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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxb5

Z-value: 1.07

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Transcription factors associated with Hoxb5

Gene Symbol Gene ID Gene Info
Hoxb5
ENSRNOG00000008010 homeo box B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb5rn6_v1_chr10_+_84152152_84152152-0.091.0e-01Click!

Activity profile of Hoxb5 motif

Sorted Z-values of Hoxb5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_164549455 169.93 ENSRNOT00000017151
Mlf1
myeloid leukemia factor 1
chr15_-_33656089 64.53 ENSRNOT00000024186
Myh7
myosin heavy chain 7
chr1_-_213650247 45.50 ENSRNOT00000019679
Cox8b
cytochrome c oxidase, subunit VIIIb
chr10_-_45480999 40.07 ENSRNOT00000078353
ENSRNOT00000084697
ENSRNOT00000087926
Obscn
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr10_-_83898527 32.90 ENSRNOT00000009815
Atp5g1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr4_+_180291389 28.75 ENSRNOT00000002465
Sspn
sarcospan
chr14_-_106393670 24.97 ENSRNOT00000011429
Mdh1
malate dehydrogenase 1
chr1_+_126523169 21.78 ENSRNOT00000051000
Tarsl2
threonyl-tRNA synthetase-like 2
chr13_-_82006005 19.74 ENSRNOT00000039581
Mettl11b
methyltransferase like 11B
chrM_+_11736 19.57 ENSRNOT00000048767
Mt-nd5
mitochondrially encoded NADH dehydrogenase 5
chr20_+_37876650 18.64 ENSRNOT00000001054
Gja1
gap junction protein, alpha 1
chr11_+_58624198 17.95 ENSRNOT00000002091
Gap43
growth associated protein 43
chr1_+_94718402 17.18 ENSRNOT00000046035
Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr16_+_21275311 15.72 ENSRNOT00000027980
LOC100911483
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-like
chr6_+_64789940 15.62 ENSRNOT00000085979
ENSRNOT00000059739
ENSRNOT00000051908
ENSRNOT00000082793
ENSRNOT00000078583
ENSRNOT00000091677
ENSRNOT00000093241
Nrcam
neuronal cell adhesion molecule
chr2_-_200762492 14.70 ENSRNOT00000056172
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr7_-_143420027 14.44 ENSRNOT00000082863
Krt2
keratin 2
chrX_+_105537602 14.15 ENSRNOT00000029833
Armcx1
armadillo repeat containing, X-linked 1
chr2_-_200762206 14.07 ENSRNOT00000068511
ENSRNOT00000086835
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr15_-_110046687 13.77 ENSRNOT00000057404
ENSRNOT00000006624
ENSRNOT00000089695
Nalcn
sodium leak channel, non-selective
chrX_-_14220662 13.61 ENSRNOT00000045753
Srpx
sushi-repeat-containing protein, X-linked
chr1_+_101012822 13.51 ENSRNOT00000027809
Rras
related RAS viral (r-ras) oncogene homolog
chrM_+_5323 13.38 ENSRNOT00000050156
Mt-co1
mitochondrially encoded cytochrome c oxidase 1
chr10_-_13115294 12.47 ENSRNOT00000005899
NEWGENE_6497122
FLYWCH family member 2
chr4_+_175431904 10.99 ENSRNOT00000032843
Pde3a
phosphodiesterase 3A
chr4_+_88584242 10.92 ENSRNOT00000008973
Pyurf
PIGY upstream reading frame
chr3_-_15376767 10.38 ENSRNOT00000044885
Ndufa8
NADH:ubiquinone oxidoreductase subunit A8
chr5_+_104362971 10.21 ENSRNOT00000058520
Adamtsl1
ADAMTS-like 1
chr14_-_6679878 10.15 ENSRNOT00000075989
ENSRNOT00000067875
Spp1
secreted phosphoprotein 1
chr13_-_109997092 9.35 ENSRNOT00000005190
Nenf
neudesin neurotrophic factor
chr16_-_69961162 8.89 ENSRNOT00000074955
Prrg3
proline rich and Gla domain 3
chr1_+_227892956 8.84 ENSRNOT00000028483
AABR07006278.1

chr18_+_25163561 8.75 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
Bin1
bridging integrator 1
chr4_+_49369296 8.70 ENSRNOT00000007822
Wnt16
wingless-type MMTV integration site family, member 16
chr5_-_28349927 8.60 ENSRNOT00000008725
Otud6b
OTU domain containing 6B
chr5_+_28395296 7.93 ENSRNOT00000009375
Tmem55a
transmembrane protein 55A
chrX_-_1718637 7.89 ENSRNOT00000064309
Cdk16
cyclin-dependent kinase 16
chr1_-_164307084 7.82 ENSRNOT00000086091
Serpinh1
serpin family H member 1
chr6_+_12415805 7.41 ENSRNOT00000022380
Gtf2a1l
general transcription factor 2A subunit 1 like
chr1_-_173682226 7.38 ENSRNOT00000020137
Ric3
RIC3 acetylcholine receptor chaperone
chr1_+_84304228 7.24 ENSRNOT00000024771
Prx
periaxin
chr14_-_60964324 6.65 ENSRNOT00000005155
Sod3
superoxide dismutase 3, extracellular
chr2_-_32518643 6.64 ENSRNOT00000061032
Mast4
microtubule associated serine/threonine kinase family member 4
chr15_+_42653148 6.53 ENSRNOT00000022095
Clu
clusterin
chr18_+_30885789 6.45 ENSRNOT00000044434
Pcdhga9
protocadherin gamma subfamily A, 9
chr12_-_38782010 6.37 ENSRNOT00000001813
Wdr66
WD repeat domain 66
chr12_+_2170630 6.24 ENSRNOT00000071928
Pet100
PET100 homolog
chr20_+_12052693 6.02 ENSRNOT00000083851
Adarb1
adenosine deaminase, RNA-specific, B1
chr2_-_27287605 5.97 ENSRNOT00000034041
Ankdd1b
ankyrin repeat and death domain containing 1B
chrX_-_106576314 5.26 ENSRNOT00000037823
Nxf3
nuclear RNA export factor 3
chrX_+_106306795 5.06 ENSRNOT00000073661
Gprasp1
G protein-coupled receptor associated sorting protein 1
chr6_-_139973811 5.05 ENSRNOT00000082875
Ighv5-2
immunoglobulin heavy variable 5-2
chr9_+_16612433 4.90 ENSRNOT00000023979
Klhdc3
kelch domain containing 3
chr5_+_144779681 4.85 ENSRNOT00000016493
LOC100294508
dyslexia susceptibility 2-like
chrX_+_151103576 4.80 ENSRNOT00000015401
Slitrk2
SLIT and NTRK-like family, member 2
chr1_-_168644038 4.79 ENSRNOT00000021304
Olr109
olfactory receptor 109
chr15_-_12889102 4.61 ENSRNOT00000061214
ENSRNOT00000084687
RGD1306063
similar to HT021
chr3_-_77402579 4.45 ENSRNOT00000043801
Olr658
olfactory receptor 658
chr5_-_144779212 4.20 ENSRNOT00000016230
Ncdn
neurochondrin
chr3_+_92640752 4.13 ENSRNOT00000007604
Slc1a2
solute carrier family 1 member 2
chr1_-_48825364 4.08 ENSRNOT00000024213
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr7_-_24102761 4.03 ENSRNOT00000008596
Btbd11
BTB domain containing 11
chr3_+_73352352 3.82 ENSRNOT00000012814
Olr472
olfactory receptor 472
chr1_-_107385257 3.80 ENSRNOT00000074296
Ccdc179
coiled-coil domain containing 179
chr2_+_187740531 3.41 ENSRNOT00000092653
Paqr6
progestin and adipoQ receptor family member 6
chr12_-_52124779 3.28 ENSRNOT00000088839
Galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chrX_-_100632562 3.23 ENSRNOT00000073416
LOC102555578
zinc finger protein 120-like
chr3_+_145882819 3.07 ENSRNOT00000042110
LOC102549291
zinc finger protein 120-like
chr2_+_196608496 3.06 ENSRNOT00000091681
Arnt
aryl hydrocarbon receptor nuclear translocator
chr6_+_27536184 3.03 ENSRNOT00000032829
Adgrf3
adhesion G protein-coupled receptor F3
chr10_+_34631398 2.80 ENSRNOT00000046027
Olr1391
olfactory receptor 1391
chr5_-_38923095 2.77 ENSRNOT00000009146
AABR07047593.1

chrX_-_61151601 2.75 ENSRNOT00000004132
Mageb4
melanoma antigen family B, 4
chr3_-_176465162 2.59 ENSRNOT00000048807
Nkain4
Sodium/potassium transporting ATPase interacting 4
chr1_+_172813394 2.55 ENSRNOT00000090059
Olr272
olfactory receptor 272
chr8_+_42046393 2.31 ENSRNOT00000072353
Olr1229
olfactory receptor 1229
chr6_+_135866739 2.26 ENSRNOT00000013460
Exoc3l4
exocyst complex component 3-like 4
chr17_+_4270207 2.26 ENSRNOT00000061391
RGD1308751
similar to Cathepsin L precursor (Major excreted protein) (MEP)
chrX_+_105427939 2.20 ENSRNOT00000057217
LOC501618
LRRGT00179
chr17_+_4256299 2.16 ENSRNOT00000083451
ENSRNOT00000061398
ENSRNOT00000090013
RGD1308751
similar to Cathepsin L precursor (Major excreted protein) (MEP)
chr10_+_48903540 2.04 ENSRNOT00000004248
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr20_+_5067330 1.97 ENSRNOT00000037482
Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr6_+_112203679 1.95 ENSRNOT00000031205
Nrxn3
neurexin 3
chr8_+_119261747 1.83 ENSRNOT00000079648
AC132539.1

chr12_+_41463922 1.74 ENSRNOT00000089378
Cfap73
cilia and flagella associated protein 73
chr1_+_72545596 1.71 ENSRNOT00000022698
Shisa7
shisa family member 7
chr10_-_87891285 1.70 ENSRNOT00000090052
Rn50_10_0877.5

chr7_+_29282305 1.65 ENSRNOT00000007623
Arl1
ADP-ribosylation factor like GTPase 1
chr1_+_169240508 1.65 ENSRNOT00000022759
Olr143
olfactory receptor 143
chr15_-_36321572 1.53 ENSRNOT00000073934
AABR07018016.1

chr3_-_76708430 1.48 ENSRNOT00000007890
Olr630
olfactory receptor 630
chr2_-_242828629 1.44 ENSRNOT00000043369
LOC499715
LRRGT00095
chr19_+_54493483 1.43 ENSRNOT00000078002
AABR07044063.1

chr1_-_65058502 1.36 ENSRNOT00000092003
AABR07002025.1

chr9_+_12633990 1.33 ENSRNOT00000066517
ENSRNOT00000077532
Dazl
deleted in azoospermia-like
chr1_-_150210403 1.30 ENSRNOT00000081156
Olr29
olfactory receptor 29
chr1_-_168029293 1.25 ENSRNOT00000020699
Olr49
olfactory receptor 49
chr1_-_82580007 1.24 ENSRNOT00000078668
Axl
Axl receptor tyrosine kinase
chr16_-_2048292 1.20 ENSRNOT00000061883
Zcchc24
zinc finger CCHC-type containing 24
chr1_+_89202527 1.19 ENSRNOT00000028526
Sbsn
suprabasin
chr10_+_103349172 1.15 ENSRNOT00000035963
Gpr142
G protein-coupled receptor 142
chr11_+_70056624 1.13 ENSRNOT00000002447
AC133403.1

chr9_+_9842585 1.13 ENSRNOT00000070806
Cd70
Cd70 molecule
chr20_+_10123651 1.11 ENSRNOT00000001559
Pde9a
phosphodiesterase 9A
chr1_+_150225373 1.10 ENSRNOT00000051266
Olr30
olfactory receptor 30
chr1_+_169741497 1.06 ENSRNOT00000072865
Olr164
olfactory receptor 164
chr20_+_4162055 1.05 ENSRNOT00000081236
Btnl3
butyrophilin-like 3
chr1_+_60248695 1.02 ENSRNOT00000079558
Vom1r9
vomeronasal 1 receptor 9
chr14_-_86868598 0.98 ENSRNOT00000087212
Nacad
NAC alpha domain containing
chr3_-_4405194 0.92 ENSRNOT00000072025
AABR07051266.1

chr4_+_1400301 0.90 ENSRNOT00000074022
LOC100911888
olfactory receptor 143-like
chr17_+_57906050 0.83 ENSRNOT00000077338
AABR07028157.1

chr3_+_16039249 0.59 ENSRNOT00000046196
Olr403
olfactory receptor 403
chr2_-_188471988 0.54 ENSRNOT00000027785
Hcn3
hyperpolarization-activated cyclic nucleotide-gated potassium channel 3
chr1_-_150173316 0.50 ENSRNOT00000044676
Olr27
olfactory receptor 27
chr1_-_82279145 0.37 ENSRNOT00000057433
Cxcl17
C-X-C motif chemokine ligand 17
chr14_-_35652709 0.20 ENSRNOT00000003080
Gsx2
GS homeobox 2
chrX_-_30831483 0.18 ENSRNOT00000004443
Glra2
glycine receptor, alpha 2
chrX_+_124894466 0.02 ENSRNOT00000080894
Mcts1
MCTS1, re-initiation and release factor
chr19_-_52186260 0.00 ENSRNOT00000020838
Mbtps1
membrane-bound transcription factor peptidase, site 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 64.5 GO:1905243 slow-twitch skeletal muscle fiber contraction(GO:0031444) response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243)
17.0 169.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
7.3 21.8 GO:0006433 prolyl-tRNA aminoacylation(GO:0006433) threonyl-tRNA aminoacylation(GO:0006435)
6.6 19.7 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
6.2 18.6 GO:0010643 cell communication by chemical coupling(GO:0010643)
4.9 58.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
4.8 28.8 GO:0034757 negative regulation of iron ion transport(GO:0034757)
3.4 10.2 GO:0006710 androgen catabolic process(GO:0006710)
3.1 15.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
2.9 8.7 GO:0060988 lipid tube assembly(GO:0060988)
2.4 7.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
2.3 13.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
2.2 11.0 GO:0060282 positive regulation of oocyte development(GO:0060282)
2.2 6.5 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.1 17.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
2.1 25.0 GO:0006108 malate metabolic process(GO:0006108)
2.0 6.0 GO:0061744 motor behavior(GO:0061744)
2.0 13.8 GO:0060075 regulation of resting membrane potential(GO:0060075)
1.8 17.9 GO:0016198 axon choice point recognition(GO:0016198)
1.7 15.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.2 8.7 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.2 32.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.8 14.4 GO:0003334 keratinocyte development(GO:0003334)
0.8 6.7 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.8 4.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.7 9.4 GO:0032099 negative regulation of appetite(GO:0032099)
0.5 6.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.5 4.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.4 19.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.4 5.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 1.2 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.3 13.5 GO:0060325 face morphogenesis(GO:0060325)
0.3 7.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.3 40.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 6.7 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 5.1 GO:0032801 receptor catabolic process(GO:0032801)
0.2 1.7 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 3.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.2 6.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 7.4 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.2 2.3 GO:0051601 exocyst localization(GO:0051601)
0.1 2.0 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 1.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.1 1.3 GO:0007135 meiosis II(GO:0007135)
0.1 7.9 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 2.0 GO:1903831 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 7.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 1.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.5 GO:1903350 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 4.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 4.2 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 4.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 2.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 2.6 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.4 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 24.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012) cellular response to zinc ion(GO:0071294)
0.0 3.3 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 64.5 GO:0005859 muscle myosin complex(GO:0005859)
3.7 58.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
2.5 32.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
2.5 20.0 GO:0032584 growth cone membrane(GO:0032584)
1.7 21.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.7 40.1 GO:0031430 M band(GO:0031430)
1.6 17.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
1.5 28.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
1.2 7.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
1.2 10.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
1.0 18.6 GO:0005916 fascia adherens(GO:0005916)
0.9 167.6 GO:0031514 motile cilium(GO:0031514)
0.9 45.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.9 24.4 GO:0043194 axon initial segment(GO:0043194)
0.7 6.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 14.4 GO:0001533 cornified envelope(GO:0001533)
0.2 6.2 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 4.1 GO:0030673 axolemma(GO:0030673)
0.1 32.2 GO:0043209 myelin sheath(GO:0043209)
0.1 10.6 GO:0005776 autophagosome(GO:0005776)
0.1 2.3 GO:0000145 exocyst(GO:0000145)
0.1 7.9 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.5 GO:0044316 cone cell pedicle(GO:0044316)
0.1 7.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0033643 host cell part(GO:0033643)
0.1 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 7.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 8.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.7 GO:0005925 focal adhesion(GO:0005925)
0.0 7.1 GO:0045177 apical part of cell(GO:0045177)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 12.7 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.0 GO:0098793 presynapse(GO:0098793)
0.0 4.9 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 21.8 GO:0004829 proline-tRNA ligase activity(GO:0004827) threonine-tRNA ligase activity(GO:0004829)
6.6 19.7 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
6.2 25.0 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
5.8 28.8 GO:0030283 testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
4.6 64.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
4.5 17.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
3.7 18.6 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
2.9 14.4 GO:0030280 structural constituent of epidermis(GO:0030280)
2.9 40.1 GO:0031432 titin binding(GO:0031432)
2.1 17.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.0 58.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.7 15.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
1.7 13.8 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
1.6 32.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.6 7.9 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
1.5 6.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
1.3 6.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.3 35.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.0 3.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.8 4.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6 11.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 9.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.4 6.5 GO:0051787 misfolded protein binding(GO:0051787)
0.4 8.7 GO:0048156 tau protein binding(GO:0048156)
0.3 4.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 8.7 GO:0005109 frizzled binding(GO:0005109)
0.2 13.5 GO:0019003 GDP binding(GO:0019003)
0.2 14.1 GO:0051082 unfolded protein binding(GO:0051082)
0.2 10.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.3 GO:0008494 translation activator activity(GO:0008494)
0.1 132.7 GO:0019904 protein domain specific binding(GO:0019904)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.2 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.1 9.4 GO:0008083 growth factor activity(GO:0008083)
0.1 2.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 3.4 GO:0005496 steroid binding(GO:0005496)
0.0 7.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 10.7 GO:0005549 odorant binding(GO:0005549)
0.0 2.0 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.3 GO:0000149 SNARE binding(GO:0000149)
0.0 13.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 6.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.0 GO:0016503 pheromone receptor activity(GO:0016503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 36.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.6 40.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 10.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.3 13.5 PID RAS PATHWAY Regulation of Ras family activation
0.2 8.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 6.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 16.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 13.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 28.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
2.1 18.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
2.1 32.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.7 13.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.7 40.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.6 25.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 12.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.4 15.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 27.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 4.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 10.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.1 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 4.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 5.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 8.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.6 REACTOME MRNA PROCESSING Genes involved in mRNA Processing