
Rras
related RAS viral (r-ras) oncogene homolog
chr10_-_64862268 5.24 ENSRNOT00000056234
Phf12
PHD finger protein 12
chr1_-_104973648 5.21 ENSRNOT00000019739
Dbx1
developing brain homeobox 1
chrX_+_71324365 4.97 ENSRNOT00000004911
Nono
non-POU domain containing, octamer-binding
chr7_+_144531814 4.82 ENSRNOT00000033300
Hoxc13
homeobox C13
chr15_-_45376324 4.74 ENSRNOT00000076969
Dleu7
deleted in lymphocytic leukemia, 7
chr15_-_45376476 4.70 ENSRNOT00000065838
Dleu7
deleted in lymphocytic leukemia, 7
chr1_+_198214797 4.45 ENSRNOT00000068543
Tbx6
T-box 6
chr17_-_1093873 4.29 ENSRNOT00000086130
Ptch1
patched 1
chr1_+_225140863 4.13 ENSRNOT00000027141
Mta2
metastasis associated 1 family, member 2
chrX_-_63204530 3.69 ENSRNOT00000076175
Zfx
zinc finger protein X-linked
chr10_+_86711240 3.67 ENSRNOT00000012812
Msl1
male specific lethal 1 homolog
chr10_-_83888823 3.36 ENSRNOT00000055500
Ube2z
ubiquitin-conjugating enzyme E2Z
chr7_-_140546908 3.05 ENSRNOT00000077502
Kmt2d
lysine methyltransferase 2D
chr3_-_151658417 2.75 ENSRNOT00000047246
LOC100910990
copine-1-like
chr4_+_140703619 2.63 ENSRNOT00000009563
Bhlhe40
basic helix-loop-helix family, member e40
chr20_+_4959294 2.59 ENSRNOT00000074223
Hspa1l
heat shock protein family A (Hsp70) member 1 like
chr12_-_21760292 2.37 ENSRNOT00000059592
LOC102550456
TSC22 domain family protein 4-like
chr1_+_154377247 2.22 ENSRNOT00000092945
Picalm
phosphatidylinositol binding clathrin assembly protein
chr1_+_78354934 2.11 ENSRNOT00000020509
Zc3h4
zinc finger CCCH-type containing 4
chr3_+_11679530 2.05 ENSRNOT00000074562
ENSRNOT00000071801
Eng
endoglin
chrX_+_71155601 1.91 ENSRNOT00000076453
ENSRNOT00000048521
Foxo4
forkhead box O4
chr10_-_88533171 1.66 ENSRNOT00000024321
Dnajc7
DnaJ heat shock protein family (Hsp40) member C7
chr10_-_85636902 1.55 ENSRNOT00000017241
Pcgf2
polycomb group ring finger 2
chr1_-_156296161 1.44 ENSRNOT00000025653
Crebzf
CREB/ATF bZIP transcription factor
chr11_-_83926524 1.08 ENSRNOT00000041777
ENSRNOT00000040029
Eif4g1
eukaryotic translation initiation factor 4 gamma, 1
chr2_-_195821608 0.95 ENSRNOT00000028389
ENSRNOT00000071442
Snx27
sorting nexin family member 27
chr20_+_4371023 0.90 ENSRNOT00000000500
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr2_-_38208719 0.60 ENSRNOT00000019189
Kif2a
kinesin family member 2A
chr1_+_199196059 0.26 ENSRNOT00000090428
Fbxl19
F-box and leucine-rich repeat protein 19
chr1_-_216080287 0.10 ENSRNOT00000027682
Th
tyrosine hydroxylase
chr1_-_80689171 0.01 ENSRNOT00000045574
Bcam
basal cell adhesion molecule (Lutheran blood group)

Network of associatons between targets according to the STRING database.

First level regulatory network of Glis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
4.1 12.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
4.1 16.2 GO:2001038 senescence-associated heterochromatin focus assembly(GO:0035986) histone H2A phosphorylation(GO:1990164) regulation of cellular response to drug(GO:2001038)
3.9 15.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
2.9 8.7 GO:0072156 distal tubule morphogenesis(GO:0072156)
2.2 8.6 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
2.0 6.0 GO:1905218 cellular response to astaxanthin(GO:1905218)
1.8 7.3 GO:0003219 cardiac right ventricle formation(GO:0003219)
1.4 4.3 GO:0021997 neural plate axis specification(GO:0021997)
1.3 12.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.3 10.7 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
1.3 8.9 GO:0010587 miRNA catabolic process(GO:0010587)
1.1 5.7 GO:0060903 positive regulation of meiosis I(GO:0060903)
1.1 7.6 GO:0040031 snRNA modification(GO:0040031)
0.9 4.4 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.7 2.2 GO:1905247 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.7 2.1 GO:0003273 cell migration involved in endocardial cushion formation(GO:0003273) cardiac jelly development(GO:1905072)
0.6 3.0 GO:0001555 oocyte growth(GO:0001555)
0.6 4.8 GO:0043587 tongue morphogenesis(GO:0043587)
0.6 6.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.6 5.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.4 5.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 1.9 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.2 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 1.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 2.6 GO:0042026 protein refolding(GO:0042026)
0.2 1.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.2 3.7 GO:0060746 parental behavior(GO:0060746)
0.1 5.6 GO:0060325 face morphogenesis(GO:0060325)
0.1 10.8 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 3.7 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 4.1 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.1 2.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.9 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0018963 phthalate metabolic process(GO:0018963)
0.0 0.9 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 6.6 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 3.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.4 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.0 1.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.6 GO:0090307 mitotic spindle assembly(GO:0090307)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.0 12.4 GO:0071564 npBAF complex(GO:0071564)
0.9 3.7 GO:0072487 MSL complex(GO:0072487)
0.9 6.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.7 5.0 GO:0042382 paraspeckles(GO:0042382)
0.4 4.3 GO:0044294 dendritic growth cone(GO:0044294)
0.3 5.2 GO:0016580 Sin3 complex(GO:0016580)
0.3 15.6 GO:0016235 aggresome(GO:0016235)
0.3 2.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 3.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.2 18.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 2.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 8.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.9 GO:0071203 WASH complex(GO:0071203)
0.1 8.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 6.4 GO:0005882 intermediate filament(GO:0005882)
0.0 10.5 GO:0016607 nuclear speck(GO:0016607)
0.0 7.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 5.6 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
1.4 4.3 GO:0005119 smoothened binding(GO:0005119)
1.1 8.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
1.0 6.0 GO:0051434 BH3 domain binding(GO:0051434)
0.8 7.3 GO:0003680 AT DNA binding(GO:0003680)
0.7 8.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.7 14.6 GO:0071837 HMG box domain binding(GO:0071837)
0.5 12.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.5 12.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 2.1 GO:0005534 galactose binding(GO:0005534)
0.4 2.6 GO:0043426 MRF binding(GO:0043426)
0.3 8.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.3 5.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 2.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 7.6 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.1 1.6 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 4.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103) nucleosomal DNA binding(GO:0031492)
0.1 3.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 5.6 GO:0019003 GDP binding(GO:0019003)
0.1 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 10.7 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 4.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 4.3 GO:0031072 heat shock protein binding(GO:0031072)
0.0 38.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 3.0 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.4 7.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 11.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 4.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 12.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 5.6 PID RAS PATHWAY Regulation of Ras family activation
0.1 6.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.1 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 6.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.3 5.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 2.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 12.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins