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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax3

Z-value: 0.39

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Transcription factors associated with Pax3

Gene Symbol Gene ID Gene Info
Pax3
ENSRNOG00000013670 paired box 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax3rn6_v1_chr9_-_84101172_84101172-0.164.6e-03Click!

Activity profile of Pax3 motif

Sorted Z-values of Pax3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_39958239 12.83 ENSRNOT00000050368
Myl2
myosin light chain 2
chr2_+_201289357 12.65 ENSRNOT00000067358
Tbx15
T-box 15
chr2_+_208750356 9.20 ENSRNOT00000041562
Chia
chitinase, acidic
chr1_+_261281543 8.36 ENSRNOT00000018890
Ankrd2
ankyrin repeat domain 2
chr15_+_28295368 8.09 ENSRNOT00000013786
Slc39a2
solute carrier family 39 member 2
chr9_-_79530821 6.77 ENSRNOT00000085619
Mreg
melanoregulin
chr5_+_119903507 6.04 ENSRNOT00000033933
Raver2
ribonucleoprotein, PTB-binding 2
chr15_+_57290849 5.90 ENSRNOT00000014909
Cpb2
carboxypeptidase B2
chrX_-_110230610 5.80 ENSRNOT00000093401
Serpina7
serpin family A member 7
chr9_-_10170428 5.62 ENSRNOT00000073048
LOC316124
similar to gonadotropin-regulated long chain acyl-CoA synthetase
chr4_+_120156659 4.64 ENSRNOT00000050584
Dnajb8
DnaJ heat shock protein family (Hsp40) member B8
chr4_-_84131030 4.63 ENSRNOT00000012196
Cpvl
carboxypeptidase, vitellogenic-like
chr12_-_18227991 4.48 ENSRNOT00000072986
AABR07035501.1

chr2_-_90568486 3.88 ENSRNOT00000059380
LOC100910852
uncharacterized LOC100910852
chr2_-_173836854 3.75 ENSRNOT00000074278
Wdr49
WD repeat domain 49
chr2_-_206222248 3.57 ENSRNOT00000026075
Olfml3
olfactomedin-like 3
chr3_+_172195844 3.50 ENSRNOT00000034915
Npepl1
aminopeptidase-like 1
chr4_+_14109864 3.44 ENSRNOT00000076349
RGD1565355
similar to fatty acid translocase/CD36
chr6_-_94932806 3.35 ENSRNOT00000006346
Ccdc175
coiled-coil domain containing 175
chr2_-_132301073 3.09 ENSRNOT00000058288
RGD1563562
similar to GTPase activating protein testicular GAP1
chr10_+_56710965 2.90 ENSRNOT00000087121
Asgr2
asialoglycoprotein receptor 2
chr11_+_76833761 2.74 ENSRNOT00000042650
Uts2b
urotensin 2B
chrY_-_1398030 2.43 ENSRNOT00000088719
Usp9y
ubiquitin specific peptidase 9, Y-linked
chr1_-_227965386 2.41 ENSRNOT00000028491
Ms4a2
membrane spanning 4-domains A2
chr17_+_15845931 2.33 ENSRNOT00000092083
Card19
caspase recruitment domain family, member 19
chr6_-_42630983 2.23 ENSRNOT00000071977
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr15_-_6587367 2.22 ENSRNOT00000038449
Zfp385d
zinc finger protein 385D
chr8_+_116311078 2.11 ENSRNOT00000037363
Rassf1
Ras association domain family member 1
chr5_+_162246217 1.52 ENSRNOT00000046115
Oog1
oogenesin 1
chr5_+_126698582 1.35 ENSRNOT00000012427
Cdcp2
CUB domain containing protein 2
chr1_+_172264473 1.27 ENSRNOT00000050651
Olr246
olfactory receptor 246
chr20_-_11620945 1.17 ENSRNOT00000079725
Krtap12-2
keratin associated protein 12-2
chr18_+_28409955 1.17 ENSRNOT00000026989
Paip2
poly(A) binding protein interacting protein 2
chr17_-_44853430 1.15 ENSRNOT00000085156
Olr1654
olfactory receptor 1654
chr11_-_78456200 0.98 ENSRNOT00000067251
ENSRNOT00000036179
Tp63
tumor protein p63
chr11_-_84037938 0.98 ENSRNOT00000002327
Abcf3
ATP binding cassette subfamily F member 3
chr4_+_148544958 0.98 ENSRNOT00000050694
Olr825
olfactory receptor 825
chr1_+_225690756 0.94 ENSRNOT00000027498
Psbpc2
prostatic steroid-binding protein C2
chr3_-_78942535 0.83 ENSRNOT00000008924
Olr731
olfactory receptor 731
chr8_-_36842370 0.77 ENSRNOT00000074011
Pate3
prostate and testis expressed 3
chr12_+_16899025 0.75 ENSRNOT00000001716
Psmg3
proteasome assembly chaperone 3
chr12_-_21761487 0.74 ENSRNOT00000082910
LOC102550456
TSC22 domain family protein 4-like
chr1_+_127604197 0.73 ENSRNOT00000018463
Lins1
lines homolog 1
chr15_-_28092023 0.72 ENSRNOT00000090835
Eddm3b
epididymal protein 3B
chr1_-_80221710 0.70 ENSRNOT00000091687
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
chr3_-_173166369 0.67 ENSRNOT00000090602
AABR07054887.1

chr3_-_73484676 0.64 ENSRNOT00000040041
Olr481
olfactory receptor 481
chr7_-_116963281 0.64 ENSRNOT00000082058
ENSRNOT00000012306
Tsta3
tissue specific transplantation antigen P35B
chr3_-_167270512 0.62 ENSRNOT00000075542
AABR07054708.1

chr13_+_92465894 0.61 ENSRNOT00000086988
LOC103693685
olfactory receptor 6P1
chr16_+_50152008 0.60 ENSRNOT00000019237
Klkb1
kallikrein B1
chr8_-_21341431 0.58 ENSRNOT00000044249
Olr1192
olfactory receptor 1192
chr18_+_25962855 0.50 ENSRNOT00000078822
Camk4
calcium/calmodulin-dependent protein kinase IV
chr3_+_5167685 0.40 ENSRNOT00000046109
Lcn4
lipocalin 4
chr5_-_22799349 0.37 ENSRNOT00000076204
Asph
aspartate-beta-hydroxylase
chr3_+_20993205 0.36 ENSRNOT00000010465
Olr419
olfactory receptor 419
chr10_-_86645529 0.30 ENSRNOT00000011947
Med24
mediator complex subunit 24
chr16_-_20511818 0.30 ENSRNOT00000026567
Lsm4
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
chr1_+_172728264 0.27 ENSRNOT00000075297
Olr267
olfactory receptor 267
chr15_+_28050975 0.23 ENSRNOT00000050944
LOC103693384
epididymal secretory protein E3-beta-like
chr5_-_29870735 0.21 ENSRNOT00000012963
Ripk2
receptor-interacting serine-threonine kinase 2
chrX_+_86126157 0.19 ENSRNOT00000006992
Klhl4
kelch-like family member 4
chr10_-_35800120 0.17 ENSRNOT00000004361
Maml1
mastermind-like transcriptional coactivator 1
chr6_-_105316024 0.17 ENSRNOT00000009483
Med6
mediator complex subunit 6
chr17_-_45746753 0.17 ENSRNOT00000077475
RGD1564243
similar to brain Zn-finger protein
chr8_+_21305250 0.17 ENSRNOT00000050206
Olr1193
olfactory receptor 1193
chr6_-_138662365 0.16 ENSRNOT00000066209
ENSRNOT00000084892
Ighm
immunoglobulin heavy constant mu
chr4_-_168656673 0.15 ENSRNOT00000009341
Gpr19
G protein-coupled receptor 19
chr5_-_137515690 0.14 ENSRNOT00000049593
LOC100912421
olfactory receptor 2D2-like
chr10_-_60942351 0.06 ENSRNOT00000026926
Olr1509
olfactory receptor 1509
chr1_+_79122608 0.03 ENSRNOT00000023663
Ceacam3
carcinoembryonic antigen-related cell adhesion molecule 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
2.0 5.9 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
1.8 9.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.6 8.4 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) regulation of myoblast proliferation(GO:2000291)
0.5 5.8 GO:0070327 thyroid hormone transport(GO:0070327)
0.4 4.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 6.8 GO:0032401 establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402)
0.3 8.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.2 1.0 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 12.7 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.2 0.6 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350)
0.2 2.4 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 0.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 2.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 2.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162)
0.0 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.2 GO:0070671 positive regulation of T-helper 1 cell differentiation(GO:0045627) response to interleukin-12(GO:0070671)
0.0 0.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.5 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 2.9 GO:0030282 bone mineralization(GO:0030282)
0.0 6.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 2.2 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 2.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.7 GO:0051412 response to corticosterone(GO:0051412)
0.0 2.7 GO:0008217 regulation of blood pressure(GO:0008217)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
1.4 12.8 GO:0097512 cardiac myofibril(GO:0097512)
0.4 2.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 8.4 GO:0000791 euchromatin(GO:0000791)
0.1 6.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 16.7 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.5 9.2 GO:0004568 chitinase activity(GO:0004568)
1.2 4.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.7 5.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 12.8 GO:0003785 actin monomer binding(GO:0003785)
0.4 2.4 GO:0019767 IgE receptor activity(GO:0019767)
0.4 12.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 8.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 5.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 4.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.5 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 0.3 GO:0042731 PH domain binding(GO:0042731)
0.1 1.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 2.0 GO:0002039 p53 binding(GO:0002039)
0.0 2.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 2.7 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 5.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 12.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.2 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway