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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-6

Z-value: 0.22

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Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
Nkx2-6
ENSRNOG00000021910 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-6rn6_v1_chr15_+_51034620_51034620-0.621.8e-35Click!

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_282251257 6.57 ENSRNOT00000015186
Prdx3
peroxiredoxin 3
chr2_+_84645084 5.34 ENSRNOT00000015448
Cmbl
carboxymethylenebutenolidase homolog
chr16_-_56900052 4.74 ENSRNOT00000017339
Msr1
macrophage scavenger receptor 1
chr17_-_43537293 4.30 ENSRNOT00000091749
Slc17a3
solute carrier family 17 member 3
chr9_+_62291405 3.54 ENSRNOT00000051463
Plcl1
phospholipase C-like 1
chrX_-_157286936 2.94 ENSRNOT00000078100
Atp2b3
ATPase plasma membrane Ca2+ transporting 3
chr17_-_81187739 2.58 ENSRNOT00000063911
Hacd1
3-hydroxyacyl-CoA dehydratase 1
chr9_+_3896337 1.65 ENSRNOT00000079166
LOC103693189
protein tyrosine phosphatase type IVA 1
chr3_+_140024043 1.51 ENSRNOT00000086409
Rin2
Ras and Rab interactor 2
chr4_-_180234804 1.35 ENSRNOT00000070957
Bhlhe41
basic helix-loop-helix family, member e41
chr9_+_51009116 1.15 ENSRNOT00000039313
Mettl21cl1
methyltransferase like 21C-like 1
chr5_-_115222075 1.06 ENSRNOT00000058163
ENSRNOT00000012503
LOC100912642
cytochrome P450 2J3-like
chr2_-_26870421 0.92 ENSRNOT00000088791
AABR07007744.2

chr1_+_185427736 0.83 ENSRNOT00000064706
Plekha7
pleckstrin homology domain containing A7
chr4_-_155421998 0.83 ENSRNOT00000041552
Gdf3
growth differentiation factor 3
chr7_+_107406962 0.77 ENSRNOT00000093254
Phf20l1
PHD finger protein 20-like protein 1
chrX_+_78042859 0.76 ENSRNOT00000003286
Lpar4
lysophosphatidic acid receptor 4
chr1_-_189460844 0.63 ENSRNOT00000020077
Thumpd1
THUMP domain containing 1
chr13_+_98231326 0.57 ENSRNOT00000003837
Cdc42bpa
CDC42 binding protein kinase alpha
chr2_+_203768729 0.55 ENSRNOT00000018895
Igsf3
immunoglobulin superfamily, member 3
chr3_+_15856289 0.53 ENSRNOT00000089297
Olr399
olfactory receptor 399
chr17_+_66579319 0.48 ENSRNOT00000071829
Heatr1
HEAT repeat containing 1
chr1_-_252922486 0.48 ENSRNOT00000076802
Ifit1bl
interferon-induced protein with tetratricopeptide repeats 1B-like
chr3_+_16117228 0.44 ENSRNOT00000049590
Olr404
olfactory receptor 404
chr10_+_49538588 0.37 ENSRNOT00000081415
Pmp22
peripheral myelin protein 22
chr3_-_74014795 0.32 ENSRNOT00000073426
Olr516
olfactory receptor 516
chr3_+_20878701 0.14 ENSRNOT00000046877
Olr413
olfactory receptor 413

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.9 2.6 GO:0071529 cementum mineralization(GO:0071529)
0.4 4.7 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.4 4.3 GO:0015747 urate transport(GO:0015747)
0.4 2.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 3.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 1.3 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 0.8 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.5 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 0.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.9 2.6 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.4 4.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) efflux transmembrane transporter activity(GO:0015562) salt transmembrane transporter activity(GO:1901702)
0.3 3.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 4.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.2 1.3 GO:0043426 MRF binding(GO:0043426)
0.2 0.8 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 2.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.5 GO:0019840 isoprenoid binding(GO:0019840)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression