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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Grhl1

Z-value: 1.15

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Transcription factors associated with Grhl1

Gene Symbol Gene ID Gene Info
Grhl1
ENSRNOG00000054989 grainyhead-like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Grhl1rn6_v1_chr6_+_43743702_43743702-0.173.1e-03Click!

Activity profile of Grhl1 motif

Sorted Z-values of Grhl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_28428117 72.38 ENSRNOT00000078202
Slc23a1
solute carrier family 23 member 1
chr3_-_10371240 59.99 ENSRNOT00000012075
Ass1
argininosuccinate synthase 1
chr2_-_187909394 55.05 ENSRNOT00000032355
Rab25
RAB25, member RAS oncogene family
chr1_+_214328071 49.01 ENSRNOT00000024725
Eps8l2
EPS8-like 2
chr9_+_95295701 42.34 ENSRNOT00000025045
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr4_-_98342887 38.89 ENSRNOT00000010156
Tacstd2
tumor-associated calcium signal transducer 2
chr12_-_23661009 33.56 ENSRNOT00000059451
Upk3bl
uroplakin 3B-like
chr13_+_52645257 33.34 ENSRNOT00000012801
Lad1
ladinin 1
chr3_-_120106697 28.00 ENSRNOT00000020354
Prom2
prominin 2
chr8_+_47674321 26.73 ENSRNOT00000026170
ENSRNOT00000078776
Trim29
tripartite motif-containing 29
chr1_+_101541266 26.23 ENSRNOT00000028436
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr2_+_93669765 25.95 ENSRNOT00000045438
Slc10a5
solute carrier family 10, member 5
chr8_+_13796021 25.38 ENSRNOT00000013927
Vstm5
V-set and transmembrane domain containing 5
chr11_+_47260641 25.14 ENSRNOT00000078856
Nfkbiz
NFKB inhibitor zeta
chr4_-_71763679 23.39 ENSRNOT00000024037
Epha1
Eph receptor A1
chrX_-_84167717 22.55 ENSRNOT00000006415
Pof1b
premature ovarian failure 1B
chr10_+_28449335 18.85 ENSRNOT00000029118
Atp10b
ATPase phospholipid transporting 10B (putative)
chr1_+_166433109 18.80 ENSRNOT00000026428
Stard10
StAR-related lipid transfer domain containing 10
chr6_-_42616548 18.30 ENSRNOT00000081433
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr16_-_19777414 17.10 ENSRNOT00000022898
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr2_+_227095487 16.78 ENSRNOT00000019647
LOC691807
hypothetical protein LOC691807
chr20_-_3605638 16.71 ENSRNOT00000074460
Sfta2
surfactant associated 2
chr11_-_28478360 16.06 ENSRNOT00000032663
Cldn17
claudin 17
chr3_+_1385654 10.81 ENSRNOT00000091805
ENSRNOT00000007593
Il36rn
interleukin 36 receptor antagonist
chr1_-_234749447 10.65 ENSRNOT00000016930
Nmrk1
nicotinamide riboside kinase 1
chr1_-_162713610 10.28 ENSRNOT00000018091
Aqp11
aquaporin 11
chr9_+_11064605 10.00 ENSRNOT00000075121
Stap2
signal transducing adaptor family member 2
chrX_-_112473822 9.16 ENSRNOT00000079180
Col4a6
collagen type IV alpha 6 chain
chr17_-_57984036 8.95 ENSRNOT00000022389
Idi1
isopentenyl-diphosphate delta isomerase 1
chr9_-_42805673 8.58 ENSRNOT00000020558
Uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_+_234749568 8.13 ENSRNOT00000016871
Ostf1
osteoclast stimulating factor 1
chr18_+_35384743 7.13 ENSRNOT00000076143
ENSRNOT00000074593
LOC100911797
serine protease inhibitor Kazal-type 5-like
chr1_-_220938814 6.85 ENSRNOT00000028081
Ovol1
ovo like transcriptional repressor 1
chr19_+_9622611 6.46 ENSRNOT00000061498
Slc38a7
solute carrier family 38, member 7
chr20_-_3728844 6.04 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr9_+_10885560 6.04 ENSRNOT00000072870
Mydgf
myeloid-derived growth factor
chr5_-_33574596 5.22 ENSRNOT00000008281
Cpne3
copine 3
chr15_-_55277713 4.64 ENSRNOT00000023037
Itm2b
integral membrane protein 2B
chr1_-_87468288 4.62 ENSRNOT00000042207
Sipa1l3
signal-induced proliferation-associated 1 like 3
chr9_+_53626592 4.23 ENSRNOT00000031267
Mfsd6
major facilitator superfamily domain containing 6
chr16_+_20110148 3.98 ENSRNOT00000080146
ENSRNOT00000025312
Jak3
Janus kinase 3
chr9_+_53627208 3.93 ENSRNOT00000083487
Mfsd6
major facilitator superfamily domain containing 6
chr2_+_257633425 3.58 ENSRNOT00000071770
Zzz3
zinc finger, ZZ-type containing 3
chr18_-_76753902 3.27 ENSRNOT00000078797
Hsbp1l1
heat shock factor binding protein 1-like 1
chr11_+_67465236 3.17 ENSRNOT00000042374
Stfa2
stefin A2
chr5_+_157434481 2.93 ENSRNOT00000088556
Tmco4
transmembrane and coiled-coil domains 4
chr11_-_83546674 2.91 ENSRNOT00000044896
Ephb3
Eph receptor B3
chr3_-_12502859 2.63 ENSRNOT00000022814
Zbtb43
zinc finger and BTB domain containing 43
chr7_+_118490560 2.21 ENSRNOT00000064873
LOC108348145
zinc finger protein 7-like
chr1_+_169115981 1.64 ENSRNOT00000067478
Olr135
olfactory receptor 135
chr20_-_27578244 1.51 ENSRNOT00000000708
Fam26d
family with sequence similarity 26, member D
chr17_+_1936163 1.18 ENSRNOT00000024466
Cdk20
cyclin-dependent kinase 20
chr1_-_89007041 1.07 ENSRNOT00000032363
Proser3
proline and serine rich 3
chrX_+_95344825 0.79 ENSRNOT00000047255
Olr10
olfactory receptor 10
chr5_+_132005738 0.69 ENSRNOT00000041421
Skint4
selection and upkeep of intraepithelial T cells 4
chr1_-_157494008 0.52 ENSRNOT00000013552
Pcf11
PCF11 cleavage and polyadenylation factor subunit
chr4_+_62780596 0.41 ENSRNOT00000073846
LOC689574
hypothetical protein LOC689574
chr18_+_70192493 0.09 ENSRNOT00000020472
Cxxc1
CXXC finger protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
24.1 72.4 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
20.0 60.0 GO:0000053 argininosuccinate metabolic process(GO:0000053)
7.8 38.9 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
5.6 28.0 GO:0048550 negative regulation of pinocytosis(GO:0048550)
4.9 49.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
4.7 42.3 GO:0052697 xenobiotic glucuronidation(GO:0052697)
2.6 55.1 GO:0031268 pseudopodium organization(GO:0031268)
2.4 18.8 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
2.2 6.5 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
2.1 8.6 GO:0006011 UDP-glucose metabolic process(GO:0006011)
2.1 10.3 GO:0015793 glycerol transport(GO:0015793)
1.8 10.8 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
1.5 9.0 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
1.3 4.0 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
1.3 5.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
1.2 4.6 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
1.1 6.9 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.9 26.2 GO:0006706 steroid catabolic process(GO:0006706)
0.8 17.1 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.7 18.9 GO:0045332 phospholipid translocation(GO:0045332)
0.7 10.6 GO:0009435 NAD biosynthetic process(GO:0009435)
0.6 15.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 9.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.6 26.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.6 18.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.3 26.7 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 4.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 6.0 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 25.1 GO:0006954 inflammatory response(GO:0006954)
0.0 1.2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 3.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 28.0 GO:0071914 microspike(GO:0044393) prominosome(GO:0071914)
4.2 55.1 GO:0031143 pseudopodium(GO:0031143)
3.7 60.0 GO:0070852 cell body fiber(GO:0070852)
3.7 18.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
2.0 111.3 GO:0009925 basal plasma membrane(GO:0009925)
1.4 18.8 GO:0046581 intercellular canaliculus(GO:0046581)
1.1 9.2 GO:0098642 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
1.0 22.6 GO:0030057 desmosome(GO:0030057)
0.9 4.6 GO:0061689 tricellular tight junction(GO:0061689)
0.5 49.0 GO:0032587 ruffle membrane(GO:0032587)
0.3 33.3 GO:0005604 basement membrane(GO:0005604)
0.2 23.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 15.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 16.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 8.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 9.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 136.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 5.2 GO:0005925 focal adhesion(GO:0005925)
0.0 13.2 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.1 72.4 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
8.7 26.2 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
3.9 23.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
3.2 60.0 GO:0015643 toxic substance binding(GO:0015643)
2.6 15.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
2.2 9.0 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
2.2 49.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
2.2 55.1 GO:0031489 myosin V binding(GO:0031489)
2.2 6.5 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
2.0 18.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.5 10.8 GO:0048019 receptor antagonist activity(GO:0048019)
1.4 42.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.3 26.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.2 8.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.9 18.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 10.3 GO:0015250 water channel activity(GO:0015250)
0.6 28.0 GO:0015485 cholesterol binding(GO:0015485)
0.4 1.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 2.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 17.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 4.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 9.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 31.8 GO:0045296 cadherin binding(GO:0045296)
0.1 5.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 4.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 8.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 28.4 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 3.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 16.1 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 4.6 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 23.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.4 4.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 9.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 16.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 9.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 42.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.2 72.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.9 8.6 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.7 18.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.5 16.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 18.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 9.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 60.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 4.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 9.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 4.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs