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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gsc2_Dmbx1

Z-value: 0.38

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Transcription factors associated with Gsc2_Dmbx1

Gene Symbol Gene ID Gene Info
Gsc2
ENSRNOG00000000282 goosecoid homeobox 2
Dmbx1
ENSRNOG00000010835 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dmbx1rn6_v1_chr5_-_134776247_134776247-0.346.0e-10Click!
Gsc2rn6_v1_chr11_+_87220618_872206180.196.9e-04Click!

Activity profile of Gsc2_Dmbx1 motif

Sorted Z-values of Gsc2_Dmbx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_80075991 11.85 ENSRNOT00000080266
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr10_+_104368247 8.87 ENSRNOT00000006519
Llgl2
LLGL2, scribble cell polarity complex component
chr7_-_143497108 7.73 ENSRNOT00000048613
Krt76
keratin 76
chr15_+_83707735 7.09 ENSRNOT00000057843
Klf5
Kruppel-like factor 5
chr3_+_43255567 6.59 ENSRNOT00000044419
Gpd2
glycerol-3-phosphate dehydrogenase 2
chr3_+_112242270 6.14 ENSRNOT00000080533
ENSRNOT00000082876
Capn3
calpain 3
chr7_-_49741540 5.67 ENSRNOT00000006523
Myf6
myogenic factor 6
chr1_+_124983452 5.06 ENSRNOT00000021262
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr7_-_115969304 4.96 ENSRNOT00000007958
Lypd2
Ly6/Plaur domain containing 2
chr4_+_151298548 4.74 ENSRNOT00000010746
Cacna2d4
calcium voltage-gated channel auxiliary subunit alpha2delta 4
chr7_+_94795214 4.53 ENSRNOT00000005722
Deptor
DEP domain containing MTOR-interacting protein
chr4_-_30276372 4.33 ENSRNOT00000011823
Pon1
paraoxonase 1
chr7_-_115969064 4.22 ENSRNOT00000075999
Lypd2
Ly6/Plaur domain containing 2
chr4_+_65801505 3.55 ENSRNOT00000018331
Tmem213
transmembrane protein 213
chr4_-_125929002 3.43 ENSRNOT00000083271
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chrX_-_25628272 3.13 ENSRNOT00000086414
Mid1
midline 1
chr5_-_135025084 3.03 ENSRNOT00000018766
Tspan1
tetraspanin 1
chr8_+_33514042 2.93 ENSRNOT00000081614
ENSRNOT00000081525
Kcnj1
potassium voltage-gated channel subfamily J member 1
chr11_+_87220618 2.91 ENSRNOT00000041975
Gsc2
goosecoid homeobox 2
chr1_+_99648658 2.71 ENSRNOT00000039531
Klk13
kallikrein related-peptidase 13
chr2_-_250981623 2.40 ENSRNOT00000018435
Clca2
chloride channel accessory 2
chr3_-_113423473 2.37 ENSRNOT00000064982
Serinc4
serine incorporator 4
chr1_+_224824799 2.34 ENSRNOT00000024757
Slc22a6
solute carrier family 22 member 6
chr20_-_5155293 2.34 ENSRNOT00000092322
Prrc2a
proline-rich coiled-coil 2A
chr6_+_26780352 2.33 ENSRNOT00000009916
Prr30
proline rich 30
chr1_+_219481575 2.24 ENSRNOT00000025507
Pold4
DNA polymerase delta 4, accessory subunit
chr9_+_51263622 2.23 ENSRNOT00000004463
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr20_-_8574082 2.11 ENSRNOT00000048845
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr8_-_115140080 2.08 ENSRNOT00000015851
Acy1
aminoacylase 1
chr18_-_74542077 1.95 ENSRNOT00000078519
Slc14a2
solute carrier family 14 member 2
chr5_+_138300107 1.93 ENSRNOT00000047151
Cldn19
claudin 19
chr5_-_115387377 1.81 ENSRNOT00000036030
ENSRNOT00000077492
RGD1560146
similar to hypothetical protein MGC34837
chr7_+_60015998 1.79 ENSRNOT00000007309
Best3
bestrophin 3
chr10_-_55560422 1.70 ENSRNOT00000006883
Rangrf
RAN guanine nucleotide release factor
chr2_-_250805445 1.63 ENSRNOT00000055362
Clca4l
chloride channel calcium activated 4-like
chr20_+_32717564 1.62 ENSRNOT00000030642
Rfx6
regulatory factor X, 6
chr3_-_113423149 1.57 ENSRNOT00000021008
Serinc4
serine incorporator 4
chr8_+_55050284 1.56 ENSRNOT00000013242
Pih1d2
PIH1 domain containing 2
chr1_-_205030567 1.48 ENSRNOT00000023404
Ctbp2
C-terminal binding protein 2
chrM_+_8599 1.35 ENSRNOT00000049683
Mt-cox3
mitochondrially encoded cytochrome C oxidase III
chr1_-_256734719 1.21 ENSRNOT00000021546
ENSRNOT00000089456
Myof
myoferlin
chr11_-_69201380 1.19 ENSRNOT00000085618
Mylk
myosin light chain kinase
chr8_-_50603591 1.16 ENSRNOT00000077748
LOC500990
similar to RIKEN cDNA 4931429L15
chr14_+_85351358 1.12 ENSRNOT00000031914
Rhbdd3
rhomboid domain containing 3
chr4_+_117962319 1.07 ENSRNOT00000057441
Tgfa
transforming growth factor alpha
chr7_+_41475163 0.98 ENSRNOT00000037844
Dusp6
dual specificity phosphatase 6
chr4_+_14001761 0.96 ENSRNOT00000076519
Cd36
CD36 molecule
chr4_-_29778039 0.90 ENSRNOT00000074177
Sgce
sarcoglycan, epsilon
chr3_-_8659102 0.88 ENSRNOT00000050908
Zdhhc12
zinc finger, DHHC-type containing 12
chr11_-_35697072 0.77 ENSRNOT00000039999
Erg
ERG, ETS transcription factor
chr19_-_38120578 0.77 ENSRNOT00000026873
Esrp2
epithelial splicing regulatory protein 2
chrM_+_7919 0.74 ENSRNOT00000046108
Mt-atp6
mitochondrially encoded ATP synthase 6
chr5_+_98387291 0.70 ENSRNOT00000046503
Tyrp1
tyrosinase-related protein 1
chr4_-_56656980 0.60 ENSRNOT00000009278
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive
chr5_-_159577134 0.57 ENSRNOT00000011114
Crocc
ciliary rootlet coiled-coil, rootletin
chr1_+_101412736 0.54 ENSRNOT00000067468
Lhb
luteinizing hormone beta polypeptide
chr4_+_28972434 0.48 ENSRNOT00000014219
Gngt1
G protein subunit gamma transducin 1
chr10_+_45966926 0.46 ENSRNOT00000067584
Olfr225
olfactory receptor 225
chr8_-_114013623 0.43 ENSRNOT00000018175
Atp2c1
ATPase secretory pathway Ca2+ transporting 1
chr1_-_199177365 0.35 ENSRNOT00000041840
Ctf2
cardiotrophin 2
chr16_+_14319777 0.31 ENSRNOT00000038771
Lrit2
leucine-rich repeat, Ig-like and transmembrane domains 2
chr2_+_60966789 0.25 ENSRNOT00000025490
Slc45a2
solute carrier family 45, member 2
chr3_+_73161632 0.24 ENSRNOT00000077865
Olr458
olfactory receptor 458
chr4_+_1601652 0.17 ENSRNOT00000072284
LOC100912152
olfactory receptor 8B3-like
chr5_+_57738321 0.16 ENSRNOT00000063849
Ubap1
ubiquitin-associated protein 1
chr2_+_46140482 0.16 ENSRNOT00000072858
Olr1262
olfactory receptor 1262
chr5_-_6186329 0.08 ENSRNOT00000012610
Sulf1
sulfatase 1
chr11_+_84827062 0.03 ENSRNOT00000058006
A930003A15Rik
RIKEN cDNA A930003A15 gene
chr16_+_14306804 0.03 ENSRNOT00000017773
Lrit1
leucine-rich repeat, Ig-like and transmembrane domains 1
chr10_-_57121584 0.03 ENSRNOT00000029421
Vmo1
vitelline membrane outer layer 1 homolog
chr4_-_1686845 0.02 ENSRNOT00000073139
LOC100912507
olfactory receptor 8B3-like
chr16_+_81153489 0.00 ENSRNOT00000024999
Grk1
G protein-coupled receptor kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
2.0 6.1 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
1.4 4.3 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
1.3 6.6 GO:0019563 glycerol catabolic process(GO:0019563)
1.0 2.9 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.7 5.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.6 11.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 7.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.5 7.7 GO:0048733 sebaceous gland development(GO:0048733)
0.4 5.1 GO:0046548 retinal rod cell development(GO:0046548)
0.4 2.3 GO:0031427 response to methotrexate(GO:0031427)
0.4 2.1 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.3 3.9 GO:0015825 L-serine transport(GO:0015825)
0.3 2.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 4.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 1.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 3.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 4.7 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.7 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.2 1.0 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 0.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 0.7 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.2 1.0 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 1.6 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.2 1.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.1 1.1 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.8 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 1.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 2.2 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.1 1.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 4.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 0.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.8 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 3.0 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.5 GO:0030823 regulation of cGMP metabolic process(GO:0030823)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0035838 growing cell tip(GO:0035838)
1.3 6.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 4.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.4 2.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 4.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.7 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.5 GO:0097470 ribbon synapse(GO:0097470)
0.1 6.1 GO:0030315 T-tubule(GO:0030315)
0.1 6.2 GO:0005901 caveola(GO:0005901)
0.1 12.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 4.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 3.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
1.4 4.3 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
1.1 11.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 2.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.7 2.1 GO:0004046 aminoacylase activity(GO:0004046)
0.4 6.1 GO:0031432 titin binding(GO:0031432)
0.4 1.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 3.9 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 1.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 2.3 GO:0031404 chloride ion binding(GO:0031404)
0.3 2.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.2 4.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 1.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.7 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.4 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 3.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 4.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.2 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 2.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 5.1 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.6 GO:0009881 photoreceptor activity(GO:0009881)
0.1 7.8 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 5.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 3.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 6.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 4.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 2.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 5.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 2.9 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 8.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.6 REACTOME OPSINS Genes involved in Opsins
0.1 1.0 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.0 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 6.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 1.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction