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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Irf4

Z-value: 0.67

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Transcription factors associated with Irf4

Gene Symbol Gene ID Gene Info
Irf4
ENSRNOG00000061070 interferon regulatory factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf4rn6_v1_chr17_-_34905117_349051170.081.7e-01Click!

Activity profile of Irf4 motif

Sorted Z-values of Irf4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_18710492 23.38 ENSRNOT00000012532
Dnase1l3
deoxyribonuclease 1-like 3
chr1_-_16687817 19.41 ENSRNOT00000091376
ENSRNOT00000081620
Myb
MYB proto-oncogene, transcription factor
chr1_+_198744050 17.25 ENSRNOT00000024404
Itgal
integrin subunit alpha L
chr17_+_72429618 16.93 ENSRNOT00000026187
Gata3
GATA binding protein 3
chr11_+_47243342 16.49 ENSRNOT00000041116
Nfkbiz
NFKB inhibitor zeta
chr1_+_260289589 15.75 ENSRNOT00000051058
Dntt
DNA nucleotidylexotransferase
chr10_+_76343847 15.46 ENSRNOT00000055674
Trim25
tripartite motif-containing 25
chr11_+_61970976 15.25 ENSRNOT00000078921
Tigit
T cell immunoreceptor with Ig and ITIM domains
chr10_-_29450644 15.06 ENSRNOT00000087937
Adra1b
adrenoceptor alpha 1B
chr4_-_176679815 14.42 ENSRNOT00000090122
Gys2
glycogen synthase 2
chr10_-_88050622 14.01 ENSRNOT00000019037
Krt15
keratin 15
chr8_-_124399494 13.90 ENSRNOT00000037883
Tgfbr2
transforming growth factor, beta receptor 2
chr9_-_4945352 13.74 ENSRNOT00000082530
Sult1c3
sulfotransferase family 1C member 3
chr4_-_31730386 13.41 ENSRNOT00000013817
Slc25a13
solute carrier family 25 member 13
chr20_-_4542073 12.01 ENSRNOT00000000477
Cfb
complement factor B
chr1_-_47331412 11.78 ENSRNOT00000046746
Ezr
ezrin
chr1_-_79930263 11.73 ENSRNOT00000019219
Foxa3
forkhead box A3
chr5_-_153924896 11.41 ENSRNOT00000065247
Grhl3
grainyhead-like transcription factor 3
chr17_-_69827112 11.07 ENSRNOT00000023835
Akr1c14
aldo-keto reductase family 1, member C14
chr10_+_34277993 10.96 ENSRNOT00000055872
ENSRNOT00000003343
Ifi47
interferon gamma inducible protein 47
chr10_+_31880918 10.87 ENSRNOT00000059448
Timd4
T-cell immunoglobulin and mucin domain containing 4
chrX_+_110789269 10.53 ENSRNOT00000086014
Rnf128
ring finger protein 128, E3 ubiquitin protein ligase
chr15_+_24141651 10.53 ENSRNOT00000082304
Lgals3
galectin 3
chr10_-_89454681 10.38 ENSRNOT00000028109
Brca1
BRCA1, DNA repair associated
chr2_-_216382244 10.05 ENSRNOT00000086695
ENSRNOT00000087259
LOC103689940
pancreatic alpha-amylase-like
chr1_-_142183884 9.38 ENSRNOT00000016032
Fes
FES proto-oncogene, tyrosine kinase
chr20_-_35450513 9.05 ENSRNOT00000087342
Man1a1
mannosidase, alpha, class 1A, member 1
chr11_+_67757928 8.90 ENSRNOT00000039215
Dtx3l
deltex E3 ubiquitin ligase 3L
chr13_-_99531959 8.78 ENSRNOT00000005059
Wdr26
WD repeat domain 26
chr2_-_30576591 8.53 ENSRNOT00000084667
Ocln
occludin
chr8_-_92942076 8.49 ENSRNOT00000056937
Fam46a
family with sequence similarity 46, member A
chr20_-_4698718 8.36 ENSRNOT00000047527
RT1-CE7
RT1 class I, locus CE7
chr2_+_248178389 8.35 ENSRNOT00000037339
Gbp5
guanylate binding protein 5
chr1_+_91857057 7.92 ENSRNOT00000077993
ENSRNOT00000081465
Ankrd27
ankyrin repeat domain 27
chr2_-_30577218 7.66 ENSRNOT00000024674
Ocln
occludin
chr13_+_82438697 7.48 ENSRNOT00000003759
Selp
selectin P
chr18_+_24540659 7.06 ENSRNOT00000061074
Ammecr1l
AMMECR1 like
chr10_-_74724472 6.87 ENSRNOT00000008846
Rad51c
RAD51 paralog C
chr15_+_34256071 6.75 ENSRNOT00000025887
Psme1
proteasome activator subunit 1
chr5_-_4975436 6.40 ENSRNOT00000062006
Xkr9
XK related 9
chr20_-_27682861 6.34 ENSRNOT00000057317
Fam26f
family with sequence similarity 26, member F
chr4_+_161685258 6.32 ENSRNOT00000008012
ENSRNOT00000008003
Foxm1
forkhead box M1
chr5_-_62153762 6.17 ENSRNOT00000066001
ENSRNOT00000086962
Trim14
tripartite motif-containing 14
chr2_-_30634243 5.98 ENSRNOT00000077537
Marveld2
MARVEL domain containing 2
chr4_+_112773938 5.77 ENSRNOT00000009321
Eva1a
eva-1 homolog A, regulator of programmed cell death
chr15_+_3996328 5.72 ENSRNOT00000088252
Ndst2
N-deacetylase and N-sulfotransferase 2
chr3_+_120726906 5.70 ENSRNOT00000051069
Bcl2l11
BCL2 like 11
chr2_-_258997138 5.64 ENSRNOT00000045020
ENSRNOT00000042256
Adgrl2
adhesion G protein-coupled receptor L2
chr2_+_185393441 5.51 ENSRNOT00000015802
Sh3d19
SH3 domain containing 19
chr5_-_107857320 5.48 ENSRNOT00000008898
Cdkn2b
cyclin-dependent kinase inhibitor 2B
chr1_+_266333440 5.47 ENSRNOT00000071243
Sfxn2
sideroflexin 2
chr5_-_59913348 4.99 ENSRNOT00000018164
LOC100359916
heterogeneous nuclear ribonucleoprotein K-like
chr4_-_157743199 4.97 ENSRNOT00000038178
Tapbpl
TAP binding protein-like
chr20_-_20713128 4.43 ENSRNOT00000000784
Rhobtb1
Rho-related BTB domain containing 1
chr1_-_40921508 4.40 ENSRNOT00000026433
Zbtb2
zinc finger and BTB domain containing 2
chr15_+_3996048 4.36 ENSRNOT00000078653
Ndst2
N-deacetylase and N-sulfotransferase 2
chr7_-_24885775 4.14 ENSRNOT00000010024
Tcp11l2
t-complex 11 like 2
chr5_-_56536772 3.89 ENSRNOT00000060765
Ddx58
DEXD/H-box helicase 58
chr6_+_147315328 3.88 ENSRNOT00000056654
Macc1
MACC1, MET transcriptional regulator
chrX_+_54390733 3.85 ENSRNOT00000004977
RGD1565785
similar to chromosome X open reading frame 21
chr15_-_29291454 3.79 ENSRNOT00000092212
AABR07017617.2

chr9_+_4107246 3.70 ENSRNOT00000078212
AABR07066160.1

chr3_+_72395218 3.60 ENSRNOT00000057616
Prg3
proteoglycan 3, pro eosinophil major basic protein 2
chr17_+_6667564 3.51 ENSRNOT00000025916
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
chr8_-_55050194 3.48 ENSRNOT00000013197
LOC100151767
hypothetical LOC100151767
chr10_-_47775055 3.34 ENSRNOT00000057864
LOC100912585
mitogen-activated protein kinase 7-like
chr1_+_196095214 3.32 ENSRNOT00000080741
LOC691716
similar to ribosomal protein S15a
chr20_+_4329811 3.17 ENSRNOT00000000513
Notch4
notch 4
chr10_-_34221928 3.06 ENSRNOT00000045545
Irgm
immunity-related GTPase M
chr10_+_108527740 2.77 ENSRNOT00000044983
Rnf213
ring finger protein 213
chr2_-_185852759 2.76 ENSRNOT00000049461
Mab21l2
mab-21 like 2
chr2_-_211690716 2.71 ENSRNOT00000027690
Fndc7
fibronectin type III domain containing 7
chr2_+_150756185 2.53 ENSRNOT00000088461
ENSRNOT00000036808
Mbnl1
muscleblind-like splicing regulator 1
chr1_+_80056755 2.53 ENSRNOT00000021221
Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
chr8_+_107826424 2.52 ENSRNOT00000019769
Dbr1
debranching RNA lariats 1
chr1_-_214252456 2.49 ENSRNOT00000023504
Irf7
interferon regulatory factor 7
chr7_+_91832988 2.44 ENSRNOT00000006410
Slc30a8
solute carrier family 30 member 8
chrX_-_76708878 2.39 ENSRNOT00000045534
Atrx
ATRX, chromatin remodeler
chr2_-_30633857 2.25 ENSRNOT00000085488
Marveld2
MARVEL domain containing 2
chr8_-_40122450 2.23 ENSRNOT00000039729
Tbrg1
transforming growth factor beta regulator 1
chr8_+_55050284 1.91 ENSRNOT00000013242
Pih1d2
PIH1 domain containing 2
chr1_+_13261876 1.88 ENSRNOT00000090703
Reps1
RALBP1 associated Eps domain containing 1
chr2_+_95077577 1.85 ENSRNOT00000046368
Mrps28
mitochondrial ribosomal protein S28
chr17_-_32015071 1.78 ENSRNOT00000070876
LOC100911107
leukocyte elastase inhibitor A-like
chr1_-_173456488 1.74 ENSRNOT00000044753
Olr282
olfactory receptor 282
chr15_+_105640097 1.60 ENSRNOT00000014300
Mbnl2
muscleblind-like splicing regulator 2
chr5_-_107858104 1.57 ENSRNOT00000092196
Cdkn2b
cyclin-dependent kinase inhibitor 2B
chr1_-_242083484 1.57 ENSRNOT00000065921
Tjp2
tight junction protein 2
chr1_-_59903339 1.55 ENSRNOT00000039037
Fpr-rs3
formyl peptide receptor, related sequence 3
chr8_+_117307339 1.51 ENSRNOT00000064571
Qrich1
glutamine-rich 1
chr13_-_102643223 1.48 ENSRNOT00000003155
Hlx
H2.0-like homeobox
chr6_+_135866739 1.29 ENSRNOT00000013460
Exoc3l4
exocyst complex component 3-like 4
chr3_+_161178117 1.29 ENSRNOT00000051826
Spint5p
serine peptidase inhibitor, Kunitz type 5
chr1_+_168136959 1.28 ENSRNOT00000020953
Olr68
olfactory receptor 68
chrX_+_31984612 1.17 ENSRNOT00000005181
Bmx
BMX non-receptor tyrosine kinase
chr1_-_123064642 1.07 ENSRNOT00000013551
Mkrn3
makorin, ring finger protein, 3
chr1_-_198008893 0.95 ENSRNOT00000025950
Il27
interleukin 27
chr4_-_10269748 0.95 ENSRNOT00000074662
Fam185a
family with sequence similarity 185, member A
chr12_-_9998779 0.94 ENSRNOT00000001265
Rpl21
ribosomal protein L21
chr5_-_69752314 0.93 ENSRNOT00000024724
Olr852
olfactory receptor 852
chr7_-_26983172 0.90 ENSRNOT00000089545
Txnrd1
thioredoxin reductase 1
chr11_+_43687107 0.82 ENSRNOT00000048343
Olr1558
olfactory receptor 1558
chrM_+_8599 0.81 ENSRNOT00000049683
Mt-cox3
mitochondrially encoded cytochrome C oxidase III
chr17_+_47662532 0.75 ENSRNOT00000081314
Stard3nl
STARD3 N-terminal like
chr8_-_6034142 0.70 ENSRNOT00000014560
Birc2
baculoviral IAP repeat-containing 2
chr17_-_89923423 0.64 ENSRNOT00000076964
Acbd5
acyl-CoA binding domain containing 5
chr2_-_210991509 0.62 ENSRNOT00000087329
Cyb561d1
cytochrome b561 family, member D1
chr9_+_64095978 0.56 ENSRNOT00000021533
Maip1
matrix AAA peptidase interacting protein 1
chr4_-_167089055 0.55 ENSRNOT00000050409
Tas2r113
taste receptor, type 2, member 113
chr15_+_30525754 0.49 ENSRNOT00000086842
AABR07017745.2

chr1_+_168204985 0.48 ENSRNOT00000049036
Olr75
olfactory receptor 75
chr8_-_18408179 0.47 ENSRNOT00000040032
AABR07069371.1

chr18_+_17550350 0.40 ENSRNOT00000078870
RGD1562608
similar to KIAA1328 protein
chr1_+_168092141 0.33 ENSRNOT00000072815
Or51t1
olfactory receptor, family 51, subfamily T, member 1
chr18_-_53181503 0.33 ENSRNOT00000066548
Fbn2
fibrillin 2
chr7_-_69982592 0.25 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr5_-_33892462 0.18 ENSRNOT00000009334
Atp6v0d2
ATPase H+ transporting V0 subunit D2
chr1_-_47213749 0.14 ENSRNOT00000024656
Dynlt1
dynein light chain Tctex-type 1
chr9_+_111028824 0.12 ENSRNOT00000041418
ENSRNOT00000056457
Pam
peptidylglycine alpha-amidating monooxygenase
chr12_+_49578633 0.05 ENSRNOT00000072683
Crybb2
crystallin, beta B2

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.4 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
5.6 16.9 GO:0002572 pro-T cell differentiation(GO:0002572)
5.0 15.1 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
4.6 13.9 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
3.5 10.5 GO:1903769 negative regulation of cell proliferation in bone marrow(GO:1903769)
3.5 10.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
3.4 13.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.9 11.8 GO:1902896 terminal web assembly(GO:1902896)
2.9 11.7 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
2.6 7.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
2.3 6.9 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
2.2 17.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.9 5.7 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
1.7 5.0 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
1.6 16.2 GO:0070673 response to interleukin-18(GO:0070673)
1.5 23.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
1.2 3.6 GO:0045575 basophil activation(GO:0045575)
1.2 3.5 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.1 10.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
1.1 12.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 3.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
1.0 3.9 GO:0009597 detection of virus(GO:0009597)
0.9 8.3 GO:0032621 interleukin-18 production(GO:0032621)
0.8 2.4 GO:1901581 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.8 15.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.8 15.2 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.8 11.4 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.7 7.5 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.7 2.2 GO:0032066 nucleolus to nucleoplasm transport(GO:0032066)
0.5 1.6 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.5 7.1 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.4 9.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.4 9.0 GO:0006491 N-glycan processing(GO:0006491)
0.4 2.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.4 10.5 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.4 6.3 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.4 1.5 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.4 6.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 8.9 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 11.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 5.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.0 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.3 2.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 6.7 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.2 2.4 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 9.7 GO:0033198 response to ATP(GO:0033198)
0.2 0.7 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.2 0.6 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.2 1.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 0.6 GO:0030242 pexophagy(GO:0030242)
0.2 8.2 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.1 7.6 GO:0045103 intermediate filament-based process(GO:0045103)
0.1 7.0 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.9 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.1 2.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 8.5 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.1 2.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.3 GO:0051601 exocyst localization(GO:0051601)
0.1 11.1 GO:0021766 hippocampus development(GO:0021766)
0.1 0.3 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 2.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 13.7 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 11.1 GO:0006954 inflammatory response(GO:0006954)
0.0 10.0 GO:0005975 carbohydrate metabolic process(GO:0005975)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
2.9 11.8 GO:0044393 TCR signalosome(GO:0036398) microspike(GO:0044393)
2.6 10.4 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
2.2 6.7 GO:0008537 proteasome activator complex(GO:0008537)
1.9 7.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.6 8.2 GO:0061689 tricellular tight junction(GO:0061689)
1.4 6.9 GO:0048476 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
1.3 7.9 GO:0097422 tubular endosome(GO:0097422)
0.8 5.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.8 2.4 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.7 27.8 GO:0001772 immunological synapse(GO:0001772)
0.7 16.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 2.5 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.3 15.8 GO:0000791 euchromatin(GO:0000791)
0.2 14.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 16.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 15.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 3.1 GO:0001891 phagocytic cup(GO:0001891)
0.1 9.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 7.6 GO:0045095 keratin filament(GO:0045095)
0.1 3.5 GO:0002102 podosome(GO:0002102)
0.1 10.1 GO:0072562 blood microparticle(GO:0072562)
0.1 4.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.3 GO:0000145 exocyst(GO:0000145)
0.0 6.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 15.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 19.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 9.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 31.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0033179 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 8.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 1.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.1 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 0.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 32.0 GO:0005829 cytosol(GO:0005829)
0.0 2.2 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
3.9 19.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
3.4 13.7 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
3.4 16.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
3.4 10.1 GO:0004556 alpha-amylase activity(GO:0004556)
2.8 13.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.8 11.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
2.7 13.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
2.1 10.5 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
2.1 14.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
1.9 7.5 GO:0042806 fucose binding(GO:0042806)
1.7 10.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.5 15.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.1 6.9 GO:0000150 recombinase activity(GO:0000150)
1.0 9.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.0 6.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.8 2.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.8 9.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.7 11.8 GO:0044548 S100 protein binding(GO:0044548)
0.7 3.5 GO:1990715 mRNA CDS binding(GO:1990715) C-rich single-stranded DNA binding(GO:1990829)
0.5 15.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 7.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 2.4 GO:0015616 DNA translocase activity(GO:0015616)
0.4 23.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.3 2.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.2 0.9 GO:0045340 mercury ion binding(GO:0045340)
0.2 5.7 GO:0070840 dynein complex binding(GO:0070840)
0.2 10.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 10.4 GO:0003684 damaged DNA binding(GO:0003684)
0.2 5.5 GO:0070064 proline-rich region binding(GO:0070064)
0.2 14.0 GO:0097110 scaffold protein binding(GO:0097110)
0.1 3.2 GO:0005112 Notch binding(GO:0005112)
0.1 3.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.5 GO:0016893 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters(GO:0016893)
0.1 11.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 9.2 GO:0000149 SNARE binding(GO:0000149)
0.1 34.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 12.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 8.9 GO:0042393 histone binding(GO:0042393)
0.0 5.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 25.0 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 6.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 4.6 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 2.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 15.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.6 12.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.6 17.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.6 17.0 PID IL27 PATHWAY IL27-mediated signaling events
0.5 36.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 13.9 PID ALK1 PATHWAY ALK1 signaling events
0.4 5.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 22.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 11.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.3 10.5 PID RAS PATHWAY Regulation of Ras family activation
0.3 16.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 10.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 15.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.2 6.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 8.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 3.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 19.4 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.3 17.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.9 12.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.8 10.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.7 13.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 10.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 11.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 11.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.4 6.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 15.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.4 45.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 17.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 13.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 3.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 10.1 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 14.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 5.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 7.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 9.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 8.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 5.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 7.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 3.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 8.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 4.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases