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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr2e3

Z-value: 1.05

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Transcription factors associated with Nr2e3

Gene Symbol Gene ID Gene Info
Nr2e3
ENSRNOG00000050690 nuclear receptor subfamily 2, group E, member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2e3rn6_v1_chr8_-_64800467_648004670.158.6e-03Click!

Activity profile of Nr2e3 motif

Sorted Z-values of Nr2e3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_118108864 51.99 ENSRNOT00000006184
Mb
myoglobin
chr18_-_28017925 51.89 ENSRNOT00000075420
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chrX_-_142164220 44.64 ENSRNOT00000064780
Fgf13
fibroblast growth factor 13
chr15_-_14737704 44.56 ENSRNOT00000011307
Synpr
synaptoporin
chr4_+_175729726 41.73 ENSRNOT00000013230
Slco1c1
solute carrier organic anion transporter family, member 1c1
chr8_-_80631873 40.80 ENSRNOT00000091661
ENSRNOT00000080662
Unc13c
unc-13 homolog C
chr4_-_727691 31.24 ENSRNOT00000008497
Shh
sonic hedgehog
chr17_-_61332391 31.09 ENSRNOT00000034599
LOC100362965
SNRPN upstream reading frame protein-like
chr9_-_85243001 30.61 ENSRNOT00000020219
Scg2
secretogranin II
chr10_-_27366665 29.27 ENSRNOT00000004725
Gabra1
gamma-aminobutyric acid type A receptor alpha1 subunit
chr3_+_137618898 28.78 ENSRNOT00000007249
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr3_+_129599353 26.21 ENSRNOT00000008734
Snap25
synaptosomal-associated protein 25
chr15_-_6587367 25.99 ENSRNOT00000038449
Zfp385d
zinc finger protein 385D
chr11_-_71750014 25.76 ENSRNOT00000072227
LOC100911042
uncharacterized LOC100911042
chr2_+_3750094 25.63 ENSRNOT00000064743
Mctp1
multiple C2 and transmembrane domain containing 1
chr14_-_112946875 25.26 ENSRNOT00000081981
LOC103690141
coiled-coil domain-containing protein 85A-like
chr4_-_64330996 24.56 ENSRNOT00000016088
Ptn
pleiotrophin
chr8_+_53411316 23.35 ENSRNOT00000011107
ENSRNOT00000086957
Tmprss5
transmembrane protease, serine 5
chrX_+_92596378 22.20 ENSRNOT00000045001
Pcdh11x
protocadherin 11 X-linked
chr4_-_29778039 20.63 ENSRNOT00000074177
Sgce
sarcoglycan, epsilon
chr1_+_25174456 20.44 ENSRNOT00000092830
Clvs2
clavesin 2
chr6_+_110410141 19.93 ENSRNOT00000013867
Esrrb
estrogen-related receptor beta
chr8_+_70603249 19.37 ENSRNOT00000067016
ENSRNOT00000072486
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chrX_+_20423401 19.01 ENSRNOT00000093162
Wnk3
WNK lysine deficient protein kinase 3
chr4_+_130332076 18.65 ENSRNOT00000083127
Mitf
melanogenesis associated transcription factor
chr3_+_58164931 18.48 ENSRNOT00000002078
Dlx1
distal-less homeobox 1
chr10_+_53740841 17.50 ENSRNOT00000004295
Myh2
myosin heavy chain 2
chr10_-_18579632 16.94 ENSRNOT00000040737
Kcnip1
potassium voltage-gated channel interacting protein 1
chr8_+_107882219 16.88 ENSRNOT00000019902
Dzip1l
DAZ interacting zinc finger protein 1-like
chr15_+_18399733 16.59 ENSRNOT00000061158
Fam107a
family with sequence similarity 107, member A
chr14_-_17582823 16.18 ENSRNOT00000087686
LOC100911949
uncharacterized LOC100911949
chr15_+_18399515 14.79 ENSRNOT00000071273
Fam107a
family with sequence similarity 107, member A
chr6_-_67084234 14.46 ENSRNOT00000050372
Nova1
NOVA alternative splicing regulator 1
chr8_+_114897011 14.24 ENSRNOT00000074683
Twf2
twinfilin actin-binding protein 2
chr16_+_39909270 13.60 ENSRNOT00000081994
Wdr17
WD repeat domain 17
chr8_+_122076759 13.20 ENSRNOT00000012545
Clasp2
cytoplasmic linker associated protein 2
chr3_-_79728879 12.70 ENSRNOT00000012425
Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr4_+_24222500 12.61 ENSRNOT00000045346
Zfp804b
zinc finger protein 804B
chr3_-_48535909 12.52 ENSRNOT00000008148
Fap
fibroblast activation protein, alpha
chr13_+_60435946 12.52 ENSRNOT00000004342
B3galt2
Beta-1,3-galactosyltransferase 2
chr7_+_64672722 12.35 ENSRNOT00000064448
ENSRNOT00000005539
Grip1
glutamate receptor interacting protein 1
chr7_+_123102493 11.82 ENSRNOT00000038612
Aco2
aconitase 2
chr15_-_4057104 11.03 ENSRNOT00000084350
ENSRNOT00000012270
Sec24c
SEC24 homolog C, COPII coat complex component
chr1_-_178195948 10.86 ENSRNOT00000081767
Btbd10
BTB domain containing 10
chr17_-_55300998 10.42 ENSRNOT00000064331
Svil
supervillin
chr6_-_76552559 10.37 ENSRNOT00000065230
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chr2_-_22385855 10.19 ENSRNOT00000083531
Thbs4
thrombospondin 4
chr10_-_40953467 10.12 ENSRNOT00000092189
Glra1
glycine receptor, alpha 1
chrX_-_112473822 9.74 ENSRNOT00000079180
Col4a6
collagen type IV alpha 6 chain
chr5_+_122019301 9.50 ENSRNOT00000068158
Pde4b
phosphodiesterase 4B
chr2_+_247248407 9.01 ENSRNOT00000082287
Unc5c
unc-5 netrin receptor C
chrX_+_15669191 8.82 ENSRNOT00000013553
Magix
MAGI family member, X-linked
chrX_-_104932508 8.80 ENSRNOT00000075325
Nox1
NADPH oxidase 1
chr4_+_163293724 8.70 ENSRNOT00000077356
Gabarapl1
GABA type A receptor associated protein like 1
chr17_-_15467320 8.44 ENSRNOT00000072490
ENSRNOT00000093561
Ogn
osteoglycin
chr11_-_81379640 8.43 ENSRNOT00000002484
Eif4a2
eukaryotic translation initiation factor 4A2
chr6_-_76608864 8.32 ENSRNOT00000010824
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chr16_-_82439441 8.30 ENSRNOT00000040315
AABR07026539.1

chr11_+_60907015 7.96 ENSRNOT00000002797
Gtpbp8
GTP-binding protein 8 (putative)
chr2_-_250232295 7.84 ENSRNOT00000082132
Lmo4
LIM domain only 4
chr14_+_32257805 7.79 ENSRNOT00000039626
AABR07014804.1

chr14_-_21127868 7.52 ENSRNOT00000020608
ENSRNOT00000092172
Rufy3
RUN and FYVE domain containing 3
chr2_+_184230459 7.46 ENSRNOT00000074187
AABR07012054.1

chr2_-_177950517 7.12 ENSRNOT00000012792
Rapgef2
Rap guanine nucleotide exchange factor 2
chr5_-_169017295 6.96 ENSRNOT00000067481
Camta1
calmodulin binding transcription activator 1
chr19_+_37229120 6.59 ENSRNOT00000076335
Hsf4
heat shock transcription factor 4
chr7_-_144319804 6.44 ENSRNOT00000070855
LOC100912282
calcium-binding and coiled-coil domain-containing protein 1-like
chr10_+_81913689 6.44 ENSRNOT00000003780
Tob1
transducer of ErbB-2.1
chr3_-_134696654 6.43 ENSRNOT00000006454
Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_+_98627372 6.01 ENSRNOT00000030370
Dzf17
zinc finger protein 17
chr3_+_2158995 5.43 ENSRNOT00000010270
Zmynd19
zinc finger, MYND-type containing 19
chr2_-_211831551 5.41 ENSRNOT00000039225
ENSRNOT00000090561
Fam102b
family with sequence similarity 102, member B
chr5_-_128186532 5.36 ENSRNOT00000012635
Prpf38a
pre-mRNA processing factor 38A
chrX_+_1787266 4.72 ENSRNOT00000011183
Ndufb11
NADH:ubiquinone oxidoreductase subunit B11
chr3_+_56802714 4.02 ENSRNOT00000077551
Erich2
glutamate-rich 2
chrX_-_25628272 3.71 ENSRNOT00000086414
Mid1
midline 1
chr20_+_4363508 3.66 ENSRNOT00000077205
Ager
advanced glycosylation end product-specific receptor
chr2_+_58462588 3.64 ENSRNOT00000083799
Nadk2
NAD kinase 2, mitochondrial
chr1_-_78521999 3.42 ENSRNOT00000021223
Arhgap35
Rho GTPase activating protein 35
chr8_-_64154396 3.35 ENSRNOT00000031262
Bbs4
Bardet-Biedl syndrome 4
chr1_-_220974597 3.21 ENSRNOT00000088799
Kat5
lysine acetyltransferase 5
chr14_+_63095720 3.16 ENSRNOT00000006071
Ppargc1a
PPARG coactivator 1 alpha
chr18_+_30808404 3.08 ENSRNOT00000060475
Pcdhga1
protocadherin gamma subfamily A, 1
chr4_-_28224858 2.82 ENSRNOT00000091075
AABR07059632.3

chr19_-_17494516 2.44 ENSRNOT00000078786
ENSRNOT00000076138
Chd9
chromodomain helicase DNA binding protein 9
chr18_+_28370085 2.43 ENSRNOT00000083993
Matr3
matrin 3
chr3_-_157099306 2.42 ENSRNOT00000022861
Chd6
chromodomain helicase DNA binding protein 6
chr1_+_237574788 2.33 ENSRNOT00000042738
AABR07006504.1

chr9_+_2202511 2.25 ENSRNOT00000017556
Satb1
SATB homeobox 1
chr1_-_126227469 2.04 ENSRNOT00000087332
Tjp1
tight junction protein 1
chr1_+_170147300 1.47 ENSRNOT00000048075
Olr200
olfactory receptor 200
chr18_+_29506128 1.47 ENSRNOT00000003878
Slc35a4
solute carrier family 35, member A4
chr6_+_10533151 1.03 ENSRNOT00000020822
Rhoq
ras homolog family member Q
chr4_+_1371401 0.73 ENSRNOT00000071676
LOC100910899
olfactory receptor 143-like
chr10_-_95262024 0.70 ENSRNOT00000066487
Bptf
bromodomain PHD finger transcription factor
chr16_+_81665540 0.69 ENSRNOT00000026546
ENSRNOT00000092644
ENSRNOT00000073240
Grtp1
growth hormone regulated TBC protein 1
chr3_+_79728796 0.64 ENSRNOT00000068124
Kbtbd4
kelch repeat and BTB domain containing 4
chr3_-_175654707 0.60 ENSRNOT00000080191
Rbbp8nl
RBBP8 N-terminal like
chr20_-_32258286 0.59 ENSRNOT00000082114
Ddx50
DExD-box helicase 50
chr5_+_107233230 0.35 ENSRNOT00000029976
Ifne
interferon, epsilon

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 52.0 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
10.4 31.2 GO:0060769 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
8.7 26.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
6.5 51.9 GO:0002091 negative regulation of receptor internalization(GO:0002091)
6.4 44.6 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
6.3 19.0 GO:2000688 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
6.2 18.5 GO:0021898 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
6.1 24.6 GO:0060221 retinal rod cell differentiation(GO:0060221) response to kainic acid(GO:1904373) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
5.8 28.8 GO:0030070 insulin processing(GO:0030070)
5.0 19.9 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831) trophectodermal cell proliferation(GO:0001834)
4.2 12.5 GO:0097325 melanocyte proliferation(GO:0097325)
3.8 41.7 GO:0070327 thyroid hormone transport(GO:0070327)
3.7 40.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
2.9 8.8 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
2.7 18.7 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
2.2 30.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
2.1 29.3 GO:0071420 cellular response to histamine(GO:0071420)
2.0 10.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
2.0 11.8 GO:0006102 isocitrate metabolic process(GO:0006102)
1.8 7.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
1.8 14.2 GO:0042989 sequestering of actin monomers(GO:0042989)
1.6 9.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.6 3.2 GO:1904638 response to resveratrol(GO:1904638)
1.5 9.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.5 17.5 GO:0001778 plasma membrane repair(GO:0001778)
1.3 10.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
1.2 3.7 GO:1905204 response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
0.9 3.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.9 12.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.8 3.4 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.8 8.0 GO:1903690 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 16.9 GO:0045760 positive regulation of action potential(GO:0045760)
0.7 6.4 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.7 6.4 GO:0003344 pericardium morphogenesis(GO:0003344)
0.6 9.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.6 3.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.4 7.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.4 2.4 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.4 10.9 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.3 20.4 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.3 6.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 2.0 GO:0071000 response to magnetism(GO:0071000)
0.3 22.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 12.7 GO:0021762 substantia nigra development(GO:0021762)
0.2 19.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.2 1.5 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.2 9.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 3.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 2.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 8.4 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 31.1 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 7.5 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 3.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 11.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 9.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 2.4 GO:0003170 heart valve development(GO:0003170)
0.1 30.4 GO:0001558 regulation of cell growth(GO:0001558)
0.1 9.5 GO:0021510 spinal cord development(GO:0021510)
0.1 23.4 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 16.9 GO:0060271 cilium morphogenesis(GO:0060271)
0.1 12.3 GO:0016358 dendrite development(GO:0016358)
0.1 1.0 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.4 GO:0033141 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) serine phosphorylation of STAT protein(GO:0042501)
0.0 0.7 GO:1990090 cellular response to nerve growth factor stimulus(GO:1990090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 26.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
5.1 40.8 GO:0044305 calyx of Held(GO:0044305)
3.4 20.6 GO:0016012 sarcoglycan complex(GO:0016012)
3.0 21.3 GO:0071438 invadopodium membrane(GO:0071438)
2.2 30.6 GO:0031045 dense core granule(GO:0031045)
1.9 17.5 GO:0005826 actomyosin contractile ring(GO:0005826)
1.9 44.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.4 29.3 GO:1902711 GABA-A receptor complex(GO:1902711)
1.2 9.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
1.1 8.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.8 3.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.8 11.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.6 44.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.6 7.5 GO:0071437 invadopodium(GO:0071437)
0.5 34.7 GO:0031594 neuromuscular junction(GO:0031594)
0.5 9.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 17.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 6.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 10.1 GO:0060077 inhibitory synapse(GO:0060077)
0.3 3.4 GO:0034464 BBSome(GO:0034464)
0.3 8.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 14.2 GO:0032420 stereocilium(GO:0032420)
0.3 10.4 GO:0043034 costamere(GO:0043034)
0.3 64.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 28.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 60.0 GO:0030133 transport vesicle(GO:0030133)
0.2 6.4 GO:0042734 presynaptic membrane(GO:0042734)
0.2 16.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 20.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 5.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 16.9 GO:0005814 centriole(GO:0005814)
0.1 3.2 GO:0097440 apical dendrite(GO:0097440)
0.1 2.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 3.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.7 GO:0016589 NURF complex(GO:0016589)
0.1 10.9 GO:0001650 fibrillar center(GO:0001650)
0.1 3.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 11.8 GO:0043209 myelin sheath(GO:0043209)
0.1 5.4 GO:0045202 synapse(GO:0045202)
0.1 63.7 GO:0097458 neuron part(GO:0097458)
0.0 2.3 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 8.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 3.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 24.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
5.9 29.3 GO:1904315 benzodiazepine receptor activity(GO:0008503) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
5.2 41.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
5.2 41.4 GO:0043237 laminin-1 binding(GO:0043237)
4.5 40.8 GO:0019992 diacylglycerol binding(GO:0019992)
3.9 11.8 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
3.7 51.9 GO:0042043 neurexin family protein binding(GO:0042043)
3.4 10.1 GO:0030977 taurine binding(GO:0030977)
3.3 50.0 GO:0005344 oxygen transporter activity(GO:0005344)
2.5 12.5 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
1.8 3.7 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
1.8 9.0 GO:0005042 netrin receptor activity(GO:0005042)
1.8 8.8 GO:0015252 hydrogen ion channel activity(GO:0015252)
1.6 19.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.3 12.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
1.2 7.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
1.1 30.6 GO:0042056 chemoattractant activity(GO:0042056)
1.1 48.0 GO:0048487 beta-tubulin binding(GO:0048487)
1.0 8.7 GO:0030957 Tat protein binding(GO:0030957)
0.9 26.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.9 20.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.8 19.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.7 12.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.5 6.4 GO:0045499 chemorepellent activity(GO:0045499)
0.5 9.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 14.2 GO:0003785 actin monomer binding(GO:0003785)
0.5 12.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 25.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 23.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 18.7 GO:0070888 E-box binding(GO:0070888)
0.4 8.0 GO:0002162 dystroglycan binding(GO:0002162) microtubule plus-end binding(GO:0051010)
0.3 1.0 GO:0032427 GBD domain binding(GO:0032427)
0.3 2.0 GO:0071253 connexin binding(GO:0071253)
0.3 26.0 GO:0002039 p53 binding(GO:0002039)
0.3 16.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 3.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 3.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 3.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 9.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.6 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 28.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 8.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 6.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 19.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 7.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 14.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 10.4 GO:0051015 actin filament binding(GO:0051015)
0.1 2.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 3.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 6.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 41.0 GO:0005215 transporter activity(GO:0005215)
0.0 6.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 8.0 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 31.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
1.1 24.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.5 21.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.5 26.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 9.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 3.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 9.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 8.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 8.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 10.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 6.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 15.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 10.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 41.7 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
2.1 55.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
1.7 29.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.9 10.1 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.7 11.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.6 11.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6 8.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 8.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.3 31.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 9.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 19.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 3.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 12.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 9.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 3.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 3.4 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 10.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF