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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf8

Z-value: 0.40

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Transcription factors associated with Klf8

Gene Symbol Gene ID Gene Info
Klf8
ENSRNOG00000039057 Kruppel-like factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf8rn6_v1_chrX_-_18890090_18890090-0.081.7e-01Click!

Activity profile of Klf8 motif

Sorted Z-values of Klf8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_15273933 11.48 ENSRNOT00000075082
LOC108348091
erythroid transcription factor
chr3_-_160730360 10.15 ENSRNOT00000075864
RGD1563818
similar to secretory leukocyte protease inhibitor
chrX_-_38196060 8.30 ENSRNOT00000006741
ENSRNOT00000006438
Sh3kbp1
SH3 domain-containing kinase-binding protein 1
chr1_-_53087474 7.19 ENSRNOT00000017302
Ccr6
C-C motif chemokine receptor 6
chr7_+_145068286 6.49 ENSRNOT00000088956
ENSRNOT00000065753
Nckap1l
NCK associated protein 1 like
chr19_-_37970537 5.85 ENSRNOT00000034722
Dpep2
dipeptidase 2
chr10_-_90999506 5.67 ENSRNOT00000034401
Gfap
glial fibrillary acidic protein
chr4_+_161685258 5.16 ENSRNOT00000008012
ENSRNOT00000008003
Foxm1
forkhead box M1
chr1_-_198460126 4.92 ENSRNOT00000082940
ENSRNOT00000086019
Maz
MYC associated zinc finger protein
chr1_-_89488223 4.87 ENSRNOT00000028624
Fxyd1
FXYD domain-containing ion transport regulator 1
chr2_+_205160405 4.80 ENSRNOT00000035605
Tspan2
tetraspanin 2
chr6_-_142372031 4.40 ENSRNOT00000063929
AABR07065814.3

chr14_-_2700977 4.20 ENSRNOT00000000086
Mtf2
metal response element binding transcription factor 2
chr1_-_42467586 4.10 ENSRNOT00000029416
Fbxo5
F-box protein 5
chr10_-_15590220 4.06 ENSRNOT00000048977
Hba-a2
hemoglobin alpha, adult chain 2
chr1_+_221872220 4.04 ENSRNOT00000028651
Nrxn2
neurexin 2
chr15_+_31243097 4.03 ENSRNOT00000042721
LOC100360891
RGD1359684 protein-like
chr7_-_121311565 4.01 ENSRNOT00000092252
Rpl3
ribosomal protein L3
chr8_-_67232298 3.94 ENSRNOT00000049441
Spesp1
sperm equatorial segment protein 1
chr1_+_63964155 3.76 ENSRNOT00000078512
AABR07002001.1

chr12_+_23544287 3.63 ENSRNOT00000001938
Orai2
ORAI calcium release-activated calcium modulator 2
chr4_-_45332420 3.43 ENSRNOT00000083039
Wnt2
wingless-type MMTV integration site family member 2
chr7_+_141249044 3.17 ENSRNOT00000084911
Aqp5
aquaporin 5
chr9_+_100137881 3.14 ENSRNOT00000036328
Gpr35
G protein-coupled receptor 35
chr10_-_89454681 3.08 ENSRNOT00000028109
Brca1
BRCA1, DNA repair associated
chr14_-_78377825 2.93 ENSRNOT00000068104
AABR07015812.1

chr6_-_146195819 2.75 ENSRNOT00000007625
Sp4
Sp4 transcription factor
chr4_-_100883275 2.64 ENSRNOT00000022846
LOC100364435
thymosin, beta 10-like
chr1_-_167347490 2.60 ENSRNOT00000076499
Rhog
ras homolog family member G
chr1_-_73682247 2.47 ENSRNOT00000079498
Lilra5
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr12_-_22478752 2.42 ENSRNOT00000089392
ENSRNOT00000086915
Ache
acetylcholinesterase
chr17_-_32558180 2.33 ENSRNOT00000022681
Serpinb1b
serine (or cysteine) peptidase inhibitor, clade B, member 1b
chr7_+_38945836 2.22 ENSRNOT00000006455
Ccer1
coiled-coil glutamate-rich protein 1
chr20_-_4943564 2.21 ENSRNOT00000049310
RT1-CE1
RT1 class I, locus1
chr10_+_55169282 2.17 ENSRNOT00000005423
Ccdc42
coiled-coil domain containing 42
chr11_-_87236445 2.08 ENSRNOT00000057806
Tssk2
testis-specific serine kinase 2
chr1_-_84168044 2.03 ENSRNOT00000084586
ENSRNOT00000028348
Shkbp1
Sh3kbp1 binding protein 1
chr1_-_142183884 1.95 ENSRNOT00000016032
Fes
FES proto-oncogene, tyrosine kinase
chr15_+_34431357 1.93 ENSRNOT00000027604
Nop9
NOP9 nucleolar protein
chr12_+_13716596 1.90 ENSRNOT00000080216
Actb
actin, beta
chr1_-_84812486 1.87 ENSRNOT00000078369
AABR07002779.1

chr13_+_79378733 1.76 ENSRNOT00000039221
Tnfsf18
tumor necrosis factor superfamily member 18
chr1_+_99648658 1.75 ENSRNOT00000039531
Klk13
kallikrein related-peptidase 13
chr1_+_72636959 1.73 ENSRNOT00000023489
Il11
interleukin 11
chr3_+_152909189 1.72 ENSRNOT00000066341
Tgif2
TGFB-induced factor homeobox 2
chr12_-_47588335 1.71 ENSRNOT00000001595
Ankrd13a
ankyrin repeat domain 13a
chr4_+_10823281 1.68 ENSRNOT00000066739
Phtf2
putative homeodomain transcription factor 2
chr3_-_161917285 1.64 ENSRNOT00000025150
Cdh22
cadherin 22
chr15_+_24267323 1.63 ENSRNOT00000015778
Fbxo34
F-box protein 34
chr2_+_262914327 1.61 ENSRNOT00000029312
Negr1
neuronal growth regulator 1
chr7_-_144960527 1.60 ENSRNOT00000086554
Zfp385a
zinc finger protein 385A
chr1_-_167347662 1.60 ENSRNOT00000027641
ENSRNOT00000076592
Rhog
ras homolog family member G
chr18_+_28594892 1.57 ENSRNOT00000067702
Ube2d2
ubiquitin-conjugating enzyme E2D 2
chr18_+_48132414 1.57 ENSRNOT00000050631
Snx2
sorting nexin 2
chr5_-_139933764 1.57 ENSRNOT00000015278
LOC680700
similar to ribosomal protein L10a
chr19_+_38669230 1.56 ENSRNOT00000027273
Cdh3
cadherin 3
chr4_-_58195143 1.51 ENSRNOT00000033706
Copg2
coatomer protein complex, subunit gamma 2
chr14_-_83062302 1.49 ENSRNOT00000086769
ENSRNOT00000085735
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr20_-_3728844 1.43 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr2_-_252359798 1.40 ENSRNOT00000021063
Spata1
spermatogenesis associated 1
chr3_-_160777092 1.40 ENSRNOT00000076624
Slpil3
antileukoproteinase-like 3
chr6_-_76079283 1.37 ENSRNOT00000082198
Ppp2r3c
protein phosphatase 2, regulatory subunit B'', gamma
chr9_+_14551758 1.37 ENSRNOT00000017157
Nfya
nuclear transcription factor Y subunit alpha
chr17_+_36334589 1.30 ENSRNOT00000081368
E2f3
E2F transcription factor 3
chr10_-_109827143 1.30 ENSRNOT00000054948
Myadml2
myeloid-associated differentiation marker-like 2
chr1_-_221041401 1.24 ENSRNOT00000064136
Pcnx3
pecanex homolog 3 (Drosophila)
chr4_-_115332052 1.18 ENSRNOT00000017643
Clec4f
C-type lectin domain family 4, member F
chr1_+_99781237 1.17 ENSRNOT00000025489
Klk5
kallikrein related-peptidase 5
chr3_-_72113680 1.12 ENSRNOT00000009708
Zdhhc5
zinc finger, DHHC-type containing 5
chr10_-_29450644 1.12 ENSRNOT00000087937
Adra1b
adrenoceptor alpha 1B
chr10_-_13075864 1.10 ENSRNOT00000005220
Paqr4
progestin and adipoQ receptor family member 4
chr10_+_69434941 1.09 ENSRNOT00000009756
Ccl11
C-C motif chemokine ligand 11
chr3_+_113976687 1.08 ENSRNOT00000022437
Eif3j
eukaryotic translation initiation factor 3, subunit J
chr7_+_142877086 1.05 ENSRNOT00000088730
Grasp
general receptor for phosphoinositides 1 associated scaffold protein
chr2_+_24024791 1.05 ENSRNOT00000089599
ENSRNOT00000066302
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
chr3_-_5693147 1.04 ENSRNOT00000008660
Fam163b
family with sequence similarity 163, member B
chr10_+_56237755 1.03 ENSRNOT00000016163
Fxr2
FMR1 autosomal homolog 2
chr2_+_251817694 1.03 ENSRNOT00000019964
RGD1560065
similar to RIKEN cDNA 2410004B18
chr1_-_80271001 0.97 ENSRNOT00000034266
Cd3eap
CD3e molecule associated protein
chr6_+_26517840 0.97 ENSRNOT00000031842
Ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr1_+_192025710 0.97 ENSRNOT00000077457
Ubfd1
ubiquitin family domain containing 1
chr1_-_72461547 0.95 ENSRNOT00000022480
Ssc5d
scavenger receptor cysteine rich family member with 5 domains
chr1_+_225015616 0.93 ENSRNOT00000026416
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr6_-_142178771 0.91 ENSRNOT00000071577
Ighv12-3
immunoglobulin heavy variable V12-3
chr6_-_141866756 0.90 ENSRNOT00000068561
AABR07065804.1

chr6_-_76079664 0.90 ENSRNOT00000033533
Ppp2r3c
protein phosphatase 2, regulatory subunit B'', gamma
chr2_+_231962517 0.88 ENSRNOT00000014570
Neurog2
neurogenin 2
chr2_+_17616401 0.82 ENSRNOT00000064991
Edil3
EGF like repeats and discoidin domains 3
chr1_-_73753128 0.82 ENSRNOT00000068459
Ttyh1
tweety family member 1
chr8_-_123371257 0.81 ENSRNOT00000017243
Stt3b
STT3B, catalytic subunit of the oligosaccharyltransferase complex
chr19_-_11669578 0.76 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr8_+_43348973 0.75 ENSRNOT00000007862
Olr1308
olfactory receptor 1308
chr8_-_117797427 0.74 ENSRNOT00000033719
Trex1
three prime repair exonuclease 1
chr1_+_214664537 0.73 ENSRNOT00000075002
AABR07006030.1

chr2_-_84437084 0.72 ENSRNOT00000077598
Ankrd33b
ankyrin repeat domain 33B
chr10_+_45798797 0.70 ENSRNOT00000039012
Jmjd4
jumonji domain containing 4
chr11_+_34598492 0.70 ENSRNOT00000065600
Ttc3
tetratricopeptide repeat domain 3
chr8_+_32018560 0.69 ENSRNOT00000007358
Adamts8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr3_+_113131327 0.60 ENSRNOT00000018460
Tubgcp4
tubulin, gamma complex associated protein 4
chr5_+_173256637 0.59 ENSRNOT00000025531
Ccnl2
cyclin L2
chr18_+_3861539 0.58 ENSRNOT00000015363
Lama3
laminin subunit alpha 3
chr20_+_4576514 0.58 ENSRNOT00000090125
ENSRNOT00000047370
Ehmt2
euchromatic histone lysine methyltransferase 2
chr1_-_4653210 0.57 ENSRNOT00000019121
Rab32
RAB32, member RAS oncogene family
chr1_+_261337594 0.56 ENSRNOT00000019874
Pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr10_+_12980674 0.55 ENSRNOT00000004638
Bicdl2
BICD family like cargo adaptor 2
chr14_-_18591394 0.52 ENSRNOT00000003716
Ereg
epiregulin
chr3_+_100769839 0.49 ENSRNOT00000077703
Bdnf
brain-derived neurotrophic factor
chr1_-_229601032 0.48 ENSRNOT00000016690
Cntf
ciliary neurotrophic factor
chr3_+_20965751 0.48 ENSRNOT00000010450
Olr417
olfactory receptor 417
chr1_-_245514252 0.47 ENSRNOT00000033724
Pum3
pumilio RNA-binding family member 3
chr1_+_98440186 0.45 ENSRNOT00000024150
Iglon5
IgLON family member 5
chr1_+_213870502 0.42 ENSRNOT00000086483
B4galnt4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr20_+_4576057 0.41 ENSRNOT00000081456
ENSRNOT00000085701
Ehmt2
euchromatic histone lysine methyltransferase 2
chr8_+_57964988 0.40 ENSRNOT00000009497
Kdelc2
KDEL motif containing 2
chr1_-_274106502 0.37 ENSRNOT00000020539
Smndc1
survival motor neuron domain containing 1
chr20_+_1861272 0.36 ENSRNOT00000044570
Olr1744
olfactory receptor 1744
chr8_+_58347736 0.36 ENSRNOT00000080227
ENSRNOT00000066222
Slc35f2
solute carrier family 35, member F2
chr4_-_121822781 0.35 ENSRNOT00000072082
Vom1r95
vomeronasal 1 receptor 95
chr19_+_37127508 0.33 ENSRNOT00000019656
Cbfb
core-binding factor, beta subunit
chr5_+_173256834 0.33 ENSRNOT00000089936
Ccnl2
cyclin L2
chr14_+_19319299 0.30 ENSRNOT00000086542
Ankrd17
ankyrin repeat domain 17
chr7_-_105592804 0.30 ENSRNOT00000006789
Adcy8
adenylate cyclase 8
chr3_-_176706896 0.28 ENSRNOT00000017337
Ptk6
protein tyrosine kinase 6
chr5_-_145418992 0.25 ENSRNOT00000037128
Gjb4
gap junction protein, beta 4
chr3_-_38741113 0.21 ENSRNOT00000006549
Prpf40a
pre-mRNA processing factor 40 homolog A
chr2_-_197935567 0.21 ENSRNOT00000085404
Rprd2
regulation of nuclear pre-mRNA domain containing 2
chr12_-_39882030 0.17 ENSRNOT00000078761
ENSRNOT00000048851
Ppp1cc
protein phosphatase 1 catalytic subunit gamma
chr15_+_34520142 0.16 ENSRNOT00000074659
Nynrin
NYN domain and retroviral integrase containing
chrX_-_156891038 0.15 ENSRNOT00000091495
Avpr2
arginine vasopressin receptor 2
chr4_-_121811539 0.14 ENSRNOT00000049591
Vom1r94
vomeronasal 1 receptor 94
chr1_-_229639187 0.13 ENSRNOT00000016804
Zfp91
zinc finger protein 91
chr4_+_1671269 0.12 ENSRNOT00000071452
Olr1251
olfactory receptor 1251
chr10_+_109107389 0.11 ENSRNOT00000068437
ENSRNOT00000005687
Baiap2
BAI1-associated protein 2
chr8_+_40345160 0.07 ENSRNOT00000076308
Olr1200
olfactory receptor 1200
chr7_+_13631975 0.06 ENSRNOT00000083548
Olr1084
olfactory receptor 1084
chr3_-_103066392 0.04 ENSRNOT00000044181
Olr776
olfactory receptor 776
chr14_-_17436897 0.04 ENSRNOT00000003277
Uso1
USO1 vesicle transport factor
chr7_-_135630654 0.02 ENSRNOT00000047388
ENSRNOT00000088223
ENSRNOT00000074793
Adamts20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_-_189911571 0.01 ENSRNOT00000080996
ENSRNOT00000088536
Zp2
zona pellucida glycoprotein 2
chr5_+_59348639 0.01 ENSRNOT00000084031
ENSRNOT00000060264
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
chrX_-_33665821 0.01 ENSRNOT00000066676
Rbbp7
RB binding protein 7, chromatin remodeling factor
chr20_+_11863082 0.01 ENSRNOT00000001640
Fam207a
family with sequence similarity 207, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.5 GO:0030221 basophil differentiation(GO:0030221)
2.2 6.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.8 7.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
1.4 4.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.2 4.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
1.2 4.9 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
1.1 3.4 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
1.0 3.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.9 5.7 GO:1904714 positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
0.7 4.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.6 4.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.6 1.8 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.6 1.1 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.5 1.6 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.5 1.5 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.5 3.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.4 1.6 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.4 3.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.3 1.0 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.3 3.4 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.3 5.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.3 3.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 2.4 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.3 4.1 GO:0015671 gas transport(GO:0015669) oxygen transport(GO:0015671)
0.2 1.0 GO:0036166 DNA methylation on cytosine within a CG sequence(GO:0010424) phenotypic switching(GO:0036166)
0.2 1.0 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.2 1.7 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.2 5.3 GO:0014002 astrocyte development(GO:0014002)
0.2 0.6 GO:0045575 basophil activation(GO:0045575)
0.2 1.1 GO:0035962 response to interleukin-13(GO:0035962)
0.1 1.3 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 4.2 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 1.2 GO:0051132 NK T cell activation(GO:0051132)
0.1 0.8 GO:0043686 co-translational protein modification(GO:0043686)
0.1 4.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 1.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.5 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.1 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.6 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 1.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 2.0 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 1.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.9 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.6 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.5 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
0.1 10.6 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.5 GO:0061193 taste bud development(GO:0061193)
0.0 12.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 6.9 GO:0007286 spermatid development(GO:0007286)
0.0 1.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.5 GO:0019236 response to pheromone(GO:0019236)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.0 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.3 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.8 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.3 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.6 GO:0007631 feeding behavior(GO:0007631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
1.0 7.2 GO:0097524 sperm plasma membrane(GO:0097524)
1.0 4.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.8 3.1 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.7 6.5 GO:0031209 SCAR complex(GO:0031209)
0.2 4.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 1.9 GO:0097433 dense body(GO:0097433)
0.2 0.6 GO:0035838 growing cell tip(GO:0035838)
0.2 0.8 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 2.4 GO:0043083 synaptic cleft(GO:0043083)
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.6 GO:0005608 laminin-3 complex(GO:0005608)
0.1 0.6 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.6 GO:0031904 endosome lumen(GO:0031904)
0.1 4.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.6 GO:0030904 retromer complex(GO:0030904)
0.0 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 4.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 12.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.5 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0005819 spindle(GO:0005819)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.4 GO:0043209 myelin sheath(GO:0043209)
0.0 1.8 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0031720 haptoglobin binding(GO:0031720)
0.8 2.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.7 7.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 5.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 4.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 1.6 GO:1990460 leptin receptor binding(GO:1990460)
0.4 3.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.4 1.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.4 1.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 1.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.3 4.0 GO:0008097 5S rRNA binding(GO:0008097)
0.3 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 1.2 GO:0005534 galactose binding(GO:0005534)
0.2 3.2 GO:0015250 water channel activity(GO:0015250)
0.2 1.9 GO:0030957 Tat protein binding(GO:0030957)
0.2 3.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 3.4 GO:0048018 receptor agonist activity(GO:0048018)
0.2 2.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.7 GO:0032407 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) adenyl deoxyribonucleotide binding(GO:0032558)
0.1 11.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 4.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 4.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 4.9 GO:0017022 myosin binding(GO:0017022)
0.1 0.5 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 8.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 12.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 6.5 GO:0005178 integrin binding(GO:0005178)
0.1 0.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 3.1 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.0 2.6 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.0 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 1.8 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.1 PID BARD1 PATHWAY BARD1 signaling events
0.1 4.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 3.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 2.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.3 3.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 8.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 4.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 3.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 4.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.8 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 1.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 5.1 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 1.0 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 3.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly