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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Irf5_Irf6

Z-value: 0.38

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Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
Irf5
ENSRNOG00000007437 interferon regulatory factor 5
Irf6
ENSRNOG00000005082 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf6rn6_v1_chr13_+_111870121_1118701210.621.6e-35Click!
Irf5rn6_v1_chr4_+_56805132_568051580.027.3e-01Click!

Activity profile of Irf5_Irf6 motif

Sorted Z-values of Irf5_Irf6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_4542073 20.74 ENSRNOT00000000477
Cfb
complement factor B
chr9_-_4945352 19.24 ENSRNOT00000082530
Sult1c3
sulfotransferase family 1C member 3
chr10_+_76343847 14.25 ENSRNOT00000055674
Trim25
tripartite motif-containing 25
chr5_-_56536772 9.59 ENSRNOT00000060765
Ddx58
DEXD/H-box helicase 58
chr11_+_67757928 9.52 ENSRNOT00000039215
Dtx3l
deltex E3 ubiquitin ligase 3L
chr2_-_30576591 9.36 ENSRNOT00000084667
Ocln
occludin
chr2_-_30577218 8.45 ENSRNOT00000024674
Ocln
occludin
chr4_-_10517832 8.38 ENSRNOT00000039953
ENSRNOT00000083964
Gsap
gamma-secretase activating protein
chr7_-_101140308 6.59 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr5_+_159845774 6.41 ENSRNOT00000012328
Epha2
Eph receptor A2
chr2_+_185393441 5.56 ENSRNOT00000015802
Sh3d19
SH3 domain containing 19
chr6_-_51257625 5.32 ENSRNOT00000012004
Hbp1
HMG-box transcription factor 1
chr1_-_193328371 5.28 ENSRNOT00000019304
ENSRNOT00000031770
ENSRNOT00000019309
Arhgap17
Rho GTPase activating protein 17
chr5_+_16526058 4.63 ENSRNOT00000011130
Lyn
LYN proto-oncogene, Src family tyrosine kinase
chr5_-_62153762 4.62 ENSRNOT00000066001
ENSRNOT00000086962
Trim14
tripartite motif-containing 14
chr15_+_3996048 4.43 ENSRNOT00000078653
Ndst2
N-deacetylase and N-sulfotransferase 2
chr4_+_145427367 4.36 ENSRNOT00000037788
Il17rc
interleukin 17 receptor C
chr15_+_3996328 4.31 ENSRNOT00000088252
Ndst2
N-deacetylase and N-sulfotransferase 2
chr10_+_13000090 4.29 ENSRNOT00000004845
Cldn6
claudin 6
chr20_+_3979035 3.71 ENSRNOT00000000529
Tap1
transporter 1, ATP binding cassette subfamily B member
chr11_+_68105369 3.37 ENSRNOT00000046888
Parp14
poly (ADP-ribose) polymerase family, member 14
chr16_+_59988603 3.35 ENSRNOT00000015176
Cldn23
claudin 23
chr10_+_59259955 3.24 ENSRNOT00000021816
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr5_+_116421894 3.13 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
Nfia
nuclear factor I/A
chrX_-_79909678 2.89 ENSRNOT00000050336
Brwd3
bromodomain and WD repeat domain containing 3
chr1_+_220948331 2.82 ENSRNOT00000036185
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr20_-_3978845 2.76 ENSRNOT00000000532
Psmb9
proteasome subunit beta 9
chr2_+_240627436 2.14 ENSRNOT00000066204
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr2_-_247988462 2.12 ENSRNOT00000022387
Pdlim5
PDZ and LIM domain 5
chr10_-_4257868 2.05 ENSRNOT00000035886
Tnfrsf17
TNF receptor superfamily member 17
chr9_-_54327958 2.04 ENSRNOT00000019465
Stat1
signal transducer and activator of transcription 1
chr16_-_19349080 2.00 ENSRNOT00000038494
Hsh2d
hematopoietic SH2 domain containing
chr2_-_127710448 1.96 ENSRNOT00000093733
Mfsd8
major facilitator superfamily domain containing 8
chrX_+_44830849 1.82 ENSRNOT00000079680
Tbl1x
transducin (beta)-like 1 X-linked
chr13_-_25262469 1.75 ENSRNOT00000019921
Rnf152
ring finger protein 152
chr10_-_82963919 1.54 ENSRNOT00000005807
Dlx4
distal-less homeobox 4
chr10_-_54467956 1.54 ENSRNOT00000065383
Usp43
ubiquitin specific peptidase 43
chrX_+_123751089 1.47 ENSRNOT00000092384
Nkap
NFKB activating protein
chr4_-_51726212 1.39 ENSRNOT00000009261
Wasl
Wiskott-Aldrich syndrome-like
chrX_+_123751293 1.11 ENSRNOT00000089883
Nkap
NFKB activating protein
chr17_+_36334147 1.01 ENSRNOT00000050261
E2f3
E2F transcription factor 3
chr1_+_78671121 0.97 ENSRNOT00000021310
Ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr17_+_6667564 0.74 ENSRNOT00000025916
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
chr1_-_220938814 0.59 ENSRNOT00000028081
Ovol1
ovo like transcriptional repressor 1
chr10_+_46940965 0.58 ENSRNOT00000005366
Llgl1
LLGL1, scribble cell polarity complex component
chr3_-_29984201 0.54 ENSRNOT00000006350
Zeb2
zinc finger E-box binding homeobox 2
chr8_+_103774358 0.47 ENSRNOT00000014481
Xrn1
5'-3' exoribonuclease 1
chr13_-_102643223 0.36 ENSRNOT00000003155
Hlx
H2.0-like homeobox
chr6_-_10592454 0.25 ENSRNOT00000020600
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr11_+_43687107 0.17 ENSRNOT00000048343
Olr1558
olfactory receptor 1558

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.6 GO:0009597 detection of virus(GO:0009597)
1.9 20.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.8 17.8 GO:0070673 response to interleukin-18(GO:0070673)
1.6 6.4 GO:0014028 notochord formation(GO:0014028) axial mesoderm morphogenesis(GO:0048319) negative regulation of lymphangiogenesis(GO:1901491)
1.5 4.6 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.2 3.7 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
1.0 8.7 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.7 14.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.7 8.4 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.7 2.8 GO:1901423 response to benzene(GO:1901423)
0.6 3.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.5 2.0 GO:0046725 negative regulation of macrophage fusion(GO:0034240) negative regulation by virus of viral protein levels in host cell(GO:0046725)
0.4 2.0 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.4 9.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 4.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.3 5.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.7 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.2 1.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 4.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 3.1 GO:0072189 ureter development(GO:0072189)
0.2 5.3 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.2 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.7 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.6 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.4 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 2.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 2.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 2.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.5 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 19.2 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.0 0.6 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 2.0 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 5.3 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 2.0 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 2.9 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 2.8 GO:0016197 endosomal transport(GO:0016197)
0.0 2.5 GO:0045216 cell-cell junction organization(GO:0045216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.9 22.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 3.7 GO:0042825 TAP complex(GO:0042825)
0.5 2.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 3.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 1.0 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 1.4 GO:0030478 actin cap(GO:0030478)
0.2 20.4 GO:0072562 blood microparticle(GO:0072562)
0.1 18.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137) myelin sheath abaxonal region(GO:0035748)
0.1 2.8 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 8.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 6.4 GO:0031256 leading edge membrane(GO:0031256)
0.0 1.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 16.7 GO:0016604 nuclear body(GO:0016604)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 3.7 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 34.7 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.2 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
1.5 8.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.4 14.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.2 3.7 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.5 4.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 4.6 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 6.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 8.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 5.6 GO:0070064 proline-rich region binding(GO:0070064)
0.2 2.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 2.8 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 3.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159) cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 9.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 20.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 11.3 GO:0042393 histone binding(GO:0042393)
0.0 5.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.5 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 12.9 GO:0019904 protein domain specific binding(GO:0019904)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 20.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 4.6 PID IL5 PATHWAY IL5-mediated signaling events
0.3 6.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 17.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 5.3 PID MYC PATHWAY C-MYC pathway
0.2 2.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 5.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 3.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.4 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 4.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 23.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.5 20.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.3 17.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 4.6 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.3 8.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 2.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 5.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 1.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 2.8 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.1 9.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 5.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)