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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfkb2

Z-value: 0.88

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
Nfkb2
ENSRNOG00000019311 nuclear factor kappa B subunit 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2rn6_v1_chr1_+_266053002_2660530020.774.8e-65Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_18315320 35.93 ENSRNOT00000006954
AABR07051626.2

chr4_+_69384145 31.34 ENSRNOT00000084834
Trbv13-2
T cell receptor beta, variable 13-2
chr3_+_18706988 30.54 ENSRNOT00000074650
AABR07051652.1

chr20_-_4070721 30.31 ENSRNOT00000000523
RT1-Ba
RT1 class II, locus Ba
chr1_-_100537377 30.08 ENSRNOT00000026599
Spib
Spi-B transcription factor
chr2_+_223121410 28.10 ENSRNOT00000087559
AABR07013116.1

chr3_-_20695952 25.45 ENSRNOT00000072306
AABR07051746.1

chr20_-_4921348 22.87 ENSRNOT00000082497
ENSRNOT00000041151
RT1-CE4
RT1 class I, locus CE4
chr1_-_89269930 22.20 ENSRNOT00000028532
Ffar2
free fatty acid receptor 2
chr20_+_5414448 21.52 ENSRNOT00000078972
ENSRNOT00000080900
RT1-A1
RT1 class Ia, locus A1
chr5_-_143120165 21.08 ENSRNOT00000012314
Zc3h12a
zinc finger CCCH type containing 12A
chr14_-_18839420 18.75 ENSRNOT00000034090
Cxcl3
chemokine (C-X-C motif) ligand 3
chr1_-_167347490 16.64 ENSRNOT00000076499
Rhog
ras homolog family member G
chr20_-_3397039 14.67 ENSRNOT00000001084
ENSRNOT00000085259
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_-_80544825 14.34 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
Relb
RELB proto-oncogene, NF-kB subunit
chr20_+_4852671 13.96 ENSRNOT00000001111
Lta
lymphotoxin alpha
chr20_+_5374985 13.49 ENSRNOT00000052270
RT1-A2
RT1 class Ia, locus A2
chr13_+_47539231 13.44 ENSRNOT00000029694
Fcamr
Fc fragment of IgA and IgM receptor
chr6_+_132702448 13.19 ENSRNOT00000005743
Yy1
YY1 transcription factor
chr4_-_115157263 13.18 ENSRNOT00000015296
Tet3
tet methylcytosine dioxygenase 3
chr7_-_143852119 13.04 ENSRNOT00000016801
Rarg
retinoic acid receptor, gamma
chr15_+_42489377 12.84 ENSRNOT00000064306
Pbk
PDZ binding kinase
chr20_+_4852496 12.01 ENSRNOT00000088936
Lta
lymphotoxin alpha
chr10_-_56412544 11.65 ENSRNOT00000020578
Tmem102
transmembrane protein 102
chr7_+_133856101 10.87 ENSRNOT00000038686
Pdzrn4
PDZ domain containing RING finger 4
chr4_+_171250818 10.81 ENSRNOT00000040576
Ptpro
protein tyrosine phosphatase, receptor type, O
chr20_-_3793985 10.63 ENSRNOT00000049540
ENSRNOT00000086293
RT1-CE16
RT1 class I, locus CE16
chr7_+_70364813 10.31 ENSRNOT00000084012
ENSRNOT00000031230
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr15_+_62406873 10.11 ENSRNOT00000047572
Olfm4
olfactomedin 4
chr13_+_111870121 10.02 ENSRNOT00000007333
Irf6
interferon regulatory factor 6
chr6_-_41039437 9.56 ENSRNOT00000005774
Trib2
tribbles pseudokinase 2
chr1_-_166413564 9.51 ENSRNOT00000026286
Atg16l2
autophagy related 16-like 2
chr14_-_18745457 9.21 ENSRNOT00000003778
Cxcl1
C-X-C motif chemokine ligand 1
chr2_-_31826867 8.76 ENSRNOT00000025687
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
chr1_+_221710670 8.21 ENSRNOT00000064798
Map4k2
mitogen activated protein kinase kinase kinase kinase 2
chr2_+_189169877 8.19 ENSRNOT00000028225
She
Src homology 2 domain containing E
chr8_-_119326938 7.75 ENSRNOT00000044467
Ccrl2
C-C motif chemokine receptor like 2
chr1_-_101046208 6.93 ENSRNOT00000091711
Prr12
proline rich 12
chr1_-_170578693 6.88 ENSRNOT00000025651
Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr15_-_28044210 6.46 ENSRNOT00000033809
Rnase1l1
ribonuclease, RNase A family, 1-like 1 (pancreatic)
chr1_+_170578889 6.09 ENSRNOT00000025906
Ilk
integrin-linked kinase
chr10_+_86514830 5.80 ENSRNOT00000048647
ENSRNOT00000009535
Zpbp2
zona pellucida binding protein 2
chr20_+_44521279 5.74 ENSRNOT00000085987
Fyn
FYN proto-oncogene, Src family tyrosine kinase
chr1_-_82580007 5.60 ENSRNOT00000078668
Axl
Axl receptor tyrosine kinase
chr1_-_266086299 5.07 ENSRNOT00000026609
Cuedc2
CUE domain containing 2
chr1_+_189549960 5.04 ENSRNOT00000019654
Exnef
exonuclease NEF-sp
chr9_+_71230108 4.93 ENSRNOT00000018326
Creb1
cAMP responsive element binding protein 1
chr6_+_52663112 4.68 ENSRNOT00000013842
Atxn7l1
ataxin 7-like 1
chr5_+_142986526 4.61 ENSRNOT00000012811
Rspo1
R-spondin 1
chr10_+_75055020 4.19 ENSRNOT00000010755
Tspoap1
TSPO associated protein 1
chr1_-_127599257 4.06 ENSRNOT00000018436
Asb7
ankyrin repeat and SOCS box-containing 7
chr3_-_105214989 3.90 ENSRNOT00000037895
Grem1
gremlin 1, DAN family BMP antagonist
chr13_+_49870976 3.86 ENSRNOT00000090170
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr14_-_18839595 3.79 ENSRNOT00000078746
Cxcl3
chemokine (C-X-C motif) ligand 3
chr7_-_143217535 2.52 ENSRNOT00000088316
Kb15
type II keratin Kb15
chr10_-_72188164 2.22 ENSRNOT00000085728
ENSRNOT00000042506
Ggnbp2
gametogenetin binding protein 2
chr20_-_3299580 1.75 ENSRNOT00000050373
Gnl1
G protein nucleolar 1
chr2_+_158097843 1.69 ENSRNOT00000016541
Ptx3
pentraxin 3
chr10_-_65200109 1.60 ENSRNOT00000030501
Nufip2
NUFIP2, FMR1 interacting protein 2
chr12_-_38638536 1.54 ENSRNOT00000001690
Mlxip
MLX interacting protein
chrX_-_68562301 1.33 ENSRNOT00000076720
Ophn1
oligophrenin 1
chr2_+_188748359 1.12 ENSRNOT00000028038
Shc1
SHC adaptor protein 1
chr13_+_50873605 0.89 ENSRNOT00000004382
Fmod
fibromodulin
chr5_-_146973932 0.87 ENSRNOT00000007761
Zfp362
zinc finger protein 362
chr10_-_74769637 0.82 ENSRNOT00000008889
LOC102555183
zinc finger protein OZF-like
chr2_+_140708397 0.61 ENSRNOT00000088846
Mgst2
microsomal glutathione S-transferase 2
chr4_-_77510202 0.46 ENSRNOT00000038550
Zfp786
zinc finger protein 786
chr3_-_112084144 0.42 ENSRNOT00000010959
Pla2g4f
phospholipase A2, group IVF
chr20_-_3299420 0.35 ENSRNOT00000090999
Gnl1
G protein nucleolar 1
chr10_-_44659707 0.09 ENSRNOT00000002064
RGD1559534
similar to Alpha enolase (2-phospho-D-glycerate hydro-lyase)

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 26.0 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
7.2 21.5 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
7.0 21.1 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
5.6 22.2 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
4.3 13.0 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
3.3 13.2 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
3.1 9.2 GO:0070948 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
2.4 9.6 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
2.0 7.9 GO:0034696 response to prostaglandin F(GO:0034696)
1.8 10.8 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
1.6 4.9 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
1.6 30.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
1.6 9.5 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.4 5.6 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
1.3 13.5 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.2 11.6 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
1.0 10.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
1.0 6.9 GO:0046015 regulation of transcription by glucose(GO:0046015)
1.0 3.9 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
1.0 5.7 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
1.0 14.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.9 8.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.9 10.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.8 5.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.8 22.5 GO:1902624 positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.8 30.1 GO:0030225 macrophage differentiation(GO:0030225)
0.7 22.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.5 16.6 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.5 8.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 4.6 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.5 10.0 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.4 1.7 GO:0052422 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
0.3 5.8 GO:0001675 acrosome assembly(GO:0001675)
0.3 12.8 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.2 3.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 6.1 GO:0032288 myelin assembly(GO:0032288)
0.1 7.8 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 2.5 GO:0031424 keratinization(GO:0031424)
0.1 6.5 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 2.2 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 1.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.4 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 1.1 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 0.9 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.9 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 57.9 GO:0042612 MHC class I protein complex(GO:0042612)
3.0 21.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
2.9 8.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
1.9 30.3 GO:0042613 MHC class II protein complex(GO:0042613)
1.6 4.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
1.6 14.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
1.5 13.2 GO:0001940 male pronucleus(GO:0001940)
1.4 6.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.8 13.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.6 10.1 GO:0042581 specific granule(GO:0042581)
0.4 5.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.4 5.6 GO:0033643 host cell part(GO:0033643)
0.3 9.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 3.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.6 GO:0042788 polysomal ribosome(GO:0042788)
0.2 10.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 6.1 GO:0043034 costamere(GO:0043034)
0.0 5.7 GO:0005884 actin filament(GO:0005884)
0.0 16.6 GO:0005925 focal adhesion(GO:0005925)
0.0 41.3 GO:0005615 extracellular space(GO:0005615)
0.0 11.6 GO:0009986 cell surface(GO:0009986)
0.0 5.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 5.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
3.1 21.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
2.7 13.4 GO:0019862 IgA binding(GO:0019862)
2.3 31.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.2 6.5 GO:0004522 ribonuclease A activity(GO:0004522)
1.9 21.1 GO:0035613 RNA stem-loop binding(GO:0035613)
1.6 4.9 GO:1990763 arrestin family protein binding(GO:1990763)
1.5 8.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.4 5.7 GO:0042610 CD8 receptor binding(GO:0042610)
1.4 4.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.4 8.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.2 43.8 GO:0042605 peptide antigen binding(GO:0042605)
1.1 13.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.8 3.9 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.7 13.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 25.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 22.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 5.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.5 9.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.5 3.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 10.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 8.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 7.8 GO:0004950 chemokine receptor activity(GO:0004950)
0.3 1.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 1.7 GO:0001849 complement component C1q binding(GO:0001849)
0.2 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 10.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 6.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 14.3 GO:0001047 core promoter binding(GO:0001047)
0.1 14.7 GO:0019902 phosphatase binding(GO:0019902)
0.1 5.0 GO:0004527 exonuclease activity(GO:0004527)
0.1 6.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 1.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 4.6 GO:0008201 heparin binding(GO:0008201)
0.0 10.1 GO:0045296 cadherin binding(GO:0045296)
0.0 17.0 GO:0008289 lipid binding(GO:0008289)
0.0 4.9 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 35.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.5 27.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 16.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.4 13.4 PID CD40 PATHWAY CD40/CD40L signaling
0.4 13.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.3 14.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.3 9.2 PID IL23 PATHWAY IL23-mediated signaling events
0.3 14.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 13.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 8.2 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.9 PID BMP PATHWAY BMP receptor signaling
0.1 1.7 ST ADRENERGIC Adrenergic Pathway
0.0 12.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 31.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.6 31.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 6.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 4.9 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 13.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 10.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 22.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 4.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation