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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax1_Pax9

Z-value: 0.54

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Transcription factors associated with Pax1_Pax9

Gene Symbol Gene ID Gene Info
Pax1
ENSRNOG00000024882 paired box 1
Pax9
ENSRNOG00000008826 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax1rn6_v1_chr3_+_141577504_141577504-0.344.2e-10Click!
Pax9rn6_v1_chr6_+_77608624_77608624-0.249.6e-06Click!

Activity profile of Pax1_Pax9 motif

Sorted Z-values of Pax1_Pax9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_179307095 30.64 ENSRNOT00000021193
Bcat1
branched chain amino acid transaminase 1
chr2_+_220298245 20.21 ENSRNOT00000022625
Plppr4
phospholipid phosphatase related 4
chrX_+_118084890 19.19 ENSRNOT00000065293
Htr2c
5-hydroxytryptamine receptor 2C
chr4_+_79557854 13.59 ENSRNOT00000013145
Npy
neuropeptide Y
chr20_+_13778178 13.12 ENSRNOT00000058314
Gstt4
glutathione S-transferase, theta 4
chr4_+_79573998 13.08 ENSRNOT00000074351
LOC100912228
pro-neuropeptide Y-like
chr18_-_1946840 11.77 ENSRNOT00000041878
Abhd3
abhydrolase domain containing 3
chr3_+_128828331 10.71 ENSRNOT00000045393
Plcb4
phospholipase C, beta 4
chr15_+_67092304 10.57 ENSRNOT00000040244
AABR07018646.1

chr1_-_18511695 10.29 ENSRNOT00000075402
AABR07000583.1

chr8_+_70603249 9.80 ENSRNOT00000067016
ENSRNOT00000072486
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr1_-_220502272 8.96 ENSRNOT00000041238
Klc2
kinesin light chain 2
chr1_-_178196294 8.88 ENSRNOT00000067170
Btbd10
BTB domain containing 10
chr5_-_57896475 7.85 ENSRNOT00000017903
RGD1561916
similar to testes development-related NYD-SP22 isoform 1
chr12_+_7208850 6.94 ENSRNOT00000001219
Katnal1
katanin catalytic subunit A1 like 1
chr5_-_39689824 6.82 ENSRNOT00000046713
AABR07047606.1

chr20_+_7484550 6.74 ENSRNOT00000044395
Anks1a
ankyrin repeat and sterile alpha motif domain containing 1A
chr1_+_18353812 6.73 ENSRNOT00000029394
AABR07000581.1

chr1_-_19522171 6.67 ENSRNOT00000045386
AABR07000595.1

chr4_+_174692331 6.52 ENSRNOT00000011770
Plekha5
pleckstrin homology domain containing A5
chr3_-_15433252 5.48 ENSRNOT00000008817
Lhx6
LIM homeobox 6
chr9_-_65737538 4.81 ENSRNOT00000014939
Trak2
trafficking kinesin protein 2
chr20_+_7484800 4.02 ENSRNOT00000081604
Anks1a
ankyrin repeat and sterile alpha motif domain containing 1A
chr16_-_24788740 3.96 ENSRNOT00000018952
Npy1r
neuropeptide Y receptor Y1
chr6_+_26390689 3.77 ENSRNOT00000079762
ENSRNOT00000091528
Ift172
intraflagellar transport 172
chr11_+_43329700 3.47 ENSRNOT00000060892
Olr1540
olfactory receptor 1540
chr1_+_198682230 3.15 ENSRNOT00000023995
Znf48
zinc finger protein 48
chr8_+_126411829 3.00 ENSRNOT00000013450
Azi2
5-azacytidine induced 2
chrX_-_157172068 2.85 ENSRNOT00000087962
Dusp9
dual specificity phosphatase 9
chr2_+_124150224 2.58 ENSRNOT00000078650
Spata5
spermatogenesis associated 5
chr5_-_50068706 2.50 ENSRNOT00000084643
Orc3
origin recognition complex, subunit 3
chr1_-_165997751 2.38 ENSRNOT00000050227
P2ry6
pyrimidinergic receptor P2Y6
chrX_-_83788325 2.23 ENSRNOT00000037149
Satl1
spermidine/spermine N1-acetyl transferase-like 1
chr16_-_24788456 1.88 ENSRNOT00000079412
Npy1r
neuropeptide Y receptor Y1
chr12_+_37709860 1.30 ENSRNOT00000086244
Mphosph9
M-phase phosphoprotein 9
chr17_-_79676499 1.05 ENSRNOT00000022711
Itga8
integrin subunit alpha 8
chr3_+_2490518 1.04 ENSRNOT00000015099
Anapc2
anaphase promoting complex subunit 2
chr8_+_43355060 0.93 ENSRNOT00000043206
Olr1309
olfactory receptor 1309
chr9_-_53732858 0.88 ENSRNOT00000029204
Nemp2
nuclear envelope integral membrane protein 2
chr6_+_53401109 0.79 ENSRNOT00000014763
Twist1
twist family bHLH transcription factor 1
chr9_-_17880706 0.67 ENSRNOT00000031549
Aars2
alanyl-tRNA synthetase 2, mitochondrial
chr18_+_64114933 0.63 ENSRNOT00000022364
Mc5r
melanocortin 5 receptor
chr6_+_135270871 0.48 ENSRNOT00000051685
ENSRNOT00000079048
Zfp839
zinc finger protein 839
chr3_+_147609095 0.32 ENSRNOT00000041456
Srxn1
sulfiredoxin 1
chr7_+_2435553 0.19 ENSRNOT00000065593
Prim1
primase (DNA) subunit 1
chr3_+_2877293 0.15 ENSRNOT00000061855
Lcn5
lipocalin 5
chr9_-_100306194 0.14 ENSRNOT00000087584
RGD1563692
similar to hypothetical protein FLJ22671
chr8_-_55276070 0.04 ENSRNOT00000041555
LOC108351703
60S ribosomal protein L27a-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax1_Pax9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 30.6 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
6.4 19.2 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583)
5.3 26.7 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
2.7 10.8 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
1.6 4.8 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
1.0 3.0 GO:0044565 dendritic cell proliferation(GO:0044565)
0.8 2.5 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.6 5.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 6.9 GO:0051013 microtubule severing(GO:0051013)
0.5 20.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.4 5.8 GO:0030432 peristalsis(GO:0030432)
0.4 2.2 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.4 10.0 GO:0007602 phototransduction(GO:0007602)
0.4 1.1 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.3 2.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.3 8.9 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.3 3.8 GO:0061525 hindgut development(GO:0061525)
0.3 11.8 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.3 0.8 GO:0033128 negative regulation of histone phosphorylation(GO:0033128) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2 0.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 9.0 GO:0008088 axo-dendritic transport(GO:0008088)
0.1 2.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.0 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 7.8 GO:0043623 cellular protein complex assembly(GO:0043623)
0.0 6.5 GO:0061458 reproductive system development(GO:0061458)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.7 7.8 GO:0002177 manchette(GO:0002177)
0.6 3.8 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.6 9.0 GO:0035253 ciliary rootlet(GO:0035253)
0.3 10.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 4.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 39.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 13.6 GO:0043195 terminal bouton(GO:0043195)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 8.9 GO:0001650 fibrillar center(GO:0001650)
0.1 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 6.9 GO:0000922 spindle pole(GO:0000922)
0.0 5.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.3 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 30.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
6.4 19.2 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
2.0 11.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.8 20.2 GO:0042577 lipid phosphatase activity(GO:0042577)
1.2 5.8 GO:0001601 peptide YY receptor activity(GO:0001601)
0.9 26.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.8 2.4 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.7 2.2 GO:0019809 spermidine binding(GO:0019809)
0.5 10.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.5 6.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.4 6.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 4.8 GO:0050811 GABA receptor binding(GO:0050811)
0.3 13.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 7.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 10.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 2.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 2.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 0.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 9.0 GO:0019894 kinesin binding(GO:0019894)
0.1 0.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 30.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 10.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 2.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 30.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
1.4 19.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 9.0 REACTOME KINESINS Genes involved in Kinesins
0.2 10.7 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.2 2.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 2.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 20.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1