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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfatc4

Z-value: 0.17

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
Nfatc4
ENSRNOG00000020482 nuclear factor of activated T-cells 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4rn6_v1_chr15_+_34493138_344931630.241.3e-05Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_32019205 3.24 ENSRNOT00000016194
Adgrb3
adhesion G protein-coupled receptor B3
chr2_+_149315189 2.93 ENSRNOT00000082464
Med12l
mediator complex subunit 12-like
chr1_-_270472866 2.92 ENSRNOT00000015979
Sorcs1
sortilin-related VPS10 domain containing receptor 1
chr3_-_52510507 2.71 ENSRNOT00000091259
Scn1a
sodium voltage-gated channel alpha subunit 1
chr4_-_159697207 1.56 ENSRNOT00000086440
Ccnd2
cyclin D2
chr10_-_38969501 1.41 ENSRNOT00000090691
ENSRNOT00000081309
ENSRNOT00000010029
Il4
interleukin 4
chr2_+_11658568 1.27 ENSRNOT00000076408
ENSRNOT00000076416
ENSRNOT00000076992
ENSRNOT00000075931
ENSRNOT00000076136
ENSRNOT00000076481
ENSRNOT00000076084
ENSRNOT00000076230
ENSRNOT00000076710
ENSRNOT00000076239
Mef2c
myocyte enhancer factor 2C
chr2_-_184263564 1.06 ENSRNOT00000015279
Fbxw7
F-box and WD repeat domain containing 7
chr3_+_8873933 0.99 ENSRNOT00000030996
Nup188
nucleoporin 188
chr2_-_123851854 0.91 ENSRNOT00000023327
Il2
interleukin 2
chr5_-_28130803 0.84 ENSRNOT00000093186
Slc26a7
solute carrier family 26 member 7
chr15_+_24479761 0.73 ENSRNOT00000016449
Ktn1
kinectin 1
chr8_-_36374673 0.71 ENSRNOT00000013763
Dcps
decapping enzyme, scavenger
chr10_-_32471454 0.62 ENSRNOT00000003224
Sgcd
sarcoglycan, delta
chr3_-_120157866 0.62 ENSRNOT00000020367
LOC100909998
zinc finger protein 2-like
chr7_+_35773928 0.59 ENSRNOT00000034639
Cep83
centrosomal protein 83
chr2_-_247446882 0.47 ENSRNOT00000021963
Bmpr1b
bone morphogenetic protein receptor type 1B
chr9_+_53013413 0.40 ENSRNOT00000005313
Ankar
ankyrin and armadillo repeat containing
chr6_+_95826546 0.25 ENSRNOT00000043587
AABR07064810.1

chr12_-_7186873 0.22 ENSRNOT00000050438
LOC103690996
uncharacterized LOC103690996
chr1_+_230268991 0.11 ENSRNOT00000083727
Olr363
olfactory receptor 363
chr17_-_14557792 0.06 ENSRNOT00000078166
LOC103690033
isoleucine--tRNA ligase, cytoplasmic-like
chr6_+_115170865 0.00 ENSRNOT00000005671
Tshr
thyroid stimulating hormone receptor
chr8_+_41365984 0.00 ENSRNOT00000074250
Olr1228
olfactory receptor 1228

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0061743 motor learning(GO:0061743)
0.5 1.4 GO:2000424 T-helper 1 cell lineage commitment(GO:0002296) negative regulation of complement-dependent cytotoxicity(GO:1903660) regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.4 1.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.3 1.3 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.2 1.0 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 0.9 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 2.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.6 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.5 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.8 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 3.2 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 2.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 2.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.2 1.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 0.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.7 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.7 GO:0019894 kinesin binding(GO:0019894)
0.0 3.2 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP