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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Onecut1_Cux2

Z-value: 1.61

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Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
Onecut1
ENSRNOG00000008095 one cut homeobox 1
Cux2
ENSRNOG00000001259 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut1rn6_v1_chr8_+_81766041_817660410.837.3e-81Click!
Cux2rn6_v1_chr12_+_40018937_400189370.194.9e-04Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_81639872 227.57 ENSRNOT00000047595
ENSRNOT00000090031
ENSRNOT00000081864
Hrg
histidine-rich glycoprotein
chr5_-_78985990 210.53 ENSRNOT00000009248
Ambp
alpha-1-microglobulin/bikunin precursor
chr5_-_124403195 205.42 ENSRNOT00000067850
C8a
complement C8 alpha chain
chr13_+_91080341 187.01 ENSRNOT00000000058
Crp
C-reactive protein
chr2_+_114413410 178.87 ENSRNOT00000015866
Slc2a2
solute carrier family 2 member 2
chr17_+_9736577 105.82 ENSRNOT00000066586
F12
coagulation factor XII
chr17_+_9736786 99.84 ENSRNOT00000081920
F12
coagulation factor XII
chr10_+_65767053 85.92 ENSRNOT00000078897
Vtn
vitronectin
chr7_-_119689938 84.81 ENSRNOT00000000200
Tmprss6
transmembrane protease, serine 6
chr9_+_95501778 78.22 ENSRNOT00000086805
Spp2
secreted phosphoprotein 2
chr1_+_83714347 73.09 ENSRNOT00000085245
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
chr19_+_23389375 66.70 ENSRNOT00000018629
Sall1
spalt-like transcription factor 1
chr10_+_96639924 61.82 ENSRNOT00000004756
Apoh
apolipoprotein H
chr10_+_89285855 61.30 ENSRNOT00000028033
G6pc
glucose-6-phosphatase, catalytic subunit
chr18_-_35071619 58.02 ENSRNOT00000075695
LOC100911558
serine protease inhibitor Kazal-type 3-like
chr10_+_89286047 57.23 ENSRNOT00000085831
G6pc
glucose-6-phosphatase, catalytic subunit
chr18_-_59819113 49.17 ENSRNOT00000065939
RGD1562699
RGD1562699
chr7_-_34406318 46.01 ENSRNOT00000007331
Amdhd1
amidohydrolase domain containing 1
chr3_+_142383278 41.50 ENSRNOT00000017742
Foxa2
forkhead box A2
chr3_-_72171078 36.97 ENSRNOT00000009817
Serping1
serpin family G member 1
chr1_-_137359072 33.69 ENSRNOT00000014553
Klhl25
kelch-like family member 25
chr8_+_117068582 32.23 ENSRNOT00000073559
Amt
aminomethyltransferase
chr7_-_102298522 31.83 ENSRNOT00000006273
A1bg
alpha-1-B glycoprotein
chr2_-_98610368 29.51 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr5_+_136683592 28.48 ENSRNOT00000085527
Slc6a9
solute carrier family 6 member 9
chr4_-_44136815 27.99 ENSRNOT00000086810
Tfec
transcription factor EC
chr2_-_258932200 27.29 ENSRNOT00000045905
Adgrl2
adhesion G protein-coupled receptor L2
chr2_-_235177275 26.68 ENSRNOT00000093153
LOC103691699
uncharacterized LOC103691699
chr2_+_68820615 25.45 ENSRNOT00000087007
ENSRNOT00000089504
Egf
epidermal growth factor
chr2_+_22909569 23.56 ENSRNOT00000073871
Homer1
homer scaffolding protein 1
chr2_-_178297172 19.62 ENSRNOT00000038543
Fnip2
folliculin interacting protein 2
chr2_-_252451999 18.56 ENSRNOT00000021861
Dnase2b
deoxyribonuclease 2 beta
chr19_+_60017746 16.01 ENSRNOT00000042623
Pard3
par-3 family cell polarity regulator
chr2_+_22910236 15.67 ENSRNOT00000078266
Homer1
homer scaffolding protein 1
chr8_-_122904913 15.60 ENSRNOT00000015188
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr9_+_112360419 13.13 ENSRNOT00000086682
Man2a1
mannosidase, alpha, class 2A, member 1
chr18_-_77579969 12.33 ENSRNOT00000034896
Sall3
spalt-like transcription factor 3
chr1_-_255815733 11.24 ENSRNOT00000047387
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr4_-_50312608 10.56 ENSRNOT00000010019
Fezf1
Fez family zinc finger 1
chr14_-_64476796 10.29 ENSRNOT00000029104
Gba3
glucosidase, beta, acid 3
chr10_+_80790168 9.80 ENSRNOT00000073315
ENSRNOT00000075163
Car10
carbonic anhydrase 10
chr6_-_108415093 9.48 ENSRNOT00000031650
Syndig1l
synapse differentiation inducing 1-like
chr8_-_87245951 9.36 ENSRNOT00000015299
Tmem30a
transmembrane protein 30A
chr18_-_52047816 8.98 ENSRNOT00000018368
ENSRNOT00000077491
LOC100174910
glutaredoxin-like protein
chr9_+_41096835 8.32 ENSRNOT00000033700
Amer3
APC membrane recruitment protein 3
chr6_-_72786830 7.65 ENSRNOT00000009020
Dtd2
D-tyrosyl-tRNA deacylase 2
chr1_-_170034892 6.84 ENSRNOT00000042936
Olr194
olfactory receptor 194
chr3_+_307204 6.68 ENSRNOT00000062080
Nxph2
neurexophilin 2
chr18_+_38847632 6.25 ENSRNOT00000014916
LOC102554034
ELMO domain-containing protein 2-like
chr1_+_249574954 6.17 ENSRNOT00000074100
Cstf2t
cleavage stimulation factor subunit 2, tau variant
chr5_-_28164326 6.08 ENSRNOT00000088165
Slc26a7
solute carrier family 26 member 7
chr15_+_44799334 5.51 ENSRNOT00000018599
Nefl
neurofilament light
chr1_-_264975132 5.46 ENSRNOT00000021748
Lbx1
ladybird homeobox 1
chr8_-_43192910 5.23 ENSRNOT00000060101
Olr1302
olfactory receptor 1302
chrX_-_72370044 4.98 ENSRNOT00000004224
Hdac8
histone deacetylase 8
chr2_+_46186105 4.90 ENSRNOT00000071256
LOC100910378
olfactory receptor 145-like
chr8_-_1450138 4.38 ENSRNOT00000008062
Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr3_-_165537940 4.10 ENSRNOT00000071119
ENSRNOT00000070964
Sall4
spalt-like transcription factor 4
chr5_-_62621737 4.07 ENSRNOT00000011573
Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
chr1_-_167732783 3.96 ENSRNOT00000024965
Olr44
olfactory receptor 44
chrX_-_113474164 2.91 ENSRNOT00000046804
Gucy2f
guanylate cyclase 2F
chr8_-_43055175 2.77 ENSRNOT00000074413
LOC103693054
olfactory receptor 8G1-like
chr2_+_179952227 2.65 ENSRNOT00000015081
Pdgfc
platelet derived growth factor C
chr15_+_35909279 2.62 ENSRNOT00000071711
Olr1279
olfactory receptor 1279
chr13_+_91768256 2.50 ENSRNOT00000071206
LOC681470
similar to olfactory receptor 1403
chr1_+_169944609 2.47 ENSRNOT00000023293
Olr188
olfactory receptor 188
chr4_-_170912629 2.40 ENSRNOT00000055691
Erp27
endoplasmic reticulum protein 27
chr3_+_73249710 2.33 ENSRNOT00000083865
Olr464
olfactory receptor 464
chr14_-_11546314 2.25 ENSRNOT00000090334
AABR07014355.1

chrX_-_15467875 2.09 ENSRNOT00000011207
Pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr15_-_33752665 2.05 ENSRNOT00000034102
Zfhx2
zinc finger homeobox 2
chr1_-_247985497 1.87 ENSRNOT00000078998
Ranbp6
RAN binding protein 6
chr1_+_169698323 1.86 ENSRNOT00000075652
Olr163
olfactory receptor 163
chr2_-_96032722 1.82 ENSRNOT00000015746
LOC100360846
proteasome subunit beta type 6-like
chr3_+_76035198 1.82 ENSRNOT00000080503
Olr596
olfactory receptor 596
chrX_+_124894466 1.58 ENSRNOT00000080894
Mcts1
MCTS1, re-initiation and release factor
chr14_-_34218961 1.53 ENSRNOT00000072588
LOC686911
similar to Exocyst complex component 1 (Exocyst complex component Sec3)
chr8_-_40564556 1.53 ENSRNOT00000075779
Olfr883
olfactory receptor 883
chr1_+_214375515 1.28 ENSRNOT00000024863
Taldo1
transaldolase 1
chr8_-_43908914 1.13 ENSRNOT00000072247
Olr1338
olfactory receptor 1338
chr9_-_5330815 1.10 ENSRNOT00000014548
Slc5a7
solute carrier family 5 member 7
chr4_-_10269748 1.07 ENSRNOT00000074662
Fam185a
family with sequence similarity 185, member A
chr3_-_103111795 0.82 ENSRNOT00000006622
Olr778
olfactory receptor 778
chrX_-_138148967 0.80 ENSRNOT00000033968
Frmd7
FERM domain containing 7
chr3_-_74256067 0.65 ENSRNOT00000047747
Olr522
olfactory receptor 522
chrX_-_37353156 0.45 ENSRNOT00000086120
AABR07038021.1

chrM_-_14061 0.38 ENSRNOT00000051268
Mt-nd6
mitochondrially encoded NADH dehydrogenase 6
chr8_+_42017493 0.35 ENSRNOT00000072062
LOC100911845
olfactory receptor 143-like
chr3_-_76626605 0.33 ENSRNOT00000051292
Olr625
olfactory receptor 625
chr5_+_57845819 0.32 ENSRNOT00000017712
Nudt2
nudix hydrolase 2
chr2_+_143475323 0.08 ENSRNOT00000044028
ENSRNOT00000015437
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr3_-_81304181 0.06 ENSRNOT00000079746
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
75.9 227.6 GO:0097037 heme export(GO:0097037)
68.6 205.7 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541)
35.8 178.9 GO:0009758 carbohydrate utilization(GO:0009758) fructose transport(GO:0015755)
31.2 187.0 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
22.2 66.7 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
21.1 210.5 GO:0018298 protein-chromophore linkage(GO:0018298)
15.5 61.8 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
15.3 46.0 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) formamide metabolic process(GO:0043606)
13.8 41.5 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
12.2 73.1 GO:0009804 coumarin metabolic process(GO:0009804)
11.9 118.5 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
8.1 32.2 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
7.8 85.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
7.7 84.8 GO:0097264 self proteolysis(GO:0097264)
5.9 194.5 GO:0019835 cytolysis(GO:0019835)
3.4 37.0 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
3.2 25.5 GO:0007262 STAT protein import into nucleus(GO:0007262)
3.1 58.0 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
2.8 11.2 GO:0045900 negative regulation of translational elongation(GO:0045900)
2.7 16.0 GO:0003383 apical constriction(GO:0003383)
2.6 10.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.6 39.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
2.6 28.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
2.6 10.3 GO:1903015 cellular oligosaccharide catabolic process(GO:0051692) regulation of exo-alpha-sialidase activity(GO:1903015)
1.8 5.5 GO:0033693 neurofilament bundle assembly(GO:0033693)
1.7 15.6 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.7 5.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.2 13.1 GO:0006013 mannose metabolic process(GO:0006013)
1.2 18.6 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.9 4.4 GO:0006553 lysine metabolic process(GO:0006553)
0.8 9.4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.8 6.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.7 12.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.7 78.2 GO:0046849 bone remodeling(GO:0046849)
0.6 5.5 GO:0048664 neuron fate determination(GO:0048664)
0.5 32.7 GO:0006446 regulation of translational initiation(GO:0006446)
0.4 1.6 GO:0002188 translation reinitiation(GO:0002188)
0.4 6.1 GO:0019532 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.3 7.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.3 1.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 1.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.2 2.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 1.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.2 4.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 14.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 19.6 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.1 2.9 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 4.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.5 GO:0051601 exocyst localization(GO:0051601)
0.1 3.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 8.3 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 2.9 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 24.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
56.9 227.6 GO:0061474 phagolysosome membrane(GO:0061474)
29.3 205.4 GO:0005579 membrane attack complex(GO:0005579)
14.3 85.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
4.8 61.8 GO:0042627 chylomicron(GO:0042627)
2.9 66.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.7 16.0 GO:0033269 internode region of axon(GO:0033269)
2.2 269.4 GO:0072562 blood microparticle(GO:0072562)
1.9 178.9 GO:0031526 brush border membrane(GO:0031526)
1.8 5.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.5 170.2 GO:0030175 filopodium(GO:0030175)
1.4 4.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.9 118.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.6 11.2 GO:1990124 CCR4-NOT complex(GO:0030014) messenger ribonucleoprotein complex(GO:1990124)
0.6 23.0 GO:0043034 costamere(GO:0043034)
0.4 33.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 6.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 13.1 GO:0005801 cis-Golgi network(GO:0005801)
0.2 339.5 GO:0005615 extracellular space(GO:0005615)
0.1 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 23.2 GO:0098793 presynapse(GO:0098793)
0.1 1.8 GO:0005839 proteasome core complex(GO:0005839)
0.1 1.5 GO:0000145 exocyst(GO:0000145)
0.1 9.4 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 15.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 21.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 7.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
42.1 210.5 GO:0019862 IgA binding(GO:0019862)
26.7 187.0 GO:0001849 complement component C1q binding(GO:0001849)
23.7 118.5 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
20.6 61.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
20.2 242.4 GO:0001848 complement binding(GO:0001848)
19.9 178.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
10.3 227.6 GO:0019865 immunoglobulin binding(GO:0019865)
7.8 39.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
6.6 46.0 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
3.7 85.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
3.4 10.3 GO:0017042 glycosylceramidase activity(GO:0017042)
2.8 19.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
2.6 73.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
2.2 28.5 GO:0005283 sodium:amino acid symporter activity(GO:0005283) glycine transmembrane transporter activity(GO:0015187)
2.0 68.4 GO:0004407 histone deacetylase activity(GO:0004407)
1.5 25.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.3 15.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.3 290.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.2 18.6 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
1.0 11.2 GO:0035613 RNA stem-loop binding(GO:0035613)
1.0 4.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.0 13.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.5 58.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 7.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 41.5 GO:0046332 SMAD binding(GO:0046332)
0.4 16.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 6.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 5.5 GO:0043274 phospholipase binding(GO:0043274)
0.2 1.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 4.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.2 27.3 GO:0030165 PDZ domain binding(GO:0030165)
0.2 9.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 2.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 2.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 32.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 1.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 10.9 GO:0005549 odorant binding(GO:0005549)
0.0 4.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 13.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.3 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 338.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
4.1 85.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
3.1 187.0 PID IL6 7 PATHWAY IL6-mediated signaling events
2.9 680.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.3 25.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.8 31.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.6 16.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.2 11.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 3.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
17.0 187.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
11.6 242.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
10.5 178.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
8.6 205.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
2.9 118.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
2.6 253.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
1.8 41.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.2 28.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.1 85.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.9 16.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.6 13.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.4 5.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 4.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 2.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 9.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 46.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 4.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.3 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism