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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Homez

Z-value: 0.82

Motif logo

Transcription factors associated with Homez

Gene Symbol Gene ID Gene Info
ENSRNOG00000014887 homeobox and leucine zipper encoding

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Homezrn6_v1_chr15_-_33527031_335270310.639.0e-37Click!

Activity profile of Homez motif

Sorted Z-values of Homez motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_200778122 42.77 ENSRNOT00000091845
hydroxyacid oxidase 2
chr1_-_54854353 26.37 ENSRNOT00000072895
sperm motility kinase 2A
chr17_+_9746485 22.44 ENSRNOT00000072298
profilin 3
chr8_+_117906014 22.27 ENSRNOT00000056180
serine peptidase inhibitor, Kazal type 8
chr2_+_154921999 20.92 ENSRNOT00000057620
similar to GTPase activating protein testicular GAP1
chr1_-_54036068 20.75 ENSRNOT00000075019
similar to putative protein kinase
chr18_-_15089988 18.68 ENSRNOT00000074116
meprin A subunit beta
chr18_+_47294292 18.60 ENSRNOT00000020109
ferritin mitochondrial
chr19_+_568287 18.58 ENSRNOT00000016419
cadherin 16
chr4_+_96831880 17.94 ENSRNOT00000068400
RSA-14-44 protein
chr2_-_132551235 17.83 ENSRNOT00000058250
rCG65904-like
chr2_+_155076464 17.78 ENSRNOT00000057619
similar to GTPase activating protein testicular GAP1
chr10_+_64174931 17.52 ENSRNOT00000035948
RGD1565611
chr1_+_55219773 15.77 ENSRNOT00000041610
similar to putative protein kinase
chr9_-_65790347 15.62 ENSRNOT00000028506

chr4_-_176294997 15.33 ENSRNOT00000015112
ENSRNOT00000051461
ENSRNOT00000000026
ENSRNOT00000039877
ENSRNOT00000049303
kidney specific organic anion transporter
chr10_+_59894340 14.17 ENSRNOT00000080446
spermatogenesis associated 22
chr7_-_145048283 12.78 ENSRNOT00000055275
gametocyte specific factor 1
chr18_-_58423196 12.71 ENSRNOT00000025556
piezo-type mechanosensitive ion channel component 2
chr7_-_54855557 12.43 ENSRNOT00000039475
GLI pathogenesis-related 1 like 1
chr16_-_7336335 12.29 ENSRNOT00000044991
PHD finger protein 7
chr14_-_2934571 11.99 ENSRNOT00000049772
ubiquitin-conjugating enzyme E2D 4 (putative)
chr13_-_56462834 11.91 ENSRNOT00000032122
crumbs 1, cell polarity complex component
chr14_+_89253373 11.83 ENSRNOT00000035922
hypothetical protein LOC688553
chr4_-_163157744 11.83 ENSRNOT00000089712
C-type lectin domain family 12, member B
chr1_+_101474334 11.61 ENSRNOT00000064245
tubby-like protein 2
chr10_+_73279119 11.47 ENSRNOT00000004698
T-box 2
chr2_+_92574038 11.45 ENSRNOT00000089422
GTPase activating protein testicular GAP1
chr10_+_71202456 11.35 ENSRNOT00000076893
HNF1 homeobox B
chr17_-_78499881 11.30 ENSRNOT00000079260
family with sequence similarity 107, member B
chr10_+_111031414 11.21 ENSRNOT00000074372
patched domain containing 3
chr8_-_17696989 11.07 ENSRNOT00000083752

chr6_+_127766470 10.96 ENSRNOT00000013138
serpin family A member 5
chr13_-_36022197 10.93 ENSRNOT00000091280
cilia and flagella associated protein 221
chr14_+_113968563 10.65 ENSRNOT00000006085
clathrin heavy chain linker domain containing 1
chr1_+_189969336 10.55 ENSRNOT00000073255
ENSRNOT00000071302
ENSRNOT00000055063
ATP-binding cassette, subfamily A (ABC1), member 14
chr18_-_45380730 10.42 ENSRNOT00000037904
pseudouridine 5'-phosphatase
chr7_+_20262680 10.40 ENSRNOT00000046378
similar to hypothetical protein 4930509O22
chr7_-_45185690 10.39 ENSRNOT00000071306
leucine-rich repeats and IQ motif containing 1
chr8_-_115274165 10.33 ENSRNOT00000056386
IQ domain-containing protein F5-like
chr2_-_238369692 10.30 ENSRNOT00000041583
Rho guanine nucleotide exchange factor 38
chrX_+_115721251 10.27 ENSRNOT00000060090
TRPC5 opposite strand
chr7_-_15483834 9.84 ENSRNOT00000057608
microrchidia 2B
chrX_+_43745604 9.83 ENSRNOT00000040825
rCG36365-like
chr14_-_84662143 9.81 ENSRNOT00000057529
ENSRNOT00000080078
HORMA domain containing 2
chr2_+_93758919 9.78 ENSRNOT00000077782
fatty acid binding protein 12
chr3_+_75906945 9.75 ENSRNOT00000047110
olfactory receptor 586
chr9_-_63291350 9.60 ENSRNOT00000058831
heat shock transcription factor, Y linked 2
chr6_+_30038777 9.57 ENSRNOT00000072340
family with sequence similarity 228, member B
chr11_+_88095170 9.29 ENSRNOT00000041557
coiled-coil domain containing 116
chr1_+_222907159 9.26 ENSRNOT00000032123
HRAS-like suppressor family, member 5
chr3_-_113376751 9.15 ENSRNOT00000030019
cation channel, sperm associated 2
chr14_+_13751231 9.08 ENSRNOT00000044244
glycerol kinase 2
chr14_+_97686121 8.94 ENSRNOT00000074877
POM121 transmembrane nucleoporin-like 12
chr10_-_107114271 8.93 ENSRNOT00000004035
dynein, axonemal, heavy chain 17
chrY_+_506149 8.90 ENSRNOT00000086056
lysine demethylase 5D
chr2_+_58448917 8.87 ENSRNOT00000082562
RAN binding protein 3-like
chr17_-_2423572 8.79 ENSRNOT00000024504
SPATA31 subfamily A, member 5
chr7_+_34402738 8.79 ENSRNOT00000030985
coiled-coil domain containing 38
chrX_+_110342718 8.74 ENSRNOT00000043861

chr14_-_37361798 8.73 ENSRNOT00000002980
cell wall biogenesis 43 C-terminal homolog
chr5_-_76261198 8.72 ENSRNOT00000087380

chr2_-_228665279 8.50 ENSRNOT00000055648
similar to T-cell activation Rho GTPase-activating protein isoform b
chrX_+_16337102 8.49 ENSRNOT00000003954
cyclin B3
chr13_-_80862963 8.38 ENSRNOT00000004864
flavin containing monooxygenase 3
chr3_-_8979889 8.38 ENSRNOT00000065128
carnitine O-acetyltransferase
chr10_+_86367596 8.36 ENSRNOT00000049070
ENSRNOT00000009114
ENSRNOT00000078744
erb-b2 receptor tyrosine kinase 2
chr9_+_4731914 8.31 ENSRNOT00000061893

chrY_-_1238420 8.22 ENSRNOT00000092078
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
chr11_+_88424414 8.21 ENSRNOT00000022328
sperm associated antigen 6-like
chrX_+_133227660 8.20 ENSRNOT00000004591
actin-related protein T1
chrX_-_143558521 8.16 ENSRNOT00000056598
hypothetical protein LOC688842
chr17_-_43504604 8.13 ENSRNOT00000083829
ENSRNOT00000066313
solute carrier family 17 member 1
chrY_+_914045 8.08 ENSRNOT00000088593
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr14_-_91996774 8.07 ENSRNOT00000005851
dopa decarboxylase
chr20_+_5057701 8.06 ENSRNOT00000001119
lymphocyte antigen 6 complex, locus G6C
chr9_-_50820290 7.99 ENSRNOT00000050748
uncharacterized LOC102548013
chr2_-_137331140 7.95 ENSRNOT00000048546
similar to T-cell activation Rho GTPase-activating protein isoform b
chrX_-_65335987 7.90 ENSRNOT00000047128

chr20_+_20577561 7.82 ENSRNOT00000081113
cyclin-dependent kinase 1
chr13_-_47331187 7.81 ENSRNOT00000035577
ENSRNOT00000049915
zona pellucida 3 receptor
chr18_+_68984051 7.76 ENSRNOT00000002969
StAR-related lipid transfer domain containing 6
chr2_-_127778202 7.74 ENSRNOT00000092191
ENSRNOT00000093683
similar to RIKEN cDNA 1700034I23
chr6_-_55711146 7.70 ENSRNOT00000036996
leucine rich repeat containing 72
chr7_+_34744483 7.67 ENSRNOT00000007465
ubiquitin specific peptidase 44
chr3_-_46942966 7.59 ENSRNOT00000087439
RNA binding motif, single stranded interacting protein 1
chrX_-_158261717 7.57 ENSRNOT00000086804
similar to RIKEN cDNA 1700001F22
chr3_-_11820549 7.53 ENSRNOT00000020660
cilia and flagella associated protein 157
chrX_-_32095867 7.48 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr18_-_26656879 7.43 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chr1_+_16910069 7.42 ENSRNOT00000020015
aldehyde dehydrogenase 8 family, member A1
chr16_+_19097391 7.38 ENSRNOT00000018018
calreticulin 3
chr1_+_221673590 7.29 ENSRNOT00000038016
CDC42 binding protein kinase gamma
chr6_+_138432550 7.23 ENSRNOT00000056829
a disintegrin and metallopeptidase domain 6
chr13_-_71276497 7.18 ENSRNOT00000029773
regulator of G-protein signaling like 1
chr14_+_22553650 7.07 ENSRNOT00000092201
ENSRNOT00000002712
UDP glucuronosyltransferase 2 family, polypeptide B35
chr8_-_16486419 7.03 ENSRNOT00000033223
similar to MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule affinity-regulating kinase-like 1)
chr17_+_15429708 6.88 ENSRNOT00000093261
hypothetical protein LOC679342
chrY_+_380382 6.73 ENSRNOT00000092110
RNA binding motif protein, Y-linked, family 1, member J
chr1_+_185356975 6.69 ENSRNOT00000086681
pleckstrin homology domain containing A7
chr5_+_147257678 6.68 ENSRNOT00000066268
ring finger protein 19B
chr7_+_95309928 6.61 ENSRNOT00000005887
MDM2 binding protein
chr17_+_14516566 6.58 ENSRNOT00000060660
ENSRNOT00000071469
similar to vitamin A-deficient testicular protein 11-like
chr10_-_35005287 6.55 ENSRNOT00000032386
nedd4 binding protein 3
chrY_+_184603 6.45 ENSRNOT00000077708
zinc finger Y-chromosomal protein 2
chr1_+_256035866 6.43 ENSRNOT00000079726
kinesin family member 11
chr11_+_45339366 6.42 ENSRNOT00000002241
transmembrane protein 30C
chr1_-_62191818 6.39 ENSRNOT00000033187

chr6_+_93385457 6.29 ENSRNOT00000010300
actin-related protein 10 homolog
chr4_-_28437676 6.25 ENSRNOT00000012995
HEPACAM family member 2
chr20_-_10013190 6.25 ENSRNOT00000084726
ENSRNOT00000089112
radial spoke head 1 homolog
chr9_+_4107246 6.21 ENSRNOT00000078212

chrX_+_97074710 6.14 ENSRNOT00000044379
similar to RIKEN cDNA 4921511C20 gene
chr20_-_45126062 6.13 ENSRNOT00000000720
similar to KIAA1919 protein
chr7_+_18668692 6.11 ENSRNOT00000009532
KN motif and ankyrin repeat domains 3
chr1_-_89539210 6.11 ENSRNOT00000077462
ENSRNOT00000028644
hepsin
chr15_+_28319136 6.08 ENSRNOT00000048723
tubulin polymerization-promoting protein family member 2
chr3_-_54593306 6.06 ENSRNOT00000087122
serine threonine kinase 39
chrX_+_15295473 6.04 ENSRNOT00000009295
histone deacetylase 6
chr10_-_54512169 5.95 ENSRNOT00000005066
cilia and flagella associated protein 52
chrX_+_45614888 5.95 ENSRNOT00000058473
uncharacterized LOC100909677
chr6_+_122729874 5.88 ENSRNOT00000039509
ENSRNOT00000040440
zinc finger CCCH type containing 14
chr14_-_8548310 5.86 ENSRNOT00000092436
Rho GTPase activating protein 24
chr8_+_80965255 5.80 ENSRNOT00000079508
WD repeat domain 72
chrX_-_100207974 5.79 ENSRNOT00000091859

chrX_+_63897664 5.77 ENSRNOT00000089271
protein gar2-like
chr1_-_72941869 5.77 ENSRNOT00000032306
EPS8-like 1
chr16_-_68700296 5.76 ENSRNOT00000060162

chrX_-_106085878 5.72 ENSRNOT00000049735
preferentially expressed antigen in melanoma
chr7_-_107223047 5.66 ENSRNOT00000007250
ENSRNOT00000084875
leucine rich repeat containing 6
chr5_+_133864798 5.61 ENSRNOT00000091977
TAL bHLH transcription factor 1, erythroid differentiation factor
chr16_+_69022792 5.58 ENSRNOT00000035985
glutamic-oxaloacetic transaminase 1-like 1
chr8_+_119064351 5.57 ENSRNOT00000051211
protease, serine, 42
chr19_+_50246402 5.54 ENSRNOT00000018795
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_3630950 5.49 ENSRNOT00000074535
pre-mRNA-splicing factor CWC22 homolog
chr2_-_88553086 5.47 ENSRNOT00000042494
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr2_-_200762206 5.46 ENSRNOT00000068511
ENSRNOT00000086835
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr7_-_107768072 5.36 ENSRNOT00000093189
N-myc downstream regulated 1
chr12_-_6078411 5.35 ENSRNOT00000001197
relaxin/insulin-like family peptide receptor 2
chr7_-_49250953 5.27 ENSRNOT00000066975
ENSRNOT00000082141
acyl-CoA synthetase short-chain family member 3
chr5_-_134638150 5.21 ENSRNOT00000013480
testis expressed 38
chr4_-_165195489 5.00 ENSRNOT00000079429
killer cell lectin-like receptor, subfamily A, member 5
chr2_-_137153551 5.00 ENSRNOT00000083443

chrX_-_156155014 4.93 ENSRNOT00000088637
L antigen family member 3-like
chr7_-_124317379 4.92 ENSRNOT00000013398
protein kinase C and casein kinase substrate in neurons 2
chr3_+_138174054 4.92 ENSRNOT00000007946
barrier to autointegration factor 2
chr10_+_76320041 4.89 ENSRNOT00000037693
coilin
chr7_-_19088972 4.87 ENSRNOT00000049266
vomeronasal 2 receptor, 57
chr1_+_83933942 4.84 ENSRNOT00000068690
cytochrome P450, family 2, subfamily f, polypeptide 4
chr6_+_8669722 4.83 ENSRNOT00000048550
calmodulin-lysine N-methyltransferase
chr14_-_21299068 4.79 ENSRNOT00000065778
amelotin
chr20_+_44680449 4.76 ENSRNOT00000000728
Traf3 interacting protein 2
chr8_+_116311078 4.76 ENSRNOT00000037363
Ras association domain family member 1
chr16_+_39144972 4.73 ENSRNOT00000086728
ADAM metallopeptidase domain 21
chrX_-_139916883 4.73 ENSRNOT00000090442
glypican 3
chrX_+_15396895 4.71 ENSRNOT00000064924
histone deacetylase 6
chr18_-_15167311 4.69 ENSRNOT00000021061
ring finger protein 138
chr3_-_72447801 4.66 ENSRNOT00000088815
purinergic receptor P2X 3
chr5_+_74874306 4.64 ENSRNOT00000076918
A-kinase anchoring protein 2
chr5_+_59783890 4.62 ENSRNOT00000066277
maternal embryonic leucine zipper kinase
chr14_-_35581031 4.60 ENSRNOT00000003077
platelet derived growth factor receptor alpha
chr14_+_37130743 4.60 ENSRNOT00000031756
leucine rich repeat containing 66
chr8_+_107508351 4.58 ENSRNOT00000081594
centrosomal protein 70
chr10_-_37099004 4.53 ENSRNOT00000075465
Nedd4 binding protein 3
chr2_+_205714267 4.52 ENSRNOT00000056084
glutamic acid-rich protein-like
chr7_-_33916338 4.52 ENSRNOT00000005492
cilia and flagella associated protein 54
chr9_+_43830630 4.51 ENSRNOT00000084742
cyclic nucleotide gated channel alpha 3
chr9_+_95398237 4.49 ENSRNOT00000025879
transient receptor potential cation channel, subfamily M, member 8
chr9_+_38536920 4.42 ENSRNOT00000060452
primase (DNA) subunit 2
chr10_+_45297937 4.42 ENSRNOT00000066367
tripartite motif-containing 17
chr3_+_100373439 4.39 ENSRNOT00000085176
kinesin family member 18A
chr7_+_18068060 4.39 ENSRNOT00000065474
vomeronasal 1 receptor 107
chr12_+_24803686 4.37 ENSRNOT00000033499
Williams-Beuren syndrome chromosome region 28
chr20_-_2701815 4.36 ENSRNOT00000061950
heat shock protein family A (Hsp70) member 1A
chr18_-_27374603 4.35 ENSRNOT00000027244
NME/NM23 family member 5
chr2_-_200762492 4.34 ENSRNOT00000056172
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_-_126211439 4.31 ENSRNOT00000014988
tight junction protein 1
chr1_-_274650363 4.29 ENSRNOT00000074341
BBSome interacting protein 1
chr16_-_6404578 4.28 ENSRNOT00000051371
calcium voltage-gated channel subunit alpha1 D
chr9_-_85528860 4.16 ENSRNOT00000063834
ENSRNOT00000088963
WD repeat and FYVE domain containing 1
chrX_-_43781586 4.12 ENSRNOT00000051551
claudin 34B
chr1_-_89094530 4.04 ENSRNOT00000031873
ets variant 2
chr14_-_81638934 3.99 ENSRNOT00000018616
family with sequence similarity 193, member A
chr9_+_115916907 3.98 ENSRNOT00000023226
laminin subunit alpha 1
chr10_+_81592114 3.97 ENSRNOT00000072783
mbt domain containing 1
chr4_-_147756294 3.92 ENSRNOT00000014537
methyl-CpG binding domain 4 DNA glycosylase
chr9_-_38495126 3.92 ENSRNOT00000016933
ENSRNOT00000090385
RAB23, member RAS oncogene family
chr1_-_7443863 3.88 ENSRNOT00000088558
phosphatase and actin regulator 2
chr5_-_107857320 3.86 ENSRNOT00000008898
cyclin-dependent kinase inhibitor 2B
chrX_-_46653165 3.86 ENSRNOT00000058456

chr1_+_282638017 3.85 ENSRNOT00000079722
ENSRNOT00000082254
carboxylesterase 2C
chr9_+_95202632 3.84 ENSRNOT00000025652
UDP glucuronosyltransferase family 1 member A5
chr8_-_68966108 3.84 ENSRNOT00000012155
SMAD family member 6
chr16_-_31301880 3.73 ENSRNOT00000084847
ENSRNOT00000083943

chr12_-_29952196 3.72 ENSRNOT00000086175
transmembrane protein 248
chrX_+_152196129 3.72 ENSRNOT00000087679
melanoma antigen, family A, 4
chr4_-_164051812 3.64 ENSRNOT00000085719

chr18_+_84162467 3.62 ENSRNOT00000047841
similar to melanoma antigen family A, 6
chr18_+_35136132 3.61 ENSRNOT00000078731
serine peptidase inhibitor, Kazal type 5
chr3_+_134440195 3.60 ENSRNOT00000072928

Network of associatons between targets according to the STRING database.

First level regulatory network of Homez

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.3 42.8 GO:0018924 mandelate metabolic process(GO:0018924)
6.0 17.9 GO:0097498 endothelial tube lumen extension(GO:0097498)
5.8 17.5 GO:0016598 protein arginylation(GO:0016598)
4.6 4.6 GO:1904404 response to formaldehyde(GO:1904404)
3.8 15.3 GO:0051958 methotrexate transport(GO:0051958)
3.8 11.5 GO:1901220 regulation of cardiac chamber morphogenesis(GO:1901219) negative regulation of cardiac chamber morphogenesis(GO:1901220)
3.8 11.4 GO:1901146 mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
3.0 9.1 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
3.0 12.0 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
2.8 8.5 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
2.7 11.0 GO:0061107 seminal vesicle development(GO:0061107)
2.6 15.9 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
2.5 7.5 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
2.5 49.2 GO:0035404 histone-serine phosphorylation(GO:0035404)
2.4 4.7 GO:0072138 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
2.2 6.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.1 8.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
2.0 6.1 GO:0034769 basement membrane disassembly(GO:0034769)
2.0 14.2 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
2.0 6.1 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
2.0 8.1 GO:0052314 phytoalexin metabolic process(GO:0052314)
1.9 5.6 GO:0006532 aspartate biosynthetic process(GO:0006532)
1.6 9.8 GO:0034757 negative regulation of iron ion transport(GO:0034757)
1.6 4.8 GO:0042197 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.6 4.8 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
1.6 4.7 GO:1904054 regulation of cholangiocyte proliferation(GO:1904054) positive regulation of cholangiocyte proliferation(GO:1904056)
1.5 8.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.5 4.4 GO:0031439 positive regulation of mRNA cleavage(GO:0031439) positive regulation of endoribonuclease activity(GO:1902380) positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904722)
1.4 18.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.4 25.9 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
1.3 6.7 GO:0045218 zonula adherens maintenance(GO:0045218)
1.3 7.8 GO:0090166 Golgi disassembly(GO:0090166)
1.2 8.4 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
1.2 4.7 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.2 11.6 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
1.1 3.4 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.1 9.8 GO:0045144 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
1.1 3.3 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
1.1 6.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
1.0 4.0 GO:2000382 positive regulation of mesoderm development(GO:2000382)
1.0 3.0 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
1.0 2.9 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.9 4.7 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.9 7.4 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.9 4.5 GO:0050955 thermoception(GO:0050955)
0.9 7.8 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.8 4.2 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.8 4.9 GO:0070836 caveola assembly(GO:0070836)
0.8 2.4 GO:2000537 immunoglobulin production in mucosal tissue(GO:0002426) T-helper 1 cell activation(GO:0035711) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) regulation of thymocyte migration(GO:2000410) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.8 3.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.8 1.5 GO:1901143 insulin catabolic process(GO:1901143)
0.7 5.8 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.7 8.3 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.7 12.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 2.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6 5.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.6 5.7 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.6 5.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.6 20.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.6 2.5 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.6 2.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.6 4.0 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.6 5.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.5 8.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.5 3.7 GO:0033504 floor plate development(GO:0033504)
0.5 9.4 GO:0046415 urate metabolic process(GO:0046415)
0.5 5.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.5 2.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.5 18.3 GO:1901998 toxin transport(GO:1901998)
0.5 2.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.5 10.9 GO:0044458 motile cilium assembly(GO:0044458)
0.5 0.9 GO:0015801 aromatic amino acid transport(GO:0015801)
0.4 1.8 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
0.4 1.3 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.4 9.3 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.4 3.8 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.4 2.5 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205)
0.4 2.0 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 1.2 GO:2000686 positive regulation of rubidium ion transport(GO:2000682) regulation of rubidium ion transmembrane transporter activity(GO:2000686) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
0.4 4.3 GO:0006228 UTP biosynthetic process(GO:0006228)
0.4 1.2 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.4 2.0 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.4 3.1 GO:0071000 response to magnetism(GO:0071000)
0.4 15.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.4 6.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 1.8 GO:0070202 regulation of establishment of protein localization to chromosome(GO:0070202)
0.3 4.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.3 1.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.3 5.8 GO:0070166 enamel mineralization(GO:0070166)
0.3 8.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.3 7.5 GO:0048240 sperm capacitation(GO:0048240)
0.3 5.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.3 2.8 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 1.2 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.2 2.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 3.9 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.2 5.4 GO:0001556 oocyte maturation(GO:0001556)
0.2 1.6 GO:0035330 regulation of hippo signaling(GO:0035330)
0.2 4.8 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.2 2.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 0.6 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.2 3.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 2.1 GO:0097264 self proteolysis(GO:0097264)
0.2 1.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 3.7 GO:0006020 inositol metabolic process(GO:0006020)
0.2 4.4 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 1.6 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.2 2.0 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 7.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 2.0 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 1.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 1.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.2 1.7 GO:0000338 protein deneddylation(GO:0000338)
0.2 9.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.2 2.0 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 0.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 1.4 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 5.0 GO:0017144 drug metabolic process(GO:0017144)
0.1 2.6 GO:0031424 keratinization(GO:0031424)
0.1 1.3 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 2.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 7.8 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 4.8 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.1 2.8 GO:0060065 uterus development(GO:0060065)
0.1 4.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 13.2 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 0.3 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.1 0.8 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 0.7 GO:2000020 positive regulation of male gonad development(GO:2000020)
0.1 2.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 3.0 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.7 GO:0046836 glycolipid transport(GO:0046836)
0.1 1.2 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.1 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 12.2 GO:0006413 translational initiation(GO:0006413)
0.1 0.7 GO:0070417 cellular response to cold(GO:0070417)
0.1 1.9 GO:0035886 vascular smooth muscle cell differentiation(GO:0035886) histone H2A acetylation(GO:0043968)
0.1 4.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 6.5 GO:0006405 RNA export from nucleus(GO:0006405)
0.1 2.2 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 1.6 GO:0042730 fibrinolysis(GO:0042730)
0.1 3.2 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 1.1 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.1 1.7 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 5.0 GO:0030101 natural killer cell activation(GO:0030101)
0.1 2.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.2 GO:1904976 cellular response to bleomycin(GO:1904976)
0.1 1.8 GO:0051642 centrosome localization(GO:0051642)
0.1 0.5 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 3.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.7 GO:0007628 adult walking behavior(GO:0007628)
0.1 1.3 GO:0007099 centriole replication(GO:0007099)
0.1 1.5 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.1 5.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 24.6 GO:0007283 spermatogenesis(GO:0007283)
0.1 1.1 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 1.7 GO:0006623 protein targeting to vacuole(GO:0006623)
0.1 1.4 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 4.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.1 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.8 GO:0001696 gastric acid secretion(GO:0001696)
0.0 1.8 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 1.2 GO:1901099 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 4.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 5.0 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 2.3 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.1 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.0 2.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.9 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.5 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0061462 protein localization to lysosome(GO:0061462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.6 GO:0034774 secretory granule lumen(GO:0034774)
2.7 49.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
2.6 7.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.6 8.2 GO:1990716 axonemal central apparatus(GO:1990716)
1.6 11.0 GO:0031094 platelet dense tubular network(GO:0031094)
1.3 9.2 GO:0036128 CatSper complex(GO:0036128)
1.0 8.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.0 4.0 GO:0005606 laminin-1 complex(GO:0005606)
0.9 8.9 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.8 6.7 GO:0044194 cytolytic granule(GO:0044194)
0.8 2.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.8 6.3 GO:0005869 dynactin complex(GO:0005869)
0.7 3.0 GO:0044299 C-fiber(GO:0044299)
0.7 4.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.7 8.4 GO:0043219 lateral loop(GO:0043219)
0.7 2.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.6 7.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.6 6.7 GO:0005915 zonula adherens(GO:0005915)
0.6 3.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.6 6.3 GO:0072687 meiotic spindle(GO:0072687)
0.5 1.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.5 4.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.5 1.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.4 11.2 GO:0097225 sperm midpiece(GO:0097225)
0.4 4.3 GO:0034464 BBSome(GO:0034464)
0.4 4.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 17.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 4.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 43.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 2.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 46.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 4.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 13.6 GO:0030286 dynein complex(GO:0030286)
0.3 3.6 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 2.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 0.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 10.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 2.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 2.1 GO:0042555 MCM complex(GO:0042555)
0.2 9.8 GO:0000795 synaptonemal complex(GO:0000795)
0.2 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 4.8 GO:0005605 basal lamina(GO:0005605)
0.2 2.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 1.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 17.7 GO:0005902 microvillus(GO:0005902)
0.2 0.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 2.7 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 2.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.2 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 1.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 5.1 GO:0035861 site of double-strand break(GO:0035861)
0.1 18.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 0.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 7.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 5.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.6 GO:0030057 desmosome(GO:0030057)
0.1 6.4 GO:0005876 spindle microtubule(GO:0005876)
0.1 4.4 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 11.6 GO:0005814 centriole(GO:0005814)
0.1 2.3 GO:0005686 U2 snRNP(GO:0005686)
0.1 1.9 GO:0032420 stereocilium(GO:0032420)
0.1 1.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.1 3.2 GO:0008180 COP9 signalosome(GO:0008180)
0.1 32.9 GO:0005813 centrosome(GO:0005813)
0.1 21.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.1 GO:0098871 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.1 6.6 GO:0000776 kinetochore(GO:0000776)
0.1 2.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 23.7 GO:0016607 nuclear speck(GO:0016607)
0.1 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.9 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.6 GO:0030496 midbody(GO:0030496)
0.0 1.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 14.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 1.6 GO:0030120 vesicle coat(GO:0030120)
0.0 5.6 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 4.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.7 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 4.6 GO:0005938 cell cortex(GO:0005938)
0.0 4.8 GO:0005929 cilium(GO:0005929)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.9 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.0 3.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.1 GO:0043204 perikaryon(GO:0043204)
0.0 0.8 GO:0043195 terminal bouton(GO:0043195)
0.0 11.0 GO:0005856 cytoskeleton(GO:0005856)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.3 42.8 GO:0052853 very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
3.8 15.3 GO:0015350 methotrexate transporter activity(GO:0015350)
3.3 49.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
3.3 9.8 GO:0004769 steroid delta-isomerase activity(GO:0004769)
3.0 9.1 GO:0004370 glycerol kinase activity(GO:0004370)
2.7 11.0 GO:0032190 acrosin binding(GO:0032190)
2.7 8.1 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
1.9 7.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
1.9 5.6 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
1.7 8.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
1.6 4.7 GO:0042903 tubulin deacetylase activity(GO:0042903)
1.5 4.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.5 4.4 GO:0031249 denatured protein binding(GO:0031249)
1.4 12.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.3 3.9 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
1.3 7.8 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.3 3.8 GO:0070698 type I activin receptor binding(GO:0070698)
1.1 8.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.0 3.9 GO:0047619 acylcarnitine hydrolase activity(GO:0047619)
0.9 18.6 GO:0008199 ferric iron binding(GO:0008199)
0.9 3.7 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829)
0.8 7.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.8 5.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.7 8.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.7 8.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.7 8.1 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.7 2.6 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 4.4 GO:0003896 DNA primase activity(GO:0003896)
0.6 2.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.6 2.3 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.5 2.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.5 4.3 GO:0071253 connexin binding(GO:0071253)
0.5 5.8 GO:0042608 T cell receptor binding(GO:0042608)
0.5 4.7 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.5 6.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.5 3.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.5 1.5 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.4 8.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 4.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.4 7.8 GO:0035173 histone kinase activity(GO:0035173)
0.4 1.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.4 2.4 GO:0033142 progesterone receptor binding(GO:0033142)
0.4 13.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 5.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.4 4.5 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 1.1 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.4 5.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 2.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.3 2.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 9.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.3 3.6 GO:0003796 lysozyme activity(GO:0003796)
0.3 7.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 3.5 GO:0070097 delta-catenin binding(GO:0070097)
0.3 32.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 7.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 4.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 15.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 8.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 4.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 0.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 4.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 4.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 0.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 4.8 GO:0019825 oxygen binding(GO:0019825)
0.2 1.4 GO:0016421 CoA carboxylase activity(GO:0016421)
0.2 8.5 GO:0070888 E-box binding(GO:0070888)
0.2 5.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.6 GO:0030172 troponin C binding(GO:0030172)
0.2 1.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 1.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 2.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 2.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.5 GO:0070052 collagen V binding(GO:0070052)
0.1 2.5 GO:0016594 glycine binding(GO:0016594)
0.1 0.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 3.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 5.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 9.3 GO:0046332 SMAD binding(GO:0046332)
0.1 3.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 2.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 2.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.0 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.9 GO:0043274 phospholipase binding(GO:0043274)
0.1 7.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 5.1 GO:0017022 myosin binding(GO:0017022)
0.1 0.7 GO:0008432 JUN kinase binding(GO:0008432)
0.1 10.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 7.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 0.3 GO:0050733 RS domain binding(GO:0050733)
0.1 1.4 GO:0030276 clathrin binding(GO:0030276)
0.1 0.5 GO:0003720 double-stranded telomeric DNA binding(GO:0003691) telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 7.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 4.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 21.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 12.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 4.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 2.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 3.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 13.3 GO:0008289 lipid binding(GO:0008289)
0.0 2.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 8.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 21.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 4.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 11.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 6.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 4.5 PID CONE PATHWAY Visual signal transduction: Cones
0.2 4.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.8 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 9.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.5 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.0 PID IL23 PATHWAY IL23-mediated signaling events
0.1 4.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.4 PID AURORA A PATHWAY Aurora A signaling
0.1 3.5 PID BMP PATHWAY BMP receptor signaling
0.1 0.9 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 4.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 2.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 8.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 13.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.1 PID E2F PATHWAY E2F transcription factor network
0.0 1.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.7 8.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.5 8.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4 6.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.4 8.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 7.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.3 11.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 4.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 3.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 10.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.3 4.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 4.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 4.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 2.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 4.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 3.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 5.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 3.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 4.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 4.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 4.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 3.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway