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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf15

Z-value: 0.74

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Transcription factors associated with Klf15

Gene Symbol Gene ID Gene Info
Klf15
ENSRNOG00000017808 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf15rn6_v1_chr4_+_122365093_1223650930.351.1e-10Click!

Activity profile of Klf15 motif

Sorted Z-values of Klf15 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_3657325 18.33 ENSRNOT00000010927
Tmem178a
transmembrane protein 178A
chr13_-_74077783 17.64 ENSRNOT00000005677
Soat1
sterol O-acyltransferase 1
chr20_+_4363508 16.58 ENSRNOT00000077205
Ager
advanced glycosylation end product-specific receptor
chrX_+_112769645 16.51 ENSRNOT00000064478
Col4a5
collagen type IV alpha 5 chain
chr20_+_4363152 15.73 ENSRNOT00000000508
ENSRNOT00000084841
ENSRNOT00000072848
ENSRNOT00000077561
Ager
advanced glycosylation end product-specific receptor
chr9_+_88357556 15.66 ENSRNOT00000020669
Col4a3
collagen type IV alpha 3 chain
chr10_+_90550147 14.85 ENSRNOT00000032944
Fzd2
frizzled class receptor 2
chr9_-_88357182 14.83 ENSRNOT00000041176
Col4a4
collagen type IV alpha 4 chain
chr12_-_22417980 14.05 ENSRNOT00000072208
Ephb4
EPH receptor B4
chr5_-_147412705 14.03 ENSRNOT00000010688
RGD1561149
similar to mKIAA1522 protein
chr9_+_80118029 13.14 ENSRNOT00000023068
Igfbp2
insulin-like growth factor binding protein 2
chr10_+_84152152 12.15 ENSRNOT00000010724
Hoxb5
homeo box B5
chr2_-_206222248 12.01 ENSRNOT00000026075
Olfml3
olfactomedin-like 3
chr1_-_263803150 11.32 ENSRNOT00000017840
Cyp2c23
cytochrome P450, family 2, subfamily c, polypeptide 23
chr20_+_48335540 11.14 ENSRNOT00000000352
Cd24
CD24 molecule
chr16_-_6404578 9.99 ENSRNOT00000051371
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr14_-_82287706 9.77 ENSRNOT00000080695
Fgfr3
fibroblast growth factor receptor 3
chr2_+_225005019 9.50 ENSRNOT00000015579
Cnn3
calponin 3
chr18_-_47513030 9.42 ENSRNOT00000083881
ENSRNOT00000074226
Lox
lysyl oxidase
chr20_+_41266566 9.41 ENSRNOT00000000653
Frk
fyn-related Src family tyrosine kinase
chr6_-_99870024 9.19 ENSRNOT00000010043
Rab15
RAB15, member RAS oncogene family
chr6_+_33885495 9.12 ENSRNOT00000086633
Sdc1
syndecan 1
chr15_+_34520142 8.48 ENSRNOT00000074659
Nynrin
NYN domain and retroviral integrase containing
chr1_-_170628915 7.86 ENSRNOT00000042865
Dchs1
dachsous cadherin-related 1
chr16_-_20592449 7.78 ENSRNOT00000026821
Isyna1
inositol-3-phosphate synthase 1
chr1_+_101610773 7.20 ENSRNOT00000032535
Rasip1
Ras interacting protein 1
chr15_+_34493138 7.00 ENSRNOT00000089584
ENSRNOT00000027789
Nfatc4
nuclear factor of activated T-cells 4
chr1_+_226435979 6.91 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
Syt7
synaptotagmin 7
chr1_+_78800754 6.91 ENSRNOT00000084601
Dact3
dishevelled-binding antagonist of beta-catenin 3
chr15_+_120372 6.85 ENSRNOT00000007828
Dlg5
discs large MAGUK scaffold protein 5
chr5_+_166533181 6.79 ENSRNOT00000045063
Clstn1
calsyntenin 1
chr1_+_80000165 6.07 ENSRNOT00000084912
Six5
SIX homeobox 5
chr6_-_122721496 6.04 ENSRNOT00000079697
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr9_+_93326283 6.03 ENSRNOT00000024578
B3gnt7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr3_+_110734105 5.71 ENSRNOT00000073587
Chst14
carbohydrate sulfotransferase 14
chr1_+_83653234 5.24 ENSRNOT00000085008
ENSRNOT00000084230
ENSRNOT00000090071
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
chr6_+_126018841 5.11 ENSRNOT00000089840
ENSRNOT00000088089
Slc24a4
solute carrier family 24 member 4
chr20_-_5064469 4.93 ENSRNOT00000001120
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr1_+_221099998 4.82 ENSRNOT00000028262
Ltbp3
latent transforming growth factor beta binding protein 3
chr19_+_49792273 4.82 ENSRNOT00000017941
ENSRNOT00000083991
Cmip
c-Maf-inducing protein
chr5_+_43603043 4.78 ENSRNOT00000009899
Epha7
Eph receptor A7
chr13_-_83842051 4.67 ENSRNOT00000004376
Mpzl1
myelin protein zero-like 1
chr20_+_5646097 4.57 ENSRNOT00000090925
Itpr3
inositol 1,4,5-trisphosphate receptor, type 3
chr9_+_93545396 4.53 ENSRNOT00000025093
LOC100359583
hypothetical protein LOC100359583
chr6_-_103470427 4.53 ENSRNOT00000091560
ENSRNOT00000088795
ENSRNOT00000079824
Actn1
actinin, alpha 1
chr6_-_3444519 4.51 ENSRNOT00000010366
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
chr1_+_282265370 4.42 ENSRNOT00000015687
Grk5
G protein-coupled receptor kinase 5
chr7_-_90318221 4.42 ENSRNOT00000050774
Trps1
transcriptional repressor GATA binding 1
chr13_+_78979321 4.27 ENSRNOT00000003857
Ankrd45
ankyrin repeat domain 45
chr7_+_97559841 4.21 ENSRNOT00000007326
Zhx2
zinc fingers and homeoboxes 2
chr11_-_38457373 4.18 ENSRNOT00000041177
Zfp295
zinc finger protein 295
chr4_-_66002444 4.16 ENSRNOT00000018645
Zc3hav1l
zinc finger CCCH-type containing, antiviral 1 like
chrX_-_22440187 4.15 ENSRNOT00000090731
Gpr173

chr9_-_16979044 4.13 ENSRNOT00000073191
ENSRNOT00000025335
Zfp318
zinc finger protein 318
chr5_-_172623899 3.94 ENSRNOT00000080591
Ski
SKI proto-oncogene
chr8_+_117068582 3.83 ENSRNOT00000073559
Amt
aminomethyltransferase
chr16_+_20740826 3.69 ENSRNOT00000038057
Crtc1
CREB regulated transcription coactivator 1
chrX_+_70596901 3.61 ENSRNOT00000088114
Dlg3
discs large MAGUK scaffold protein 3
chr3_+_58632476 3.56 ENSRNOT00000010630
Rapgef4
Rap guanine nucleotide exchange factor 4
chr8_+_117780891 3.52 ENSRNOT00000077236
Shisa5
shisa family member 5
chr5_-_100647727 3.50 ENSRNOT00000067435
Nfib
nuclear factor I/B
chr14_+_83510278 3.42 ENSRNOT00000081161
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr2_+_207923775 3.40 ENSRNOT00000019997
ENSRNOT00000051835
Kcnd3
potassium voltage-gated channel subfamily D member 3
chr2_+_198823366 3.38 ENSRNOT00000083769
ENSRNOT00000028814
Pias3
protein inhibitor of activated STAT, 3
chr5_-_100647298 3.35 ENSRNOT00000067538
ENSRNOT00000013092
Nfib
nuclear factor I/B
chr18_+_72005581 3.32 ENSRNOT00000072519
Zbtb7c
zinc finger and BTB domain containing 7C
chr1_+_226091774 3.30 ENSRNOT00000027693
Fads3
fatty acid desaturase 3
chr1_-_199395363 3.22 ENSRNOT00000090368
ENSRNOT00000026587
Prss36
protease, serine, 36
chr1_+_225096598 3.20 ENSRNOT00000035650
Ganab
glucosidase II alpha subunit
chr5_+_74649765 3.11 ENSRNOT00000075952
Palm2
paralemmin 2
chr7_+_123381077 3.10 ENSRNOT00000082603
ENSRNOT00000056041
Srebf2
sterol regulatory element binding transcription factor 2
chr13_-_52256196 3.07 ENSRNOT00000011105
Ipo9
importin 9
chr8_-_55408464 2.95 ENSRNOT00000066893
Sik2
salt-inducible kinase 2
chr20_+_5526975 2.92 ENSRNOT00000059548
Phf1
PHD finger protein 1
chr8_+_117737117 2.91 ENSRNOT00000028039
Pfkfb4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr4_+_10631073 2.89 ENSRNOT00000081939
ENSRNOT00000017907
Ptpn12
protein tyrosine phosphatase, non-receptor type 12
chr7_-_139318455 2.83 ENSRNOT00000092029
Hdac7
histone deacetylase 7
chr5_+_78483893 2.80 ENSRNOT00000059183
ENSRNOT00000059181
Rgs3
regulator of G-protein signaling 3
chrX_-_118615798 2.74 ENSRNOT00000045463
Lrch2
leucine rich repeats and calponin homology domain containing 2
chrX_-_157172068 2.71 ENSRNOT00000087962
Dusp9
dual specificity phosphatase 9
chr6_-_43493816 2.62 ENSRNOT00000077786
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr9_+_61720583 2.60 ENSRNOT00000020536
Mob4
MOB family member 4, phocein
chr6_+_105364668 2.50 ENSRNOT00000009513
ENSRNOT00000087090
Ttc9
tetratricopeptide repeat domain 9
chr20_+_5527181 2.40 ENSRNOT00000091364
Phf1
PHD finger protein 1
chr19_+_25181564 2.34 ENSRNOT00000008104
Rfx1
regulatory factor X1
chr8_+_117737387 2.29 ENSRNOT00000090164
ENSRNOT00000091573
Pfkfb4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr1_+_220992770 2.25 ENSRNOT00000045233
Rela
RELA proto-oncogene, NF-kB subunit
chr10_-_46332172 2.21 ENSRNOT00000004475
Rasd1
ras related dexamethasone induced 1
chr7_+_130474279 2.18 ENSRNOT00000092388
Shank3
SH3 and multiple ankyrin repeat domains 3
chr17_-_85141210 2.16 ENSRNOT00000000162
Dnajc1
DnaJ heat shock protein family (Hsp40) member C1
chr10_+_59585072 2.14 ENSRNOT00000025009
Camkk1
calcium/calmodulin-dependent protein kinase kinase 1
chr19_-_645937 2.06 ENSRNOT00000016521
Car7
carbonic anhydrase 7
chr8_+_45797315 2.05 ENSRNOT00000059997
AABR07070046.1

chr14_+_60857989 2.01 ENSRNOT00000034411
Ccdc149
coiled-coil domain containing 149
chr10_+_66690133 1.96 ENSRNOT00000046262
Nf1
neurofibromin 1
chr6_-_75670135 1.93 ENSRNOT00000007300
Snx6
sorting nexin 6
chr7_-_77162148 1.91 ENSRNOT00000008350
Klf10
Kruppel-like factor 10
chr2_+_189615948 1.87 ENSRNOT00000092144
Crtc2
CREB regulated transcription coactivator 2
chr1_-_190965115 1.83 ENSRNOT00000023483
AC103221.1

chr7_+_130474508 1.79 ENSRNOT00000085191
Shank3
SH3 and multiple ankyrin repeat domains 3
chr3_-_164095878 1.71 ENSRNOT00000079414
B4galt5
beta-1,4-galactosyltransferase 5
chr4_-_115157263 1.68 ENSRNOT00000015296
Tet3
tet methylcytosine dioxygenase 3
chr6_-_26685235 1.67 ENSRNOT00000066743
Atraid
all-trans retinoic acid-induced differentiation factor
chr3_-_91839009 1.66 ENSRNOT00000083703
Ldlrad3
low density lipoprotein receptor class A domain containing 3
chr6_-_26771164 1.64 ENSRNOT00000009090
Tcf23
transcription factor 23
chr1_+_190964885 1.50 ENSRNOT00000039186
Mettl9
methyltransferase like 9
chr11_+_24263281 1.43 ENSRNOT00000086946
Gabpa
GA binding protein transcription factor, alpha subunit
chr10_+_59360765 1.38 ENSRNOT00000036278
Zzef1
zinc finger ZZ-type and EF-hand domain containing 1
chr20_+_4576514 1.31 ENSRNOT00000090125
ENSRNOT00000047370
Ehmt2
euchromatic histone lysine methyltransferase 2
chr19_-_41798383 1.24 ENSRNOT00000021744
Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
chr9_+_99720856 1.21 ENSRNOT00000047487
Olr1346
olfactory receptor 1346
chr10_-_19164505 1.20 ENSRNOT00000009058
Foxi1
forkhead box I1
chr13_+_49660356 1.01 ENSRNOT00000012844
Lrrn2
leucine rich repeat neuronal 2
chr5_-_82168347 0.99 ENSRNOT00000084959
ENSRNOT00000084147
Astn2
astrotactin 2
chr8_+_20230082 0.95 ENSRNOT00000044463
Olr1165
olfactory receptor 1165
chr16_-_36373546 0.93 ENSRNOT00000079552
Hand2
heart and neural crest derivatives expressed transcript 2
chr6_-_115352681 0.85 ENSRNOT00000005873
Gtf2a1
general transcription factor 2A subunit 1
chr8_+_128087345 0.84 ENSRNOT00000019777
Acvr2b
activin A receptor type 2B
chr10_-_13542077 0.82 ENSRNOT00000008736
Atp6v0c
ATPase H+ transporting V0 subunit C
chr2_-_94730978 0.82 ENSRNOT00000087598
Zbtb10
zinc finger and BTB domain containing 10
chr18_-_5314511 0.79 ENSRNOT00000022637
ENSRNOT00000079682
Zfp521
zinc finger protein 521
chr7_+_122818975 0.78 ENSRNOT00000000206
Ep300
E1A binding protein p300
chr16_+_60925093 0.78 ENSRNOT00000015813
Tnks
tankyrase
chr7_+_144014173 0.78 ENSRNOT00000019403
Sp1
Sp1 transcription factor
chr3_-_7422738 0.75 ENSRNOT00000088339
Gtf3c4
general transcription factor IIIC subunit 4
chr20_+_4576057 0.69 ENSRNOT00000081456
ENSRNOT00000085701
Ehmt2
euchromatic histone lysine methyltransferase 2
chr11_+_71533078 0.58 ENSRNOT00000002405
Slc51a
solute carrier family 51, alpha subunit
chr10_-_64862268 0.57 ENSRNOT00000056234
Phf12
PHD finger protein 12
chrX_-_107542510 0.56 ENSRNOT00000074140
Rab9b
RAB9B, member RAS oncogene family
chr10_-_59360661 0.51 ENSRNOT00000036942
Cyb5d2
cytochrome b5 domain containing 2
chr10_+_103972888 0.49 ENSRNOT00000067838
Kctd2
potassium channel tetramerization domain containing 2
chr1_-_80367313 0.49 ENSRNOT00000023392
ENSRNOT00000084882
Mark4
microtubule affinity regulating kinase 4
chr8_+_65686648 0.44 ENSRNOT00000017233
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr5_-_169167831 0.35 ENSRNOT00000012407
Phf13
PHD finger protein 13
chr20_-_32052855 0.28 ENSRNOT00000074989
LOC100364027
hexokinase 1-like
chr3_-_2727616 0.07 ENSRNOT00000061904
C8g
complement C8 gamma chain
chr7_-_14302552 0.06 ENSRNOT00000091368
Brd4
bromodomain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 32.3 GO:1905204 response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
5.0 14.9 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
3.9 7.9 GO:0003192 mitral valve formation(GO:0003192)
3.7 11.1 GO:0002840 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
3.5 14.1 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
2.9 17.6 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
2.3 30.5 GO:0032836 glomerular basement membrane development(GO:0032836)
2.3 7.0 GO:2000297 negative regulation of synapse maturation(GO:2000297)
2.3 6.9 GO:1990926 short-term synaptic potentiation(GO:1990926)
2.3 9.1 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
2.0 9.8 GO:0061144 alveolar secondary septum development(GO:0061144)
1.8 3.6 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
1.7 6.9 GO:0071896 protein localization to adherens junction(GO:0071896)
1.7 6.8 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
1.6 4.8 GO:1902462 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.4 8.5 GO:0015074 DNA integration(GO:0015074)
1.1 16.5 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
1.0 7.8 GO:0006021 inositol biosynthetic process(GO:0006021)
1.0 3.8 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.9 9.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.9 3.7 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.9 10.0 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.8 4.8 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.8 4.0 GO:1904717 regulation of AMPA glutamate receptor clustering(GO:1904717)
0.8 3.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.8 3.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.8 4.6 GO:0007223 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Wnt signaling pathway, calcium modulating pathway(GO:0007223) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) sensory perception of umami taste(GO:0050917)
0.8 5.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.8 2.3 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.7 5.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.7 20.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.7 5.7 GO:0050655 dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.6 9.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.6 4.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.5 4.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.5 6.1 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.5 2.0 GO:0036166 DNA methylation on cytosine within a CG sequence(GO:0010424) phenotypic switching(GO:0036166)
0.5 6.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.5 11.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.5 13.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 3.6 GO:0046710 GDP metabolic process(GO:0046710)
0.4 1.7 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.4 2.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.4 3.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.4 5.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 4.5 GO:0051764 actin crosslink formation(GO:0051764)
0.3 3.3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3 4.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 1.9 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.3 2.8 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.3 0.9 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 0.8 GO:0018076 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) N-terminal peptidyl-lysine acetylation(GO:0018076)
0.3 0.8 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.3 0.8 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.2 4.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 3.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.2 1.0 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.2 5.1 GO:0097186 amelogenesis(GO:0097186)
0.2 9.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 4.9 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 1.7 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.1 1.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.4 GO:1903350 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 7.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 6.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 2.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.8 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.1 0.8 GO:0048617 foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617) lymphatic endothelial cell differentiation(GO:0060836)
0.1 6.6 GO:0001570 vasculogenesis(GO:0001570)
0.1 2.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.1 2.9 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 6.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 7.2 GO:0045446 endothelial cell differentiation(GO:0045446)
0.0 2.9 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 2.6 GO:0021762 substantia nigra development(GO:0021762)
0.0 2.6 GO:0006900 membrane budding(GO:0006900)
0.0 0.4 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 3.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 3.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.7 GO:0070613 regulation of protein processing(GO:0070613)
0.0 3.9 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 1.2 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.2 GO:0021766 hippocampus development(GO:0021766)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 47.0 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
1.0 3.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.9 4.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.8 10.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.7 3.6 GO:0044316 cone cell pedicle(GO:0044316)
0.7 6.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.6 6.9 GO:0032009 early phagosome(GO:0032009)
0.6 11.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.6 32.3 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.0 GO:0060187 cell pole(GO:0060187)
0.3 1.9 GO:0097422 tubular endosome(GO:0097422)
0.3 5.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.7 GO:0001940 male pronucleus(GO:0001940)
0.2 4.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 3.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 9.3 GO:0005581 collagen trimer(GO:0005581)
0.1 2.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 3.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 12.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 5.2 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.4 GO:0043293 apoptosome(GO:0043293)
0.1 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.8 GO:0031594 neuromuscular junction(GO:0031594)
0.1 60.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 15.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.1 4.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 16.0 GO:0045177 apical part of cell(GO:0045177)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.0 9.2 GO:0010008 endosome membrane(GO:0010008)
0.0 15.8 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.6 GO:0044432 endoplasmic reticulum part(GO:0044432)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 32.3 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
1.9 9.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
1.5 13.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.4 5.6 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
1.3 7.5 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.2 9.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.0 5.7 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.9 18.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.9 14.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.8 4.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.7 4.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.7 5.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.7 3.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.6 17.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.6 40.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.6 4.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.6 5.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.6 16.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.5 11.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.5 3.9 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.5 6.3 GO:0070097 delta-catenin binding(GO:0070097)
0.5 5.2 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.5 9.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.5 2.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.4 1.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.4 3.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.4 4.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 7.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 4.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.3 12.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 2.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 2.0 GO:0045545 syndecan binding(GO:0045545)
0.2 1.9 GO:0034452 dynactin binding(GO:0034452)
0.2 8.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 4.5 GO:0017166 vinculin binding(GO:0017166)
0.2 3.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 7.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 2.8 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 3.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 4.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 6.0 GO:0008378 galactosyltransferase activity(GO:0008378)
0.2 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 9.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 6.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 7.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0034711 inhibin binding(GO:0034711)
0.1 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.5 GO:0050699 WW domain binding(GO:0050699)
0.1 3.6 GO:0030552 cAMP binding(GO:0030552)
0.1 2.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 4.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 4.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 10.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 2.2 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 21.0 ST JAK STAT PATHWAY Jak-STAT Pathway
1.1 56.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.6 30.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.5 14.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.5 16.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 10.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 4.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 4.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 7.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 4.6 ST GAQ PATHWAY G alpha q Pathway
0.2 8.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 2.3 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 3.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.3 PID FGF PATHWAY FGF signaling pathway
0.1 7.9 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 4.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 18.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.9 PID BMP PATHWAY BMP receptor signaling
0.1 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.1 3.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 9.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 32.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.0 44.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.8 9.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.6 13.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 9.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 4.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.4 3.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 6.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 4.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 3.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 2.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 3.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 2.1 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.2 4.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 7.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 5.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 5.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 13.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 11.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 3.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 5.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 3.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation