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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-9

Z-value: 1.06

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Transcription factors associated with Nkx2-9

Gene Symbol Gene ID Gene Info

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-8rn6_v1_chr6_-_77508585_775085850.322.9e-09Click!

Activity profile of Nkx2-9 motif

Sorted Z-values of Nkx2-9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_107952530 46.58 ENSRNOT00000052043
Cldn18
claudin 18
chr6_-_138662365 40.53 ENSRNOT00000066209
ENSRNOT00000084892
Ighm
immunoglobulin heavy constant mu
chr6_-_142903440 31.74 ENSRNOT00000075707
AABR07065823.2

chr10_-_31493419 28.27 ENSRNOT00000009211
Itk
IL2-inducible T-cell kinase
chr6_-_140880070 24.73 ENSRNOT00000073779
LOC691828
uncharacterized LOC691828
chr6_-_140102325 24.25 ENSRNOT00000072238
AABR07065750.2

chr5_-_157199441 24.05 ENSRNOT00000022559
Pla2g2f
phospholipase A2, group IIF
chr14_+_48726045 21.41 ENSRNOT00000086646
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_105390580 21.23 ENSRNOT00000077547
Btk
Bruton tyrosine kinase
chr7_+_28654733 21.02 ENSRNOT00000006174
Pmch
pro-melanin-concentrating hormone
chr6_+_139405966 20.74 ENSRNOT00000088974
AABR07065693.3

chr6_-_142353308 20.00 ENSRNOT00000066416
AABR07065814.2

chr2_-_241472694 19.83 ENSRNOT00000051498
Bank1
B-cell scaffold protein with ankyrin repeats 1
chr6_-_143702033 19.31 ENSRNOT00000051410
AABR07065886.1

chr6_-_143131118 18.74 ENSRNOT00000074930
AABR07065834.1

chr15_+_61826937 16.53 ENSRNOT00000084005
ENSRNOT00000079417
Elf1
E74-like factor 1
chr14_+_108826831 16.13 ENSRNOT00000083146
ENSRNOT00000009421
Bcl11a
B-cell CLL/lymphoma 11A
chr4_-_131694755 15.97 ENSRNOT00000013271
Foxp1
forkhead box P1
chr9_+_81427730 15.32 ENSRNOT00000019109
ENSRNOT00000081711
Cxcr2
C-X-C motif chemokine receptor 2
chr1_+_279798187 14.41 ENSRNOT00000024065
Pnlip
pancreatic lipase
chr6_-_138736203 13.77 ENSRNOT00000052021
LOC100360169
rCG21044-like
chr4_+_145489869 13.12 ENSRNOT00000082618
Fancd2
Fanconi anemia, complementation group D2
chr20_-_4132604 12.97 ENSRNOT00000077630
ENSRNOT00000048332
RT1-Da
RT1 class II, locus Da
chr6_-_140642221 12.63 ENSRNOT00000081996
AABR07065772.2

chr15_-_29369504 12.51 ENSRNOT00000060297
AABR07017624.1

chr1_-_174047572 12.04 ENSRNOT00000019597
Stk33
serine/threonine kinase 33
chrX_+_120624518 11.97 ENSRNOT00000007967
Slc6a14
solute carrier family 6 member 14
chr9_-_93404883 11.87 ENSRNOT00000025024
Nmur1
neuromedin U receptor 1
chr17_-_54808483 11.82 ENSRNOT00000075683
AABR07028049.1

chr8_+_29453643 11.70 ENSRNOT00000090643
Opcml
opioid binding protein/cell adhesion molecule-like
chr2_+_251983339 11.69 ENSRNOT00000020230
Mcoln3
mucolipin 3
chr7_-_12346475 11.36 ENSRNOT00000060708
Mum1
melanoma associated antigen (mutated) 1
chr14_+_39964588 11.35 ENSRNOT00000003240
Gabrg1
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr7_+_141355994 11.35 ENSRNOT00000081195
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr16_+_22979444 11.32 ENSRNOT00000017822
Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_+_52663112 11.29 ENSRNOT00000013842
Atxn7l1
ataxin 7-like 1
chr7_-_55604403 10.75 ENSRNOT00000088732
Atxn7l3b
ataxin 7-like 3B
chr11_+_81358592 10.69 ENSRNOT00000002487
Rfc4
replication factor C subunit 4
chr5_-_12526962 10.58 ENSRNOT00000092104
St18
suppression of tumorigenicity 18
chr9_-_29337922 10.05 ENSRNOT00000018896
RGD1309049
similar to RIKEN cDNA 4933415F23
chr1_-_84812486 9.69 ENSRNOT00000078369
AABR07002779.1

chr3_+_172719432 9.36 ENSRNOT00000033863
Zfp831
zinc finger protein 831
chr1_-_233140237 9.34 ENSRNOT00000083372
Psat1
phosphoserine aminotransferase 1
chr1_+_256786124 9.17 ENSRNOT00000034563
Ffar4
free fatty acid receptor 4
chr10_+_45893018 9.16 ENSRNOT00000004280
ENSRNOT00000086710
Nlrp3
NLR family, pyrin domain containing 3
chr2_-_60657712 9.13 ENSRNOT00000040348
Rai14
retinoic acid induced 14
chr1_-_7801438 9.01 ENSRNOT00000022273
AABR07000276.1

chr5_-_58455819 8.81 ENSRNOT00000078082
Fancg
Fanconi anemia, complementation group G
chr1_+_156552328 8.59 ENSRNOT00000055401
Dlg2
discs large MAGUK scaffold protein 2
chr7_-_68549763 8.50 ENSRNOT00000078014
Slc16a7
solute carrier family 16 member 7
chr5_-_137112927 7.84 ENSRNOT00000078302
Ptprf
protein tyrosine phosphatase, receptor type, F
chr5_+_139963002 7.60 ENSRNOT00000048506
Col9a2
collagen type IX alpha 2 chain
chr6_-_108660063 7.32 ENSRNOT00000006240
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
chr19_-_14945302 7.32 ENSRNOT00000079391
AABR07042936.2

chr4_+_145413230 7.22 ENSRNOT00000056508
Il17re
interleukin 17 receptor E
chr5_+_122019301 7.17 ENSRNOT00000068158
Pde4b
phosphodiesterase 4B
chr15_+_80040842 6.91 ENSRNOT00000043065
RGD1306441
similar to RIKEN cDNA 4921530L21
chrX_-_70428364 6.79 ENSRNOT00000045907
P2ry4
pyrimidinergic receptor P2Y4
chr1_+_220423426 6.69 ENSRNOT00000072647
Brms1
breast cancer metastasis-suppressor 1
chr6_-_145777767 6.35 ENSRNOT00000046799
Rpl32
ribosomal protein L32
chr13_+_51972974 6.34 ENSRNOT00000008164
Arl8a
ADP-ribosylation factor like GTPase 8A
chr5_-_153184940 5.86 ENSRNOT00000079536
Tmem57
transmembrane protein 57
chr3_-_46051096 5.53 ENSRNOT00000081302
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr8_-_61917125 5.36 ENSRNOT00000085049
RGD1305464
similar to human chromosome 15 open reading frame 39
chr9_+_69953440 5.31 ENSRNOT00000034740
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr9_+_81644355 5.28 ENSRNOT00000071700
Catip
ciliogenesis associated TTC17 interacting protein
chr1_+_161401527 5.22 ENSRNOT00000015181
Tenm4
teneurin transmembrane protein 4
chr13_+_44812567 5.17 ENSRNOT00000005372
R3hdm1
R3H domain containing 1
chr2_-_188559882 5.03 ENSRNOT00000088199
Trim46
tripartite motif-containing 46
chr18_+_27190974 4.66 ENSRNOT00000037690
Pkd2l2
polycystin 2 like 2, transient receptor potential cation channel
chr11_+_60072727 4.65 ENSRNOT00000090230
Tagln3
transgelin 3
chr10_-_15228235 4.49 ENSRNOT00000027121
Wdr90
WD repeat domain 90
chr1_+_79831534 4.45 ENSRNOT00000057965
Nova2
NOVA alternative splicing regulator 2
chr18_+_30010918 4.23 ENSRNOT00000084132
Pcdha4
protocadherin alpha 4
chr10_-_87407634 4.17 ENSRNOT00000016657
Krt23
keratin 23
chr5_-_73494030 4.04 ENSRNOT00000022291
Actl7b
actin-like 7b
chr17_-_43675934 3.92 ENSRNOT00000081345
Hist1h1t
histone cluster 1 H1 family member t
chr20_+_41184287 3.77 ENSRNOT00000081117
Col10a1
collagen type X alpha 1 chain
chr11_+_57505005 3.77 ENSRNOT00000002942
LOC103693564
transgelin-3
chr10_-_97647822 3.68 ENSRNOT00000065781
AC106648.1

chr2_-_23260965 3.49 ENSRNOT00000046772
LOC103691423
60S ribosomal protein L36 pseudogene
chr14_+_109533792 3.45 ENSRNOT00000067690
LOC108348154
ankyrin repeat domain-containing protein 29-like
chr17_+_47721977 3.43 ENSRNOT00000080800
LOC100910792
amphiphysin-like
chr10_+_70134729 3.40 ENSRNOT00000076739
Lig3
DNA ligase 3
chr18_+_27576129 3.23 ENSRNOT00000070930
Kdm3b
lysine demethylase 3B
chrX_-_15467875 3.16 ENSRNOT00000011207
Pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr19_-_41010122 3.04 ENSRNOT00000088770
Vac14
Vac14, PIKFYVE complex component
chr18_-_25997555 2.90 ENSRNOT00000027755
Stard4
StAR-related lipid transfer domain containing 4
chr10_+_15241590 2.89 ENSRNOT00000037372
ENSRNOT00000037381
Mettl26
methyltransferase like 26
chr5_+_50381244 2.88 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr6_-_143537030 2.76 ENSRNOT00000071876
LOC100360610
rCG64220-like
chr11_-_67037115 2.62 ENSRNOT00000003137
Ildr1
immunoglobulin-like domain containing receptor 1
chrX_-_64908682 2.55 ENSRNOT00000084107
Zc4h2
zinc finger C4H2-type containing
chr3_+_161018511 2.51 ENSRNOT00000019804
ENSRNOT00000039664
Wfdc2
WAP four-disulfide core domain 2
chrX_-_106116886 2.47 ENSRNOT00000052009
Tcp11x2
t-complex 11 family, X-linked 2
chr14_-_44375804 2.43 ENSRNOT00000042825
LOC100362751
ribosomal protein P2-like
chr5_-_127273656 2.32 ENSRNOT00000057341
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr15_+_28696378 2.28 ENSRNOT00000017476
Tox4
TOX high mobility group box family member 4
chr9_-_15375365 2.27 ENSRNOT00000018550
Usp49
ubiquitin specific peptidase 49
chr15_-_58171049 2.13 ENSRNOT00000001371
Gpalpp1
GPALPP motifs containing 1
chr15_+_58170967 2.09 ENSRNOT00000001366
Nufip1
NUFIP1, FMR1 interacting protein 1
chr15_+_28695912 1.96 ENSRNOT00000081830
Tox4
TOX high mobility group box family member 4
chr17_+_54280851 1.65 ENSRNOT00000024022
Arhgap12
Rho GTPase activating protein 12
chr1_-_90961717 1.58 ENSRNOT00000071180
LOC108348106
alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
chr18_-_52017734 1.56 ENSRNOT00000081020
March3
membrane associated ring-CH-type finger 3
chr7_+_35773928 1.45 ENSRNOT00000034639
Cep83
centrosomal protein 83
chr7_+_142106465 1.29 ENSRNOT00000042786
ENSRNOT00000088681
Letmd1
LETM1 domain containing 1
chrX_-_152367861 1.12 ENSRNOT00000089414
LOC103690371
melanoma-associated antigen 10-like
chr6_+_84293402 1.12 ENSRNOT00000072657
LOC108351365
uncharacterized LOC108351365
chr15_-_28696122 0.95 ENSRNOT00000060467
Rab2b
RAB2B, member RAS oncogene family
chrX_+_128493614 0.93 ENSRNOT00000044240
Stag2
stromal antigen 2
chr5_-_35831712 0.91 ENSRNOT00000010126
Prdm13
PR/SET domain 13
chr12_-_45801842 0.89 ENSRNOT00000078837
AABR07036513.1

chr6_-_98666007 0.84 ENSRNOT00000082695
AABR07064867.1

chr9_+_99720856 0.82 ENSRNOT00000047487
Olr1346
olfactory receptor 1346
chr6_-_93562314 0.79 ENSRNOT00000010871
ENSRNOT00000088790
Timm9
translocase of inner mitochondrial membrane 9
chr8_+_85951191 0.74 ENSRNOT00000037665
Cd109
CD109 molecule
chr7_+_120923274 0.71 ENSRNOT00000049247
Gtpbp1
GTP binding protein 1
chr15_-_29672591 0.68 ENSRNOT00000060298
LOC100911282
uncharacterized LOC100911282
chr6_-_141866756 0.66 ENSRNOT00000068561
AABR07065804.1

chr12_-_11144754 0.53 ENSRNOT00000084637
Zfp655
zinc finger protein 655
chr9_+_66058047 0.33 ENSRNOT00000071819
Cdk15
cyclin-dependent kinase 15
chr5_-_147823232 0.29 ENSRNOT00000074345
Iqcc
IQ motif containing C

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 46.6 GO:2001205 negative regulation of osteoclast development(GO:2001205)
5.4 16.1 GO:1903860 negative regulation of dendrite extension(GO:1903860)
5.3 16.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)
5.3 21.2 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344) cellular response to molecule of fungal origin(GO:0071226)
4.2 21.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
3.8 11.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
3.1 15.3 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
2.6 28.3 GO:0001865 NK T cell differentiation(GO:0001865)
2.3 9.2 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
2.2 13.0 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.9 13.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.9 9.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.7 5.2 GO:0032289 central nervous system myelin formation(GO:0032289)
1.7 8.5 GO:1901475 pyruvate transmembrane transport(GO:1901475)
1.7 19.8 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
1.4 11.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
1.3 7.8 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.2 7.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.2 10.7 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.1 3.4 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.8 6.8 GO:0030321 transepithelial chloride transport(GO:0030321)
0.8 8.6 GO:0046710 GDP metabolic process(GO:0046710)
0.7 6.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.7 2.9 GO:0070859 lipid transport involved in lipid storage(GO:0010877) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.7 24.1 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.6 2.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 1.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.3 11.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 9.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.3 5.0 GO:0099612 protein localization to axon(GO:0099612)
0.3 11.9 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.3 2.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 3.2 GO:0072718 response to cisplatin(GO:0072718)
0.2 9.2 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.2 2.9 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.2 8.9 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.2 0.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.7 GO:0072675 osteoclast fusion(GO:0072675)
0.1 8.8 GO:0001541 ovarian follicle development(GO:0001541)
0.1 3.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 3.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 6.3 GO:0097421 liver regeneration(GO:0097421)
0.1 14.4 GO:0009791 post-embryonic development(GO:0009791)
0.1 12.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 3.2 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 3.0 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 7.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 12.0 GO:0006520 cellular amino acid metabolic process(GO:0006520)
0.0 5.3 GO:0030041 actin filament polymerization(GO:0030041)
0.0 0.7 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 4.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.6 GO:0090277 positive regulation of peptide hormone secretion(GO:0090277)
0.0 14.0 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 11.4 GO:0006281 DNA repair(GO:0006281)
0.0 4.4 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 4.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 12.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.9 GO:0045921 positive regulation of exocytosis(GO:0045921)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0005594 collagen type IX trimer(GO:0005594)
1.8 10.7 GO:0005663 DNA replication factor C complex(GO:0005663)
1.8 5.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.3 9.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
1.3 36.6 GO:0042629 mast cell granule(GO:0042629)
1.1 3.4 GO:0070421 DNA ligase III-XRCC1 complex(GO:0070421)
1.0 5.0 GO:1990769 proximal neuron projection(GO:1990769)
0.9 11.3 GO:0071564 npBAF complex(GO:0071564)
0.8 13.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 8.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 8.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 2.6 GO:0061689 tricellular tight junction(GO:0061689)
0.4 3.0 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.4 2.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.4 7.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 4.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.3 6.7 GO:0070822 Sin3-type complex(GO:0070822)
0.3 44.2 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 11.4 GO:0034707 chloride channel complex(GO:0034707)
0.2 6.3 GO:0051233 spindle midzone(GO:0051233)
0.2 11.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 19.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 12.0 GO:0031526 brush border membrane(GO:0031526)
0.1 11.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 8.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 15.7 GO:0000793 condensed chromosome(GO:0000793)
0.1 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 24.0 GO:0060076 excitatory synapse(GO:0060076)
0.1 9.1 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 4.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 1.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 6.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 21.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.3 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0004918 interleukin-8 receptor activity(GO:0004918)
3.8 11.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
2.3 6.8 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
2.0 7.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.7 8.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.1 10.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.9 7.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.9 2.6 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.9 8.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.8 42.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.8 14.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.7 24.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.7 13.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.7 9.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.7 11.4 GO:0050811 GABA receptor binding(GO:0050811)
0.7 13.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 21.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.5 28.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 16.0 GO:0050681 androgen receptor binding(GO:0050681)
0.4 12.0 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.4 7.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 3.4 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 9.3 GO:0008483 transaminase activity(GO:0008483)
0.3 9.2 GO:0008527 taste receptor activity(GO:0008527)
0.2 3.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 11.4 GO:0031491 nucleosome binding(GO:0031491)
0.2 6.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 8.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 11.3 GO:0032947 protein complex scaffold(GO:0032947)
0.1 16.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 53.3 GO:0005198 structural molecule activity(GO:0005198)
0.1 1.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 2.1 GO:0030515 snoRNA binding(GO:0030515)
0.0 6.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 4.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 11.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 14.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 8.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.9 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 5.5 GO:0008134 transcription factor binding(GO:0008134)
0.0 6.3 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 49.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.6 32.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.6 15.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.5 21.4 PID ARF6 PATHWAY Arf6 signaling events
0.4 16.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 9.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 14.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 24.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
1.4 46.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
1.3 13.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.0 28.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.8 9.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 10.7 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.6 8.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 21.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6 6.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.5 12.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 9.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 8.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.5 20.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.5 11.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 15.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 3.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 7.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 29.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.2 7.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 23.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 11.7 REACTOME TRANSLATION Genes involved in Translation
0.0 1.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import