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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa7_Hoxc8

Z-value: 0.77

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Transcription factors associated with Hoxa7_Hoxc8

Gene Symbol Gene ID Gene Info
Hoxa7
ENSRNOG00000049858 homeobox A7
Hoxc8
ENSRNOG00000028619 homeobox C8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc8rn6_v1_chr7_+_144605058_1446050580.636.1e-37Click!
Hoxa7rn6_v1_chr4_-_82271893_822718930.164.9e-03Click!

Activity profile of Hoxa7_Hoxc8 motif

Sorted Z-values of Hoxa7_Hoxc8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_64789940 63.79 ENSRNOT00000085979
ENSRNOT00000059739
ENSRNOT00000051908
ENSRNOT00000082793
ENSRNOT00000078583
ENSRNOT00000091677
ENSRNOT00000093241
Nrcam
neuronal cell adhesion molecule
chr3_-_15278645 27.43 ENSRNOT00000032204
Ttll11
tubulin tyrosine ligase like11
chr9_+_73378057 26.09 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
Map2
microtubule-associated protein 2
chr2_-_57935334 21.75 ENSRNOT00000022319
ENSRNOT00000085599
ENSRNOT00000077790
ENSRNOT00000035821
Slc1a3
solute carrier family 1 member 3
chr9_+_73418607 19.16 ENSRNOT00000092547
Map2
microtubule-associated protein 2
chr1_-_236900904 18.56 ENSRNOT00000066846
AABR07006480.1

chr14_+_39964588 17.91 ENSRNOT00000003240
Gabrg1
gamma-aminobutyric acid type A receptor gamma 1 subunit
chrX_+_84064427 17.77 ENSRNOT00000046364
Zfp711
zinc finger protein 711
chr2_+_145174876 16.97 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr1_-_236729412 16.31 ENSRNOT00000054794
Prune2
prune homolog 2
chr8_+_33239139 15.73 ENSRNOT00000011589
Arhgap32
Rho GTPase activating protein 32
chr15_+_62406873 15.55 ENSRNOT00000047572
Olfm4
olfactomedin 4
chr9_+_67234303 13.76 ENSRNOT00000050179
Abi2
abl-interactor 2
chr4_+_94696965 12.58 ENSRNOT00000064696
Grid2
glutamate ionotropic receptor delta type subunit 2
chr2_-_33025271 12.13 ENSRNOT00000074941
NEWGENE_1310139
microtubule associated serine/threonine kinase family member 4
chr1_+_170205591 11.94 ENSRNOT00000071063
LOC686660
similar to olfactory receptor 692
chrX_+_14019961 10.05 ENSRNOT00000004785
Sytl5
synaptotagmin-like 5
chr3_+_48096954 9.27 ENSRNOT00000068238
ENSRNOT00000064344
ENSRNOT00000044638
Slc4a10
solute carrier family 4 member 10
chr18_+_30036887 8.61 ENSRNOT00000077824
Pcdha4
protocadherin alpha 4
chr2_-_35870578 8.48 ENSRNOT00000066069
Rnf180
ring finger protein 180
chrX_+_131381134 7.92 ENSRNOT00000007474
AABR07041481.1

chr12_-_52658275 7.88 ENSRNOT00000041981
Zfp605
zinc finger protein 605
chr4_-_150485781 7.70 ENSRNOT00000008763
Zfp248
zinc finger protein 248
chr10_-_74679858 7.55 ENSRNOT00000003859
Ppm1e
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr8_-_128754514 7.31 ENSRNOT00000025019
Cx3cr1
C-X3-C motif chemokine receptor 1
chr8_-_17696989 6.80 ENSRNOT00000083752
AABR07069336.1

chr18_+_14757679 6.53 ENSRNOT00000071364
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_-_52849907 6.51 ENSRNOT00000041096
Scn7a
sodium voltage-gated channel alpha subunit 7
chr2_+_72006099 6.47 ENSRNOT00000034044
Cdh12
cadherin 12
chr18_+_30592794 6.29 ENSRNOT00000027133
Pcdhb22
protocadherin beta 22
chr8_+_82038967 6.28 ENSRNOT00000079535
Myo5a
myosin VA
chr10_+_84135116 6.24 ENSRNOT00000031035
Hoxb7
homeo box B7
chr9_+_84203072 6.19 ENSRNOT00000018882
Sgpp2
sphingosine-1-phosphate phosphatase 2
chr5_-_133959447 6.07 ENSRNOT00000011985
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr4_+_148208260 5.95 ENSRNOT00000015742
Zfand4
zinc finger AN1-type containing 4
chr9_+_71915421 5.80 ENSRNOT00000020447
Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
chr5_+_58661049 5.73 ENSRNOT00000078274
Unc13b
unc-13 homolog B
chr2_-_98610368 5.69 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr4_-_18396035 5.67 ENSRNOT00000034692
Sema3a
semaphorin 3A
chrX_-_69218526 5.60 ENSRNOT00000092321
ENSRNOT00000074071
ENSRNOT00000092571
Pja1
praja ring finger ubiquitin ligase 1
chr3_-_64095120 5.54 ENSRNOT00000016837
Sestd1
SEC14 and spectrin domain containing 1
chr6_+_44225233 5.49 ENSRNOT00000066593
Kidins220
kinase D-interacting substrate 220
chr20_+_27366213 5.43 ENSRNOT00000000302
ENSRNOT00000057939
Tet1
tet methylcytosine dioxygenase 1
chr3_-_52447622 5.31 ENSRNOT00000083552
Scn1a
sodium voltage-gated channel alpha subunit 1
chr5_+_58995249 5.07 ENSRNOT00000023411
Ccdc107
coiled-coil domain containing 107
chr1_+_99505677 5.02 ENSRNOT00000024645
Zfp719
zinc finger protein 719
chrX_+_9956370 4.74 ENSRNOT00000082316
LOC100910506
peripheral plasma membrane protein CASK-like
chr5_+_22392732 4.69 ENSRNOT00000087182
Clvs1
clavesin 1
chr20_+_3830164 4.66 ENSRNOT00000045533
ENSRNOT00000084117
Col11a2
collagen type XI alpha 2 chain
chr16_+_48513432 4.64 ENSRNOT00000044934
LOC685135
similar to NADH-ubiquinone oxidoreductase B9 subunit (Complex I-B9) (CI-B9)
chrX_-_32095867 4.62 ENSRNOT00000049947
ENSRNOT00000080730
Ace2
angiotensin I converting enzyme 2
chr8_+_122076759 4.50 ENSRNOT00000012545
Clasp2
cytoplasmic linker associated protein 2
chr9_-_30251388 4.50 ENSRNOT00000035033
Sdhaf4
succinate dehydrogenase complex assembly factor 4
chr8_-_39460844 4.50 ENSRNOT00000048875
Pknox2
PBX/knotted 1 homeobox 2
chr1_+_87224677 4.48 ENSRNOT00000028070
Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_69841998 4.36 ENSRNOT00000072231
Zfp773-ps1
zinc finger protein 773, pseudogene 1
chr11_+_53081025 4.35 ENSRNOT00000002700
Bbx
BBX, HMG-box containing
chr1_-_23556241 4.29 ENSRNOT00000072943
LOC100910446
syntaxin-7-like
chr2_-_185852759 4.26 ENSRNOT00000049461
Mab21l2
mab-21 like 2
chr2_-_139528162 4.17 ENSRNOT00000014317
Slc7a11
solute carrier family 7 member 11
chr7_-_107203897 3.99 ENSRNOT00000086263
Lrrc6
leucine rich repeat containing 6
chr3_-_21904133 3.96 ENSRNOT00000090576
ENSRNOT00000087611
ENSRNOT00000066377
Strbp
spermatid perinuclear RNA binding protein
chr3_-_160561741 3.68 ENSRNOT00000018364
Kcns1
potassium voltage-gated channel, modifier subfamily S, member 1
chr7_+_23854846 3.58 ENSRNOT00000037290
Bpifc
BPI fold containing family C
chr18_+_30880020 3.27 ENSRNOT00000060468
Pcdhgb5
protocadherin gamma subfamily B, 5
chr2_+_196462554 3.22 ENSRNOT00000056380
Fam63a
family with sequence similarity 63, member A
chr17_+_34704616 3.21 ENSRNOT00000090706
ENSRNOT00000083674
ENSRNOT00000077110
Exoc2
exocyst complex component 2
chr8_-_33121002 3.12 ENSRNOT00000047211
LOC100362981
LRRGT00010-like
chr6_+_106052212 3.10 ENSRNOT00000010626
Sipa1l1
signal-induced proliferation-associated 1 like 1
chr8_+_71591360 3.04 ENSRNOT00000090096
Csnk1g1
casein kinase 1, gamma 1
chr8_-_7426611 3.02 ENSRNOT00000031492
Arhgap42
Rho GTPase activating protein 42
chr10_-_71441389 2.97 ENSRNOT00000003699
Tada2a
transcriptional adaptor 2A
chr10_+_90230711 2.90 ENSRNOT00000055185
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr1_-_43638161 2.88 ENSRNOT00000024460
Ipcef1
interaction protein for cytohesin exchange factors 1
chr8_-_87419564 2.84 ENSRNOT00000015365
Filip1
filamin A interacting protein 1
chr4_+_157524423 2.75 ENSRNOT00000036654
Zfp384
zinc finger protein 384
chr4_+_29535852 2.69 ENSRNOT00000087619
NEWGENE_621351
collagen, type I, alpha 2
chr17_-_2705123 2.60 ENSRNOT00000024940
Olr1652
olfactory receptor 1652
chr12_+_25430464 2.58 ENSRNOT00000002020
Gtf2i
general transcription factor II I
chr8_-_69508024 2.58 ENSRNOT00000083564
AABR07070416.3

chr11_-_61287914 2.40 ENSRNOT00000086286
Spice1
spindle and centriole associated protein 1
chr2_+_226563050 2.38 ENSRNOT00000065111
Bcar3
breast cancer anti-estrogen resistance 3
chrM_+_9870 2.29 ENSRNOT00000044582
Mt-nd4l
mitochondrially encoded NADH 4L dehydrogenase
chr1_-_212633304 2.25 ENSRNOT00000025611
Olr286
olfactory receptor 286
chrX_+_144994139 2.25 ENSRNOT00000071783
LOC102546596
pre-mRNA-splicing factor CWC22 homolog
chr4_-_131694755 2.23 ENSRNOT00000013271
Foxp1
forkhead box P1
chr3_+_77047466 2.19 ENSRNOT00000089424
Olr648
olfactory receptor 648
chr11_+_70056624 2.14 ENSRNOT00000002447
AC133403.1

chr5_+_6373583 2.08 ENSRNOT00000084749
AABR07046778.1

chr18_+_30820321 2.07 ENSRNOT00000060472
Pcdhga3
protocadherin gamma subfamily A, 3
chr17_-_14627937 2.07 ENSRNOT00000020532
NEWGENE_1308171
osteoglycin
chr1_+_217345545 1.95 ENSRNOT00000071741
Shank2
SH3 and multiple ankyrin repeat domains 2
chr1_+_141767940 1.93 ENSRNOT00000064034
Zfp710
zinc finger protein 710
chr2_-_170301348 1.92 ENSRNOT00000088131
Si
sucrase-isomaltase
chr3_+_172550258 1.89 ENSRNOT00000075148
Tubb1
tubulin, beta 1 class VI
chr1_-_241046249 1.85 ENSRNOT00000067796
ENSRNOT00000081866
Smc5
structural maintenance of chromosomes 5
chr17_+_11683862 1.82 ENSRNOT00000024766
Msx2
msh homeobox 2
chr3_-_45169118 1.79 ENSRNOT00000086371
Ccdc148
coiled-coil domain containing 148
chrX_-_16532089 1.75 ENSRNOT00000093156
Dgkk
diacylglycerol kinase kappa
chr3_+_148654668 1.72 ENSRNOT00000081370
Tm9sf4
transmembrane 9 superfamily member 4
chr18_+_59748444 1.70 ENSRNOT00000024752
St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr2_+_112914375 1.67 ENSRNOT00000092737
Nceh1
neutral cholesterol ester hydrolase 1
chr11_+_46737892 1.54 ENSRNOT00000052182
AABR07033979.1

chr10_+_76320041 1.49 ENSRNOT00000037693
Coil
coilin
chr1_+_227892956 1.49 ENSRNOT00000028483
AABR07006278.1

chr20_+_42966140 1.49 ENSRNOT00000000707
Marcks
myristoylated alanine rich protein kinase C substrate
chr3_-_141411170 1.43 ENSRNOT00000017364
Nkx2-2
NK2 homeobox 2
chr20_+_1172867 1.34 ENSRNOT00000041189
Olr1708
olfactory receptor 1708
chr1_+_201337416 1.30 ENSRNOT00000067742
Btbd16
BTB domain containing 16
chr8_+_5833359 1.27 ENSRNOT00000033306
Mmp20
matrix metallopeptidase 20
chr3_+_31802999 1.26 ENSRNOT00000041305
AABR07051996.1

chrX_-_70835089 1.25 ENSRNOT00000076351
Tex11
testis expressed 11
chr3_-_90751055 1.21 ENSRNOT00000040741
LOC499843
LRRGT00091
chr1_+_86429262 1.16 ENSRNOT00000045789
Vom1r3
vomeronasal 1 receptor 3
chr16_+_24978527 1.14 ENSRNOT00000019363
Tma16
translation machinery associated 16 homolog
chr18_-_74059533 1.05 ENSRNOT00000038767
RGD1308601
similar to hypothetical protein
chr9_+_71247781 1.03 ENSRNOT00000049654
Creb1
cAMP responsive element binding protein 1
chr10_+_61685645 0.88 ENSRNOT00000003933
Mnt
MAX network transcriptional repressor
chr6_+_2216623 0.87 ENSRNOT00000008045
Rmdn2
regulator of microtubule dynamics 2
chr1_+_255579474 0.79 ENSRNOT00000024465
Btaf1
B-TFIID TATA-box binding protein associated factor 1
chr8_-_20173107 0.72 ENSRNOT00000045215
Olr1163
olfactory receptor 1163
chr4_+_2593876 0.70 ENSRNOT00000092992
Ube3c
ubiquitin protein ligase E3C
chr10_+_91126689 0.55 ENSRNOT00000004046
Nmt1
N-myristoyltransferase 1
chr7_+_9262982 0.54 ENSRNOT00000047647
Olr1063
olfactory receptor 1063
chr3_-_72081079 0.50 ENSRNOT00000007914
Tmx2
thioredoxin-related transmembrane protein 2
chrX_-_106607352 0.47 ENSRNOT00000082858
AABR07040624.1

chr4_+_6827429 0.46 ENSRNOT00000071737
Rheb
Ras homolog enriched in brain
chr15_-_55209342 0.44 ENSRNOT00000021752
Rb1
RB transcriptional corepressor 1
chr11_+_43309759 0.35 ENSRNOT00000040089
Olr1539
olfactory receptor 1539
chr18_-_26656879 0.35 ENSRNOT00000086729
Epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr12_-_19167015 0.34 ENSRNOT00000001797
Gjc3
gap junction protein, gamma 3
chr10_+_95770154 0.31 ENSRNOT00000030300
Helz
helicase with zinc finger
chr7_-_3707226 0.28 ENSRNOT00000064380
Olr879
olfactory receptor 879
chr16_-_74496731 0.25 ENSRNOT00000015790
Mrps31
mitochondrial ribosomal protein S31
chr7_+_58570579 0.21 ENSRNOT00000081227
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr10_-_62184874 0.17 ENSRNOT00000004229
Rpa1
replication protein A1
chr7_-_4183525 0.14 ENSRNOT00000047673
Olr889
olfactory receptor 889
chr8_+_5790034 0.12 ENSRNOT00000061887
Mmp27
matrix metallopeptidase 27
chr1_-_165606375 0.06 ENSRNOT00000024290
Mrpl48
mitochondrial ribosomal protein L48
chr8_+_22648323 0.05 ENSRNOT00000013165
Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr6_+_123034304 0.04 ENSRNOT00000078938
Cpg1
candidate plasticity gene 1
chr5_-_28164326 0.04 ENSRNOT00000088165
Slc26a7
solute carrier family 26 member 7
chr10_+_88227360 0.03 ENSRNOT00000041033
Eif1
eukaryotic translation initiation factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 63.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
5.4 21.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.7 27.4 GO:0018095 protein polyglutamylation(GO:0018095)
2.0 13.8 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
1.8 5.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
1.8 7.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
1.6 6.3 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.6 15.5 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
1.5 4.6 GO:0015827 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
1.4 5.7 GO:0021888 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
1.2 49.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.0 3.0 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.9 5.5 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.9 12.6 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 5.7 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808) presynaptic dense core granule exocytosis(GO:0099525)
0.8 4.7 GO:0060023 soft palate development(GO:0060023)
0.7 2.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.7 2.1 GO:0060988 lipid tube assembly(GO:0060988)
0.6 1.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.6 9.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.6 1.7 GO:1990743 protein sialylation(GO:1990743)
0.5 5.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 6.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.5 7.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.5 8.5 GO:0042428 serotonin metabolic process(GO:0042428)
0.5 1.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.5 3.2 GO:2000535 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.4 4.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.4 17.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 2.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.3 1.0 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.3 5.5 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.3 1.8 GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.3 4.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 3.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 4.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.3 0.5 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.2 1.2 GO:0035822 meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.2 1.5 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.2 5.8 GO:0032288 myelin assembly(GO:0032288)
0.2 6.2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 2.0 GO:0098880 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.2 4.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 10.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 3.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 0.4 GO:1903944 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 1.7 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 2.4 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 6.5 GO:0055078 sodium ion homeostasis(GO:0055078)
0.1 1.9 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 20.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 1.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 4.3 GO:0048278 vesicle docking(GO:0048278)
0.1 0.8 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 3.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 3.1 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 17.0 GO:0043010 camera-type eye development(GO:0043010)
0.0 15.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 4.5 GO:0035690 cellular response to drug(GO:0035690)
0.0 1.3 GO:0097186 amelogenesis(GO:0097186)
0.0 1.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 13.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.9 GO:0051225 spindle assembly(GO:0051225)
0.0 3.6 GO:0060348 bone development(GO:0060348)
0.0 1.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.9 GO:0007569 cell aging(GO:0007569)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 54.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
2.6 69.1 GO:0043194 axon initial segment(GO:0043194)
2.1 6.3 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.6 4.7 GO:0005592 collagen type XI trimer(GO:0005592)
1.5 13.8 GO:0031209 SCAR complex(GO:0031209)
0.9 15.5 GO:0042581 specific granule(GO:0042581)
0.7 5.7 GO:0044305 calyx of Held(GO:0044305)
0.6 4.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.6 5.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 3.0 GO:0000125 PCAF complex(GO:0000125)
0.4 6.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 3.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 1.8 GO:0035061 interchromatin granule(GO:0035061)
0.3 1.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.3 17.9 GO:0034707 chloride channel complex(GO:0034707)
0.3 6.5 GO:0035371 microtubule plus-end(GO:0035371)
0.2 14.5 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.2 7.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 6.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 3.2 GO:0000145 exocyst(GO:0000145)
0.1 24.8 GO:0043197 dendritic spine(GO:0043197)
0.1 1.2 GO:0000801 central element(GO:0000801)
0.1 4.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 4.3 GO:0031201 SNARE complex(GO:0031201)
0.1 5.0 GO:0034704 calcium channel complex(GO:0034704)
0.1 11.4 GO:0001650 fibrillar center(GO:0001650)
0.1 4.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 8.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 10.1 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.5 GO:0005770 late endosome(GO:0005770)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 8.3 GO:0045202 synapse(GO:0045202)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 6.1 GO:0030425 dendrite(GO:0030425)
0.0 1.9 GO:0005903 brush border(GO:0005903)
0.0 1.7 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.8 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 60.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
4.3 21.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
2.2 49.8 GO:0002162 dystroglycan binding(GO:0002162)
2.1 6.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
1.5 7.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
1.4 4.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
1.4 5.4 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
1.2 4.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
1.1 17.9 GO:0050811 GABA receptor binding(GO:0050811)
0.7 5.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.6 1.9 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.6 5.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.6 1.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.5 12.6 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.4 13.8 GO:0070064 proline-rich region binding(GO:0070064)
0.4 5.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 10.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.4 11.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.3 6.3 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.3 1.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.3 9.3 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.2 8.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 3.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 3.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 4.5 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.0 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.1 4.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 10.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.7 GO:0042301 phosphate ion binding(GO:0042301)
0.1 1.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 7.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 7.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.3 GO:0070330 aromatase activity(GO:0070330)
0.1 4.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.3 GO:0050681 androgen receptor binding(GO:0050681)
0.1 15.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 2.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 14.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 4.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 5.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.5 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 6.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 17.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 6.5 GO:0008017 microtubule binding(GO:0008017)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 12.1 GO:0043565 sequence-specific DNA binding(GO:0043565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 46.3 PID LKB1 PATHWAY LKB1 signaling events
0.2 2.9 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 13.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 15.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 3.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 4.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.2 PID INSULIN PATHWAY Insulin Pathway
0.0 5.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 70.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 5.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.4 25.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 5.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 9.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 1.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 5.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.5 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.2 6.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 7.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis