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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.43

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Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6

Gene Symbol Gene ID Gene Info
Msx1
ENSRNOG00000006876 msh homeobox 1
Lhx9
ENSRNOG00000010357 LIM homeobox 9
Barx1
ENSRNOG00000016915 BARX homeobox 1
Rax
ENSRNOG00000016944 retina and anterior neural fold homeobox
Dlx6
ENSRNOG00000010822 distal-less homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dlx6rn6_v1_chr4_+_32373641_32373641-0.543.9e-25Click!
Lhx9rn6_v1_chr13_-_55878094_55878094-0.479.1e-19Click!
Msx1rn6_v1_chr14_+_77712240_77712240-0.375.7e-12Click!
Raxrn6_v1_chr18_-_61642056_616420560.172.0e-03Click!
Barx1rn6_v1_chr17_-_14828329_148283290.063.0e-01Click!

Activity profile of Msx1_Lhx9_Barx1_Rax_Dlx6 motif

Sorted Z-values of Msx1_Lhx9_Barx1_Rax_Dlx6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_5709236 16.84 ENSRNOT00000061201
ENSRNOT00000070887
Dbh
dopamine beta-hydroxylase
chr7_-_143497108 10.33 ENSRNOT00000048613
Krt76
keratin 76
chr10_-_87468711 9.97 ENSRNOT00000039983
Krtap3-3
keratin associated protein 3-3
chr10_-_87232723 9.29 ENSRNOT00000015150
Krt25
keratin 25
chr7_-_107391184 8.68 ENSRNOT00000056793
Tmem71
transmembrane protein 71
chr3_-_165537940 7.91 ENSRNOT00000071119
ENSRNOT00000070964
Sall4
spalt-like transcription factor 4
chr6_-_36876805 7.46 ENSRNOT00000006482
Msgn1
mesogenin 1
chr6_-_128149220 7.23 ENSRNOT00000014204
Gsc
goosecoid homeobox
chr10_-_87521514 6.67 ENSRNOT00000084668
ENSRNOT00000071705
Krtap2-4l
keratin associated protein 2-4-like
chr7_-_143228060 6.07 ENSRNOT00000088923
ENSRNOT00000012640
Krt75
keratin 75
chr16_+_22361998 6.05 ENSRNOT00000016193
Slc18a1
solute carrier family 18 member A1
chr8_+_47674321 5.78 ENSRNOT00000026170
ENSRNOT00000078776
Trim29
tripartite motif-containing 29
chr10_-_87286387 5.51 ENSRNOT00000044206
Krt28
keratin 28
chr16_+_2634603 5.31 ENSRNOT00000019113
Hesx1
HESX homeobox 1
chr7_-_73130740 4.57 ENSRNOT00000075584
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chr12_-_45801842 4.02 ENSRNOT00000078837
AABR07036513.1

chr14_+_59611434 3.76 ENSRNOT00000065366
Cckar
cholecystokinin A receptor
chr2_-_192027225 3.69 ENSRNOT00000016430
Prr9
proline rich 9
chr10_-_84920886 3.67 ENSRNOT00000068083
Sp2
Sp2 transcription factor
chr1_-_127337882 3.64 ENSRNOT00000085158
Aldh1a3
aldehyde dehydrogenase 1 family, member A3
chr14_-_21252538 3.43 ENSRNOT00000005003
Ambn
ameloblastin
chr12_-_47142852 3.17 ENSRNOT00000001591
Pop5
POP5 homolog, ribonuclease P/MRP subunit
chr20_-_3728844 3.12 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr1_+_105284753 3.06 ENSRNOT00000041950
Slc6a5
solute carrier family 6 member 5
chr6_+_8886591 2.97 ENSRNOT00000091510
ENSRNOT00000089174
Six3
SIX homeobox 3
chr7_+_143122269 2.81 ENSRNOT00000082542
ENSRNOT00000045495
ENSRNOT00000081386
ENSRNOT00000067422
Krt86
keratin 86
chr14_+_23330933 2.51 ENSRNOT00000088552
Tmprss11d
transmembrane protease, serine 11d
chr4_+_147832136 2.51 ENSRNOT00000064603
Rho
rhodopsin
chr1_+_279633671 2.42 ENSRNOT00000036012
ENSRNOT00000091669
Ccdc172
coiled-coil domain containing 172
chr10_+_53740841 2.32 ENSRNOT00000004295
Myh2
myosin heavy chain 2
chr4_+_61924013 2.32 ENSRNOT00000090717
Bpgm
bisphosphoglycerate mutase
chr7_+_41475163 2.31 ENSRNOT00000037844
Dusp6
dual specificity phosphatase 6
chr7_+_133856101 2.29 ENSRNOT00000038686
Pdzrn4
PDZ domain containing RING finger 4
chr20_+_44680449 2.24 ENSRNOT00000000728
Traf3ip2
Traf3 interacting protein 2
chr7_-_69982592 2.23 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr17_+_25082056 2.22 ENSRNOT00000037041
AABR07027339.1

chr3_+_9403840 2.21 ENSRNOT00000071380
NEWGENE_735020
pyroglutamylated RFamide peptide
chr2_-_33025271 2.20 ENSRNOT00000074941
NEWGENE_1310139
microtubule associated serine/threonine kinase family member 4
chrM_+_7006 2.15 ENSRNOT00000043693
Mt-co2
mitochondrially encoded cytochrome c oxidase II
chr3_-_90751055 2.10 ENSRNOT00000040741
LOC499843
LRRGT00091
chr7_-_49732764 2.04 ENSRNOT00000006453
Myf5
myogenic factor 5
chr2_-_138833933 2.01 ENSRNOT00000013343
Pcdh18
protocadherin 18
chr11_-_60679555 1.99 ENSRNOT00000059735
Ccdc80
coiled-coil domain containing 80
chr14_+_76732650 1.97 ENSRNOT00000088197
Clnk
cytokine-dependent hematopoietic cell linker
chr10_+_95770154 1.95 ENSRNOT00000030300
Helz
helicase with zinc finger
chr10_-_88172910 1.89 ENSRNOT00000046956
Krt42
keratin 42
chr4_+_119225040 1.87 ENSRNOT00000012365
Bmp10
bone morphogenetic protein 10
chr11_-_29710849 1.84 ENSRNOT00000029345
Krtap11-1
keratin associated protein 11-1
chr18_+_81694808 1.83 ENSRNOT00000020446
Cyb5a
cytochrome b5 type A
chr12_+_24978483 1.78 ENSRNOT00000040069
Eln
elastin
chr1_-_101095594 1.71 ENSRNOT00000027944
Fcgrt
Fc fragment of IgG receptor and transporter
chr13_-_73056765 1.68 ENSRNOT00000000049
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr2_+_42829413 1.59 ENSRNOT00000065528
Actbl2
actin, beta-like 2
chr15_+_44441856 1.56 ENSRNOT00000018006
Gnrh1
gonadotropin releasing hormone 1
chr4_-_172063391 1.56 ENSRNOT00000010158
Slc15a5
solute carrier family 15, member 5
chr2_+_210880777 1.51 ENSRNOT00000026237
Gnat2
G protein subunit alpha transducin 2
chr6_-_125723732 1.49 ENSRNOT00000084815
Fbln5
fibulin 5
chr20_-_30947484 1.44 ENSRNOT00000065614
Pald1
phosphatase domain containing, paladin 1
chr6_-_21600451 1.42 ENSRNOT00000047674
Ltbp1
latent transforming growth factor beta binding protein 1
chr2_-_61692487 1.37 ENSRNOT00000078544
LOC499541
LRRGT00045
chr3_+_122544788 1.37 ENSRNOT00000063828
Tgm3
transglutaminase 3
chr1_-_101819478 1.36 ENSRNOT00000056181
Grwd1
glutamate-rich WD repeat containing 1
chr6_-_77508585 1.32 ENSRNOT00000011562
Nkx2-8
NK2 homeobox 8
chr11_+_45751812 1.31 ENSRNOT00000079336
RGD1310935
similar to Dermal papilla derived protein 7
chr10_-_87503591 1.30 ENSRNOT00000037980
Krtap1-1
keratin associated protein 1-1
chr4_-_168517177 1.27 ENSRNOT00000009151
Dusp16
dual specificity phosphatase 16
chr14_+_23405717 1.22 ENSRNOT00000029805
Tmprss11c
transmembrane protease, serine 11C
chr15_-_95514259 1.20 ENSRNOT00000038433
Slitrk6
SLIT and NTRK-like family, member 6
chr11_+_47924970 1.20 ENSRNOT00000060577
Zpld1
zona pellucida-like domain containing 1
chr7_-_126382449 1.18 ENSRNOT00000085540
7530416G11Rik
RIKEN cDNA 7530416G11 gene
chr11_+_28780446 1.18 ENSRNOT00000072546
Krtap15-1
keratin associated protein 15-1
chrM_+_8599 1.05 ENSRNOT00000049683
Mt-cox3
mitochondrially encoded cytochrome C oxidase III
chr1_-_134871167 1.05 ENSRNOT00000076300
Chd2
chromodomain helicase DNA binding protein 2
chr8_-_40137390 1.01 ENSRNOT00000042717
Panx3
pannexin 3
chr2_+_240642847 0.99 ENSRNOT00000079694
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_-_122329443 0.91 ENSRNOT00000032232
Mkl1
megakaryoblastic leukemia (translocation) 1
chr16_+_10267482 0.90 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chr4_+_1658278 0.90 ENSRNOT00000073845
Olr1250
olfactory receptor 1250
chr5_+_50381244 0.88 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr8_+_71914867 0.83 ENSRNOT00000023372
Dapk2
death-associated protein kinase 2
chr4_+_158088505 0.75 ENSRNOT00000026643
Vwf
von Willebrand factor
chr8_-_63291966 0.74 ENSRNOT00000077762
AABR07070278.1

chr3_+_77047466 0.72 ENSRNOT00000089424
Olr648
olfactory receptor 648
chr3_+_56766475 0.69 ENSRNOT00000078819
Sp5
Sp5 transcription factor
chr6_-_77421286 0.68 ENSRNOT00000011453
Nkx2-1
NK2 homeobox 1
chr2_+_266315036 0.67 ENSRNOT00000055245
Wls
wntless Wnt ligand secretion mediator
chr1_+_101178104 0.63 ENSRNOT00000028072
Pth2
parathyroid hormone 2
chr4_-_67610710 0.59 ENSRNOT00000039067
Mrps33
mitochondrial ribosomal protein S33
chr1_+_260093641 0.58 ENSRNOT00000019521
Ccnj
cyclin J
chr1_-_220938814 0.56 ENSRNOT00000028081
Ovol1
ovo like transcriptional repressor 1
chr4_-_88684415 0.46 ENSRNOT00000009001
LOC500148
similar to 40S ribosomal protein S7 (S8)
chr3_+_61620192 0.44 ENSRNOT00000065426
Hoxd9
homeo box D9
chr13_+_49005405 0.44 ENSRNOT00000092560
ENSRNOT00000076457
Lemd1
LEM domain containing 1
chr4_+_1671269 0.42 ENSRNOT00000071452
Olr1251
olfactory receptor 1251
chr2_-_32518643 0.40 ENSRNOT00000061032
Mast4
microtubule associated serine/threonine kinase family member 4
chr14_+_96499520 0.39 ENSRNOT00000074692
AABR07016310.1

chr17_-_53713408 0.38 ENSRNOT00000022445
LOC100912163
AT-rich interactive domain-containing protein 4B-like
chr5_+_25253010 0.36 ENSRNOT00000061333
Rbm12b
RNA binding motif protein 12B
chr4_-_80395502 0.33 ENSRNOT00000014437
Npvf
neuropeptide VF precursor
chrX_+_131381134 0.33 ENSRNOT00000007474
AABR07041481.1

chr10_-_74679858 0.33 ENSRNOT00000003859
Ppm1e
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr5_+_25725683 0.28 ENSRNOT00000087602
LOC679087
similar to swan
chr6_-_115616766 0.24 ENSRNOT00000006143
ENSRNOT00000045870
Sel1l
SEL1L ERAD E3 ligase adaptor subunit
chr4_+_1591444 0.23 ENSRNOT00000078277
Olr1245
olfactory receptor 1245
chr8_+_5790034 0.22 ENSRNOT00000061887
Mmp27
matrix metallopeptidase 27
chr19_-_17399548 0.22 ENSRNOT00000075991
Chd9
chromodomain helicase DNA binding protein 9
chr13_+_79378733 0.09 ENSRNOT00000039221
Tnfsf18
tumor necrosis factor superfamily member 18
chr4_+_2055615 0.09 ENSRNOT00000007646
Rnf32
ring finger protein 32
chr5_-_7941822 0.07 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr3_+_77431389 0.04 ENSRNOT00000042848
Olr660
olfactory receptor 660
chr2_+_198755262 0.03 ENSRNOT00000028807
Rbm8a
RNA binding motif protein 8A
chr2_-_235249571 0.02 ENSRNOT00000093631
ENSRNOT00000085096
Rrh
retinal pigment epithelium derived rhodopsin homolog

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
1.5 3.0 GO:0014016 neuroblast differentiation(GO:0014016)
1.2 3.6 GO:0060166 olfactory pit development(GO:0060166)
1.2 6.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.9 3.8 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.8 5.3 GO:0030916 otic vesicle formation(GO:0030916)
0.7 10.3 GO:0048733 sebaceous gland development(GO:0048733)
0.6 3.1 GO:0036233 glycine import(GO:0036233)
0.6 7.2 GO:0014029 neural crest formation(GO:0014029)
0.6 1.8 GO:0071298 cellular response to L-ascorbic acid(GO:0071298)
0.5 7.5 GO:0007379 segment specification(GO:0007379)
0.4 7.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 2.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 1.9 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.3 9.3 GO:0045109 intermediate filament organization(GO:0045109)
0.3 2.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.3 0.8 GO:2000424 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.3 1.6 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.3 2.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.3 2.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 1.2 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.7 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 2.3 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.7 GO:0060486 Clara cell differentiation(GO:0060486)
0.1 1.5 GO:0046549 retinal cone cell development(GO:0046549)
0.1 5.1 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.7 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.1 0.9 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 1.0 GO:0034214 protein hexamerization(GO:0034214)
0.1 2.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.2 GO:0097264 self proteolysis(GO:0097264)
0.1 1.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.7 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.6 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 2.2 GO:0007625 grooming behavior(GO:0007625)
0.1 0.3 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.9 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 5.8 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 1.4 GO:0071305 cellular response to vitamin D(GO:0071305)
0.0 3.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.1 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 0.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.2 GO:0009409 response to cold(GO:0009409)
0.0 0.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 6.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 3.7 GO:0048144 fibroblast proliferation(GO:0048144)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 1.6 GO:0046718 viral entry into host cell(GO:0046718)
0.0 2.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.0 GO:0031214 biomineral tissue development(GO:0031214)
0.0 2.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.3 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.8 GO:0034774 secretory granule lumen(GO:0034774)
0.7 3.3 GO:0071953 elastic fiber(GO:0071953)
0.5 3.2 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.5 39.0 GO:0045095 keratin filament(GO:0045095)
0.4 1.6 GO:1990005 granular vesicle(GO:1990005)
0.3 2.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 14.6 GO:0005882 intermediate filament(GO:0005882)
0.2 3.7 GO:0001533 cornified envelope(GO:0001533)
0.1 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 7.9 GO:0000792 heterochromatin(GO:0000792)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0005921 gap junction(GO:0005921)
0.0 3.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.8 GO:0043195 terminal bouton(GO:0043195)
0.0 0.7 GO:0032590 dendrite membrane(GO:0032590)
0.0 6.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.9 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
2.0 6.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.9 3.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.7 2.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.6 1.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.6 2.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 1.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 3.6 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 1.7 GO:0019770 IgG receptor activity(GO:0019770)
0.3 3.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 2.5 GO:0009881 photoreceptor activity(GO:0009881)
0.3 5.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 1.9 GO:0031433 telethonin binding(GO:0031433)
0.3 1.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 3.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 7.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 3.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 10.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 7.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 36.0 GO:0005198 structural molecule activity(GO:0005198)
0.1 1.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.8 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 9.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.4 GO:0005179 hormone activity(GO:0005179)
0.0 3.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 8.2 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 7.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 4.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 17.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.4 9.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 2.5 REACTOME OPSINS Genes involved in Opsins
0.2 1.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 2.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 0.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi