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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa1

Z-value: 1.37

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Transcription factors associated with Hoxa1

Gene Symbol Gene ID Gene Info
Hoxa1
ENSRNOG00000005628 homeo box A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa1rn6_v1_chr4_-_82127051_821270660.141.3e-02Click!

Activity profile of Hoxa1 motif

Sorted Z-values of Hoxa1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_96131880 78.49 ENSRNOT00000004578
Cacng5
calcium voltage-gated channel auxiliary subunit gamma 5
chr4_-_184096806 74.49 ENSRNOT00000055433
LOC100362344
mKIAA1238 protein-like
chr9_-_88256115 73.28 ENSRNOT00000076472
Col4a4
collagen type IV alpha 4 chain
chr8_+_13796021 72.75 ENSRNOT00000013927
Vstm5
V-set and transmembrane domain containing 5
chr3_+_154863072 58.49 ENSRNOT00000055200
Snhg11
small nucleolar RNA host gene 11
chr11_-_64421248 54.15 ENSRNOT00000066997
Igsf11
immunoglobulin superfamily, member 11
chr3_+_51883559 42.63 ENSRNOT00000007197
Csrnp3
cysteine and serine rich nuclear protein 3
chr15_-_88036354 41.88 ENSRNOT00000014747
Ednrb
endothelin receptor type B
chr1_-_170397191 41.19 ENSRNOT00000090181
Apbb1
amyloid beta precursor protein binding family B member 1
chr4_-_155275161 40.17 ENSRNOT00000032690
Rimklb
ribosomal modification protein rimK-like family member B
chr20_-_4489281 39.08 ENSRNOT00000031548
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
chr13_+_46169963 36.84 ENSRNOT00000005212
Thsd7b
thrombospondin type 1 domain containing 7B
chr8_-_2045817 35.71 ENSRNOT00000009542
ENSRNOT00000081171
ENSRNOT00000078765
Gria4
glutamate ionotropic receptor AMPA type subunit 4
chr4_-_4473307 33.88 ENSRNOT00000045773
Dpp6
dipeptidyl peptidase like 6
chr13_+_77485113 28.03 ENSRNOT00000080254
Tnr
tenascin R
chr10_+_42614713 26.14 ENSRNOT00000081136
ENSRNOT00000073148
Gria1
glutamate ionotropic receptor AMPA type subunit 1
chr9_+_118849302 25.66 ENSRNOT00000087592
Dlgap1
DLG associated protein 1
chr16_+_46731403 25.44 ENSRNOT00000017624
Tenm3
teneurin transmembrane protein 3
chr9_-_60255746 24.66 ENSRNOT00000093710
Dnah7
dynein, axonemal, heavy chain 7
chr5_-_126395668 24.08 ENSRNOT00000010396
Acot11
acyl-CoA thioesterase 11
chr15_+_43007908 23.23 ENSRNOT00000084753
ENSRNOT00000091567
ENSRNOT00000087709
Stmn4
stathmin 4
chr1_-_7443863 21.96 ENSRNOT00000088558
Phactr2
phosphatase and actin regulator 2
chr1_-_260992291 20.56 ENSRNOT00000035415
ENSRNOT00000034758
Slit1
slit guidance ligand 1
chr2_+_3662763 19.18 ENSRNOT00000017828
Mctp1
multiple C2 and transmembrane domain containing 1
chr7_+_123482255 17.86 ENSRNOT00000064487
LOC688613
hypothetical protein LOC688613
chr2_+_145174876 17.26 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr4_-_170860225 16.24 ENSRNOT00000007577
Mgp
matrix Gla protein
chr8_+_82257849 16.24 ENSRNOT00000011963
ENSRNOT00000075708
Gnb5
G protein subunit beta 5
chr3_-_158328881 16.18 ENSRNOT00000044466
Ptprt
protein tyrosine phosphatase, receptor type, T
chr1_+_264796812 15.58 ENSRNOT00000021171
Sfxn3
sideroflexin 3
chr5_+_124021366 15.15 ENSRNOT00000009977
Dab1
DAB1, reelin adaptor protein
chr7_+_70753101 13.69 ENSRNOT00000090001
R3hdm2
R3H domain containing 2
chr7_+_29435444 12.94 ENSRNOT00000008613
Slc5a8
solute carrier family 5 member 8
chr6_+_26387877 12.24 ENSRNOT00000076105
Fndc4

chr17_+_4846789 12.07 ENSRNOT00000073271
Gas1
growth arrest-specific 1
chr20_-_31956649 11.95 ENSRNOT00000072429
Hk1
hexokinase 1
chr7_+_124680294 11.86 ENSRNOT00000014720
Mpped1
metallophosphoesterase domain containing 1
chr13_+_84474319 11.82 ENSRNOT00000031367
ENSRNOT00000072244
ENSRNOT00000072897
ENSRNOT00000064168
ENSRNOT00000074954
ENSRNOT00000073696
Ildr2
immunoglobulin-like domain containing receptor 2
chr15_+_41448064 11.40 ENSRNOT00000019551
Sacs
sacsin molecular chaperone
chr12_+_11179329 11.34 ENSRNOT00000001302
Zfp394
zinc finger protein 394
chr10_-_25910298 10.83 ENSRNOT00000065633
ENSRNOT00000079646
Ccng1
cyclin G1
chr5_-_7941822 10.48 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_49419582 10.05 ENSRNOT00000082998
RGD1306556
similar to hypothetical protein A530094D01
chr14_+_3506339 9.82 ENSRNOT00000002867
Tgfbr3
transforming growth factor beta receptor 3
chr10_-_14443010 9.79 ENSRNOT00000022142
Tmem204
transmembrane protein 204
chr5_-_6083083 9.64 ENSRNOT00000072411
Sulf1
sulfatase 1
chr10_+_84200880 9.39 ENSRNOT00000011213
Hoxb2
homeobox B2
chr19_-_39267928 9.19 ENSRNOT00000027686
Tmed6
transmembrane p24 trafficking protein 6
chr12_+_13323547 8.74 ENSRNOT00000074138
Zfp853
zinc finger protein 853
chr11_-_25078740 8.70 ENSRNOT00000002109
Cyyr1
cysteine and tyrosine rich 1
chr12_+_17735740 8.56 ENSRNOT00000001775
Pdgfa
platelet derived growth factor subunit A
chr3_-_133122691 8.56 ENSRNOT00000083637
Tasp1
taspase 1
chr13_+_71107465 8.41 ENSRNOT00000003239
Rgs8
regulator of G-protein signaling 8
chr10_-_8498422 8.18 ENSRNOT00000082332
Rbfox1
RNA binding protein, fox-1 homolog 1
chrX_+_82143789 7.50 ENSRNOT00000003724
Pou3f4
POU class 3 homeobox 4
chr16_+_24980723 7.41 ENSRNOT00000082142
Tma16
translation machinery associated 16 homolog
chr4_+_31333970 7.28 ENSRNOT00000064866
LOC100911994
coiled-coil domain-containing protein 132-like
chr15_-_18675431 7.20 ENSRNOT00000080794
Abhd6
abhydrolase domain containing 6
chr16_+_4997461 7.19 ENSRNOT00000071042
LOC102547963
leucine-rich repeat and transmembrane domain-containing protein 1-like
chr10_-_87153982 6.35 ENSRNOT00000014414
Krt222
keratin 222
chr12_+_13810180 5.70 ENSRNOT00000084865
ENSRNOT00000038203
Tnrc18
trinucleotide repeat containing 18
chr1_+_243375981 5.11 ENSRNOT00000080689
Kank1
KN motif and ankyrin repeat domains 1
chr1_-_215838209 4.81 ENSRNOT00000050760
Igf2
insulin-like growth factor 2
chr20_-_6556350 4.03 ENSRNOT00000035819
Lemd2
LEM domain containing 2
chr1_-_222350173 3.93 ENSRNOT00000030625
Flrt1
fibronectin leucine rich transmembrane protein 1
chr5_+_168078748 3.43 ENSRNOT00000024798
Uts2
urotensin 2
chr10_-_95062987 3.10 ENSRNOT00000019781
Smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr2_+_248398917 2.94 ENSRNOT00000045855
Gbp1
guanylate binding protein 1
chr3_+_148438939 2.84 ENSRNOT00000064196
Ttll9
tubulin tyrosine ligase like 9
chr6_+_145546595 2.62 ENSRNOT00000007112
Rapgef5
Rap guanine nucleotide exchange factor 5
chr8_-_19386384 2.54 ENSRNOT00000051572
Olr1145
olfactory receptor 1145
chr13_+_75059927 2.25 ENSRNOT00000080801
LOC680254
hypothetical protein LOC680254
chr5_-_155381732 2.08 ENSRNOT00000033670
Zbtb40
zinc finger and BTB domain containing 40
chr16_-_62241361 1.94 ENSRNOT00000090036
Gsr
glutathione-disulfide reductase
chr16_+_83522162 1.89 ENSRNOT00000057386
Col4a1
collagen type IV alpha 1 chain
chr16_+_34795971 1.85 ENSRNOT00000043510
LOC100912321
myeloid-associated differentiation marker-like
chr1_+_230030914 1.69 ENSRNOT00000075730
Olr354
olfactory receptor 354
chr1_+_229443102 1.58 ENSRNOT00000067320
Olr334
olfactory receptor 334
chr1_+_229480184 1.36 ENSRNOT00000044115
Olr387
olfactory receptor 387
chr17_-_66397653 1.30 ENSRNOT00000024098
Actn2
actinin alpha 2
chr2_+_205488182 1.16 ENSRNOT00000024270
Sike1
suppressor of IKBKE 1
chr2_-_209582627 0.97 ENSRNOT00000024351
Olr392
olfactory receptor 392
chr4_+_149908375 0.95 ENSRNOT00000019504
LOC100909657
uncharacterized LOC100909657
chr1_+_167811491 0.79 ENSRNOT00000072109
LOC684171
similar to olfactory receptor 555
chr2_+_92549479 0.70 ENSRNOT00000082912
tGap1
GTPase activating protein testicular GAP1
chr6_+_26566494 0.62 ENSRNOT00000079292
Gtf3c2
general transcription factor IIIC subunit 2
chr10_-_62366044 0.38 ENSRNOT00000045673
Olr1474
olfactory receptor 1474
chr16_-_20640720 0.37 ENSRNOT00000083254
AABR07024877.1

chr10_-_65507581 0.21 ENSRNOT00000016759
Supt6h
SPT6 homolog, histone chaperone
chr8_+_20535478 0.05 ENSRNOT00000049066
Olr1174
olfactory receptor 1174

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 41.9 GO:0014826 vein smooth muscle contraction(GO:0014826)
6.4 82.9 GO:0032836 glomerular basement membrane development(GO:0032836)
5.1 20.6 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
5.0 15.1 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
4.7 28.0 GO:0048690 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682) regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
3.7 26.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
3.3 9.8 GO:0060939 transforming growth factor beta receptor complex assembly(GO:0007181) cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939)
3.2 25.7 GO:0070842 aggresome assembly(GO:0070842)
3.1 9.4 GO:0021570 rhombomere 3 development(GO:0021569) rhombomere 4 development(GO:0021570)
3.1 15.6 GO:0006842 tricarboxylic acid transport(GO:0006842)
2.9 78.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.9 8.6 GO:1990401 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
2.8 39.1 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705)
2.3 25.4 GO:0097264 self proteolysis(GO:0097264)
2.0 11.9 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
1.8 7.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.6 35.7 GO:0060992 response to fungicide(GO:0060992)
1.5 24.7 GO:0036159 inner dynein arm assembly(GO:0036159)
1.3 5.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.2 12.1 GO:0042473 outer ear morphogenesis(GO:0042473)
1.1 3.4 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
1.0 11.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
1.0 3.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
1.0 16.2 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.8 35.2 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.8 8.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.7 41.2 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.7 4.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.6 7.5 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.5 2.9 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.5 42.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 5.7 GO:0031507 heterochromatin assembly(GO:0031507)
0.4 10.8 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.4 8.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.4 9.8 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.4 1.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.4 4.0 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.4 23.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 24.1 GO:0009409 response to cold(GO:0009409)
0.2 11.8 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.2 16.2 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 10.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 1.9 GO:0010041 response to iron(III) ion(GO:0010041)
0.1 16.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 11.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 43.4 GO:0040008 regulation of growth(GO:0040008)
0.1 17.3 GO:0043010 camera-type eye development(GO:0043010)
0.1 0.2 GO:0070827 chromatin maintenance(GO:0070827)
0.0 19.2 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 79.1 GO:0036211 cellular protein modification process(GO:0006464) protein modification process(GO:0036211)
0.0 0.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 41.2 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
9.4 75.2 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
6.2 24.7 GO:0036156 inner dynein arm(GO:0036156)
6.0 35.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
5.6 28.0 GO:0072534 perineuronal net(GO:0072534)
4.4 26.1 GO:0044308 axonal spine(GO:0044308)
3.3 9.8 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
2.8 85.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 2.9 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.6 5.7 GO:0005677 chromatin silencing complex(GO:0005677)
0.4 12.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 16.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 11.9 GO:0097228 sperm principal piece(GO:0097228)
0.3 33.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 12.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 23.2 GO:0030426 growth cone(GO:0030426)
0.1 40.8 GO:0014069 postsynaptic density(GO:0014069)
0.1 51.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 8.6 GO:0005902 microvillus(GO:0005902)
0.1 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 43.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 8.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 6.4 GO:0005882 intermediate filament(GO:0005882)
0.0 92.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 15.6 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 10.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 3.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 10.3 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 78.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 3.5 GO:0005840 ribosome(GO:0005840)
0.0 82.1 GO:0005737 cytoplasm(GO:0005737)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
38.2 114.7 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
12.4 61.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
8.4 41.9 GO:0004962 endothelin receptor activity(GO:0004962)
3.4 33.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
3.1 15.6 GO:0015142 tricarboxylic acid transmembrane transporter activity(GO:0015142)
2.9 20.6 GO:0048495 Roundabout binding(GO:0048495)
2.4 9.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.0 11.9 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.0 25.7 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
2.0 41.2 GO:0048156 tau protein binding(GO:0048156)
1.4 78.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.4 91.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.4 39.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
1.2 16.2 GO:0070097 alpha-catenin binding(GO:0045294) delta-catenin binding(GO:0070097)
1.1 8.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 9.8 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.9 16.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.7 7.5 GO:0003680 AT DNA binding(GO:0003680)
0.7 2.9 GO:0019002 GMP binding(GO:0019002)
0.7 22.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.6 11.4 GO:0070628 proteasome binding(GO:0070628)
0.6 7.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 10.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 8.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 15.1 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 2.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 19.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 1.9 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.3 4.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 1.3 GO:0051373 FATZ binding(GO:0051373)
0.3 28.0 GO:0005178 integrin binding(GO:0005178)
0.3 8.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 3.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 11.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 5.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 23.2 GO:0015631 tubulin binding(GO:0015631)
0.1 36.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 3.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.2 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 21.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 8.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 3.4 GO:0005179 hormone activity(GO:0005179)
0.0 5.7 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 8.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 2.8 GO:0016874 ligase activity(GO:0016874)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 75.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.7 41.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.6 16.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.5 12.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.5 41.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 15.1 PID REELIN PATHWAY Reelin signaling pathway
0.4 25.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 15.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 16.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 10.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 15.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 12.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 11.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 8.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 28.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 10.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 9.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 63.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.7 75.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.7 16.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.4 20.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 45.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.2 11.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 4.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 12.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 8.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 8.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter