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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ikzf2

Z-value: 0.89

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Transcription factors associated with Ikzf2

Gene Symbol Gene ID Gene Info
Ikzf2
ENSRNOG00000027430 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ikzf2rn6_v1_chr9_-_76768770_767688060.611.7e-33Click!

Activity profile of Ikzf2 motif

Sorted Z-values of Ikzf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_19918644 24.46 ENSRNOT00000083345
ENSRNOT00000023926
Plvap
plasmalemma vesicle associated protein
chr6_+_99356509 24.06 ENSRNOT00000008416
Akap5
A-kinase anchoring protein 5
chr17_-_43798383 22.55 ENSRNOT00000075069
LOC684828
similar to Histone H1.2 (H1 VAR.1) (H1c)
chr1_+_78711077 21.42 ENSRNOT00000064332
Slc1a5
solute carrier family 1 member 5
chr9_-_76768770 20.87 ENSRNOT00000087779
ENSRNOT00000057849
Ikzf2
IKAROS family zinc finger 2
chr6_-_131914028 19.33 ENSRNOT00000007602
Bcl11b
B-cell CLL/lymphoma 11B
chr4_+_147333056 18.18 ENSRNOT00000012137
Pparg
peroxisome proliferator-activated receptor gamma
chr7_-_107634287 16.26 ENSRNOT00000093672
ENSRNOT00000087116
Sla
src-like adaptor
chr2_+_236233239 15.81 ENSRNOT00000013694
Lef1
lymphoid enhancer binding factor 1
chr9_+_52023295 15.62 ENSRNOT00000004956
Col3a1
collagen type III alpha 1 chain
chr8_-_107952530 14.93 ENSRNOT00000052043
Cldn18
claudin 18
chr2_+_150756185 14.67 ENSRNOT00000088461
ENSRNOT00000036808
Mbnl1
muscleblind-like splicing regulator 1
chrX_+_78259409 13.57 ENSRNOT00000049779
RGD1560455
similar to RIKEN cDNA A630033H20 gene
chr10_+_23914894 13.41 ENSRNOT00000071435
Ebf1
early B-cell factor 1
chr15_-_33250546 12.95 ENSRNOT00000017857
RGD1565222
similar to RIKEN cDNA 4931414P19
chrX_+_78042859 12.05 ENSRNOT00000003286
Lpar4
lysophosphatidic acid receptor 4
chr3_+_103192683 11.92 ENSRNOT00000037551
LOC100363452
ribosomal protein S8-like
chr1_+_141767940 11.80 ENSRNOT00000064034
Zfp710
zinc finger protein 710
chr13_-_89874008 11.43 ENSRNOT00000051368
Ptma
prothymosin alpha
chr20_+_27975549 11.31 ENSRNOT00000092075
Lims1
LIM zinc finger domain containing 1
chrX_+_15155230 11.29 ENSRNOT00000073289
ENSRNOT00000051439
Was
Wiskott-Aldrich syndrome
chr11_+_84745904 11.28 ENSRNOT00000002617
Klhl6
kelch-like family member 6
chr3_+_149790856 10.72 ENSRNOT00000075275
LOC100911637
high mobility group protein B1-like
chr1_-_260254600 10.65 ENSRNOT00000019014
Blnk
B-cell linker
chr18_+_30562178 10.21 ENSRNOT00000040998
LOC108348771
protocadherin beta-16-like
chr10_+_23661343 10.06 ENSRNOT00000047970
Ebf1
early B-cell factor 1
chr7_-_104541392 9.93 ENSRNOT00000078116
Fam49b
family with sequence similarity 49, member B
chr9_+_40975836 9.86 ENSRNOT00000084470
Ptpn18
protein tyrosine phosphatase, non-receptor type 18
chr13_+_90244681 9.47 ENSRNOT00000078162
Cd84
CD84 molecule
chr4_-_29778039 9.37 ENSRNOT00000074177
Sgce
sarcoglycan, epsilon
chr9_+_71915421 9.35 ENSRNOT00000020447
Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
chr14_+_43694183 9.31 ENSRNOT00000046342
RGD1563570
similar to ribosomal protein S23
chr12_-_51702730 9.24 ENSRNOT00000046920
Ttc28
tetratricopeptide repeat domain 28
chr1_+_266255797 9.21 ENSRNOT00000027047
Trim8
tripartite motif-containing 8
chr6_-_42630983 9.07 ENSRNOT00000071977
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr14_-_43694584 9.02 ENSRNOT00000041866
AABR07072400.1

chr8_-_49158971 8.96 ENSRNOT00000020573
Kmt2a
lysine methyltransferase 2A
chr10_+_84135116 8.74 ENSRNOT00000031035
Hoxb7
homeo box B7
chrX_-_29648359 8.60 ENSRNOT00000086721
ENSRNOT00000006777
Gpm6b
glycoprotein m6b
chr11_-_14304603 8.58 ENSRNOT00000040202
ENSRNOT00000082143
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr8_-_118378460 8.48 ENSRNOT00000047247
RGD1563705
similar to ribosomal protein S23
chr8_+_118378059 8.37 ENSRNOT00000043247
AABR07071482.1

chr1_+_253221812 8.31 ENSRNOT00000085880
ENSRNOT00000054753
Kif20b
kinesin family member 20B
chr6_-_77421286 7.97 ENSRNOT00000011453
Nkx2-1
NK2 homeobox 1
chr3_+_93920013 7.67 ENSRNOT00000083527
Lmo2
LIM domain only 2
chr7_-_51515373 7.45 ENSRNOT00000080285
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
chr3_+_44025300 7.39 ENSRNOT00000006319
Galnt5
polypeptide N-acetylgalactosaminyltransferase 5
chrX_-_31851715 6.70 ENSRNOT00000068601
Vegfd
vascular endothelial growth factor D
chr3_+_113918629 6.68 ENSRNOT00000078978
ENSRNOT00000037168
Ctdspl2
CTD small phosphatase like 2
chr13_+_46169963 6.36 ENSRNOT00000005212
Thsd7b
thrombospondin type 1 domain containing 7B
chr18_+_30487264 6.28 ENSRNOT00000040125
Pcdhb10
protocadherin beta 10
chr6_+_104475036 6.14 ENSRNOT00000070995
Susd6
sushi domain containing 6
chr7_-_124020574 6.12 ENSRNOT00000055988
Poldip3
DNA polymerase delta interacting protein 3
chr11_-_35749464 6.11 ENSRNOT00000078818
ENSRNOT00000078425
Erg
ERG, ETS transcription factor
chr12_+_25450286 6.09 ENSRNOT00000092956
Gtf2i
general transcription factor II I
chr3_+_8873933 6.04 ENSRNOT00000030996
Nup188
nucleoporin 188
chr3_+_93920447 5.97 ENSRNOT00000012625
Lmo2
LIM domain only 2
chr18_+_30496318 5.75 ENSRNOT00000027179
Pcdhb11
protocadherin beta 11
chr14_+_88549947 5.74 ENSRNOT00000086177
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr10_-_92476109 5.71 ENSRNOT00000089029
Kansl1
KAT8 regulatory NSL complex subunit 1
chr17_+_10559680 5.53 ENSRNOT00000023320
Nop16
NOP16 nucleolar protein
chr6_+_28235695 5.50 ENSRNOT00000047210
Dnmt3a
DNA methyltransferase 3 alpha
chr7_-_120770435 5.47 ENSRNOT00000077000
Ddx17
DEAD-box helicase 17
chr4_+_100407658 5.46 ENSRNOT00000018562
Capg
capping actin protein, gelsolin like
chr14_-_112946204 5.34 ENSRNOT00000056813
LOC103690141
coiled-coil domain-containing protein 85A-like
chr3_+_11554457 5.26 ENSRNOT00000073087
Fam102a
family with sequence similarity 102, member A
chr3_-_3855981 5.11 ENSRNOT00000079882
Inpp5e
inositol polyphosphate-5-phosphatase E
chr10_-_65066612 4.90 ENSRNOT00000043448
Myo18a
myosin XVIIIa
chr12_-_51965779 4.84 ENSRNOT00000056733
LOC100362927
replication protein A3-like
chr6_-_44361908 4.77 ENSRNOT00000009491
Id2
inhibitor of DNA binding 2, HLH protein
chr2_-_80667481 4.51 ENSRNOT00000016784
Trio
trio Rho guanine nucleotide exchange factor
chr6_+_60566196 4.51 ENSRNOT00000006709
ENSRNOT00000075193
Dock4
dedicator of cytokinesis 4
chr2_-_235951275 4.43 ENSRNOT00000050291
AABR07013410.1

chr2_-_208225888 4.39 ENSRNOT00000054860
AABR07012775.1

chr8_+_52127632 4.19 ENSRNOT00000079797
Cadm1
cell adhesion molecule 1
chr19_-_24614019 4.00 ENSRNOT00000005124
Scoc
short coiled-coil protein
chr9_-_116222374 3.98 ENSRNOT00000090111
ENSRNOT00000067900
Arhgap28
Rho GTPase activating protein 28
chr7_-_51515131 3.97 ENSRNOT00000006773
ENSRNOT00000041473
ENSRNOT00000050037
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
chr9_+_73433252 3.84 ENSRNOT00000092540
Map2
microtubule-associated protein 2
chr6_-_26828972 3.81 ENSRNOT00000010932
Emilin1
elastin microfibril interfacer 1
chr4_+_66091641 3.78 ENSRNOT00000043147
AABR07060287.1

chr3_+_61634005 3.72 ENSRNOT00000002145
Hoxd4
homeo box D4
chr17_+_56109549 3.65 ENSRNOT00000022190
Map3k8
mitogen-activated protein kinase kinase kinase 8
chr15_+_34493138 3.64 ENSRNOT00000089584
ENSRNOT00000027789
Nfatc4
nuclear factor of activated T-cells 4
chr10_-_56409017 3.57 ENSRNOT00000020152
Fgf11
fibroblast growth factor 11
chrX_+_84064427 3.51 ENSRNOT00000046364
Zfp711
zinc finger protein 711
chr7_-_125497691 3.40 ENSRNOT00000049445
AABR07058578.1

chr15_+_24479761 3.32 ENSRNOT00000016449
Ktn1
kinectin 1
chr9_-_46206605 3.29 ENSRNOT00000018640
Tbc1d8
TBC1 domain family, member 8
chrX_+_10430847 3.25 ENSRNOT00000047936
Rpl21
ribosomal protein L21
chr18_-_53181503 3.23 ENSRNOT00000066548
Fbn2
fibrillin 2
chr8_-_45375435 3.23 ENSRNOT00000010873
Ubash3b
ubiquitin associated and SH3 domain containing, B
chr9_+_65172194 3.14 ENSRNOT00000040493
AC128084.1

chr10_-_66848388 3.12 ENSRNOT00000018891
Omg
oligodendrocyte-myelin glycoprotein
chr6_-_76552559 3.04 ENSRNOT00000065230
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chr4_-_180722358 2.94 ENSRNOT00000040645
Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
chr14_+_8080275 2.84 ENSRNOT00000065965
ENSRNOT00000092542
Mapk10
mitogen activated protein kinase 10
chr9_+_94316717 2.76 ENSRNOT00000077005
ENSRNOT00000092534
Eif4e2
eukaryotic translation initiation factor 4E family member 2
chr10_-_56365084 2.73 ENSRNOT00000068013
Polr2a
RNA polymerase II subunit A
chr13_+_57243877 2.60 ENSRNOT00000083693
Kcnt2
potassium sodium-activated channel subfamily T member 2
chrX_-_105417323 2.56 ENSRNOT00000015494
Gla
galactosidase, alpha
chr13_+_98311827 2.49 ENSRNOT00000082844
Cdc42bpa
CDC42 binding protein kinase alpha
chr19_+_49495892 2.43 ENSRNOT00000015180
Atmin
ATM interactor
chr15_-_29465807 2.35 ENSRNOT00000075046
AABR07017635.1

chrX_-_25590048 2.35 ENSRNOT00000004873
Mid1
midline 1
chr2_-_198120041 2.18 ENSRNOT00000079621
ENSRNOT00000028747
Plekho1
pleckstrin homology domain containing O1
chr10_-_21265026 2.11 ENSRNOT00000011922
Tenm2
teneurin transmembrane protein 2
chr2_+_60920257 2.04 ENSRNOT00000025170
C1qtnf3
C1q and tumor necrosis factor related protein 3
chr16_+_24980723 1.98 ENSRNOT00000082142
Tma16
translation machinery associated 16 homolog
chr2_+_31378743 1.84 ENSRNOT00000050384
AABR07007853.1

chr10_+_17327275 1.78 ENSRNOT00000005486
Ubtd2
ubiquitin domain containing 2
chr5_-_154393697 1.68 ENSRNOT00000090019
Rpl11
ribosomal protein L11
chr1_-_70485888 1.63 ENSRNOT00000020514
Olr7
olfactory receptor 7
chr2_-_41784929 1.43 ENSRNOT00000086851
Rab3c
RAB3C, member RAS oncogene family
chr6_-_86713370 1.40 ENSRNOT00000005821
Klhl28
kelch-like family member 28
chr7_+_122160171 1.31 ENSRNOT00000074499
LOC100362980
CG3918-like
chr2_+_198755262 0.92 ENSRNOT00000028807
Rbm8a
RNA binding motif protein 8A
chr4_+_28989115 0.38 ENSRNOT00000075326
Gng11
G protein subunit gamma 11
chr3_-_59688692 0.32 ENSRNOT00000078752
Sp3
Sp3 transcription factor
chr1_+_172242504 0.29 ENSRNOT00000043135
Olr245
olfactory receptor 245
chr4_-_34194764 0.24 ENSRNOT00000045270
Col28a1
collagen type XXVIII alpha 1 chain
chr9_-_94495333 0.24 ENSRNOT00000021507
Kcnj13
potassium voltage-gated channel subfamily J member 13
chr14_+_8080565 0.00 ENSRNOT00000092395
Mapk10
mitogen activated protein kinase 10

Network of associatons between targets according to the STRING database.

First level regulatory network of Ikzf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
6.0 24.1 GO:0036394 amylase secretion(GO:0036394)
5.9 35.1 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
5.0 14.9 GO:2001205 negative regulation of osteoclast development(GO:2001205)
3.9 15.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
3.3 9.9 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
3.1 21.4 GO:0006868 glutamine transport(GO:0006868)
3.0 9.0 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
2.8 22.6 GO:0016584 nucleosome positioning(GO:0016584)
2.8 8.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
2.4 9.5 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
1.9 11.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.7 8.6 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.6 4.9 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
1.6 4.8 GO:0001966 thigmotaxis(GO:0001966)
1.5 6.0 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
1.5 4.5 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
1.3 8.0 GO:0021759 globus pallidus development(GO:0021759)
1.3 24.5 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
1.2 3.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.0 11.4 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
1.0 6.1 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
1.0 13.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
1.0 6.7 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
1.0 5.7 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.9 5.5 GO:0044027 hypermethylation of CpG island(GO:0044027) C-5 methylation of cytosine(GO:0090116)
0.9 6.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.8 4.2 GO:0009826 unidimensional cell growth(GO:0009826)
0.8 3.2 GO:0071694 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.8 25.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.8 11.3 GO:0002467 germinal center formation(GO:0002467)
0.7 5.8 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.6 11.4 GO:0043486 histone exchange(GO:0043486)
0.5 14.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.5 9.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.4 6.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.4 2.9 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.4 4.0 GO:0061635 regulation of protein complex stability(GO:0061635)
0.4 2.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 6.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.3 9.3 GO:0032288 myelin assembly(GO:0032288)
0.3 5.5 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.3 5.1 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.3 1.7 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 2.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.3 4.0 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 3.2 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.3 2.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.3 8.7 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 5.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 5.7 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.3 2.0 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.3 11.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 9.1 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.3 8.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.2 2.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.2 2.2 GO:0051451 myoblast migration(GO:0051451)
0.2 16.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 2.1 GO:0097264 self proteolysis(GO:0097264)
0.2 2.5 GO:0007097 nuclear migration(GO:0007097)
0.2 22.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 3.1 GO:0048679 regulation of axon regeneration(GO:0048679)
0.1 3.8 GO:0070207 protein homotrimerization(GO:0070207)
0.1 9.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 5.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 2.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 6.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 3.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 4.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 3.7 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 7.6 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 7.4 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 2.8 GO:0006413 translational initiation(GO:0006413)
0.0 7.7 GO:0007346 regulation of mitotic cell cycle(GO:0007346)
0.0 1.4 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 2.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 6.1 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)
0.0 4.3 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
2.0 6.0 GO:0044611 nuclear pore inner ring(GO:0044611)
1.9 5.7 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
1.8 9.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.6 24.1 GO:0032591 dendritic spine membrane(GO:0032591)
1.6 9.4 GO:0016012 sarcoglycan complex(GO:0016012)
1.3 15.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 11.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.8 25.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.8 5.5 GO:0090543 Flemming body(GO:0090543)
0.7 9.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 8.3 GO:0097431 mitotic spindle pole(GO:0097431) mitotic spindle midzone(GO:1990023)
0.5 14.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.5 5.5 GO:0000791 euchromatin(GO:0000791)
0.4 2.2 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 6.1 GO:0000346 transcription export complex(GO:0000346)
0.3 3.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 2.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 14.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 4.2 GO:0070852 cell body fiber(GO:0070852)
0.2 24.5 GO:0005901 caveola(GO:0005901)
0.2 2.8 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 11.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 18.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 16.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 11.3 GO:0016605 PML body(GO:0016605)
0.1 3.8 GO:0008305 integrin complex(GO:0008305)
0.1 4.5 GO:0032420 stereocilium(GO:0032420)
0.1 2.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 11.3 GO:0005884 actin filament(GO:0005884)
0.1 7.4 GO:0042641 actomyosin(GO:0042641)
0.1 25.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 4.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 48.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 11.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 6.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.0 9.9 GO:0005929 cilium(GO:0005929)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 19.0 GO:0097458 neuron part(GO:0097458)
0.0 8.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 7.3 GO:0016604 nuclear body(GO:0016604)
0.0 4.8 GO:0000785 chromatin(GO:0000785)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 20.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 2.6 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0001069 regulatory region RNA binding(GO:0001069)
3.3 9.9 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
3.0 12.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
2.6 18.2 GO:0050692 DBD domain binding(GO:0050692)
2.2 24.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
1.9 39.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
1.8 9.0 GO:0045322 unmethylated CpG binding(GO:0045322)
1.8 21.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.6 9.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.3 10.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.3 3.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
1.2 9.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.1 15.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.1 5.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.0 9.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.8 5.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.7 6.7 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.7 2.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 7.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.7 8.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.6 5.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.5 8.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 5.7 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.5 11.3 GO:0043274 phospholipase binding(GO:0043274)
0.5 11.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 13.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 2.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.3 2.6 GO:0016936 galactoside binding(GO:0016936)
0.3 6.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 2.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 8.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 16.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 5.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 22.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 11.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 6.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 3.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 2.6 GO:0002162 dystroglycan binding(GO:0002162)
0.1 4.9 GO:0043531 ADP binding(GO:0043531)
0.1 27.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.4 GO:0070840 dynein complex binding(GO:0070840)
0.1 2.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 5.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.1 3.3 GO:0019894 kinesin binding(GO:0019894)
0.1 52.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 15.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 4.8 GO:0044325 ion channel binding(GO:0044325)
0.0 6.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 25.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 16.8 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 6.4 GO:0003682 chromatin binding(GO:0003682)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 3.0 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.5 27.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.4 21.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.4 15.6 PID ENDOTHELIN PATHWAY Endothelins
0.4 10.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4 17.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 4.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.3 20.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 20.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 3.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 11.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 13.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 8.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.9 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 6.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 4.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.6 PID LKB1 PATHWAY LKB1 signaling events
0.1 5.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 3.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 7.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 12.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.8 9.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.7 24.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.7 11.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 21.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 10.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.5 14.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.5 11.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 39.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 5.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.4 15.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 9.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 4.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 4.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 2.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 6.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 3.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 2.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 2.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.2 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.1 7.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 6.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 2.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 4.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 4.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta