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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hsf1

Z-value: 0.79

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Transcription factors associated with Hsf1

Gene Symbol Gene ID Gene Info
Hsf1
ENSRNOG00000021732 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hsf1rn6_v1_chr7_+_117538523_1175385230.122.7e-02Click!

Activity profile of Hsf1 motif

Sorted Z-values of Hsf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_17225389 33.85 ENSRNOT00000052035
Art3
ADP-ribosyltransferase 3
chr10_+_70262361 29.86 ENSRNOT00000064625
ENSRNOT00000076973
Unc45b
unc-45 myosin chaperone B
chr6_-_94980004 19.56 ENSRNOT00000006373
Rtn1
reticulon 1
chr6_-_127248372 17.78 ENSRNOT00000085517
Asb2
ankyrin repeat and SOCS box-containing 2
chr8_+_70603249 15.35 ENSRNOT00000067016
ENSRNOT00000072486
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr5_+_58393233 13.46 ENSRNOT00000000142
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr4_-_161757447 12.19 ENSRNOT00000008737
Fkbp4
FK506 binding protein 4
chr7_+_11737293 11.51 ENSRNOT00000046059
Lingo3
leucine rich repeat and Ig domain containing 3
chr9_+_10172832 10.53 ENSRNOT00000074555
Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr8_+_55178289 10.35 ENSRNOT00000059127
Cryab
crystallin, alpha B
chr14_-_43143973 10.29 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr20_+_8109635 9.92 ENSRNOT00000000609
Armc12
armadillo repeat containing 12
chr1_-_222293148 9.66 ENSRNOT00000028743
Stip1
stress-induced phosphoprotein 1
chr1_-_12952906 9.47 ENSRNOT00000078193
LOC100360362
hypothetical protein LOC100360362
chr8_-_111965889 9.05 ENSRNOT00000032376
Bfsp2
beaded filament structural protein 2
chr7_+_129595192 8.98 ENSRNOT00000071151
Zdhhc25
zinc finger, DHHC-type containing 25
chr3_+_112228720 8.81 ENSRNOT00000079079
Capn3
calpain 3
chr11_-_61530567 7.75 ENSRNOT00000076277
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr10_+_5930298 7.65 ENSRNOT00000044626
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
chr9_+_73334618 7.55 ENSRNOT00000092717
Map2
microtubule-associated protein 2
chrX_+_45213228 7.54 ENSRNOT00000088538
LOC103690319
odorant-binding protein
chr4_+_89079014 6.96 ENSRNOT00000087451
Herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr7_-_116106368 6.63 ENSRNOT00000035678
Ly6k
lymphocyte antigen 6 complex, locus K
chr20_+_4188766 6.61 ENSRNOT00000081438
ENSRNOT00000060378
Tesb
testis specific basic protein
chr7_-_117440342 6.45 ENSRNOT00000018528
Tssk5
testis-specific serine kinase 5
chr2_-_173087648 6.43 ENSRNOT00000091079
Iqcj
IQ motif containing J
chr18_-_1946840 6.34 ENSRNOT00000041878
Abhd3
abhydrolase domain containing 3
chr2_+_84678948 6.20 ENSRNOT00000046325
Fam173b
family with sequence similarity 173, member B
chr11_-_81379640 5.85 ENSRNOT00000002484
Eif4a2
eukaryotic translation initiation factor 4A2
chr8_+_17421557 5.69 ENSRNOT00000030569
Chordc1
cysteine and histidine rich domain containing 1
chr1_-_216971183 5.60 ENSRNOT00000077911
Mrgpre
MAS related GPR family member E
chr3_+_38367556 5.33 ENSRNOT00000049144
RGD1559995
similar to developmental pluripotency associated 5
chrX_-_83864150 5.31 ENSRNOT00000073734
Obp1f
odorant binding protein I f
chr11_-_81379871 5.11 ENSRNOT00000089294
Eif4a2
eukaryotic translation initiation factor 4A2
chr11_+_84396033 4.95 ENSRNOT00000002316
Abcc5
ATP binding cassette subfamily C member 5
chrX_-_45284341 4.94 ENSRNOT00000045436
Obp1f
odorant binding protein I f
chr16_+_20336638 4.85 ENSRNOT00000080467
Kcnn1
potassium calcium-activated channel subfamily N member 1
chr2_-_187668677 4.75 ENSRNOT00000056898
ENSRNOT00000092563
Tsacc
TSSK6 activating co-chaperone
chr8_+_98745310 4.64 ENSRNOT00000019938
Zic4
Zic family member 4
chr1_-_48033343 4.63 ENSRNOT00000019531
ENSRNOT00000076422
Tcp1
t-complex 1
chr10_-_105787803 4.60 ENSRNOT00000064671
Jmjd6
jumonji domain containing 6
chr10_+_105787935 4.54 ENSRNOT00000000266
Mettl23
methyltransferase like 23
chr11_-_28672956 4.54 ENSRNOT00000002137
LOC100363136
hypothetical protein LOC100363136
chr15_+_29208606 4.46 ENSRNOT00000073722
ENSRNOT00000086054
LOC100911980
uncharacterized LOC100911980
chrX_-_112328642 4.35 ENSRNOT00000083150
Psmd10
proteasome 26S subunit, non-ATPase 10
chr5_+_169357517 4.35 ENSRNOT00000000079
Acot7
acyl-CoA thioesterase 7
chr6_+_93539271 4.34 ENSRNOT00000078791
Tomm20l
translocase of outer mitochondrial membrane 20 homolog (yeast)-like
chr15_+_87886783 4.33 ENSRNOT00000065710
Slain1
SLAIN motif family, member 1
chr2_+_80948658 4.05 ENSRNOT00000074689
Dnah5
dynein, axonemal, heavy chain 5
chr7_+_40318490 3.74 ENSRNOT00000081374
LOC500827
similar to hypothetical protein FLJ35821
chr14_+_7169519 3.44 ENSRNOT00000003026
Klhl8
kelch-like family member 8
chr3_+_122928964 3.44 ENSRNOT00000074724
LOC100365450
rCG26795-like
chr11_-_27141881 3.21 ENSRNOT00000002169
Cct8
chaperonin containing TCP1 subunit 8
chr7_-_69982592 3.15 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr11_+_28692708 3.12 ENSRNOT00000002135
Krtap13-1
keratin associated protein 13-1
chr1_+_221443896 3.10 ENSRNOT00000073942
Tmem262
transmembrane protein 262
chr5_+_160095427 2.98 ENSRNOT00000077609
AABR07050298.1

chr13_-_79899479 2.96 ENSRNOT00000035815
RGD1309106
similar to hypothetical protein
chr4_-_154044493 2.90 ENSRNOT00000076318
Iqsec3
IQ motif and Sec7 domain 3
chr1_-_89045586 2.83 ENSRNOT00000063808
Zbtb32
zinc finger and BTB domain containing 32
chr3_-_14571640 2.76 ENSRNOT00000060013
Ggta1l1
glycoprotein, alpha-galactosyltransferase 1-like 1
chr15_+_32386816 2.45 ENSRNOT00000060322
AABR07017901.1

chr3_+_94035905 2.44 ENSRNOT00000014767
RGD1563222
similar to RIKEN cDNA A930018P22
chr12_-_6956914 2.42 ENSRNOT00000072129
ENSRNOT00000001210
Uspl1
ubiquitin specific peptidase like 1
chr10_-_56488723 2.41 ENSRNOT00000065524
Tmem95
transmembrane protein 95
chr19_+_10167797 2.25 ENSRNOT00000085440
Cngb1
cyclic nucleotide gated channel beta 1
chrX_+_15321713 2.25 ENSRNOT00000071835
LOC108348138
GTPase ERas
chr7_-_125497691 2.24 ENSRNOT00000049445
AABR07058578.1

chr10_+_86564928 2.16 ENSRNOT00000039892
Lrrc3c
leucine rich repeat containing 3C
chr11_+_28739219 1.97 ENSRNOT00000061620
Krtap13-2
keratin associated protein 13-2
chr1_+_192025357 1.90 ENSRNOT00000025072
Ubfd1
ubiquitin family domain containing 1
chr8_-_58293102 1.79 ENSRNOT00000011913
Rab39a
RAB39A, member RAS oncogene family
chr2_-_84678790 1.74 ENSRNOT00000015886
Cct5
chaperonin containing TCP1 subunit 5
chr12_-_23841049 1.43 ENSRNOT00000031555
Hspb1
heat shock protein family B (small) member 1
chr20_+_4118461 1.35 ENSRNOT00000083085
RT1-Db2
RT1 class II, locus Db2
chr3_+_154043873 1.33 ENSRNOT00000072502
ENSRNOT00000034166
Nnat
neuronatin
chr20_+_3149114 1.27 ENSRNOT00000084770
RT1-N2
RT1 class Ib, locus N2
chr12_+_38274297 1.08 ENSRNOT00000087905
ENSRNOT00000057788
Rsrc2
arginine and serine rich coiled-coil 2
chr12_+_12756452 1.06 ENSRNOT00000001382
ENSRNOT00000092462
Ankrd61
ankyrin repeat domain 61
chr12_-_31323810 0.94 ENSRNOT00000001247
Ran
RAN, member RAS oncogene family
chr14_-_108273938 0.88 ENSRNOT00000084642
Ahsa2
AHA1, activator of heat shock protein ATPase 2
chr2_+_178354890 0.87 ENSRNOT00000037890
Ppid
peptidylprolyl isomerase D
chr12_-_30501860 0.50 ENSRNOT00000001227
Cct6a
chaperonin containing TCP1 subunit 6A
chr17_+_36771639 0.46 ENSRNOT00000015147
Gpr50
G protein-coupled receptor 50
chr14_+_88543630 0.46 ENSRNOT00000060515
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr8_+_132828091 0.46 ENSRNOT00000008269
Ccr9
C-C motif chemokine receptor 9
chr1_-_192025350 0.40 ENSRNOT00000071946
Ears2
glutamyl-tRNA synthetase 2, mitochondrial
chr20_-_44255064 0.29 ENSRNOT00000000735
Wisp3
WNT1 inducible signaling pathway protein 3
chr5_-_151768123 0.23 ENSRNOT00000079380
Nudc
nuclear distribution C, dynein complex regulator
chr1_+_105094411 0.20 ENSRNOT00000036258
Htatip2
HIV-1 Tat interactive protein 2
chr18_-_29611212 0.17 ENSRNOT00000022685
Dnd1
DND microRNA-mediated repression inhibitor 1
chrX_-_45187149 0.16 ENSRNOT00000080431
Pbsn
probasin
chr9_-_61690956 0.16 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr1_+_80135391 0.13 ENSRNOT00000021893
Gpr4
G protein-coupled receptor 4
chr2_+_187668796 0.13 ENSRNOT00000025824
Cct3
chaperonin containing TCP1 subunit 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
2.5 7.6 GO:0033058 directional locomotion(GO:0033058)
1.9 5.7 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
1.5 4.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
1.4 4.3 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115)
1.3 10.3 GO:0007021 tubulin complex assembly(GO:0007021)
1.3 10.1 GO:1903405 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
1.2 33.8 GO:0006471 protein ADP-ribosylation(GO:0006471)
1.2 4.6 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
1.1 10.3 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.9 7.7 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.7 12.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.6 9.1 GO:0070307 lens fiber cell development(GO:0070307)
0.6 2.4 GO:0030576 Cajal body organization(GO:0030576)
0.5 28.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 1.8 GO:0090383 phagosome acidification(GO:0090383)
0.3 4.1 GO:0021670 lateral ventricle development(GO:0021670)
0.3 2.8 GO:0030259 lipid glycosylation(GO:0030259)
0.2 11.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 6.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.2 17.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 2.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 7.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 13.5 GO:0006986 response to unfolded protein(GO:0006986)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 2.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 10.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 3.1 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.1 0.4 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.5 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.1 5.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.4 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 2.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.0 0.5 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 11.5 GO:0007409 axonogenesis(GO:0007409)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 4.9 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 4.9 GO:0032868 response to insulin(GO:0032868)
0.0 1.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 2.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 14.8 GO:0030182 neuron differentiation(GO:0030182)
0.0 4.5 GO:0032259 methylation(GO:0032259)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
1.3 11.8 GO:0097512 cardiac myofibril(GO:0097512)
1.1 7.7 GO:0031415 NatA complex(GO:0031415)
0.8 7.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.8 10.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.7 7.6 GO:0098839 postsynaptic density membrane(GO:0098839)
0.7 4.1 GO:0036157 outer dynein arm(GO:0036157)
0.5 19.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 4.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 12.2 GO:0044295 axonal growth cone(GO:0044295)
0.2 0.9 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.2 2.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 10.3 GO:1904115 axon cytoplasm(GO:1904115)
0.2 0.5 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.1 8.8 GO:0030315 T-tubule(GO:0030315)
0.1 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 9.1 GO:0005882 intermediate filament(GO:0005882)
0.0 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 5.9 GO:0043209 myelin sheath(GO:0043209)
0.0 1.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 68.2 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 33.8 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
2.6 10.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
2.4 12.2 GO:0032767 copper-dependent protein binding(GO:0032767)
1.2 4.6 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
1.1 4.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
1.1 6.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.9 36.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.9 19.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.9 10.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.8 7.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.7 4.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.7 2.8 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.6 8.8 GO:0031432 titin binding(GO:0031432)
0.6 7.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 11.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 7.5 GO:0002162 dystroglycan binding(GO:0002162)
0.3 9.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 2.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.2 0.9 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 2.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 11.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 13.0 GO:0051087 chaperone binding(GO:0051087)
0.1 2.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 15.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 4.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 17.1 GO:0005549 odorant binding(GO:0005549)
0.0 9.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 4.5 GO:0008168 methyltransferase activity(GO:0008168)
0.0 2.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 4.0 GO:0003924 GTPase activity(GO:0003924)
0.0 6.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 7.6 PID REELIN PATHWAY Reelin signaling pathway
0.2 12.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 7.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.5 11.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.4 7.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 2.8 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 4.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 5.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 9.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 15.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 4.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation