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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nr5a2
Z-value: 1.47
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Transcription factors associated with Nr5a2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr5a2 | rn6_v1_chr13_-_53870428_53870428 | -0.54 | 1.7e-25 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_33656089 Show fit | 67.79 |
ENSRNOT00000024186
|
myosin heavy chain 7 |
|
| chr8_-_130429132 Show fit | 66.37 |
ENSRNOT00000026261
|
hedgehog acyltransferase-like |
|
| chr9_+_82741920 Show fit | 46.61 |
ENSRNOT00000027337
|
solute carrier family 4 member 3 |
|
| chr13_+_52625441 Show fit | 43.58 |
ENSRNOT00000012095
|
troponin I1, slow skeletal type |
|
| chr8_-_84632817 Show fit | 41.95 |
ENSRNOT00000076942
|
muscular LMNA-interacting protein |
|
| chr11_-_71419223 Show fit | 41.90 |
ENSRNOT00000002407
|
transferrin receptor |
|
| chr5_+_173640780 Show fit | 40.46 |
ENSRNOT00000027476
|
PPARGC1 and ESRR induced regulator, muscle 1 |
|
| chr4_-_176720012 Show fit | 40.00 |
ENSRNOT00000017965
|
lactate dehydrogenase B |
|
| chr12_-_30566032 Show fit | 36.09 |
ENSRNOT00000093378
|
glioblastoma amplified sequence |
|
| chr1_+_72882806 Show fit | 36.07 |
ENSRNOT00000024640
|
troponin I3, cardiac type |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr5a2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 76.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 22.6 | 67.8 | GO:1905243 | slow-twitch skeletal muscle fiber contraction(GO:0031444) response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243) |
| 4.8 | 67.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 11.1 | 66.6 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 11.1 | 66.4 | GO:1903059 | regulation of protein lipidation(GO:1903059) |
| 0.8 | 65.4 | GO:0006342 | chromatin silencing(GO:0006342) |
| 12.1 | 48.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 7.6 | 45.7 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 4.4 | 43.6 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 4.7 | 41.9 | GO:0033572 | transferrin transport(GO:0033572) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 154.5 | GO:0000786 | nucleosome(GO:0000786) |
| 1.6 | 80.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 69.4 | GO:0030018 | Z disc(GO:0030018) |
| 5.6 | 67.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 16.0 | 64.0 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 5.4 | 43.6 | GO:0005861 | troponin complex(GO:0005861) |
| 7.0 | 41.9 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 3.4 | 41.0 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 1.4 | 39.8 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.5 | 38.0 | GO:0005581 | collagen trimer(GO:0005581) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 136.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 89.9 | GO:0003779 | actin binding(GO:0003779) |
| 4.8 | 67.8 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 1.1 | 65.7 | GO:0009055 | electron carrier activity(GO:0009055) |
| 16.0 | 64.0 | GO:0030172 | troponin C binding(GO:0030172) |
| 1.8 | 49.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 43.8 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 4.7 | 41.9 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 13.7 | 41.0 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 10.0 | 40.0 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 74.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 32.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 25.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.7 | 24.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 22.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 20.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.4 | 18.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.6 | 15.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 12.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 12.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 125.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.8 | 107.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 4.3 | 77.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 2.6 | 54.0 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 2.0 | 52.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 1.4 | 41.9 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 1.1 | 37.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.2 | 25.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 1.4 | 24.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 22.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |