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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxc13_Hoxd13

Z-value: 0.51

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Transcription factors associated with Hoxc13_Hoxd13

Gene Symbol Gene ID Gene Info
Hoxc13
ENSRNOG00000028679 homeobox C13
Hoxd13
ENSRNOG00000001588 homeo box D13

Activity profile of Hoxc13_Hoxd13 motif

Sorted Z-values of Hoxc13_Hoxd13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_61070599 14.56 ENSRNOT00000005251
Rgs1
regulator of G-protein signaling 1
chr1_-_2627747 12.94 ENSRNOT00000022003
Ust
uronyl-2-sulfotransferase
chr9_+_67699379 12.91 ENSRNOT00000091237
ENSRNOT00000088183
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr4_+_98337367 12.36 ENSRNOT00000042165
AABR07060872.1

chr4_-_159192526 11.98 ENSRNOT00000026731
Kcna1
potassium voltage-gated channel subfamily A member 1
chr7_-_143228060 11.61 ENSRNOT00000088923
ENSRNOT00000012640
Krt75
keratin 75
chr12_-_21760292 9.33 ENSRNOT00000059592
LOC102550456
TSC22 domain family protein 4-like
chrX_-_77675487 9.21 ENSRNOT00000042799
Cysltr1
cysteinyl leukotriene receptor 1
chr16_-_61091169 8.72 ENSRNOT00000016328
Dusp4
dual specificity phosphatase 4
chr6_+_96834525 7.29 ENSRNOT00000077935
Hif1a
hypoxia inducible factor 1 alpha subunit
chr10_-_88533829 6.97 ENSRNOT00000080521
Dnajc7
DnaJ heat shock protein family (Hsp40) member C7
chr1_-_271275989 6.24 ENSRNOT00000075570
LOC100912218
inositol 1,4,5-trisphosphate receptor-interacting protein-like
chr6_-_41039437 6.17 ENSRNOT00000005774
Trib2
tribbles pseudokinase 2
chr5_-_154332940 5.69 ENSRNOT00000014458
Pithd1
PITH domain containing 1
chr1_-_43638161 5.67 ENSRNOT00000024460
Ipcef1
interaction protein for cytohesin exchange factors 1
chr7_-_143453544 5.52 ENSRNOT00000034450
ENSRNOT00000083956
Krt1
Krt5
keratin 1
keratin 5
chr9_+_10044756 5.50 ENSRNOT00000071188
Pspn
persephin
chr10_-_29196563 5.10 ENSRNOT00000005205
Fabp6
fatty acid binding protein 6
chr1_-_206282575 5.09 ENSRNOT00000024974
Adam12
ADAM metallopeptidase domain 12
chr3_-_165700489 5.01 ENSRNOT00000017008
Zfp93
zinc finger protein 93
chr20_-_27578244 4.80 ENSRNOT00000000708
Fam26d
family with sequence similarity 26, member D
chr8_+_96551245 3.94 ENSRNOT00000039850
Bcl2a1
BCL2-related protein A1
chr10_-_87954055 3.90 ENSRNOT00000018048
Krt34
keratin 34
chr3_-_154490851 3.67 ENSRNOT00000017213
Tti1
TELO2 interacting protein 1
chr10_+_108132105 3.65 ENSRNOT00000072534
Cbx2
chromobox 2
chr5_-_146795866 3.59 ENSRNOT00000065640
Tlr12
toll-like receptor 12
chr20_+_37876650 3.43 ENSRNOT00000001054
Gja1
gap junction protein, alpha 1
chr10_-_88009576 3.18 ENSRNOT00000018566
Krt35
keratin 35
chr5_+_122019301 3.13 ENSRNOT00000068158
Pde4b
phosphodiesterase 4B
chr17_-_84247038 3.09 ENSRNOT00000068553
Nebl
nebulette
chr8_-_46694613 3.06 ENSRNOT00000084514
AC133265.1

chr10_+_42614713 3.02 ENSRNOT00000081136
ENSRNOT00000073148
Gria1
glutamate ionotropic receptor AMPA type subunit 1
chr3_+_110574417 3.01 ENSRNOT00000031231
Disp2
dispatched RND transporter family member 2
chr15_-_34392066 3.00 ENSRNOT00000027315
Tgm1
transglutaminase 1
chr1_-_84353725 2.99 ENSRNOT00000057177
Pld3
phospholipase D family, member 3
chr15_+_41643541 2.98 ENSRNOT00000019646
Arl11
ADP-ribosylation factor like GTPase 11
chr17_-_11037738 2.90 ENSRNOT00000043796
AABR07027015.1

chr8_+_122197027 2.85 ENSRNOT00000013050
Ubp1
upstream binding protein 1 (LBP-1a)
chr19_-_19315357 2.70 ENSRNOT00000018888
Cyld
CYLD lysine 63 deubiquitinase
chr4_+_140247313 2.47 ENSRNOT00000040255
ENSRNOT00000064025
ENSRNOT00000041130
ENSRNOT00000043646
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
chr7_-_143085833 2.43 ENSRNOT00000031257
ENSRNOT00000077286
Krt83
keratin 83
chr6_+_123034304 2.28 ENSRNOT00000078938
Cpg1
candidate plasticity gene 1
chr7_-_140437467 2.20 ENSRNOT00000087181
Fkbp11
FK506 binding protein 11
chr15_-_37831031 2.20 ENSRNOT00000091562
Eef1akmt1
eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
chr2_+_40554146 1.94 ENSRNOT00000015138
Pde4d
phosphodiesterase 4D
chr5_-_125345726 1.90 ENSRNOT00000011244
LOC688684
similar to 60S ribosomal protein L32
chr4_-_82186190 1.86 ENSRNOT00000071729
LOC100911622
homeobox protein Hox-A7-like
chr6_-_104289668 1.83 ENSRNOT00000085646
Erh
enhancer of rudimentary homolog (Drosophila)
chrX_-_106607352 1.69 ENSRNOT00000082858
AABR07040624.1

chr9_+_65534704 1.67 ENSRNOT00000016730
Cflar
CASP8 and FADD-like apoptosis regulator
chr4_-_2201749 1.61 ENSRNOT00000089327
Lmbr1
limb development membrane protein 1
chr9_-_43454078 1.61 ENSRNOT00000023550
Tmem131
transmembrane protein 131
chr10_-_87459652 1.55 ENSRNOT00000018804
Krt40
keratin 40
chr8_+_99568958 1.54 ENSRNOT00000073400
Plscr5
phospholipid scramblase family, member 5
chr15_-_11912806 1.44 ENSRNOT00000068171
ENSRNOT00000008759
ENSRNOT00000049771
Slc4a7
solute carrier family 4 member 7
chr3_+_131351587 1.40 ENSRNOT00000010835
Btbd3
BTB domain containing 3
chr1_-_93949187 1.30 ENSRNOT00000018956
Zfp536
zinc finger protein 536
chr15_-_40542495 1.29 ENSRNOT00000063943
Nup58
nucleoporin 58
chr17_-_80860195 1.28 ENSRNOT00000038651
Trdmt1
tRNA aspartic acid methyltransferase 1
chr11_-_28842287 1.26 ENSRNOT00000061610
Krtap19-5
keratin associated protein 19-5
chr2_-_9472384 1.24 ENSRNOT00000084295
Adgrv1
adhesion G protein-coupled receptor V1
chr8_+_17421557 1.24 ENSRNOT00000030569
Chordc1
cysteine and histidine rich domain containing 1
chr3_-_77677349 1.23 ENSRNOT00000084989
Olr669
olfactory receptor 669
chr18_-_40218225 1.21 ENSRNOT00000004723
Pggt1b
protein geranylgeranyltransferase type 1 subunit beta
chr10_-_92008082 1.17 ENSRNOT00000006361
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr10_-_88000423 1.13 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
Krt32
keratin 32
chr20_-_6556350 1.10 ENSRNOT00000035819
Lemd2
LEM domain containing 2
chr1_+_168378637 1.07 ENSRNOT00000028936
Olr86
olfactory receptor 86
chr2_-_46042636 1.07 ENSRNOT00000087161
AABR07008152.1

chr1_-_225077079 1.06 ENSRNOT00000074747
Uqcc3
ubiquinol-cytochrome c reductase complex assembly factor 3
chr7_+_66717434 1.05 ENSRNOT00000077878
Mon2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr11_-_29710849 1.04 ENSRNOT00000029345
Krtap11-1
keratin associated protein 11-1
chr9_+_79659251 1.03 ENSRNOT00000021656
Xrcc5
X-ray repair cross complementing 5
chr1_-_134867001 1.01 ENSRNOT00000090149
Chd2
chromodomain helicase DNA binding protein 2
chr17_-_29895386 0.96 ENSRNOT00000048757
Cdyl
chromodomain Y-like
chr14_-_23002011 0.95 ENSRNOT00000002736
Ythdc1
YTH domain containing 1
chr3_-_105663457 0.92 ENSRNOT00000067646
Zfp770
zinc finger protein 770
chr8_+_67615635 0.90 ENSRNOT00000008971
Itga11
integrin subunit alpha 11
chr6_+_69971227 0.89 ENSRNOT00000075349
Foxg1
forkhead box G1
chr7_-_143187594 0.88 ENSRNOT00000011732
ENSRNOT00000083466
Krt84
keratin 84
chr7_+_107406962 0.78 ENSRNOT00000093254
Phf20l1
PHD finger protein 20-like protein 1
chr1_+_154131926 0.73 ENSRNOT00000035257
LOC102549852
ferritin light chain 1-like
chr5_-_16140896 0.72 ENSRNOT00000029503
Xkr4
XK related 4
chr1_+_261753364 0.70 ENSRNOT00000076659
R3hcc1l
R3H domain and coiled-coil containing 1-like
chr7_-_3123297 0.56 ENSRNOT00000061878
Rab5b
RAB5B, member RAS oncogene family
chr3_+_76179214 0.55 ENSRNOT00000071281
LOC686677
similar to olfactory receptor 1161
chr2_-_173800761 0.54 ENSRNOT00000039524
Wdr49
WD repeat domain 49
chrX_+_20216587 0.50 ENSRNOT00000073114
AABR07037412.2
FYVE, RhoGEF and PH domain-containing protein 1
chr18_-_5314511 0.42 ENSRNOT00000022637
ENSRNOT00000079682
Zfp521
zinc finger protein 521
chr9_+_88494676 0.41 ENSRNOT00000089451
LOC102556337
mitochondrial fission factor-like
chr10_-_61232331 0.41 ENSRNOT00000065045
Rap1gap2
RAP1 GTPase activating protein 2
chr17_+_70262363 0.37 ENSRNOT00000048933
Fam208b
family with sequence similarity 208, member B
chr4_-_34194764 0.37 ENSRNOT00000045270
Col28a1
collagen type XXVIII alpha 1 chain
chr14_+_17210733 0.36 ENSRNOT00000003075
Cxcl10
C-X-C motif chemokine ligand 10
chr7_-_63045728 0.27 ENSRNOT00000039532
Lemd3
LEM domain containing 3
chr8_+_115546712 0.26 ENSRNOT00000079801
Dcaf1
DDB1 and CUL4 associated factor 1
chr2_-_43067956 0.25 ENSRNOT00000090616
Gpbp1
GC-rich promoter binding protein 1
chr9_-_93125014 0.22 ENSRNOT00000023829
Htr2b
5-hydroxytryptamine receptor 2B
chr16_-_37177033 0.15 ENSRNOT00000014015
Fbxo8
F-box protein 8
chr20_+_11655967 0.12 ENSRNOT00000064565
LOC690478
similar to keratin associated protein 10-7
chr16_-_85464002 0.10 ENSRNOT00000037018
AABR07026596.1

chr19_-_19896421 0.09 ENSRNOT00000020793
Heatr3
HEAT repeat containing 3
chr3_+_46185360 0.06 ENSRNOT00000051344
LOC100361645
LRRGT00075-like
chr10_+_38918748 0.05 ENSRNOT00000009999
Kif3a
kinesin family member 3a
chr11_-_28614260 0.05 ENSRNOT00000074102
Krtap26-1
keratin associated protein 26-1
chr5_+_127489418 0.01 ENSRNOT00000065275
RGD1559786
similar to RIKEN cDNA 0610037L13

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 23.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
2.6 12.9 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
2.4 7.3 GO:0080033 cellular response to carbon monoxide(GO:0071245) cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033)
2.4 12.0 GO:0050975 sensory perception of touch(GO:0050975)
1.5 6.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.1 3.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
1.0 3.1 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.9 9.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.9 2.7 GO:1990108 protein linear deubiquitination(GO:1990108)
0.8 5.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.8 7.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.7 2.0 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.6 8.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 3.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 1.2 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.4 5.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 2.5 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 1.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.3 1.4 GO:0021747 cochlear nucleus development(GO:0021747)
0.3 1.0 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.2 1.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.2 3.0 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.2 1.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 3.6 GO:0042832 defense response to protozoan(GO:0042832)
0.2 6.2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 1.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 5.1 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 1.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 1.4 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.9 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 1.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 12.9 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 0.6 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 15.6 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 4.7 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.1 0.2 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.1 1.8 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.2 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.9 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.1 0.4 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.0 1.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 2.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 5.3 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.1 GO:2000769 regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771)
0.0 2.3 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 2.4 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0 1.6 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 2.2 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 3.6 GO:0045137 development of primary sexual characteristics(GO:0045137)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.6 2.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.5 3.0 GO:0044308 axonal spine(GO:0044308)
0.5 3.7 GO:0031931 TORC1 complex(GO:0031931)
0.4 12.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.3 1.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 19.7 GO:0045095 keratin filament(GO:0045095)
0.3 1.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) Ku70:Ku80 complex(GO:0043564)
0.2 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.2 1.2 GO:1990696 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.2 2.7 GO:0097542 ciliary tip(GO:0097542)
0.2 3.4 GO:0005916 fascia adherens(GO:0005916)
0.2 3.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 7.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.8 GO:0034709 methylosome(GO:0034709)
0.1 14.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 7.0 GO:0005882 intermediate filament(GO:0005882)
0.1 1.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 3.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.8 9.2 GO:0004974 leukotriene receptor activity(GO:0004974)
1.1 5.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.8 3.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.7 3.4 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.6 2.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.6 5.1 GO:0032052 bile acid binding(GO:0032052)
0.5 12.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 3.0 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.4 2.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 14.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 6.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 1.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.3 1.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.3 1.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.3 3.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 3.9 GO:0051400 BH domain binding(GO:0051400)
0.2 8.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 3.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 12.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.2 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 3.1 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.1 GO:1901612 cardiolipin binding(GO:1901612)
0.1 1.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 1.7 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 7.0 GO:0031072 heat shock protein binding(GO:0031072)
0.1 4.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 2.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 1.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 4.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 5.4 GO:0008083 growth factor activity(GO:0008083)
0.0 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 19.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 1.2 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 5.5 ST GAQ PATHWAY G alpha q Pathway
0.3 5.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3 8.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 12.9 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.2 9.2 PID ENDOTHELIN PATHWAY Endothelins
0.2 1.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 5.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 15.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 3.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 3.9 PID BCR 5PATHWAY BCR signaling pathway
0.1 2.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 3.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 4.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.6 8.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.5 12.9 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.4 5.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.4 3.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.4 7.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 12.9 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 4.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 11.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 14.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 5.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides