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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Phox2a

Z-value: 0.33

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Transcription factors associated with Phox2a

Gene Symbol Gene ID Gene Info
Phox2a
ENSRNOG00000019706 paired-like homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Phox2arn6_v1_chr1_+_166893734_166893734-0.434.7e-16Click!

Activity profile of Phox2a motif

Sorted Z-values of Phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_84506328 10.24 ENSRNOT00000064754
Mlip
muscular LMNA-interacting protein
chr14_-_19159923 8.24 ENSRNOT00000003879
Afp
alpha-fetoprotein
chr4_+_180291389 6.92 ENSRNOT00000002465
Sspn
sarcospan
chrX_+_78042859 6.38 ENSRNOT00000003286
Lpar4
lysophosphatidic acid receptor 4
chr11_+_58624198 5.08 ENSRNOT00000002091
Gap43
growth associated protein 43
chr14_-_84334066 4.49 ENSRNOT00000006160
Mtfp1
mitochondrial fission process 1
chr1_-_215033460 4.37 ENSRNOT00000044565
Dusp8
dual specificity phosphatase 8
chr3_-_165537940 4.33 ENSRNOT00000071119
ENSRNOT00000070964
Sall4
spalt-like transcription factor 4
chr2_+_113984646 4.30 ENSRNOT00000016799
Tnik
TRAF2 and NCK interacting kinase
chr17_-_84247038 3.80 ENSRNOT00000068553
Nebl
nebulette
chr20_-_13994794 3.32 ENSRNOT00000093466
Ggt5
gamma-glutamyltransferase 5
chr4_-_18396035 2.87 ENSRNOT00000034692
Sema3a
semaphorin 3A
chr13_+_90943255 2.76 ENSRNOT00000011539
Vsig8
V-set and immunoglobulin domain containing 8
chr6_+_80108655 2.72 ENSRNOT00000006137
Gemin2
gem (nuclear organelle) associated protein 2
chrX_-_111191932 2.68 ENSRNOT00000088050
ENSRNOT00000083613
Morc4
MORC family CW-type zinc finger 4
chr20_+_42966140 2.39 ENSRNOT00000000707
Marcks
myristoylated alanine rich protein kinase C substrate
chr5_+_36566783 2.10 ENSRNOT00000077650
Fbxl4
F-box and leucine-rich repeat protein 4
chr3_+_14889510 2.08 ENSRNOT00000080760
Dab2ip
DAB2 interacting protein
chr2_-_158156444 2.02 ENSRNOT00000088559
Veph1
ventricular zone expressed PH domain-containing 1
chr2_+_158097843 2.01 ENSRNOT00000016541
Ptx3
pentraxin 3
chr2_+_239415046 1.79 ENSRNOT00000072196
Cxxc4
CXXC finger protein 4
chr2_+_145174876 1.70 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr7_-_126382449 1.58 ENSRNOT00000085540
7530416G11Rik
RIKEN cDNA 7530416G11 gene
chrM_+_2740 1.51 ENSRNOT00000047550
Mt-nd1
mitochondrially encoded NADH dehydrogenase 1
chr1_-_101095594 1.38 ENSRNOT00000027944
Fcgrt
Fc fragment of IgG receptor and transporter
chr4_-_58250798 1.31 ENSRNOT00000048436
Klf14
Kruppel-like factor 14
chr2_-_170301348 1.06 ENSRNOT00000088131
Si
sucrase-isomaltase
chr5_+_58995249 0.89 ENSRNOT00000023411
Ccdc107
coiled-coil domain containing 107
chr7_-_140291620 0.88 ENSRNOT00000088323
Adcy6
adenylate cyclase 6
chr9_-_30844199 0.87 ENSRNOT00000017169
Col19a1
collagen type XIX alpha 1 chain
chr2_+_118910587 0.87 ENSRNOT00000065518
Zfp639
zinc finger protein 639
chr13_-_90405591 0.79 ENSRNOT00000006849
Vangl2
VANGL planar cell polarity protein 2
chr10_-_88000423 0.79 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
Krt32
keratin 32
chr7_-_143967484 0.66 ENSRNOT00000081758
Sp7
Sp7 transcription factor
chr9_+_15166118 0.54 ENSRNOT00000020432
Mdfi
MyoD family inhibitor
chr7_+_9294709 0.43 ENSRNOT00000048396
Olr1065
olfactory receptor 1065
chr1_-_276228574 0.32 ENSRNOT00000021746
Gucy2g
guanylate cyclase 2G
chr16_-_29936307 0.27 ENSRNOT00000088707
Ddx60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_69982592 0.25 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr12_-_2174131 0.22 ENSRNOT00000001313
Pcp2
Purkinje cell protein 2
chr2_+_252090669 0.19 ENSRNOT00000020656
Lpar3
lysophosphatidic acid receptor 3
chr1_-_190370499 0.19 ENSRNOT00000084389
AABR07005618.1

chr12_-_35979193 0.05 ENSRNOT00000071104
Tmem132b
transmembrane protein 132B

Network of associatons between targets according to the STRING database.

First level regulatory network of Phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.7 2.9 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.5 2.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.5 8.2 GO:0042448 progesterone metabolic process(GO:0042448)
0.5 5.1 GO:0016198 axon choice point recognition(GO:0016198)
0.5 2.0 GO:1903015 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
0.4 3.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.4 10.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 2.4 GO:0031584 activation of phospholipase D activity(GO:0031584) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.3 4.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 0.8 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 4.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 6.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 4.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.9 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
0.1 1.4 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.1 4.5 GO:0000266 mitochondrial fission(GO:0000266)
0.1 2.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.3 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.9 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 1.5 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 1.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.2 GO:0032060 bleb assembly(GO:0032060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:1990032 parallel fiber(GO:1990032)
0.6 5.1 GO:0032584 growth cone membrane(GO:0032584)
0.6 2.4 GO:0042585 germinal vesicle(GO:0042585) dendritic branch(GO:0044307)
0.4 2.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.4 6.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 0.8 GO:0060187 cell pole(GO:0060187)
0.1 10.2 GO:0016605 PML body(GO:0016605)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.3 GO:0000792 heterochromatin(GO:0000792)
0.0 3.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 5.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.6 3.3 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.4 1.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.3 2.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.3 2.0 GO:0001849 complement component C1q binding(GO:0001849)
0.3 1.4 GO:0019770 IgG receptor activity(GO:0019770)
0.3 4.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 2.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 3.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 10.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 4.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.9 GO:0043621 protein self-association(GO:0043621)
0.0 1.8 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 8.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 8.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.0 ST ADRENERGIC Adrenergic Pathway
0.1 1.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 2.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 2.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA