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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr1h2

Z-value: 0.89

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Transcription factors associated with Nr1h2

Gene Symbol Gene ID Gene Info
Nr1h2
ENSRNOG00000019812 nuclear receptor subfamily 1, group H, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h2rn6_v1_chr1_-_100559942_100559942-0.123.3e-02Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_7058314 39.14 ENSRNOT00000045996
Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr15_+_33632416 35.30 ENSRNOT00000068212
AC130940.1

chr9_+_27402381 31.59 ENSRNOT00000077372
Gsta3
glutathione S-transferase alpha 3
chr10_-_62273119 31.05 ENSRNOT00000004322
Serpinf2
serpin family F member 2
chr2_+_60337667 28.06 ENSRNOT00000024035
Agxt2
alanine-glyoxylate aminotransferase 2
chr13_-_82758004 26.68 ENSRNOT00000003932
Atp1b1
ATPase Na+/K+ transporting subunit beta 1
chr1_+_224824799 26.39 ENSRNOT00000024757
Slc22a6
solute carrier family 22 member 6
chr16_-_81797815 24.86 ENSRNOT00000026666
Proz
protein Z, vitamin K-dependent plasma glycoprotein
chr4_+_122365093 24.81 ENSRNOT00000024011
Klf15
Kruppel-like factor 15
chr12_+_9446940 22.32 ENSRNOT00000074791
Urad
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
chr1_-_162385575 19.72 ENSRNOT00000016540
Thrsp
thyroid hormone responsive
chr3_+_150910398 18.47 ENSRNOT00000055310
Tp53inp2
tumor protein p53 inducible nuclear protein 2
chr3_+_8832740 17.43 ENSRNOT00000022552
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr4_-_117790350 17.20 ENSRNOT00000088557
Nat8b
N-acetyltransferase 8B
chr1_+_282557426 16.93 ENSRNOT00000088966
AABR07007134.1

chr1_+_100161872 16.69 ENSRNOT00000025777
Klk1c3
kallikrein 1-related peptidase C3
chr5_+_4982348 16.52 ENSRNOT00000010369
Lactb2
lactamase, beta 2
chr2_-_100372252 16.41 ENSRNOT00000011890
Hnf4g
hepatocyte nuclear factor 4, gamma
chr4_-_117607428 16.19 ENSRNOT00000021243
LOC103690139
probable N-acetyltransferase CML6
chr8_+_50537009 15.51 ENSRNOT00000080658
Apoa4
apolipoprotein A4
chr20_+_20236151 13.84 ENSRNOT00000079630
Ank3
ankyrin 3
chr4_-_145390447 13.24 ENSRNOT00000091965
ENSRNOT00000012136
Cidec
cell death-inducing DFFA-like effector c
chr2_-_140464607 13.11 ENSRNOT00000058190
Ndufc1
NADH:ubiquinone oxidoreductase subunit C1
chr4_+_51614676 12.62 ENSRNOT00000060494
Asb15
ankyrin repeat and SOCS box containing 15
chr5_-_138470096 12.08 ENSRNOT00000011392
Ppcs
phosphopantothenoylcysteine synthetase
chr3_+_98297554 11.84 ENSRNOT00000006524
Kcna4
potassium voltage-gated channel subfamily A member 4
chr5_-_169212170 11.62 ENSRNOT00000013385
Tas1r1
taste 1 receptor member 1
chrX_+_68752597 11.38 ENSRNOT00000077039
Stard8
StAR-related lipid transfer domain containing 8
chr20_+_21316826 11.16 ENSRNOT00000000785
RGD1306739
similar to RIKEN cDNA 1700040L02
chr9_+_81631409 10.63 ENSRNOT00000089580
Pnkd
paroxysmal nonkinesigenic dyskinesia
chr19_-_10653800 10.43 ENSRNOT00000022128
Cx3cl1
C-X3-C motif chemokine ligand 1
chr13_-_111765944 10.17 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr14_-_89238094 9.96 ENSRNOT00000006818
Sun3
Sad1 and UNC84 domain containing 3
chr1_+_190072420 9.50 ENSRNOT00000037026
Abca15
ATP-binding cassette, subfamily A (ABC1), member 15
chr10_-_56558487 9.31 ENSRNOT00000023256
Slc2a4
solute carrier family 2 member 4
chr20_+_13827660 9.26 ENSRNOT00000093131
Ddt
D-dopachrome tautomerase
chr5_+_120340646 9.14 ENSRNOT00000086259
ENSRNOT00000086539
Dnajc6
DnaJ heat shock protein family (Hsp40) member C6
chr3_-_94808861 9.00 ENSRNOT00000038464
Prrg4
proline rich and Gla domain 4
chr10_-_46582854 8.73 ENSRNOT00000004753
Srebf1
sterol regulatory element binding transcription factor 1
chr1_-_188407132 8.70 ENSRNOT00000073233
Gde1
glycerophosphodiester phosphodiesterase 1
chr9_-_60255746 8.36 ENSRNOT00000093710
Dnah7
dynein, axonemal, heavy chain 7
chr9_+_16647598 8.02 ENSRNOT00000087413
Klc4
kinesin light chain 4
chr12_-_38995570 7.48 ENSRNOT00000001806
Orai1
ORAI calcium release-activated calcium modulator 1
chr10_-_82785142 7.47 ENSRNOT00000005381
Sgca
sarcoglycan, alpha
chr9_+_64066579 7.33 ENSRNOT00000013511
RGD1306941
similar to CG31122-PA
chr9_-_16647458 7.24 ENSRNOT00000024380
Mrpl2
mitochondrial ribosomal protein L2
chr1_-_70235091 7.03 ENSRNOT00000075745
Apeg3
antisense paternally expressed gene 3
chr7_+_141034982 7.00 ENSRNOT00000091050
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr5_+_138470069 6.84 ENSRNOT00000076343
ENSRNOT00000064073
Zmynd12
zinc finger, MYND-type containing 12
chr1_+_140477868 6.41 ENSRNOT00000025008
Mrps11
mitochondrial ribosomal protein S11
chr1_-_220786615 6.35 ENSRNOT00000038198
Tsga10ip
testis specific 10 interacting protein
chr9_-_10047507 6.18 ENSRNOT00000072118
Alkbh7
alkB homolog 7
chr6_+_76675418 6.05 ENSRNOT00000076169
ENSRNOT00000010948
ENSRNOT00000082286
Brms1l
Brms1l
breast cancer metastasis-suppressor 1-like
breast cancer metastasis-suppressor 1-like
chrX_+_26294066 6.01 ENSRNOT00000037862
Hccs
holocytochrome c synthase
chr5_-_78376032 5.83 ENSRNOT00000075916
Alad
aminolevulinate dehydratase
chr6_+_99444013 5.53 ENSRNOT00000058642
Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr10_+_15485905 5.13 ENSRNOT00000027609
Tmem8a
transmembrane protein 8A
chr5_+_117698764 5.07 ENSRNOT00000011486
Angptl3
angiopoietin-like 3
chr3_-_123206828 4.98 ENSRNOT00000030192
Ddrgk1
DDRGK domain containing 1
chr1_+_88182155 4.95 ENSRNOT00000083176
Yif1b
Yip1 interacting factor homolog B, membrane trafficking protein
chrX_-_72515057 4.75 ENSRNOT00000076850
ENSRNOT00000041138
Phka1
phosphorylase kinase, alpha 1
chr10_-_86355006 4.70 ENSRNOT00000075076
Pgap3
post-GPI attachment to proteins 3
chr12_+_41543696 4.65 ENSRNOT00000079639
Tpcn1
two pore segment channel 1
chr14_+_80195715 4.65 ENSRNOT00000010784
Sh3tc1
SH3 domain and tetratricopeptide repeats 1
chr12_+_45905371 4.40 ENSRNOT00000039275
Hspb8
heat shock protein family B (small) member 8
chr7_-_129919946 4.30 ENSRNOT00000079976
AABR07058658.1

chr1_-_153096269 4.27 ENSRNOT00000022578
Tmem135
transmembrane protein 135
chr1_-_80689171 4.03 ENSRNOT00000045574
Bcam
basal cell adhesion molecule (Lutheran blood group)
chr15_-_32925673 3.90 ENSRNOT00000081045
Olr1646
olfactory receptor 1646
chrX_-_72515320 3.70 ENSRNOT00000076725
Phka1
phosphorylase kinase, alpha 1
chr5_+_157423213 3.46 ENSRNOT00000023431
Tmco4
transmembrane and coiled-coil domains 4
chr15_+_8739589 3.39 ENSRNOT00000071751
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr1_+_88182585 3.32 ENSRNOT00000044145
Yif1b
Yip1 interacting factor homolog B, membrane trafficking protein
chrX_-_13116743 3.30 ENSRNOT00000004305
Mid1ip1
MID1 interacting protein 1
chr3_+_123754057 3.29 ENSRNOT00000034201
ENSRNOT00000084671
Ap5s1
adaptor-related protein complex 5, sigma 1 subunit
chr7_-_144269486 3.27 ENSRNOT00000090051
Atp5g2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr4_+_156482446 3.22 ENSRNOT00000039327
Vom2r50
vomeronasal 2 receptor, 50
chr8_+_119121669 3.21 ENSRNOT00000028479
Prss46
protease, serine, 46
chr10_-_14061703 3.21 ENSRNOT00000017917
Gfer
growth factor, augmenter of liver regeneration
chr1_+_87180624 3.19 ENSRNOT00000056933
ENSRNOT00000027987
LOC103689986
protein YIF1B
chr16_-_70705128 3.14 ENSRNOT00000071258
Rnf170
ring finger protein 170
chr3_+_114869459 3.09 ENSRNOT00000056083
Bloc1s6
biogenesis of lysosomal organelles complex 1 subunit 6
chr1_-_175657485 3.08 ENSRNOT00000024561
rnf141
ring finger protein 141
chr12_+_11347643 2.96 ENSRNOT00000038175
ENSRNOT00000075986
Kpna7
karyopherin subunit alpha 7
chr16_+_47368768 2.95 ENSRNOT00000017966
Wwc2
WW and C2 domain containing 2
chr18_-_29290447 2.94 ENSRNOT00000025353
Pfdn1
prefoldin subunit 1
chr2_-_188727670 2.94 ENSRNOT00000074920
Lenep
lens epithelial protein
chr3_-_74738366 2.91 ENSRNOT00000012938
Olr490
olfactory receptor 490
chr9_+_53626592 2.76 ENSRNOT00000031267
Mfsd6
major facilitator superfamily domain containing 6
chr14_+_11095163 2.75 ENSRNOT00000003076
Tmem150c
transmembrane protein 150C
chr9_+_37462693 2.73 ENSRNOT00000016316
Lgsn
lengsin, lens protein with glutamine synthetase domain
chr15_-_4026637 2.71 ENSRNOT00000012372
Chchd1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr6_+_99625306 2.62 ENSRNOT00000008573
Plekhg3
pleckstrin homology and RhoGEF domain containing G3
chr17_+_507377 2.54 ENSRNOT00000023638
Npepo
aminopeptidase O
chr6_-_129509720 2.52 ENSRNOT00000006131
Atg2b
autophagy related 2B
chr12_-_49412796 2.48 ENSRNOT00000092480
Tmem211
transmembrane protein 211
chr7_-_144837395 2.39 ENSRNOT00000089024
Cbx5
chromobox 5
chr13_-_99982358 2.17 ENSRNOT00000004114
LOC690271
similar to mitochondrial ribosomal protein S11
chr17_-_24182425 2.15 ENSRNOT00000024206
Mcur1
mitochondrial calcium uniporter regulator 1
chr20_+_5100415 2.14 ENSRNOT00000001122
Ly6g5c
lymphocyte antigen 6 complex, locus G5C
chr1_-_140477796 2.14 ENSRNOT00000067172
Mrpl46
mitochondrial ribosomal protein L46
chr5_+_141530211 2.14 ENSRNOT00000056546
4933427I04Rik
Riken cDNA 4933427I04 gene
chr4_+_1566448 2.12 ENSRNOT00000088227
Olr1243
olfactory receptor 1243
chr1_+_172728264 2.10 ENSRNOT00000075297
Olr267
olfactory receptor 267
chr4_+_157181795 2.07 ENSRNOT00000017090
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr3_-_73178585 2.05 ENSRNOT00000043965
Olr459
olfactory receptor 459
chr8_+_42017493 2.04 ENSRNOT00000072062
LOC100911845
olfactory receptor 143-like
chr9_+_99763768 2.03 ENSRNOT00000049910
Olr1351
olfactory receptor 1351
chr1_+_214562897 1.96 ENSRNOT00000085125
Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
chr5_+_69784806 1.96 ENSRNOT00000024722
Olr853
olfactory receptor 853
chr3_-_73124644 1.93 ENSRNOT00000012711
Olr455
olfactory receptor 455
chr5_+_144281614 1.84 ENSRNOT00000014383
Trappc3
trafficking protein particle complex 3
chr1_+_87790104 1.83 ENSRNOT00000074580
LOC103690114
zinc finger protein 383-like
chr10_+_49368314 1.81 ENSRNOT00000004392
Cdrt4
CMT1A duplicated region transcript 4
chr9_+_99776886 1.80 ENSRNOT00000056602
Olr1352
olfactory receptor 1352
chr3_+_73138229 1.77 ENSRNOT00000092148
Olr456
olfactory receptor 456
chr20_+_4188766 1.75 ENSRNOT00000081438
ENSRNOT00000060378
Tesb
testis specific basic protein
chr6_+_101288951 1.68 ENSRNOT00000046901
RGD1562540
RGD1562540
chr4_+_59365399 1.68 ENSRNOT00000034929
LOC689042
hypothetical protein LOC689042
chr2_+_188561429 1.66 ENSRNOT00000076458
ENSRNOT00000027867
Krtcap2
keratinocyte associated protein 2
chr10_-_89084885 1.65 ENSRNOT00000027452
Plekhh3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr2_-_137404996 1.63 ENSRNOT00000090907
LOC365791
similar to T-cell activation Rho GTPase-activating protein isoform b
chr2_+_30685840 1.58 ENSRNOT00000031385
Ccdc125
coiled-coil domain containing 125
chr4_+_87608301 1.57 ENSRNOT00000058702
Vom1r71
vomeronasal 1 receptor 71
chr4_+_119465253 1.53 ENSRNOT00000080213
Vom1r102
vomeronasal 1 receptor 102
chr4_+_1625754 1.51 ENSRNOT00000075645
Olr1248
olfactory receptor 1248
chr12_+_18516946 1.51 ENSRNOT00000029485
Dhrsx
dehydrogenase/reductase X-linked
chr8_+_42549930 1.46 ENSRNOT00000050959
Olr1260
olfactory receptor 1260
chr3_+_80555196 1.43 ENSRNOT00000067318
Arhgap1
Rho GTPase activating protein 1
chr3_-_5330466 1.37 ENSRNOT00000081193
AABR07051348.1

chr12_+_10255416 1.37 ENSRNOT00000092720
Gpr12
G protein-coupled receptor 12
chr1_-_172943853 1.35 ENSRNOT00000047040
Olr278
olfactory receptor 278
chr3_+_11476883 1.24 ENSRNOT00000072241
Naif1
nuclear apoptosis inducing factor 1
chr8_+_42338410 1.24 ENSRNOT00000073541
Olr1246
olfactory receptor 1246
chr4_-_161658519 1.22 ENSRNOT00000007634
ENSRNOT00000067895
Tulp3
tubby-like protein 3
chr20_+_28920616 1.18 ENSRNOT00000070897
P4ha1
prolyl 4-hydroxylase subunit alpha 1
chr17_-_66511870 1.14 ENSRNOT00000044662
Lgals8
galectin 8
chr8_+_61901128 1.12 ENSRNOT00000033209
LOC691110
similar to taste receptor protein 1
chr10_-_104163634 1.10 ENSRNOT00000005198
Mif4gd
MIF4G domain containing
chr1_-_172486268 1.10 ENSRNOT00000083135
Olr255
olfactory receptor 255
chr4_+_1436254 1.08 ENSRNOT00000088564
Olr1232
olfactory receptor 1232
chr3_-_158936972 1.03 ENSRNOT00000074733
Olr1254
olfactory receptor 1254
chr4_+_1601652 1.00 ENSRNOT00000072284
LOC100912152
olfactory receptor 8B3-like
chr7_-_58286770 0.98 ENSRNOT00000005258
Rab21
RAB21, member RAS oncogene family
chr11_+_61531416 0.91 ENSRNOT00000093263
Atp6v1a
ATPase H+ transporting V1 subunit A
chrX_+_92596378 0.90 ENSRNOT00000045001
Pcdh11x
protocadherin 11 X-linked
chr20_-_32628953 0.89 ENSRNOT00000000451
Gprc6a
G protein-coupled receptor, class C, group 6, member A
chrX_-_43781586 0.82 ENSRNOT00000051551
Cldn34b
claudin 34B
chr8_+_12284528 0.81 ENSRNOT00000008566
Mtmr2
myotubularin related protein 2
chr1_+_63333283 0.79 ENSRNOT00000086294
Vom1r30
vomeronasal 1 receptor 30
chr11_-_28900376 0.73 ENSRNOT00000061606
Krtap16-5
keratin associated protein 16-5
chr20_+_1197746 0.70 ENSRNOT00000045794
Olr1710
olfactory receptor 1710
chr11_+_61531571 0.68 ENSRNOT00000093467
ENSRNOT00000002727
Atp6v1a
ATPase H+ transporting V1 subunit A
chr3_-_73401074 0.68 ENSRNOT00000012848
Olr476
olfactory receptor 476
chr3_+_51687809 0.67 ENSRNOT00000087242
Scn2a
sodium voltage-gated channel alpha subunit 2
chr14_+_79401834 0.66 ENSRNOT00000082704
Tbc1d14
TBC1 domain family, member 14
chr3_-_151600140 0.64 ENSRNOT00000026451
Fer1l4
fer-1-like family member 4
chr3_-_103043741 0.61 ENSRNOT00000052294
Olr775
olfactory receptor 775
chr1_-_172465446 0.61 ENSRNOT00000088386
LOC103690410
olfactory receptor 484-like
chr3_+_38742072 0.55 ENSRNOT00000006774
Arl6ip6
ADP ribosylation factor like GTPase 6 interacting protein 6
chr6_-_38007162 0.54 ENSRNOT00000044583
AABR07063632.1

chr4_-_97567844 0.50 ENSRNOT00000042169
Vom1r89
vomeronasal 1 receptor 89
chr6_-_105160470 0.48 ENSRNOT00000008367
Adam4
a disintegrin and metalloprotease domain 4
chr18_-_33414236 0.47 ENSRNOT00000020385
Yipf5
Yip1 domain family, member 5
chr1_+_214664537 0.42 ENSRNOT00000075002
AABR07006030.1

chr7_-_144837583 0.36 ENSRNOT00000055289
Cbx5
chromobox 5
chr4_+_87516218 0.35 ENSRNOT00000090182
Vom1r66
vomeronasal 1 receptor 66
chr7_+_120202601 0.34 ENSRNOT00000082862
AC096473.3

chr5_+_136406130 0.33 ENSRNOT00000093099
Eri3
ERI1 exoribonuclease family member 3
chr1_+_260798239 0.29 ENSRNOT00000036791
Lcor
ligand dependent nuclear receptor corepressor
chr10_-_87459652 0.24 ENSRNOT00000018804
Krt40
keratin 40
chr4_-_121811539 0.24 ENSRNOT00000049591
Vom1r94
vomeronasal 1 receptor 94
chr9_+_65534704 0.23 ENSRNOT00000016730
Cflar
CASP8 and FADD-like apoptosis regulator
chrX_+_22788660 0.21 ENSRNOT00000071886
AABR07037510.1

chr8_+_42347811 0.04 ENSRNOT00000073897
LOC100912186
olfactory receptor 8B3-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 31.6 GO:0046223 toxin catabolic process(GO:0009407) mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) secondary metabolite catabolic process(GO:0090487) organic heteropentacyclic compound catabolic process(GO:1901377)
9.8 39.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
9.4 28.1 GO:0019265 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265)
8.9 26.7 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
6.2 31.1 GO:0002034 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
5.2 15.5 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
4.4 26.4 GO:0031427 response to methotrexate(GO:0031427)
3.5 13.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.3 7.0 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
2.3 9.1 GO:0072318 clathrin coat disassembly(GO:0072318)
2.1 10.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
2.1 6.2 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
1.9 11.6 GO:0050917 sensory perception of umami taste(GO:0050917)
1.7 10.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
1.7 5.0 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
1.3 5.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
1.2 10.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.1 28.5 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.0 13.2 GO:0034389 lipid particle organization(GO:0034389)
1.0 5.8 GO:0010266 response to vitamin B1(GO:0010266) response to platinum ion(GO:0070541)
0.9 24.8 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.8 8.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.7 12.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.7 26.8 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.6 3.2 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.5 9.3 GO:0042438 melanin biosynthetic process(GO:0042438)
0.5 3.0 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.5 8.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.5 24.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.4 0.8 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.4 7.5 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 9.3 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.4 7.5 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 3.1 GO:0043476 endosome to melanosome transport(GO:0035646) pigment accumulation(GO:0043476) cellular pigment accumulation(GO:0043482) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.3 1.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.3 1.4 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.2 3.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 6.0 GO:0017004 cytochrome complex assembly(GO:0017004)
0.2 1.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 24.6 GO:0010508 positive regulation of autophagy(GO:0010508)
0.2 6.4 GO:0000028 ribosomal small subunit assembly(GO:0000028) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 14.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.2 2.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 9.9 GO:0032543 mitochondrial translation(GO:0032543)
0.2 1.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 4.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 2.5 GO:0044804 nucleophagy(GO:0044804)
0.2 10.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 3.4 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.2 3.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 4.9 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 0.7 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.1 2.7 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.1 4.7 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.1 1.0 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 10.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.2 GO:1903943 negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 2.5 GO:0043171 peptide catabolic process(GO:0043171)
0.1 6.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.7 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.1 6.1 GO:0016575 histone deacetylation(GO:0016575)
0.1 3.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 11.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.8 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0 1.2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 3.3 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 33.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 4.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 5.0 GO:0030522 intracellular receptor signaling pathway(GO:0030522)
0.0 2.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.7 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.6 GO:0021549 cerebellum development(GO:0021549)
0.0 6.9 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 31.1 GO:0005577 fibrinogen complex(GO:0005577)
2.2 26.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
2.1 8.4 GO:0036156 inner dynein arm(GO:0036156)
1.4 10.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.4 13.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.2 7.5 GO:0016012 sarcoglycan complex(GO:0016012)
1.2 15.5 GO:0042627 chylomicron(GO:0042627)
1.1 8.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.7 1.4 GO:0097443 sorting endosome(GO:0097443)
0.7 9.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 17.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.5 17.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.4 2.9 GO:0016272 prefoldin complex(GO:0016272)
0.3 1.0 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
0.3 1.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.3 6.1 GO:0070822 Sin3-type complex(GO:0070822)
0.3 26.6 GO:0005776 autophagosome(GO:0005776)
0.3 13.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 3.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 26.4 GO:0005901 caveola(GO:0005901)
0.2 6.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 3.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 62.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 1.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 11.4 GO:0005811 lipid particle(GO:0005811)
0.2 1.8 GO:0030008 TRAPP complex(GO:0030008)
0.2 2.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.8 GO:0010369 chromocenter(GO:0010369)
0.1 8.0 GO:0005871 kinesin complex(GO:0005871)
0.1 11.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 49.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 2.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 11.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 3.0 GO:0005643 nuclear pore(GO:0005643)
0.0 4.7 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.1 GO:0005769 early endosome(GO:0005769)
0.0 3.5 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 28.1 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
3.3 26.4 GO:0031404 chloride ion binding(GO:0031404)
3.1 9.3 GO:0004167 dopachrome isomerase activity(GO:0004167)
2.9 8.7 GO:0032810 sterol response element binding(GO:0032810)
2.5 17.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.2 15.5 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
2.1 10.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
2.0 38.5 GO:0030955 potassium ion binding(GO:0030955)
1.9 5.8 GO:0004655 porphobilinogen synthase activity(GO:0004655)
1.8 7.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.7 8.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
1.4 39.1 GO:0019825 oxygen binding(GO:0019825)
1.4 8.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.1 3.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
1.0 9.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.9 4.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.9 6.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.8 31.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.7 6.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.6 12.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.5 22.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 2.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.4 7.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.4 11.6 GO:0008527 taste receptor activity(GO:0008527)
0.3 24.8 GO:0051213 dioxygenase activity(GO:0051213)
0.3 3.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.3 10.4 GO:0008009 chemokine activity(GO:0008009)
0.3 14.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.3 31.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 44.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 9.6 GO:0030507 spectrin binding(GO:0030507)
0.2 16.4 GO:0003777 microtubule motor activity(GO:0003777)
0.2 11.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 5.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 5.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 6.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 3.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 18.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 10.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 12.8 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 2.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 4.0 GO:0043236 laminin binding(GO:0043236)
0.1 3.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 2.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 17.0 GO:0005549 odorant binding(GO:0005549)
0.0 4.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 2.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 5.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 16.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 9.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 32.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 2.8 PID AURORA B PATHWAY Aurora B signaling
0.1 9.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 5.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 39.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
2.5 24.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.4 26.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
2.2 28.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.1 31.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.9 12.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.9 26.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.6 7.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.6 9.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.6 16.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.6 12.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 8.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 9.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 5.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 31.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 10.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 8.7 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.3 8.0 REACTOME KINESINS Genes involved in Kinesins
0.2 11.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 13.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 2.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 12.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 3.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 12.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis