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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pitx1

Z-value: 0.90

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Transcription factors associated with Pitx1

Gene Symbol Gene ID Gene Info
Pitx1
ENSRNOG00000011423 paired-like homeodomain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pitx1rn6_v1_chr17_+_8878270_88782700.497.0e-21Click!

Activity profile of Pitx1 motif

Sorted Z-values of Pitx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_224824799 44.24 ENSRNOT00000024757
Slc22a6
solute carrier family 22 member 6
chr10_+_53818818 29.09 ENSRNOT00000057260
Myh8
myosin heavy chain 8
chr20_+_20378861 25.44 ENSRNOT00000091044
Ank3
ankyrin 3
chrX_+_159158194 24.12 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
Fhl1
four and a half LIM domains 1
chr3_+_55910177 23.41 ENSRNOT00000009969
Klhl41
kelch-like family member 41
chr3_+_113318563 22.44 ENSRNOT00000089230
Ckmt1
creatine kinase, mitochondrial 1
chr3_+_80075991 21.39 ENSRNOT00000080266
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr4_-_51199570 20.89 ENSRNOT00000010788
Slc13a1
solute carrier family 13 member 1
chr8_+_33514042 18.03 ENSRNOT00000081614
ENSRNOT00000081525
Kcnj1
potassium voltage-gated channel subfamily J member 1
chr3_+_56355431 17.88 ENSRNOT00000037188
Myo3b
myosin IIIB
chr5_-_135025084 17.44 ENSRNOT00000018766
Tspan1
tetraspanin 1
chr1_+_137799185 17.35 ENSRNOT00000083590
ENSRNOT00000092778
Agbl1
ATP/GTP binding protein-like 1
chr4_+_65801505 16.03 ENSRNOT00000018331
Tmem213
transmembrane protein 213
chr10_-_88036040 16.02 ENSRNOT00000018851
Krt13
keratin 13
chr3_+_117421604 15.93 ENSRNOT00000008860
ENSRNOT00000008857
Slc12a1
solute carrier family 12 member 1
chr7_-_49741540 15.82 ENSRNOT00000006523
Myf6
myogenic factor 6
chr10_+_104368247 14.53 ENSRNOT00000006519
Llgl2
LLGL2, scribble cell polarity complex component
chr18_-_24929091 14.40 ENSRNOT00000019596
Proc
protein C
chr14_+_84306466 14.28 ENSRNOT00000006116
Sec14l4
SEC14-like lipid binding 4
chr5_+_29538380 14.25 ENSRNOT00000010845
Calb1
calbindin 1
chr8_-_105462141 13.83 ENSRNOT00000066731
ENSRNOT00000078760
Clstn2
calsyntenin 2
chr20_-_5123073 13.80 ENSRNOT00000001126
Apom
apolipoprotein M
chr8_-_114449956 13.49 ENSRNOT00000056414
Col6a6
collagen type VI alpha 6 chain
chr7_+_94795214 12.77 ENSRNOT00000005722
Deptor
DEP domain containing MTOR-interacting protein
chr18_+_56193978 11.49 ENSRNOT00000041533
ENSRNOT00000080177
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr1_+_89008117 11.34 ENSRNOT00000028401
Hspb6
heat shock protein family B (small) member 6
chr13_+_85818427 11.26 ENSRNOT00000077227
ENSRNOT00000006117
Rxrg
retinoid X receptor gamma
chr3_+_112242270 11.25 ENSRNOT00000080533
ENSRNOT00000082876
Capn3
calpain 3
chr15_+_83707735 11.10 ENSRNOT00000057843
Klf5
Kruppel-like factor 5
chr10_-_82887301 10.89 ENSRNOT00000035894
Itga3
integrin subunit alpha 3
chr9_+_81816872 10.81 ENSRNOT00000041407
Plcd4
phospholipase C, delta 4
chr11_-_35697072 10.43 ENSRNOT00000039999
Erg
ERG, ETS transcription factor
chr2_-_259382765 9.77 ENSRNOT00000091407
St6galnac3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr2_+_45104305 9.75 ENSRNOT00000014559
Esm1
endothelial cell-specific molecule 1
chr8_+_62925357 9.61 ENSRNOT00000011074
ENSRNOT00000090588
Stra6
stimulated by retinoic acid 6
chr16_+_2670618 9.61 ENSRNOT00000030102
Il17rd
interleukin 17 receptor D
chr5_-_6186329 9.38 ENSRNOT00000012610
Sulf1
sulfatase 1
chr4_+_130332076 9.30 ENSRNOT00000083127
Mitf
melanogenesis associated transcription factor
chr7_-_44771458 8.91 ENSRNOT00000006007
Alx1
ALX homeobox 1
chr1_-_166943592 8.89 ENSRNOT00000026962
Folr1
folate receptor 1
chr6_+_56625650 8.80 ENSRNOT00000008803
Meox2
mesenchyme homeobox 2
chr4_-_171591882 8.77 ENSRNOT00000009328
Eps8
epidermal growth factor receptor pathway substrate 8
chrX_+_51286737 8.47 ENSRNOT00000035692
Dmd
dystrophin
chr10_-_88050622 8.31 ENSRNOT00000019037
Krt15
keratin 15
chrX_-_25628272 8.08 ENSRNOT00000086414
Mid1
midline 1
chr7_+_60015998 7.67 ENSRNOT00000007309
Best3
bestrophin 3
chr18_-_74542077 7.50 ENSRNOT00000078519
Slc14a2
solute carrier family 14 member 2
chr17_-_84830185 7.27 ENSRNOT00000040697
Skida1
SKI/DACH domain containing 1
chr5_+_15043955 7.17 ENSRNOT00000047093
Rp1
retinitis pigmentosa 1
chr1_-_2846200 7.11 ENSRNOT00000017688
Sash1
SAM and SH3 domain containing 1
chr10_-_87407634 7.05 ENSRNOT00000016657
Krt23
keratin 23
chr7_-_143497108 6.73 ENSRNOT00000048613
Krt76
keratin 76
chr2_-_206222248 6.70 ENSRNOT00000026075
Olfml3
olfactomedin-like 3
chr5_+_138300107 6.66 ENSRNOT00000047151
Cldn19
claudin 19
chr2_-_147392062 6.58 ENSRNOT00000021535
Tm4sf1
transmembrane 4 L six family member 1
chr1_+_268189277 6.43 ENSRNOT00000065001
Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr9_+_81631409 6.29 ENSRNOT00000089580
Pnkd
paroxysmal nonkinesigenic dyskinesia
chr7_-_117732339 6.13 ENSRNOT00000092917
ENSRNOT00000020696
Foxh1
forkhead box H1
chr1_-_256734719 5.87 ENSRNOT00000021546
ENSRNOT00000089456
Myof
myoferlin
chr5_+_104362971 5.76 ENSRNOT00000058520
Adamtsl1
ADAMTS-like 1
chr2_+_241909832 5.64 ENSRNOT00000047975
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
chr4_-_30276372 5.25 ENSRNOT00000011823
Pon1
paraoxonase 1
chr9_+_46962288 5.16 ENSRNOT00000082146
Il1r1
interleukin 1 receptor type 1
chr9_-_30844199 4.98 ENSRNOT00000017169
Col19a1
collagen type XIX alpha 1 chain
chr3_-_113423473 4.93 ENSRNOT00000064982
Serinc4
serine incorporator 4
chr6_+_23337571 4.81 ENSRNOT00000011832
RGD1304963
similar to hypothetical protein MGC38716
chr10_-_55851235 4.62 ENSRNOT00000010790
Gucy2d
guanylate cyclase 2D, retinal
chr4_-_16669368 4.59 ENSRNOT00000007608
Pclo
piccolo (presynaptic cytomatrix protein)
chr1_+_107344904 4.26 ENSRNOT00000082582
Gas2
growth arrest-specific 2
chr2_+_225645568 4.15 ENSRNOT00000017878
Abca4
ATP binding cassette subfamily A member 4
chr2_-_60657712 3.70 ENSRNOT00000040348
Rai14
retinoic acid induced 14
chr20_-_7943575 3.67 ENSRNOT00000066897
Tulp1
tubby like protein 1
chr5_+_21830882 3.56 ENSRNOT00000008901
Chd7
chromodomain helicase DNA binding protein 7
chr7_-_11648322 3.52 ENSRNOT00000026871
Gadd45b
growth arrest and DNA-damage-inducible, beta
chr8_-_55171718 3.33 ENSRNOT00000080736
LOC689959
hypothetical protein LOC689959
chr2_-_45480798 3.30 ENSRNOT00000066764
Snx18
sorting nexin 18
chr11_+_30550141 3.20 ENSRNOT00000002866
Hunk
hormonally upregulated Neu-associated kinase
chr12_+_12374790 3.17 ENSRNOT00000001347
Tecpr1
tectonin beta-propeller repeat containing 1
chr11_-_69201380 3.13 ENSRNOT00000085618
Mylk
myosin light chain kinase
chrM_+_8599 3.11 ENSRNOT00000049683
Mt-cox3
mitochondrially encoded cytochrome C oxidase III
chr1_-_278042312 3.10 ENSRNOT00000018693
Ablim1
actin-binding LIM protein 1
chr2_+_145174876 3.10 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr1_+_99648658 3.07 ENSRNOT00000039531
Klk13
kallikrein related-peptidase 13
chr3_-_91195981 3.04 ENSRNOT00000056935
RGD1309730
similar to RIKEN cDNA B230118H07
chr3_-_50120392 3.01 ENSRNOT00000006175
Fign
fidgetin, microtubule severing factor
chr7_-_70476340 2.98 ENSRNOT00000006800
Arhgef25
Rho guanine nucleotide exchange factor 25
chr4_-_125929002 2.94 ENSRNOT00000083271
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_+_3662763 2.90 ENSRNOT00000017828
Mctp1
multiple C2 and transmembrane domain containing 1
chr10_-_63176463 2.84 ENSRNOT00000004717
Slc6a4
solute carrier family 6 member 4
chr15_+_3938075 2.68 ENSRNOT00000065644
Camk2g
calcium/calmodulin-dependent protein kinase II gamma
chr1_+_220854403 2.67 ENSRNOT00000080520
ENSRNOT00000052315
ENSRNOT00000078619
Efemp2
EGF-containing fibulin-like extracellular matrix protein 2
chr3_+_113423693 2.55 ENSRNOT00000021091
Hypk
Huntingtin interacting protein K
chr18_+_71395830 2.55 ENSRNOT00000024831
Smad7
SMAD family member 7
chr4_+_155532109 2.50 ENSRNOT00000077245
Nanog
Nanog homeobox
chr1_+_124983452 2.39 ENSRNOT00000021262
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr2_-_210282352 2.39 ENSRNOT00000075653
Slc6a17
solute carrier family 6 member 17
chr19_-_38120578 2.32 ENSRNOT00000026873
Esrp2
epithelial splicing regulatory protein 2
chr16_+_49185560 2.25 ENSRNOT00000014360
Helt
helt bHLH transcription factor
chr3_-_44086006 2.16 ENSRNOT00000034449
ENSRNOT00000082604
Ermn
ermin
chr1_-_24191908 2.15 ENSRNOT00000061157
Sgk1
serum/glucocorticoid regulated kinase 1
chr14_-_108372068 2.14 ENSRNOT00000088116
ENSRNOT00000091143
ENSRNOT00000085886
RGD1305110
similar to KIAA1841 protein
chr8_+_42511520 2.14 ENSRNOT00000042974
Olr1259
olfactory receptor 1259
chr1_-_66254989 2.07 ENSRNOT00000025981
ENSRNOT00000079249
Zfp606
zinc finger protein 606
chr9_-_121972055 2.01 ENSRNOT00000089735
AABR07068851.1
clusterin-like protein 1
chr6_-_103949275 2.00 ENSRNOT00000047825
AABR07065012.1

chr4_+_30313102 1.98 ENSRNOT00000012657
Asb4
ankyrin repeat and SOCS box-containing 4
chr11_+_57207656 1.79 ENSRNOT00000038207
ENSRNOT00000085754
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_12916784 1.79 ENSRNOT00000004589
Zfp13
zinc finger protein 13
chr1_-_4011161 1.71 ENSRNOT00000044778
Stxbp5
syntaxin binding protein 5
chr3_-_76718684 1.69 ENSRNOT00000050173
Olr631
olfactory receptor 631
chr3_+_97723901 1.66 ENSRNOT00000080416
Mpped2
metallophosphoesterase domain containing 2
chr8_-_42381997 1.55 ENSRNOT00000052324
LOC100912580
olfactory receptor 8B3-like
chr4_+_1535100 1.49 ENSRNOT00000074575
LOC100912488
olfactory receptor 147-like
chr3_-_113423149 1.49 ENSRNOT00000021008
Serinc4
serine incorporator 4
chr2_+_203768729 1.44 ENSRNOT00000018895
Igsf3
immunoglobulin superfamily, member 3
chr1_-_227067915 1.39 ENSRNOT00000067235
Ms4a18
membrane spanning 4-domains A18
chr12_+_47179664 1.32 ENSRNOT00000001551
Cabp1
calcium binding protein 1
chr3_-_74631883 1.26 ENSRNOT00000013215
Olr539
olfactory receptor 539
chr12_+_13097269 1.20 ENSRNOT00000087094
Rac1
ras-related C3 botulinum toxin substrate 1
chr10_-_55560422 1.16 ENSRNOT00000006883
Rangrf
RAN guanine nucleotide release factor
chr18_-_37096132 0.97 ENSRNOT00000041188
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
chr20_-_8574082 0.94 ENSRNOT00000048845
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr11_-_80981415 0.93 ENSRNOT00000002499
ENSRNOT00000002496
St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr4_+_72480540 0.92 ENSRNOT00000007163
Olr812
olfactory receptor 812
chr16_+_23317953 0.82 ENSRNOT00000075287
AABR07024972.1

chr18_+_56544652 0.76 ENSRNOT00000024171
Pde6a
phosphodiesterase 6A
chr8_-_68525911 0.73 ENSRNOT00000080588
ENSRNOT00000011109
Iqch
IQ motif containing H
chr9_-_23454316 0.66 ENSRNOT00000072826
Cyp2ac1
cytochrome P450, family 2, subfamily ac, polypeptide 1
chr11_+_81796891 0.66 ENSRNOT00000058402
Crygs
crystallin, gamma S
chr7_+_120176530 0.64 ENSRNOT00000087548
Triobp
TRIO and F-actin binding protein
chr3_-_73049251 0.47 ENSRNOT00000048041
Olr450
olfactory receptor 450
chr10_-_85435016 0.45 ENSRNOT00000079921
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr6_-_103807838 0.43 ENSRNOT00000058328
AABR07064998.1

chr12_-_35979193 0.39 ENSRNOT00000071104
Tmem132b
transmembrane protein 132B
chr8_+_41936959 0.38 ENSRNOT00000042601
Olr1222
olfactory receptor 1222
chr12_-_39697465 0.35 ENSRNOT00000078683
Vps29
VPS29 retromer complex component
chr6_-_104409005 0.31 ENSRNOT00000040965
Ccdc177
coiled-coil domain containing 177
chr1_-_8885967 0.29 ENSRNOT00000016102
Gje1
gap junction protein, epsilon 1
chr5_+_135997052 0.27 ENSRNOT00000024921
Tctex1d4
Tctex1 domain containing 4
chr1_-_216744066 0.25 ENSRNOT00000087961
Nap1l4
nucleosome assembly protein 1-like 4
chr7_+_5593735 0.22 ENSRNOT00000042179
Olr917
olfactory receptor 917
chr19_-_43215077 0.22 ENSRNOT00000082151
Aars
alanyl-tRNA synthetase
chr3_+_73161632 0.20 ENSRNOT00000077865
Olr458
olfactory receptor 458
chr2_+_46066780 0.20 ENSRNOT00000073226
LOC108350225
olfactory receptor 8B8-like
chr20_+_28989491 0.16 ENSRNOT00000074524
Pla2g12b
phospholipase A2, group XIIB
chr16_+_14319777 0.15 ENSRNOT00000038771
Lrit2
leucine-rich repeat, Ig-like and transmembrane domains 2
chr2_+_128461224 0.15 ENSRNOT00000018872
Jade1
jade family PHD finger 1
chr5_+_133864798 0.15 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr5_+_49311030 0.08 ENSRNOT00000010850
Cnr1
cannabinoid receptor 1
chr7_-_120490061 0.06 ENSRNOT00000016247
Slc16a8
solute carrier family 16 member 8
chr2_+_60966789 0.02 ENSRNOT00000025490
Slc45a2
solute carrier family 45, member 2
chr16_+_10277775 0.02 ENSRNOT00000090679
Rbp3
retinol binding protein 3
chr1_+_256955652 0.01 ENSRNOT00000020411
Lgi1
leucine-rich, glioma inactivated 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 44.2 GO:0031427 response to methotrexate(GO:0031427)
6.4 25.4 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
6.3 19.0 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
6.0 18.0 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
5.3 15.9 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
3.7 11.2 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
3.6 14.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
3.6 14.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
3.2 9.6 GO:0046865 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
3.1 9.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
3.0 8.9 GO:0060974 cell migration involved in heart formation(GO:0060974)
2.9 8.8 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
2.9 17.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
2.8 8.5 GO:0021629 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
2.6 29.1 GO:0030049 muscle filament sliding(GO:0030049)
2.4 9.7 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
2.4 14.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
2.3 11.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628)
2.0 6.1 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
2.0 15.8 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
1.9 5.6 GO:1905203 regulation of connective tissue replacement(GO:1905203)
1.8 7.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.8 8.8 GO:0001757 somite specification(GO:0001757)
1.7 10.4 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
1.7 5.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.7 23.4 GO:0031272 regulation of pseudopodium assembly(GO:0031272) regulation of myoblast proliferation(GO:2000291)
1.6 9.3 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
1.4 4.1 GO:0006649 phospholipid transfer to membrane(GO:0006649)
1.3 16.0 GO:0043587 tongue morphogenesis(GO:0043587)
1.3 6.3 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
1.2 7.5 GO:0071918 urea transmembrane transport(GO:0071918)
1.2 3.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.1 21.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.1 8.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.9 11.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.9 9.6 GO:0046548 retinal rod cell development(GO:0046548)
0.8 14.3 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.8 10.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.8 2.4 GO:0015820 leucine transport(GO:0015820)
0.8 3.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 4.6 GO:0099526 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.7 8.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 3.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.6 8.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.6 9.8 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.6 2.8 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.5 24.1 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.5 6.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 5.9 GO:0001778 plasma membrane repair(GO:0001778)
0.4 6.7 GO:0048733 sebaceous gland development(GO:0048733)
0.4 2.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.4 11.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.4 14.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.4 2.5 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.4 1.8 GO:0010728 regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.4 11.3 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.3 0.9 GO:1990743 protein sialylation(GO:1990743)
0.3 6.4 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.3 1.2 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.3 1.3 GO:0010649 regulation of cell communication by electrical coupling(GO:0010649)
0.3 10.8 GO:0007340 acrosome reaction(GO:0007340)
0.2 8.9 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.2 1.2 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.2 2.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 2.7 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.2 3.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 13.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.2 GO:0001967 suckling behavior(GO:0001967)
0.2 0.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 2.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 16.8 GO:0021549 cerebellum development(GO:0021549)
0.1 1.4 GO:0032808 lacrimal gland development(GO:0032808)
0.1 3.0 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 16.5 GO:0050821 protein stabilization(GO:0050821)
0.1 2.3 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 1.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 7.8 GO:0043271 negative regulation of ion transport(GO:0043271)
0.0 0.1 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
0.0 3.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:0046037 GMP metabolic process(GO:0046037)
0.0 1.0 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.6 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 4.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 3.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.4 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 2.2 GO:0001763 morphogenesis of a branching structure(GO:0001763)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
2.9 11.5 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
2.8 13.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
2.5 25.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.9 29.1 GO:0032982 myosin filament(GO:0032982)
1.8 23.4 GO:0031143 pseudopodium(GO:0031143)
1.5 4.6 GO:0044317 rod spherule(GO:0044317)
1.3 17.9 GO:0032426 stereocilium tip(GO:0032426)
1.0 6.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.9 5.6 GO:0005955 calcineurin complex(GO:0005955)
0.8 2.4 GO:0035838 growing cell tip(GO:0035838)
0.7 5.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 7.2 GO:0097542 ciliary tip(GO:0097542)
0.5 8.5 GO:0031527 filopodium membrane(GO:0031527)
0.5 8.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 46.3 GO:0005901 caveola(GO:0005901)
0.4 2.2 GO:0033269 internode region of axon(GO:0033269)
0.3 5.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 24.4 GO:0045095 keratin filament(GO:0045095)
0.3 2.5 GO:0016342 catenin complex(GO:0016342)
0.2 2.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 7.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.2 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.2 GO:0060091 kinocilium(GO:0060091)
0.1 3.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 9.8 GO:0043197 dendritic spine(GO:0043197)
0.1 7.1 GO:0005882 intermediate filament(GO:0005882)
0.1 11.2 GO:0030018 Z disc(GO:0030018)
0.1 1.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 19.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 9.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 22.4 GO:0043209 myelin sheath(GO:0043209)
0.1 9.4 GO:0005795 Golgi stack(GO:0005795)
0.1 26.7 GO:0014069 postsynaptic density(GO:0014069)
0.1 17.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 24.8 GO:0005925 focal adhesion(GO:0005925)
0.1 14.6 GO:0016324 apical plasma membrane(GO:0016324)
0.1 48.2 GO:0005794 Golgi apparatus(GO:0005794)
0.1 3.0 GO:0030017 sarcomere(GO:0030017)
0.1 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 9.5 GO:0016607 nuclear speck(GO:0016607)
0.0 2.8 GO:0010008 endosome membrane(GO:0010008)
0.0 3.7 GO:0005938 cell cortex(GO:0005938)
0.0 16.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 3.3 GO:0030141 secretory granule(GO:0030141)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 44.2 GO:0031404 chloride ion binding(GO:0031404)
5.3 15.9 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
4.8 14.4 GO:0070012 oligopeptidase activity(GO:0070012)
4.5 18.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
3.6 14.2 GO:0099510 calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
3.2 9.7 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
3.2 22.4 GO:0004111 creatine kinase activity(GO:0004111)
2.3 9.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.2 8.9 GO:0051870 methotrexate binding(GO:0051870)
2.1 47.0 GO:0000146 microfilament motor activity(GO:0000146)
2.0 9.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
1.9 21.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.9 11.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
1.7 5.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
1.7 5.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
1.4 5.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.3 6.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
1.2 9.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.1 7.5 GO:0015204 urea transmembrane transporter activity(GO:0015204)
1.0 11.2 GO:0031432 titin binding(GO:0031432)
1.0 11.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 2.8 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.9 14.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.8 4.1 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.8 3.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.6 17.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 10.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 8.5 GO:0050998 vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998)
0.4 2.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.4 14.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 16.5 GO:0030507 spectrin binding(GO:0030507)
0.3 7.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 9.6 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 10.9 GO:0001968 fibronectin binding(GO:0001968)
0.3 2.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 2.5 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.3 22.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 4.6 GO:0005522 profilin binding(GO:0005522)
0.2 7.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 0.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 8.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.2 3.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 1.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 13.8 GO:0016209 antioxidant activity(GO:0016209)
0.1 3.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 14.4 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 7.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 8.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 2.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 25.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 10.0 GO:0008017 microtubule binding(GO:0008017)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.5 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 14.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 14.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 10.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 14.6 NABA COLLAGENS Genes encoding collagen proteins
0.3 11.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 13.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 14.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 2.5 PID IFNG PATHWAY IFN-gamma pathway
0.2 3.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 9.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 19.0 PID CMYB PATHWAY C-MYB transcription factor network
0.2 9.6 PID FGF PATHWAY FGF signaling pathway
0.2 5.2 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 5.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 4.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.1 PID AURORA B PATHWAY Aurora B signaling
0.1 15.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.7 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 1.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 44.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.5 20.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.4 14.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.0 37.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.7 25.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.7 10.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.7 11.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 10.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.4 12.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 6.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 8.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 7.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 6.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 5.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 4.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 3.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 4.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 11.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 5.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 5.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 6.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 6.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 7.1 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 3.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects