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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hmbox1

Z-value: 0.73

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Transcription factors associated with Hmbox1

Gene Symbol Gene ID Gene Info
Hmbox1
ENSRNOG00000013326 homeobox containing 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmbox1rn6_v1_chr15_-_48284548_482845480.277.0e-07Click!

Activity profile of Hmbox1 motif

Sorted Z-values of Hmbox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_139780386 65.52 ENSRNOT00000081147
AABR07041779.2

chr17_-_69460321 27.04 ENSRNOT00000058367
Akr1c1
aldo-keto reductase family 1, member C1
chr7_-_116425003 23.15 ENSRNOT00000076694
Ly6i
lymphocyte antigen 6 complex, locus I
chr4_-_51199570 20.00 ENSRNOT00000010788
Slc13a1
solute carrier family 13 member 1
chr1_+_219964429 16.25 ENSRNOT00000088288
Sptbn2
spectrin, beta, non-erythrocytic 2
chr10_+_84871680 14.97 ENSRNOT00000073292
Prr15l
proline rich 15-like
chr2_+_114413410 13.25 ENSRNOT00000015866
Slc2a2
solute carrier family 2 member 2
chr1_-_13915594 11.93 ENSRNOT00000015927
Arfgef3
ARFGEF family member 3
chr10_-_65692016 11.70 ENSRNOT00000085074
ENSRNOT00000038690
Slc13a2
solute carrier family 13 member 2
chr20_+_20236151 10.38 ENSRNOT00000079630
Ank3
ankyrin 3
chr1_+_23906717 9.83 ENSRNOT00000022798
Tcf21
transcription factor 21
chr2_-_233743866 9.49 ENSRNOT00000087062
Enpep
glutamyl aminopeptidase
chr2_-_172459165 9.17 ENSRNOT00000057473
Schip1
schwannomin interacting protein 1
chr8_+_54925607 8.25 ENSRNOT00000059210
Plet1
placenta expressed transcript 1
chr10_-_82852660 7.91 ENSRNOT00000005641
Pdk2
pyruvate dehydrogenase kinase 2
chr8_+_107882219 7.53 ENSRNOT00000019902
Dzip1l
DAZ interacting zinc finger protein 1-like
chr10_+_90929423 7.17 ENSRNOT00000093180
Higd1b
HIG1 hypoxia inducible domain family, member 1B
chr9_-_27452902 7.14 ENSRNOT00000018325
Gsta1
glutathione S-transferase alpha 1
chr20_-_44220702 6.94 ENSRNOT00000036853
Fam229b
family with sequence similarity 229, member B
chr18_+_32336102 6.81 ENSRNOT00000018577
Fgf1
fibroblast growth factor 1
chr18_+_70739492 6.75 ENSRNOT00000085601
Acaa2
acetyl-CoA acyltransferase 2
chr1_+_127802978 6.73 ENSRNOT00000055877
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr9_+_117538009 6.66 ENSRNOT00000022878
Epb41l3
erythrocyte membrane protein band 4.1-like 3
chr10_+_90930010 6.17 ENSRNOT00000003765
Higd1b
HIG1 hypoxia inducible domain family, member 1B
chr8_-_73122740 6.14 ENSRNOT00000012026
Tln2
talin 2
chr7_-_29070928 6.06 ENSRNOT00000080939
Chpt1
choline phosphotransferase 1
chr14_-_114484127 6.05 ENSRNOT00000056706
Eml6
echinoderm microtubule associated protein like 6
chr4_-_31730386 5.97 ENSRNOT00000013817
Slc25a13
solute carrier family 25 member 13
chrX_-_111179152 5.56 ENSRNOT00000089115
Morc4
MORC family CW-type zinc finger 4
chr5_+_172488708 5.36 ENSRNOT00000019930
Morn1
MORN repeat containing 1
chr20_+_28078500 5.33 ENSRNOT00000030005
Ccdc138
coiled-coil domain containing 138
chr18_+_61377051 5.21 ENSRNOT00000066659
Oacyl
O-acyltransferase like
chrX_+_40460047 5.20 ENSRNOT00000010970
Phex
phosphate regulating endopeptidase homolog, X-linked
chr15_+_47470863 5.16 ENSRNOT00000072438
LOC683422
similar to Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin) (Fletcher factor)
chr8_-_47404010 5.07 ENSRNOT00000038647
Tmem136
transmembrane protein 136
chr9_+_117538346 4.89 ENSRNOT00000022849
Epb41l3
erythrocyte membrane protein band 4.1-like 3
chr4_-_118578815 4.89 ENSRNOT00000080502
Anxa4
annexin A4
chr1_+_204617852 4.88 ENSRNOT00000022971
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr6_-_105261549 4.86 ENSRNOT00000009122
Synj2bp
synaptojanin 2 binding protein
chr5_+_34040258 4.69 ENSRNOT00000009758
Ggh
gamma-glutamyl hydrolase
chr9_+_117795132 4.67 ENSRNOT00000086943
Akain1
A-kinase anchor inhibitor 1
chr14_-_19132208 4.62 ENSRNOT00000060535
Afm
afamin
chr14_+_107785029 4.46 ENSRNOT00000013097
ENSRNOT00000087091
Fam161a
family with sequence similarity 161, member A
chr2_-_120316600 4.29 ENSRNOT00000084521
Ccdc39
coiled-coil domain containing 39
chr8_-_71337746 4.22 ENSRNOT00000021554
Zfp609
zinc finger protein 609
chr6_+_26686205 4.19 ENSRNOT00000082623
Slc5a6
solute carrier family 5 member 6
chr1_+_229039889 4.19 ENSRNOT00000054800
Glyatl1
glycine-N-acyltransferase-like 1
chr9_+_81821346 4.18 ENSRNOT00000022234
Plcd4
phospholipase C, delta 4
chr1_-_215284548 4.11 ENSRNOT00000090375
Cttn
cortactin
chr10_-_40764185 4.01 ENSRNOT00000017486
Sparc
secreted protein acidic and cysteine rich
chr8_-_114010277 3.81 ENSRNOT00000045087
Atp2c1
ATPase secretory pathway Ca2+ transporting 1
chr13_+_82072497 3.79 ENSRNOT00000063810
ENSRNOT00000085135
Kifap3
kinesin-associated protein 3
chr7_-_107223047 3.66 ENSRNOT00000007250
ENSRNOT00000084875
Lrrc6
leucine rich repeat containing 6
chr17_-_78499881 3.65 ENSRNOT00000079260
Fam107b
family with sequence similarity 107, member B
chr2_+_208749996 3.65 ENSRNOT00000086321
Chia
chitinase, acidic
chr15_-_3410423 3.65 ENSRNOT00000080274
Adk
adenosine kinase
chr4_+_117780533 3.58 ENSRNOT00000021211
Tprkb
Tp53rk binding protein
chr6_-_15191660 3.52 ENSRNOT00000092654
Nrxn1
neurexin 1
chr7_+_94795214 3.49 ENSRNOT00000005722
Deptor
DEP domain containing MTOR-interacting protein
chr6_+_26686033 3.47 ENSRNOT00000081167
Slc5a6
solute carrier family 5 member 6
chr19_-_601469 3.44 ENSRNOT00000016462
Pdp2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr17_-_15566332 3.43 ENSRNOT00000093743
Ecm2
extracellular matrix protein 2
chr14_+_70164650 3.14 ENSRNOT00000004385
Qdpr
quinoid dihydropteridine reductase
chr1_-_82610350 3.12 ENSRNOT00000028177
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
chrX_+_25737292 3.08 ENSRNOT00000004893
RGD1563947
similar to RIKEN cDNA 4933400A11
chr18_+_30840868 3.06 ENSRNOT00000027026
Pcdhga5
protocadherin gamma subfamily A, 5
chr1_-_46329682 2.89 ENSRNOT00000046311
Tmem242
transmembrane protein 242
chr15_-_77736892 2.88 ENSRNOT00000057924
Pcdh9
protocadherin 9
chr17_+_54181419 2.81 ENSRNOT00000023861
Kif5b
kinesin family member 5B
chr13_-_104080631 2.81 ENSRNOT00000032865
Lyplal1
lysophospholipase-like 1
chr3_+_101010899 2.76 ENSRNOT00000073258
Lin7c
lin-7 homolog C, crumbs cell polarity complex component
chr3_-_122813583 2.75 ENSRNOT00000009681
Idh3B
isocitrate dehydrogenase 3 (NAD+) beta
chr9_+_121831716 2.72 ENSRNOT00000056250
ENSRNOT00000056251
Yes1
YES proto-oncogene 1, Src family tyrosine kinase
chr16_+_50016857 2.70 ENSRNOT00000035781
Tlr3
toll-like receptor 3
chr1_-_24302298 2.67 ENSRNOT00000083452
Sgk1
serum/glucocorticoid regulated kinase 1
chr20_+_4374807 2.57 ENSRNOT00000084557
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr6_+_92229686 2.56 ENSRNOT00000046085
Atl1
atlastin GTPase 1
chr10_+_96661696 2.56 ENSRNOT00000077567
AABR07030630.1

chr20_+_28920616 2.50 ENSRNOT00000070897
P4ha1
prolyl 4-hydroxylase subunit alpha 1
chrX_+_106390759 2.43 ENSRNOT00000049375
Bhlhb9
basic helix-loop-helix domain containing, class B, 9
chr1_-_263269762 2.39 ENSRNOT00000022309
Got1
glutamic-oxaloacetic transaminase 1
chr1_-_215536770 2.38 ENSRNOT00000078030
Ifitm10
interferon induced transmembrane protein 10
chr4_+_67378188 2.33 ENSRNOT00000030892
Ndufb2
NADH:ubiquinone oxidoreductase subunit B2
chr16_-_28716885 2.33 ENSRNOT00000059750
Spock3
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
chr5_+_118574801 2.30 ENSRNOT00000035949
Ube2u
ubiquitin-conjugating enzyme E2U (putative)
chr1_-_60088406 2.26 ENSRNOT00000091192
Vom1r7
vomeronasal 1 receptor 7
chr8_+_49077053 2.24 ENSRNOT00000087922
Ift46
intraflagellar transport 46
chr3_+_111135021 2.23 ENSRNOT00000018970
Dll4
delta like canonical Notch ligand 4
chr4_-_181348799 2.17 ENSRNOT00000033743
LOC690784
hypothetical protein LOC690783
chr10_+_70629250 2.09 ENSRNOT00000013687
Rasl10b
RAS-like, family 10, member B
chr1_+_86429262 2.04 ENSRNOT00000045789
Vom1r3
vomeronasal 1 receptor 3
chr10_+_77762900 2.03 ENSRNOT00000003308
Mmd
monocyte to macrophage differentiation-associated
chrX_-_31799560 2.03 ENSRNOT00000044103
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr2_-_89498395 2.01 ENSRNOT00000068507
AABR07009224.1

chr13_-_89594738 1.98 ENSRNOT00000004641
Tomm40l
translocase of outer mitochondrial membrane 40 like
chr5_+_166464252 1.87 ENSRNOT00000055562
Ctnnbip1
catenin, beta-interacting protein 1
chr4_-_182600258 1.84 ENSRNOT00000067970
Ergic2
ERGIC and golgi 2
chr10_+_59743544 1.84 ENSRNOT00000093497
ENSRNOT00000056460
Tax1bp3
Tax1 binding protein 3
chr2_+_189582991 1.63 ENSRNOT00000022627
Rab13
RAB13, member RAS oncogene family
chr1_-_221251329 1.58 ENSRNOT00000031678
Tigd3
tigger transposable element derived 3
chr5_+_104394119 1.55 ENSRNOT00000093557
ENSRNOT00000093462
Adamtsl1
ADAMTS-like 1
chr8_+_59769994 1.53 ENSRNOT00000020309
Fbxo22
F-box protein 22
chrX_+_96667863 1.53 ENSRNOT00000042552
RGD1561151
similar to hypothetical protein 4932411N23
chr2_-_120316357 1.51 ENSRNOT00000065469
Ccdc39
coiled-coil domain containing 39
chr11_-_72109964 1.46 ENSRNOT00000058917
AABR07034445.1

chr2_-_165600748 1.45 ENSRNOT00000013216
Ift80
intraflagellar transport 80
chrM_+_5323 1.43 ENSRNOT00000050156
Mt-co1
mitochondrially encoded cytochrome c oxidase 1
chr10_-_52290657 1.40 ENSRNOT00000005293
Map2k4
mitogen activated protein kinase kinase 4
chr4_+_166986350 1.36 ENSRNOT00000040828
Tas2r117
taste receptor, type 2, member 117
chr4_-_165828814 1.32 ENSRNOT00000007481
Tas2r105
taste receptor, type 2, member 105
chr3_+_75712483 1.30 ENSRNOT00000049264
Olr575
olfactory receptor 575
chr8_-_23130877 1.26 ENSRNOT00000019140
Elof1
elongation factor 1 homolog
chr6_-_55001464 1.25 ENSRNOT00000006618
Ahr
aryl hydrocarbon receptor
chr4_-_147657847 1.19 ENSRNOT00000013889
Tmem40
transmembrane protein 40
chr15_+_27330558 1.18 ENSRNOT00000085155
LOC103693383
olfactory receptor 11G2-like
chr19_-_37303788 1.16 ENSRNOT00000084734
Fhod1
formin homology 2 domain containing 1
chr13_-_43566680 1.15 ENSRNOT00000073921
LOC100909582
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A-like
chr4_-_129544429 1.11 ENSRNOT00000091507
ENSRNOT00000083461
ENSRNOT00000087215
Tmf1
TATA element modulatory factor 1
chr5_+_126976456 1.10 ENSRNOT00000014275
Ndc1
NDC1 transmembrane nucleoporin
chr2_-_227582895 1.08 ENSRNOT00000020574
Mettl14
methyltransferase like 14
chr4_-_157347803 1.06 ENSRNOT00000020785
Usp5
ubiquitin specific peptidase 5
chr20_+_1889652 1.05 ENSRNOT00000068508
ENSRNOT00000000996
Olr1746
olfactory receptor 1746
chr3_+_38559914 1.04 ENSRNOT00000085545
Fmnl2
formin-like 2
chr19_+_551708 1.03 ENSRNOT00000015811
Fam96b
family with sequence similarity 96, member B
chr1_+_266482858 1.02 ENSRNOT00000027223
As3mt
arsenite methyltransferase
chr6_+_106052212 0.97 ENSRNOT00000010626
Sipa1l1
signal-induced proliferation-associated 1 like 1
chr16_+_29674793 0.96 ENSRNOT00000059724
Anxa10
annexin A10
chr1_-_169882454 0.95 ENSRNOT00000043339
Olr181
olfactory receptor 181
chrX_-_25628272 0.93 ENSRNOT00000086414
Mid1
midline 1
chr1_-_53014466 0.92 ENSRNOT00000049831
Sft2d1
SFT2 domain containing 1
chr2_-_242828629 0.92 ENSRNOT00000043369
LOC499715
LRRGT00095
chr5_+_129448879 0.89 ENSRNOT00000011765
Faf1
Fas associated factor 1
chrX_-_70461553 0.86 ENSRNOT00000076110
ENSRNOT00000003872
ENSRNOT00000076812
Pdzd11
PDZ domain containing 11
chr2_+_250995517 0.84 ENSRNOT00000018905
Odf2l
outer dense fiber of sperm tails 2-like
chr1_+_170205591 0.83 ENSRNOT00000071063
LOC686660
similar to olfactory receptor 692
chr5_-_172488822 0.78 ENSRNOT00000019620
Rer1
retention in endoplasmic reticulum sorting receptor 1
chr1_-_71173216 0.75 ENSRNOT00000020523
Zfp28
zinc finger protein 28
chr8_+_42443442 0.74 ENSRNOT00000015986
Vwa5a
von Willebrand factor A domain containing 5A
chr3_-_73124644 0.73 ENSRNOT00000012711
Olr455
olfactory receptor 455
chr7_-_117257402 0.63 ENSRNOT00000081021
Plec
plectin
chr1_+_103064285 0.62 ENSRNOT00000075356
Vom1r70
vomeronasal 1 receptor 70
chr6_-_131648661 0.59 ENSRNOT00000057179
LOC100910833
histone-lysine N-methyltransferase setd3-like
chr20_+_1944801 0.59 ENSRNOT00000075060
Olr1750
olfactory receptor 1750
chr2_+_150106292 0.57 ENSRNOT00000073078
LOC100910567
arylacetamide deacetylase-like 2-like
chr4_-_166869399 0.54 ENSRNOT00000007521
Tas2r121
taste receptor, type 2, member 121
chr6_-_115513354 0.47 ENSRNOT00000005881
Ston2
stonin 2
chr4_-_165774126 0.45 ENSRNOT00000007453
Tas2r107
taste receptor, type 2, member 107
chr17_-_69711689 0.42 ENSRNOT00000041925
Akr1c12
aldo-keto reductase family 1, member C12
chrX_+_112311251 0.41 ENSRNOT00000086698
AABR07040855.1

chr1_+_67340809 0.40 ENSRNOT00000045266
LOC100362054
mCG114696-like
chr9_+_88493593 0.40 ENSRNOT00000020712
LOC102556337
mitochondrial fission factor-like
chr8_-_84506328 0.39 ENSRNOT00000064754
Mlip
muscular LMNA-interacting protein
chr4_+_71795768 0.33 ENSRNOT00000031921
Tas2r135
taste receptor, type 2, member 135
chr10_-_41491554 0.26 ENSRNOT00000035759
LOC102552619
uncharacterized LOC102552619
chr1_+_168623150 0.22 ENSRNOT00000021282
Olr107
olfactory receptor 107
chrY_-_1305026 0.19 ENSRNOT00000092901
Usp9y
ubiquitin specific peptidase 9, Y-linked
chr3_-_73854363 0.17 ENSRNOT00000051169
Olr496
olfactory receptor 496
chr13_-_78885464 0.17 ENSRNOT00000003828
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
chr10_-_65200109 0.12 ENSRNOT00000030501
Nufip2
NUFIP2, FMR1 interacting protein 2
chr17_-_55300998 0.11 ENSRNOT00000064331
Svil
supervillin
chr1_-_173469699 0.08 ENSRNOT00000040345
Olr281
olfactory receptor 281
chr16_+_12510827 0.05 ENSRNOT00000077763
AABR07024716.1

chr10_-_59743315 0.04 ENSRNOT00000093646
Emc6
ER membrane protein complex subunit 6
chr12_+_19314251 0.01 ENSRNOT00000001827
Ap4m1
adaptor-related protein complex 4, mu 1 subunit
chr7_+_120106901 0.00 ENSRNOT00000063876
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmbox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.0 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
3.3 16.7 GO:0009758 carbohydrate utilization(GO:0009758)
3.3 9.8 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
2.6 10.4 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.0 6.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
2.0 7.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.9 11.5 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205)
1.9 9.5 GO:0002003 angiotensin maturation(GO:0002003)
1.7 5.2 GO:1904383 response to sodium phosphate(GO:1904383)
1.5 6.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.4 6.8 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.4 16.3 GO:0016081 synaptic vesicle docking(GO:0016081)
1.4 6.8 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
1.3 3.8 GO:0032472 Golgi calcium ion transport(GO:0032472)
1.2 3.6 GO:0009153 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) AMP salvage(GO:0044209) adenosine biosynthetic process(GO:0046086)
1.2 20.0 GO:1902358 sulfate transmembrane transport(GO:1902358)
1.1 9.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
1.0 7.7 GO:0051182 coenzyme transport(GO:0051182)
0.8 2.4 GO:0006532 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.8 6.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.7 2.2 GO:1903588 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.7 3.7 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.7 3.5 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.7 2.8 GO:0002084 protein depalmitoylation(GO:0002084)
0.7 4.9 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.7 2.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.7 2.7 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.6 3.6 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.6 2.8 GO:1905150 stress granule disassembly(GO:0035617) regulation of voltage-gated sodium channel activity(GO:1905150)
0.5 7.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.5 1.6 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.5 4.1 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.5 11.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.5 2.8 GO:0006102 isocitrate metabolic process(GO:0006102)
0.4 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.4 9.2 GO:0008210 estrogen metabolic process(GO:0008210)
0.4 3.1 GO:0006559 L-phenylalanine catabolic process(GO:0006559) tetrahydrobiopterin biosynthetic process(GO:0006729) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.4 4.9 GO:1903671 negative regulation of sprouting angiogenesis(GO:1903671)
0.4 1.1 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.4 1.4 GO:0072709 cellular response to sorbitol(GO:0072709)
0.3 3.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 1.3 GO:0003241 growth involved in heart morphogenesis(GO:0003241) regulation of growth rate(GO:0040009)
0.3 1.9 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633)
0.3 2.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 2.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 3.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 8.3 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.2 4.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.2 1.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 2.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.2 4.7 GO:0006541 glutamine metabolic process(GO:0006541)
0.2 1.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 1.8 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.1 4.6 GO:0051180 vitamin transport(GO:0051180)
0.1 2.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.1 GO:0080009 mRNA methylation(GO:0080009)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 3.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 4.2 GO:0007340 acrosome reaction(GO:0007340)
0.1 2.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 1.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 2.6 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 1.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 2.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 2.7 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1 2.0 GO:0019835 cytolysis(GO:0019835)
0.1 1.0 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 2.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 2.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.2 GO:0042073 intraciliary transport(GO:0042073)
0.1 0.4 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.1 0.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 2.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 2.3 GO:0016574 histone ubiquitination(GO:0016574)
0.0 1.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 10.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 1.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 3.6 GO:0008033 tRNA processing(GO:0008033)
0.0 10.1 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 3.4 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 0.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.6 16.3 GO:0008091 spectrin(GO:0008091)
1.3 10.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.0 4.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.9 2.8 GO:0045242 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
0.8 3.8 GO:0016939 kinesin II complex(GO:0016939)
0.7 11.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.7 2.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.7 4.1 GO:0099571 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.7 9.5 GO:0031983 vesicle lumen(GO:0031983)
0.6 2.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.6 2.3 GO:0033503 HULC complex(GO:0033503)
0.4 6.1 GO:0005916 fascia adherens(GO:0005916)
0.4 2.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 34.0 GO:0031225 anchored component of membrane(GO:0031225)
0.3 7.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 1.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 20.9 GO:0031526 brush border membrane(GO:0031526)
0.2 2.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 4.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 2.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 1.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 1.0 GO:0097361 CIA complex(GO:0097361)
0.2 2.8 GO:0035253 ciliary rootlet(GO:0035253)
0.2 1.1 GO:0036396 MIS complex(GO:0036396)
0.2 3.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 10.1 GO:0036064 ciliary basal body(GO:0036064)
0.1 3.5 GO:0044295 axonal growth cone(GO:0044295)
0.1 5.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 4.0 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 4.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.6 GO:1903293 phosphatase complex(GO:1903293)
0.0 9.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.7 GO:0005884 actin filament(GO:0005884)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 10.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 6.8 GO:0005938 cell cortex(GO:0005938)
0.0 23.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.0 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
2.0 7.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.5 13.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
1.3 20.0 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
1.2 4.9 GO:0070699 type II activin receptor binding(GO:0070699)
1.2 6.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
1.0 3.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
1.0 4.9 GO:0004427 inorganic diphosphatase activity(GO:0004427)
1.0 6.8 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
1.0 7.7 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.8 2.4 GO:0080130 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.8 6.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.7 2.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 4.2 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.7 2.8 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.7 3.4 GO:0070052 collagen V binding(GO:0070052)
0.6 3.1 GO:0070404 NADH binding(GO:0070404)
0.6 2.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.6 3.7 GO:0004568 chitinase activity(GO:0004568)
0.6 2.8 GO:0097016 L27 domain binding(GO:0097016)
0.5 3.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 11.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 4.7 GO:0008242 omega peptidase activity(GO:0008242)
0.4 1.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.4 9.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 7.1 GO:0043295 glutathione binding(GO:0043295)
0.4 2.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 3.8 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.4 41.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 6.8 GO:0044548 S100 protein binding(GO:0044548)
0.4 1.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.3 4.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 2.0 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 1.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.3 9.8 GO:0050681 androgen receptor binding(GO:0050681)
0.2 4.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 2.0 GO:0015266 protein channel activity(GO:0015266)
0.2 2.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 4.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 5.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 3.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 5.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.2 GO:0005112 Notch binding(GO:0005112)
0.1 11.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.6 GO:0008527 taste receptor activity(GO:0008527)
0.1 11.7 GO:0015293 symporter activity(GO:0015293)
0.1 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 3.8 GO:0019894 kinesin binding(GO:0019894)
0.1 4.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 4.6 GO:0019842 vitamin binding(GO:0019842)
0.0 4.9 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 2.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.2 GO:0043621 protein self-association(GO:0043621)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.0 GO:0008276 protein methyltransferase activity(GO:0008276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 4.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.8 PID FGF PATHWAY FGF signaling pathway
0.1 4.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 6.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 7.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 31.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.8 13.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.8 26.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.7 11.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5 6.8 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.4 5.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 2.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 6.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 7.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 3.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 8.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 2.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.2 2.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.5 REACTOME KINESINS Genes involved in Kinesins
0.1 2.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 3.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 3.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 4.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation