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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hivep1

Z-value: 1.08

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Transcription factors associated with Hivep1

Gene Symbol Gene ID Gene Info
Hivep1
ENSRNOG00000014460 human immunodeficiency virus type I enhancer binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hivep1rn6_v1_chr17_-_22311392_223113920.108.1e-02Click!

Activity profile of Hivep1 motif

Sorted Z-values of Hivep1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_163049084 77.23 ENSRNOT00000091644
Cd69
Cd69 molecule
chr6_+_139405966 37.09 ENSRNOT00000088974
AABR07065693.3

chr6_+_109562587 34.30 ENSRNOT00000011563
Batf
basic leucine zipper ATF-like transcription factor
chr20_-_4698718 34.28 ENSRNOT00000047527
RT1-CE7
RT1 class I, locus CE7
chr20_-_4921348 32.74 ENSRNOT00000082497
ENSRNOT00000041151
RT1-CE4
RT1 class I, locus CE4
chr20_+_2057878 31.88 ENSRNOT00000051480
RT1-M6-1
RT1 class I, locus M6, gene 1
chr4_+_69384145 31.32 ENSRNOT00000084834
Trbv13-2
T cell receptor beta, variable 13-2
chr20_-_157665 30.16 ENSRNOT00000048858
ENSRNOT00000079494
RT1-CE10
RT1 class I, locus CE10
chr10_+_88764732 30.05 ENSRNOT00000026662
Stat5a
signal transducer and activator of transcription 5A
chr14_+_43810119 29.19 ENSRNOT00000003327
Rbm47
RNA binding motif protein 47
chr2_-_219097619 28.44 ENSRNOT00000078806
Vcam1
vascular cell adhesion molecule 1
chr20_-_4863198 27.75 ENSRNOT00000001108
Ltb
lymphotoxin beta
chr8_-_48850671 26.63 ENSRNOT00000016580
Cxcr5
C-X-C motif chemokine receptor 5
chr13_+_111870121 25.76 ENSRNOT00000007333
Irf6
interferon regulatory factor 6
chr20_-_4896970 24.54 ENSRNOT00000061114
ENSRNOT00000060980
RT1-CE7
RT1-CE5
RT1 class I, locus CE7
RT1 class I, locus CE5
chr20_-_4863011 24.19 ENSRNOT00000079503
Ltb
lymphotoxin beta
chr20_+_5414448 23.81 ENSRNOT00000078972
ENSRNOT00000080900
RT1-A1
RT1 class Ia, locus A1
chr8_-_77398156 23.30 ENSRNOT00000091858
ENSRNOT00000085349
ENSRNOT00000082763
Lipc
lipase C, hepatic type
chr4_-_115157263 23.13 ENSRNOT00000015296
Tet3
tet methylcytosine dioxygenase 3
chr20_+_2057689 22.89 ENSRNOT00000086007
RT1-M6-1
RT1 class I, locus M6, gene 1
chr17_+_56109549 21.84 ENSRNOT00000022190
Map3k8
mitogen-activated protein kinase kinase kinase 8
chr10_+_63803309 21.69 ENSRNOT00000036666
Myo1c
myosin 1C
chr10_+_39109522 21.34 ENSRNOT00000010968
Irf1
interferon regulatory factor 1
chr1_-_80544825 21.18 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
Relb
RELB proto-oncogene, NF-kB subunit
chr6_-_76270457 20.97 ENSRNOT00000009894
Nfkbia
NFKB inhibitor alpha
chr20_-_3796258 20.92 ENSRNOT00000048076
ENSRNOT00000044520
RT1-CE16
RT1 class I, locus CE16
chr6_-_140642221 20.88 ENSRNOT00000081996
AABR07065772.2

chr1_+_252589785 20.82 ENSRNOT00000025928
Fas
Fas cell surface death receptor
chr20_+_5184515 20.64 ENSRNOT00000089411
LOC103694381
lymphotoxin-beta
chr18_-_11858744 20.53 ENSRNOT00000061417
ENSRNOT00000082891
Dsc2
desmocollin 2
chr1_-_141471010 20.48 ENSRNOT00000082164
Plin1
perilipin 1
chr5_+_168019058 20.03 ENSRNOT00000077202
Tnfrsf9
TNF receptor superfamily member 9
chr5_-_150704117 19.72 ENSRNOT00000067455
Sesn2
sestrin 2
chr1_+_199217016 18.73 ENSRNOT00000025732
Orai3
ORAI calcium release-activated calcium modulator 3
chr10_-_83655182 18.27 ENSRNOT00000007897
Abi3
ABI family, member 3
chr20_+_2076267 18.09 ENSRNOT00000041500
RT1-M6-2
RT1 class I, locus M6, gene 2
chr6_-_128727374 17.67 ENSRNOT00000082152
Syne3
spectrin repeat containing, nuclear envelope family member 3
chr20_+_10438444 17.61 ENSRNOT00000071248
ENSRNOT00000075545
Cryaa
crystallin, alpha A
chr7_-_125795980 16.40 ENSRNOT00000017420
Arhgap8
Rho GTPase activating protein 8
chr10_+_86860685 16.24 ENSRNOT00000084644
Rara
retinoic acid receptor, alpha
chr3_-_176958880 16.23 ENSRNOT00000078661
Zbtb46
zinc finger and BTB domain containing 46
chr8_-_50531423 15.69 ENSRNOT00000090985
ENSRNOT00000074942
Apoc3
apolipoprotein C3
chr20_+_5509059 15.53 ENSRNOT00000065349
Kifc1
kinesin family member C1
chr9_+_112360419 15.19 ENSRNOT00000086682
Man2a1
mannosidase, alpha, class 2A, member 1
chrX_+_54390733 15.12 ENSRNOT00000004977
RGD1565785
similar to chromosome X open reading frame 21
chr3_+_95233874 13.46 ENSRNOT00000079743
LOC691083
hypothetical protein LOC691083
chr4_-_23135354 13.33 ENSRNOT00000011432
Steap4
STEAP4 metalloreductase
chrX_+_122724129 13.04 ENSRNOT00000017746
LOC100360218
interleukin 13 receptor, alpha 1-like
chr14_+_13192347 12.86 ENSRNOT00000000092
Antxr2
anthrax toxin receptor 2
chr7_+_144078496 12.81 ENSRNOT00000055302
Pcbp2
poly(rC) binding protein 2
chr14_+_17210733 12.73 ENSRNOT00000003075
Cxcl10
C-X-C motif chemokine ligand 10
chr1_-_166413564 12.54 ENSRNOT00000026286
Atg16l2
autophagy related 16-like 2
chr6_-_138685656 12.52 ENSRNOT00000041706
AABR07065651.7

chr1_-_261853495 11.07 ENSRNOT00000021144
Loxl4
lysyl oxidase-like 4
chr4_+_153217782 10.95 ENSRNOT00000015499
Cecr2
CECR2, histone acetyl-lysine reader
chr15_+_34552410 10.79 ENSRNOT00000027802
Khnyn
KH and NYN domain containing
chr1_+_164502389 10.56 ENSRNOT00000043554
Arrb1
arrestin, beta 1
chr18_+_80939875 10.22 ENSRNOT00000021729
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr5_-_107858104 9.19 ENSRNOT00000092196
Cdkn2b
cyclin-dependent kinase inhibitor 2B
chr3_+_138715570 8.99 ENSRNOT00000064723
Sec23b
Sec23 homolog B, coat complex II component
chr5_-_56536772 8.82 ENSRNOT00000060765
Ddx58
DEXD/H-box helicase 58
chr12_+_24978483 8.44 ENSRNOT00000040069
Eln
elastin
chr4_-_10995792 7.92 ENSRNOT00000078733
AABR07059243.1

chr1_+_104635989 7.88 ENSRNOT00000078477
Nav2
neuron navigator 2
chr4_-_129846642 7.85 ENSRNOT00000010717
Frmd4b
FERM domain containing 4B
chr18_+_24397369 7.76 ENSRNOT00000022761
Sap130
Sin3A associated protein 130
chr2_+_60169517 7.75 ENSRNOT00000080974
Prlr
prolactin receptor
chr7_+_14529482 7.64 ENSRNOT00000090844
ENSRNOT00000060284
ENSRNOT00000093239
Cyp4f5
Cyp4f17
cytochrome P450, family 4, subfamily f, polypeptide 5
cytochrome P450, family 4, subfamily f, polypeptide 17
chr1_-_167347662 7.52 ENSRNOT00000027641
ENSRNOT00000076592
Rhog
ras homolog family member G
chr8_-_119265157 7.42 ENSRNOT00000056100
Rtp3
receptor (chemosensory) transporter protein 3
chr7_-_36499784 7.40 ENSRNOT00000011948
AC124896.1
suppressor of cytokine signaling 2
chr1_-_183630695 7.29 ENSRNOT00000036330
AABR07005506.1

chr15_+_27739251 7.29 ENSRNOT00000011840
Parp2
poly (ADP-ribose) polymerase 2
chr8_-_39093277 7.04 ENSRNOT00000043344
LOC100911068
roundabout homolog 4-like
chr10_-_65963932 6.98 ENSRNOT00000011726
Nlk
nemo like kinase
chr8_+_52753011 6.85 ENSRNOT00000047264
Nxpe1
neurexophilin and PC-esterase domain family, member 1
chr18_+_57011575 6.84 ENSRNOT00000026679
Il17b
interleukin 17B
chr3_+_80676820 6.78 ENSRNOT00000084809
Ambra1
autophagy and beclin 1 regulator 1
chr2_+_188253220 6.72 ENSRNOT00000027629
Ash1l
ASH1 like histone lysine methyltransferase
chr6_+_135866739 6.33 ENSRNOT00000013460
Exoc3l4
exocyst complex component 3-like 4
chr1_-_89590490 6.29 ENSRNOT00000028660
Gramd1a
GRAM domain containing 1A
chr16_-_50501921 6.18 ENSRNOT00000081023
Fat1
FAT atypical cadherin 1
chr10_-_88611105 6.16 ENSRNOT00000024718
Dhx58
DEXH-box helicase 58
chr10_+_109446444 6.11 ENSRNOT00000066736
Bahcc1
BAH domain and coiled-coil containing 1
chrX_+_111122552 6.00 ENSRNOT00000083566
ENSRNOT00000085078
ENSRNOT00000090928
Cldn2
claudin 2
chrX_-_31138675 5.93 ENSRNOT00000004456
Fancb
Fanconi anemia, complementation group B
chr1_+_1784078 5.78 ENSRNOT00000020098
Lats1
large tumor suppressor kinase 1
chr13_-_90977734 5.53 ENSRNOT00000011869
Slamf8
SLAM family member 8
chr5_+_48011864 5.30 ENSRNOT00000067610
Mdn1
midasin AAA ATPase 1
chr15_-_37056892 5.24 ENSRNOT00000047731
Zmym5
zinc finger MYM-type containing 5
chr1_-_80716143 5.22 ENSRNOT00000092048
ENSRNOT00000025829
Cblc
Cbl proto-oncogene C
chr13_+_49870976 4.80 ENSRNOT00000090170
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr10_-_74769637 4.29 ENSRNOT00000008889
LOC102555183
zinc finger protein OZF-like
chrX_-_38196060 4.06 ENSRNOT00000006741
ENSRNOT00000006438
Sh3kbp1
SH3 domain-containing kinase-binding protein 1
chr14_-_18862407 4.05 ENSRNOT00000003823
Cxcl6
C-X-C motif chemokine ligand 6
chr2_+_188253378 3.99 ENSRNOT00000085690
Ash1l
ASH1 like histone lysine methyltransferase
chr3_-_29996865 3.78 ENSRNOT00000080382
Zeb2
zinc finger E-box binding homeobox 2
chr10_-_72196437 3.75 ENSRNOT00000029769
Pigw
phosphatidylinositol glycan anchor biosynthesis, class W
chr18_-_24397551 3.61 ENSRNOT00000023032
Slc25a46
solute carrier family 25, member 46
chr3_+_47439076 3.58 ENSRNOT00000011794
Tank
TRAF family member-associated NFKB activator
chr20_-_4380084 3.48 ENSRNOT00000000499
Egfl8
EGF-like-domain, multiple 8
chr6_-_47904437 3.46 ENSRNOT00000092867
Rps7
ribosomal protein S7
chr1_-_86948845 3.37 ENSRNOT00000027212
Nfkbib
NFKB inhibitor beta
chr1_-_178367828 3.35 ENSRNOT00000050823
AABR07071968.1

chr1_+_166433109 3.20 ENSRNOT00000026428
Stard10
StAR-related lipid transfer domain containing 10
chr6_-_47904163 3.09 ENSRNOT00000011333
Rps7
ribosomal protein S7
chr3_-_79121620 2.99 ENSRNOT00000087141
Olr741
olfactory receptor 741
chr18_+_32273770 2.93 ENSRNOT00000087408
Fgf1
fibroblast growth factor 1
chr6_-_41039437 2.66 ENSRNOT00000005774
Trib2
tribbles pseudokinase 2
chr4_+_72637035 2.49 ENSRNOT00000007235
Olr819
olfactory receptor 819
chr5_+_133864798 2.20 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr4_+_155654911 1.80 ENSRNOT00000087883
Foxj2
forkhead box J2
chr9_-_4447715 1.77 ENSRNOT00000061882
Kat2b
lysine acetyltransferase 2B
chr10_-_88645364 1.75 ENSRNOT00000030344
Rab5c
RAB5C, member RAS oncogene family
chr18_-_32207749 1.72 ENSRNOT00000090882
ENSRNOT00000018843
Arhgap26
Rho GTPase activating protein 26
chr17_+_88963981 1.69 ENSRNOT00000025053
Myo3a
myosin IIIA
chr5_+_98469047 1.65 ENSRNOT00000041374
Lurap1l
leucine rich adaptor protein 1-like
chr1_-_252550394 1.48 ENSRNOT00000083468
Acta2
actin, alpha 2, smooth muscle, aorta
chr18_-_36322320 1.47 ENSRNOT00000060260
Grxcr2
glutaredoxin and cysteine rich domain containing 2
chr15_-_3773340 1.34 ENSRNOT00000063831
LOC103689945
zinc finger SWIM domain-containing protein 8-like
chr12_-_38638536 1.28 ENSRNOT00000001690
Mlxip
MLX interacting protein
chr2_-_199563386 1.21 ENSRNOT00000075261
AABR07012616.1

chr1_-_168994253 1.20 ENSRNOT00000039946
Hbg1
hemoglobin subunit gamma 1
chr10_+_65448950 1.00 ENSRNOT00000082348
ENSRNOT00000037016
Rab34
RAB34, member RAS oncogene family
chr3_+_64190973 0.88 ENSRNOT00000011342
AABR07052587.1

chr5_+_48012231 0.65 ENSRNOT00000077040
Mdn1
midasin AAA ATPase 1
chr1_+_219764001 0.55 ENSRNOT00000082388
Pc
pyruvate carboxylase
chr3_-_93216495 0.43 ENSRNOT00000010580
Ehf
ets homologous factor
chr6_-_33507542 0.38 ENSRNOT00000007928
Gdf7
growth differentiation factor 7
chr5_+_5866897 0.36 ENSRNOT00000011940
Slco5a1
solute carrier organic anion transporter family, member 5A1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hivep1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 32.2 GO:0060375 regulation of mast cell differentiation(GO:0060375)
7.9 23.8 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
7.8 23.3 GO:0010034 response to acetate(GO:0010034)
7.3 29.2 GO:0016554 cytidine to uridine editing(GO:0016554)
7.2 21.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
6.7 20.0 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
6.0 42.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
5.8 23.1 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
5.5 77.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
5.2 15.7 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) regulation of high-density lipoprotein particle clearance(GO:0010982)
4.9 19.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
4.2 12.7 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
4.2 21.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
4.2 20.8 GO:0036337 ovarian follicle atresia(GO:0001552) Fas signaling pathway(GO:0036337)
4.1 16.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
3.6 10.7 GO:1903699 tarsal gland development(GO:1903699)
3.6 160.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
3.3 13.0 GO:0035772 interleukin-13-mediated signaling pathway(GO:0035772)
3.1 34.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
2.9 17.6 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
2.8 28.4 GO:0022614 membrane to membrane docking(GO:0022614)
2.8 8.4 GO:0071298 cellular response to L-ascorbic acid(GO:0071298)
2.6 10.6 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
2.6 20.5 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
2.4 7.3 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
2.3 16.2 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
2.2 17.7 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
2.2 8.8 GO:0009597 detection of virus(GO:0009597)
2.1 12.5 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
2.0 7.9 GO:0021564 vagus nerve development(GO:0021564)
1.9 5.8 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
1.7 13.3 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.5 6.2 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
1.5 21.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.5 5.9 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168)
1.4 12.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.4 26.6 GO:0048535 lymph node development(GO:0048535)
1.4 33.5 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
1.4 5.5 GO:0060266 leukocyte chemotaxis involved in inflammatory response(GO:0002232) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of neutrophil migration(GO:1902623)
1.4 15.2 GO:0006013 mannose metabolic process(GO:0006013)
1.3 4.0 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
1.3 2.7 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.3 3.8 GO:0061373 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
1.2 10.9 GO:0001842 neural fold formation(GO:0001842)
1.2 3.6 GO:0090149 mitochondrial membrane fission(GO:0090149)
1.2 3.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.8 18.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.7 2.9 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.7 6.6 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.6 1.8 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.6 20.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.5 9.2 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.5 6.8 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.5 3.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.5 6.3 GO:0051601 exocyst localization(GO:0051601)
0.4 6.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.4 6.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 3.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 15.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 1.5 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.4 7.4 GO:0051205 protein insertion into membrane(GO:0051205)
0.3 7.6 GO:0006691 leukotriene metabolic process(GO:0006691)
0.3 10.2 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.3 7.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.3 4.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.3 12.9 GO:1901998 toxin transport(GO:1901998)
0.3 7.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.3 1.8 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.2 6.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 6.2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 0.5 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 1.0 GO:0044351 macropinocytosis(GO:0044351)
0.1 3.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 7.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 0.4 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 9.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 16.4 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.1 1.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 1.2 GO:0015671 oxygen transport(GO:0015671)
0.0 7.0 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 11.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 10.5 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 4.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 22.6 GO:0006955 immune response(GO:0006955)
0.0 1.7 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 5.2 GO:0022604 regulation of cell morphogenesis(GO:0022604)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.4 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
7.0 111.2 GO:0042612 MHC class I protein complex(GO:0042612)
5.1 45.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
4.2 20.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
2.6 15.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
2.6 23.1 GO:0001940 male pronucleus(GO:0001940)
2.5 17.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
2.5 19.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
2.4 21.7 GO:0016461 unconventional myosin complex(GO:0016461)
1.7 8.4 GO:0071953 elastic fiber(GO:0071953)
1.0 10.9 GO:0031010 ISWI-type complex(GO:0031010)
1.0 23.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.9 20.5 GO:0030057 desmosome(GO:0030057)
0.8 10.6 GO:0031143 pseudopodium(GO:0031143)
0.8 6.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.6 9.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.6 7.8 GO:0030914 STAGA complex(GO:0030914)
0.4 12.5 GO:0000421 autophagosome membrane(GO:0000421)
0.4 149.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 7.9 GO:0005614 interstitial matrix(GO:0005614)
0.4 5.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.4 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 22.2 GO:0005811 lipid particle(GO:0005811)
0.3 6.3 GO:0000145 exocyst(GO:0000145)
0.2 3.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 15.5 GO:0005871 kinesin complex(GO:0005871)
0.2 11.6 GO:0005801 cis-Golgi network(GO:0005801)
0.2 4.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.7 GO:0032426 stereocilium tip(GO:0032426)
0.1 7.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 14.8 GO:0005923 bicellular tight junction(GO:0005923)
0.1 21.2 GO:0030027 lamellipodium(GO:0030027)
0.1 1.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 6.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 10.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 4.1 GO:0030139 endocytic vesicle(GO:0030139)
0.1 7.9 GO:0001726 ruffle(GO:0001726)
0.1 23.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 102.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 6.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 13.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 72.8 GO:0043120 tumor necrosis factor binding(GO:0043120)
5.8 23.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
5.2 15.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
4.1 24.5 GO:0046979 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
3.9 23.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
3.5 10.6 GO:0031893 follicle-stimulating hormone receptor binding(GO:0031762) vasopressin receptor binding(GO:0031893)
3.4 23.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.3 19.7 GO:0070728 leucine binding(GO:0070728)
3.2 103.0 GO:0042605 peptide antigen binding(GO:0042605)
3.0 26.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
2.8 8.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
2.6 28.4 GO:0008131 primary amine oxidase activity(GO:0008131)
2.6 7.7 GO:0004925 prolactin receptor activity(GO:0004925)
2.6 12.8 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
2.6 10.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132)
2.5 12.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.2 13.3 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.2 11.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
2.0 16.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.8 23.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
1.5 7.4 GO:0031849 olfactory receptor binding(GO:0031849)
1.2 3.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.2 10.7 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
1.2 15.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
1.1 20.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.0 18.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.9 6.6 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.8 21.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.8 7.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.8 17.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 11.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7 21.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 4.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 1.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.4 15.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 27.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 7.0 GO:0004707 MAP kinase activity(GO:0004707)
0.2 69.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 2.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 3.8 GO:0070412 R-SMAD binding(GO:0070412)
0.2 7.6 GO:0070330 aromatase activity(GO:0070330)
0.2 0.5 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.2 15.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 15.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.7 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 2.9 GO:0044548 S100 protein binding(GO:0044548)
0.1 7.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 5.8 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 41.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 5.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 31.9 GO:0000975 regulatory region DNA binding(GO:0000975)
0.1 7.9 GO:0008201 heparin binding(GO:0008201)
0.0 6.3 GO:0000149 SNARE binding(GO:0000149)
0.0 5.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 10.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 9.3 GO:0003924 GTPase activity(GO:0003924)
0.0 8.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.0 3.7 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 24.1 GO:0003723 RNA binding(GO:0003723)
0.0 6.0 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 41.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
1.8 30.0 PID IL5 PATHWAY IL5-mediated signaling events
1.7 21.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.4 15.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.1 19.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.8 23.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.7 21.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.7 20.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.7 21.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.6 18.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.3 16.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 7.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 7.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 7.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 3.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.2 45.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 4.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 4.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 9.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 11.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 39.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.0 30.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.8 33.2 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
1.5 20.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
1.4 20.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.3 75.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.9 21.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.8 41.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.7 15.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.5 15.5 REACTOME KINESINS Genes involved in Kinesins
0.5 7.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.4 10.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 17.7 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.3 9.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 7.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.3 5.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 5.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 2.9 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 16.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 4.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 6.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 4.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 1.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 18.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 6.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis