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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hes5_Hes7

Z-value: 0.70

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Transcription factors associated with Hes5_Hes7

Gene Symbol Gene ID Gene Info
Hes5
ENSRNOG00000013850 hes family bHLH transcription factor 5
Hes7
ENSRNOG00000007391 hes family bHLH transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hes7rn6_v1_chr10_+_55707164_557071640.462.1e-18Click!
Hes5rn6_v1_chr5_+_172364421_172364421-0.261.7e-06Click!

Activity profile of Hes5_Hes7 motif

Sorted Z-values of Hes5_Hes7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_92117923 106.59 ENSRNOT00000044726
Grb10
growth factor receptor bound protein 10
chr2_+_92549479 27.14 ENSRNOT00000082912
tGap1
GTPase activating protein testicular GAP1
chr8_+_64489942 23.32 ENSRNOT00000083666
Pkm
pyruvate kinase, muscle
chr1_+_190072420 22.48 ENSRNOT00000037026
Abca15
ATP-binding cassette, subfamily A (ABC1), member 15
chr8_+_128972311 22.31 ENSRNOT00000025460
Myrip
myosin VIIA and Rab interacting protein
chr2_+_197682000 21.74 ENSRNOT00000066821
Hormad1
HORMA domain containing 1
chr1_-_220787238 17.38 ENSRNOT00000083656
Tsga10ip
testis specific 10 interacting protein
chr13_-_111765944 17.01 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr2_+_147006830 16.45 ENSRNOT00000080780
AABR07010672.1

chr7_+_38945836 15.81 ENSRNOT00000006455
Ccer1
coiled-coil glutamate-rich protein 1
chr2_-_196415530 15.21 ENSRNOT00000064238
RGD1359334
similar to hypothetical protein FLJ20519
chr4_-_157331905 15.16 ENSRNOT00000020647
Tpi1
triosephosphate isomerase 1
chr10_-_82852660 14.66 ENSRNOT00000005641
Pdk2
pyruvate dehydrogenase kinase 2
chr9_+_20213776 13.98 ENSRNOT00000071439
LOC100911515
triosephosphate isomerase-like
chr4_-_58216711 13.23 ENSRNOT00000015134
Tsga13
testis specific, 13
chr16_+_71889235 13.09 ENSRNOT00000038266
Adam32
ADAM metallopeptidase domain 32
chr6_-_26486695 12.77 ENSRNOT00000073236
Krtcap3
keratinocyte associated protein 3
chr19_-_25134055 12.74 ENSRNOT00000007519
Misp3
MISP family member 3
chr20_-_5754773 11.26 ENSRNOT00000035977
Ip6k3
inositol hexakisphosphate kinase 3
chr16_-_73827488 11.05 ENSRNOT00000064070
Ank1
ankyrin 1
chr4_-_82194927 11.02 ENSRNOT00000072302
LOC103692128
homeobox protein Hox-A9
chr3_+_152143811 9.47 ENSRNOT00000026578
LOC100911109
sperm-associated antigen 4 protein-like
chr7_+_77966722 9.13 ENSRNOT00000006142
Cthrc1
collagen triple helix repeat containing 1
chr5_-_27180819 8.97 ENSRNOT00000045483
AABR07047293.1

chr10_-_15960673 8.41 ENSRNOT00000036447
RGD1311343
similar to RIKEN cDNA 4930524B15
chr6_-_59950586 8.38 ENSRNOT00000005800
Arl4a
ADP-ribosylation factor like GTPase 4A
chr10_-_36716601 8.30 ENSRNOT00000038838
LOC497899
similar to hypothetical protein 4930503F14
chr14_-_114868328 8.06 ENSRNOT00000034584
RGD1562229
similar to hypothetical protein FLJ40298
chr2_+_85377318 8.03 ENSRNOT00000016506
ENSRNOT00000085094
Sema5a
semaphorin 5A
chr10_-_74119009 7.83 ENSRNOT00000085712
ENSRNOT00000006926
Dhx40
DEAH-box helicase 40
chr1_-_164590562 7.66 ENSRNOT00000024157
Tpbgl
trophoblast glycoprotein-like
chr3_-_92290919 6.89 ENSRNOT00000007077
Fjx1
four jointed box 1
chr8_-_36760742 6.79 ENSRNOT00000017307
Ddx25
DEAD-box helicase 25
chr5_-_160158386 6.76 ENSRNOT00000089345
Fblim1
filamin binding LIM protein 1
chr5_-_156141537 6.71 ENSRNOT00000019004
Alpl
alkaline phosphatase, liver/bone/kidney
chr4_-_155561324 6.35 ENSRNOT00000085447
Slc2a3
solute carrier family 2 member 3
chr5_-_136112344 5.74 ENSRNOT00000050195
RGD1563714
RGD1563714
chr17_-_13393243 5.73 ENSRNOT00000018252
Gadd45g
growth arrest and DNA-damage-inducible, gamma
chr10_-_46145548 5.45 ENSRNOT00000033483
Pld6
phospholipase D family, member 6
chr3_+_56030915 5.24 ENSRNOT00000010489
Phospho2
phosphatase, orphan 2
chr10_-_12916784 5.10 ENSRNOT00000004589
Zfp13
zinc finger protein 13
chr3_+_148082790 5.04 ENSRNOT00000009930
ENSRNOT00000080767
Defb36
defensin beta 36
chr7_-_12905339 4.80 ENSRNOT00000088330
Cdc34
cell division cycle 34
chr7_+_77899322 4.72 ENSRNOT00000006195
Fzd6
frizzled class receptor 6
chr4_-_157486844 4.54 ENSRNOT00000038281
ENSRNOT00000022874
Cops7a
COP9 signalosome subunit 7A
chr20_-_13458110 4.47 ENSRNOT00000072183
Slc5a4
solute carrier family 5 member 4
chr1_+_265883355 4.46 ENSRNOT00000025938
Elovl3
ELOVL fatty acid elongase 3
chr3_-_56030744 4.42 ENSRNOT00000089637
Ccdc173
coiled-coil domain containing 173
chr3_+_138770574 4.18 ENSRNOT00000012510
ENSRNOT00000066986
Dtd1
D-tyrosyl-tRNA deacylase 1
chr9_+_118842787 4.13 ENSRNOT00000090512
Dlgap1
DLG associated protein 1
chr5_-_156105867 4.00 ENSRNOT00000078851
Alpl
alkaline phosphatase, liver/bone/kidney
chr2_+_211176556 3.93 ENSRNOT00000055880
Psrc1
proline and serine rich coiled-coil 1
chr1_+_185673177 3.83 ENSRNOT00000048020
Sox6
SRY box 6
chr11_+_24266345 3.66 ENSRNOT00000046973
Jam2
junctional adhesion molecule 2
chr17_-_56909992 3.56 ENSRNOT00000021801
Bambi
BMP and activin membrane-bound inhibitor
chrX_-_15520712 3.52 ENSRNOT00000011994
Kcnd1
potassium voltage-gated channel subfamily D member 1
chr5_-_117612123 3.37 ENSRNOT00000065112
Dock7
dedicator of cytokinesis 7
chr2_+_189400696 3.31 ENSRNOT00000046919
ENSRNOT00000089801
LOC361985
similar to NICE-3
chr9_-_82419288 3.24 ENSRNOT00000004797
Tuba4a
tubulin, alpha 4A
chr3_-_92242318 3.22 ENSRNOT00000007018
Trim44
tripartite motif-containing 44
chr16_-_21348391 3.16 ENSRNOT00000083537
Lpar2
lysophosphatidic acid receptor 2
chr16_-_755990 3.09 ENSRNOT00000013501
Polr3a
RNA polymerase III subunit A
chr14_+_7171613 3.00 ENSRNOT00000081600
Klhl8
kelch-like family member 8
chr11_+_47090245 2.95 ENSRNOT00000060645
AABR07033987.1

chr4_-_157679962 2.95 ENSRNOT00000050443
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr19_-_25914689 2.95 ENSRNOT00000091994
ENSRNOT00000039354
Nf1x
nuclear factor 1 X
chr16_-_21347968 2.72 ENSRNOT00000068554
Lpar2
lysophosphatidic acid receptor 2
chr16_+_19068783 2.67 ENSRNOT00000017424
Cherp
calcium homeostasis endoplasmic reticulum protein
chr7_+_63094911 2.57 ENSRNOT00000006426
Wif1
Wnt inhibitory factor 1
chr10_-_84789832 2.47 ENSRNOT00000071719
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr2_-_189400323 2.43 ENSRNOT00000024364
Ubap2l
ubiquitin associated protein 2-like
chr5_+_60809762 2.32 ENSRNOT00000016839
Frmpd1
FERM and PDZ domain containing 1
chr1_+_220307394 2.25 ENSRNOT00000071891
LOC108348052
equilibrative nucleoside transporter 2
chr20_-_43108198 2.24 ENSRNOT00000000742
Hdac2
histone deacetylase 2
chr5_+_152681101 2.23 ENSRNOT00000076052
ENSRNOT00000022574
Stmn1
stathmin 1
chr10_+_45659143 2.17 ENSRNOT00000058327
Wnt9a
wingless-type MMTV integration site family, member 9A
chr16_+_83206004 2.11 ENSRNOT00000018870
Ankrd10
ankyrin repeat domain 10
chr1_+_82089922 1.97 ENSRNOT00000071251
Zfp526
zinc finger protein 526
chr1_-_169598835 1.90 ENSRNOT00000072996
Olr156
olfactory receptor 156
chr10_+_35133252 1.89 ENSRNOT00000051916
Scgb3a1
secretoglobin, family 3A, member 1
chr5_+_128215711 1.86 ENSRNOT00000011670
Cc2d1b
coiled-coil and C2 domain containing 1B
chr7_-_12779862 1.84 ENSRNOT00000080292
Tmem259
transmembrane protein 259
chrY_+_151937 1.80 ENSRNOT00000077988
ENSRNOT00000083382
Tspy1
testis specific protein, Y-linked 1
chr18_+_63599425 1.80 ENSRNOT00000023145
Cep192
centrosomal protein 192
chr7_+_126096793 1.78 ENSRNOT00000047234
ENSRNOT00000088042
Fbln1
fibulin 1
chr20_+_7718282 1.73 ENSRNOT00000000593
Scube3
signal peptide, CUB domain and EGF like domain containing 3
chr12_+_52359310 1.68 ENSRNOT00000071857
ENSRNOT00000065893
Fbrsl1
fibrosin-like 1
chr7_+_77678968 1.48 ENSRNOT00000006917
Atp6v1c1
ATPase H+ transporting V1 subunit C1
chr1_+_78546012 1.45 ENSRNOT00000058172
Gng5
G protein subunit gamma 5
chr1_+_102017263 1.44 ENSRNOT00000028680
Nomo1
nodal modulator 1
chr2_+_95320283 1.37 ENSRNOT00000015537
Hey1
hes-related family bHLH transcription factor with YRPW motif 1
chr5_+_150459713 1.37 ENSRNOT00000081681
ENSRNOT00000074251
Taf12
TATA-box binding protein associated factor 12
chr2_-_93641497 1.33 ENSRNOT00000013720
Chmp4c
charged multivesicular body protein 4C
chr1_+_148862493 1.09 ENSRNOT00000073451
LOC100912097
olfactory receptor 10A5-like
chr10_+_91710495 1.02 ENSRNOT00000033276
Rprml
reprimo-like
chr16_-_9709347 0.89 ENSRNOT00000083933
Mapk8
mitogen-activated protein kinase 8
chr3_+_125503638 0.78 ENSRNOT00000028900
Crls1
cardiolipin synthase 1
chr2_+_40000313 0.77 ENSRNOT00000014270
Depdc1b
DEP domain containing 1B
chr1_-_282251257 0.75 ENSRNOT00000015186
Prdx3
peroxiredoxin 3
chr9_+_80118029 0.65 ENSRNOT00000023068
Igfbp2
insulin-like growth factor binding protein 2
chr18_+_72005581 0.63 ENSRNOT00000072519
Zbtb7c
zinc finger and BTB domain containing 7C
chr16_-_75855745 0.60 ENSRNOT00000031291
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr10_+_36530719 0.59 ENSRNOT00000046476
Olr1409
olfactory receptor 1409
chr20_-_48758905 0.58 ENSRNOT00000000710
Ddo
D-aspartate oxidase
chr1_+_171095325 0.56 ENSRNOT00000026503
Olr227
olfactory receptor 227
chrX_+_124228270 0.54 ENSRNOT00000035449
Rhox11
reproductive homeobox 11
chr19_-_57422093 0.45 ENSRNOT00000025512
RGD1559896
similar to RIKEN cDNA 2310022B05
chr3_+_73064092 0.36 ENSRNOT00000072178
LOC684539
similar to olfactory receptor Olr490
chr20_+_4576057 0.33 ENSRNOT00000081456
ENSRNOT00000085701
Ehmt2
euchromatic histone lysine methyltransferase 2
chr3_+_138508899 0.32 ENSRNOT00000009437
Kat14
lysine acetyltransferase 14
chr8_-_43249887 0.30 ENSRNOT00000060094
Olr1305
olfactory receptor 1305
chr2_+_150211898 0.28 ENSRNOT00000018767
Sucnr1
succinate receptor 1
chr15_-_28446785 0.28 ENSRNOT00000015439
Olr1638
olfactory receptor 1638
chr18_+_30398113 0.22 ENSRNOT00000027206
Pcdhb5
protocadherin beta 5
chr3_+_47439076 0.19 ENSRNOT00000011794
Tank
TRAF family member-associated NFKB activator
chr5_-_137617258 0.19 ENSRNOT00000071641
Olfr1330-ps1
olfactory receptor 1330, pseudogene 1
chr20_+_11168298 0.17 ENSRNOT00000032240
Trappc10
trafficking protein particle complex 10
chr10_+_10889488 0.17 ENSRNOT00000071746
Ubald1
UBA-like domain containing 1
chr1_+_224933920 0.15 ENSRNOT00000066823
Wdr74
WD repeat domain 74
chr11_+_83883879 0.06 ENSRNOT00000050927
LOC108348101
chloride channel protein 2
chr10_+_83476107 0.04 ENSRNOT00000075733
Phb
prohibitin
chr10_+_11338306 0.01 ENSRNOT00000033695
LOC100910875
protein FAM100A-like
chr2_-_57600820 0.01 ENSRNOT00000083247
Nipbl
NIPBL, cohesin loading factor

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.2 106.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
3.7 14.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
3.6 10.7 GO:0071529 cementum mineralization(GO:0071529)
3.1 21.7 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
3.0 15.2 GO:0019563 glycerol catabolic process(GO:0019563)
2.3 23.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
2.3 9.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
1.8 5.4 GO:0007315 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
1.6 4.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
1.0 5.1 GO:0010728 regulation of hydrogen peroxide biosynthetic process(GO:0010728)
1.0 8.0 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
1.0 2.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.9 4.5 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.7 2.2 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.7 14.0 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.6 3.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.6 6.3 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.6 4.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951) positive regulation of inclusion body assembly(GO:0090261)
0.6 1.8 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
0.6 2.2 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.5 4.1 GO:0070842 aggresome assembly(GO:0070842)
0.5 6.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.5 3.4 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.5 1.4 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.5 11.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.4 4.5 GO:0000338 protein deneddylation(GO:0000338)
0.4 2.5 GO:0071569 protein ufmylation(GO:0071569)
0.3 2.4 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.3 11.1 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 5.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 1.3 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.3 3.6 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.3 0.9 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.3 0.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 2.7 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.2 22.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 1.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 2.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 4.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 4.5 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 5.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 9.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 3.9 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 8.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 2.2 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.2 0.8 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.2 16.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 0.8 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.1 1.8 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 3.1 GO:0010842 retina layer formation(GO:0010842)
0.1 2.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 23.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 1.9 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 6.8 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 2.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 1.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 1.4 GO:0031648 protein destabilization(GO:0031648)
0.0 7.1 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 3.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.5 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.0 GO:0050847 progesterone receptor signaling pathway(GO:0050847)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.4 22.3 GO:0031045 dense core granule(GO:0031045)
1.3 10.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
1.1 11.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 1.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 21.7 GO:0000795 synaptonemal complex(GO:0000795)
0.4 2.9 GO:0097452 GAIT complex(GO:0097452)
0.4 1.8 GO:0071953 elastic fiber(GO:0071953)
0.3 6.8 GO:0033391 chromatoid body(GO:0033391)
0.3 2.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.3 1.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.3 6.8 GO:0045120 pronucleus(GO:0045120)
0.2 1.4 GO:0000125 PCAF complex(GO:0000125)
0.2 6.3 GO:0002080 acrosomal membrane(GO:0002080)
0.2 4.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.3 GO:0090543 Flemming body(GO:0090543)
0.2 3.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 2.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 21.2 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.1 2.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.8 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 7.8 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.9 GO:0005581 collagen trimer(GO:0005581)
0.0 2.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 7.9 GO:0005874 microtubule(GO:0005874)
0.0 26.3 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 29.1 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
5.8 23.3 GO:0004743 pyruvate kinase activity(GO:0004743)
3.7 14.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
3.5 94.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.2 11.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
2.1 6.3 GO:0033222 xylose binding(GO:0033222)
2.0 8.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.3 10.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.3 11.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.7 2.2 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.7 2.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.7 3.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.6 6.8 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 13.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 1.4 GO:0035939 microsatellite binding(GO:0035939)
0.4 4.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 4.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 22.3 GO:0051018 protein kinase A binding(GO:0051018)
0.3 4.1 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.3 1.8 GO:0070051 fibrinogen binding(GO:0070051)
0.3 4.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 3.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 0.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 5.7 GO:0005109 frizzled binding(GO:0005109)
0.2 1.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 11.4 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 22.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 4.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 9.7 GO:0030276 clathrin binding(GO:0030276)
0.1 0.9 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 13.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 2.5 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 7.3 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.8 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.6 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 8.3 GO:0005525 GTP binding(GO:0005525)
0.0 0.0 GO:0031871 proteinase activated receptor binding(GO:0031871)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 106.6 PID IGF1 PATHWAY IGF1 pathway
0.6 16.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 5.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 4.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 5.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 3.6 PID BMP PATHWAY BMP receptor signaling
0.1 13.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID AURORA B PATHWAY Aurora B signaling
0.0 2.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 5.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 106.6 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
1.0 14.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5 18.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 8.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.4 6.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 6.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 10.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 3.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 3.1 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 3.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.8 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 4.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 5.9 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 2.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation