ISMARA results: Nfatc2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfatc2

Z-value: 2.04

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Transcription factors associated with Nfatc2

Gene Symbol	Gene ID	Gene Info
Nfatc2 NCBI RGD Ensembl	ENSRNOG00000012175	nuclear factor of activated T-cells 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nfatc2	rn6_v1_chr3_-_165360292_165360292	-0.12	3.4e-02	Click!

Activity profile of Nfatc2 motif

Sorted Z-values of Nfatc2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_82533689 Show fit	80.58	ENSRNOT00000014124	Tmod2 NCBI RGD Ensembl Show fit	tropomodulin 2
chrX_+_6791136 Show fit	63.06	ENSRNOT00000003984	LOC100909913 NCBI RGD Ensembl Show fit	norrin-like
chr2_+_58448917 Show fit	51.66	ENSRNOT00000082562	Ranbp3l NCBI RGD Ensembl Show fit	RAN binding protein 3-like
chr17_-_81187739 Show fit	46.59	ENSRNOT00000063911	Hacd1 NCBI RGD Ensembl Show fit	3-hydroxyacyl-CoA dehydratase 1
chr5_+_64294321 Show fit	46.32	ENSRNOT00000083796	Msantd3 NCBI RGD Ensembl Show fit	Myb/SANT DNA binding domain containing 3
chr4_-_29778039 Show fit	46.30	ENSRNOT00000074177	Sgce NCBI RGD Ensembl Show fit	sarcoglycan, epsilon
chrX_+_107323215 Show fit	45.94	ENSRNOT00000071874	Tceal3 NCBI RGD Ensembl Show fit	transcription elongation factor A like 3
chr2_-_102370757 Show fit	44.65	ENSRNOT00000074255	Tceal6 NCBI RGD Ensembl Show fit	transcription elongation factor A (SII)-like 6
chr9_-_32019205 Show fit	44.32	ENSRNOT00000016194	Adgrb3 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor B3
chr3_-_48535909 Show fit	43.64	ENSRNOT00000008148	Fap NCBI RGD Ensembl Show fit	fibroblast activation protein, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	464.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5	88.7	GO:0060070	canonical Wnt signaling pathway(GO:0060070)
10.1	80.6	GO:0051694	pointed-end actin filament capping(GO:0051694)
24.2	72.6	GO:0097325	melanocyte proliferation(GO:0097325)
0.3	65.7	GO:0001822	kidney development(GO:0001822)
9.6	57.4	GO:1901843	membrane depolarization during bundle of His cell action potential(GO:0086048) positive regulation of high voltage-gated calcium channel activity(GO:1901843)
16.1	48.3	GO:0072254	metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254)
15.5	46.6	GO:0071529	cementum mineralization(GO:0071529)
8.9	44.3	GO:0061743	motor learning(GO:0061743)
7.2	43.0	GO:0033227	dsRNA transport(GO:0033227)

Showing 1 to 10 of 326 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	441.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.4	121.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
12.4	87.0	GO:0071438	invadopodium membrane(GO:0071438)
0.4	76.0	GO:0030427	site of polarized growth(GO:0030427)
1.9	69.8	GO:0046930	pore complex(GO:0046930)
10.7	64.0	GO:0016012	sarcoglycan complex(GO:0016012)
4.8	57.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.4	57.0	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.3	54.4	GO:0031012	extracellular matrix(GO:0031012)
4.5	53.5	GO:0098839	postsynaptic density membrane(GO:0098839)

Showing 1 to 10 of 149 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	565.6	GO:0005509	calcium ion binding(GO:0005509)
5.0	89.5	GO:0005523	tropomyosin binding(GO:0005523)
1.2	83.1	GO:0005518	collagen binding(GO:0005518)
7.3	72.6	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
1.1	63.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.7	63.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6	63.4	GO:0016503	pheromone receptor activity(GO:0016503)
19.1	57.4	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
15.5	46.6	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.2	44.5	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 233 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	120.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.4	115.8	NABA COLLAGENS	Genes encoding collagen proteins
1.2	54.9	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.8	54.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.1	45.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.2	43.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.5	43.1	PID CMYB PATHWAY	C-MYB transcription factor network
0.7	32.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
1.7	30.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.7	28.2	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	119.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.7	48.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.7	47.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
3.4	47.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.6	44.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
2.4	42.6	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.0	39.8	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
1.0	37.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.4	35.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
2.2	33.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 10 of 98 entries

Results for Nfatc2

Z-value: 2.04

Motif logo

Transcription factors associated with Nfatc2

Activity-expression correlation:

Activity profile of Nfatc2 motif

Sorted Z-values of Nfatc2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: