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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pitx3

Z-value: 1.07

Motif logo

Transcription factors associated with Pitx3

Gene Symbol Gene ID Gene Info
ENSRNOG00000019194 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pitx3rn6_v1_chr1_-_265899958_2658999580.271.0e-06Click!

Activity profile of Pitx3 motif

Sorted Z-values of Pitx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_29152442 42.59 ENSRNOT00000079774
myosin binding protein C, slow type
chr12_+_23752844 31.57 ENSRNOT00000001953
scavenger receptor cysteine rich family member with 4 domains
chr18_+_63098144 29.10 ENSRNOT00000024968
cell death-inducing DFFA-like effector a
chr1_+_91716383 28.08 ENSRNOT00000016919
solute carrier family 7 member 9
chr7_+_11769400 26.36 ENSRNOT00000044417
junctional sarcoplasmic reticulum protein 1
chr9_-_93404883 24.54 ENSRNOT00000025024
neuromedin U receptor 1
chr12_-_48048540 23.17 ENSRNOT00000071335
ENSRNOT00000078807
myosin 1H
chr7_-_145174771 23.17 ENSRNOT00000055270
glycosylation dependent cell adhesion molecule 1
chr1_-_102255459 22.56 ENSRNOT00000067392
USH1 protein network component harmonin
chr1_+_215666628 22.43 ENSRNOT00000040598
ENSRNOT00000066135
ENSRNOT00000051425
ENSRNOT00000080339
ENSRNOT00000066896
ENSRNOT00000063918
troponin T3, fast skeletal type
chr10_-_88050622 22.41 ENSRNOT00000019037
keratin 15
chr10_-_40525008 22.12 ENSRNOT00000016440
solute carrier family 36 member 2
chr12_+_22153983 21.79 ENSRNOT00000080775
ENSRNOT00000001894
procollagen C-endopeptidase enhancer
chr2_-_187706300 21.71 ENSRNOT00000092349
ENSRNOT00000026414
transmembrane protein 79
chr1_+_48273611 21.56 ENSRNOT00000022254
ENSRNOT00000022068
solute carrier family 22 member 1
chr1_-_216663720 21.30 ENSRNOT00000078944
ENSRNOT00000077409
cyclin-dependent kinase inhibitor 1C
chr18_+_35574002 20.27 ENSRNOT00000093442
ENSRNOT00000070817
ENSRNOT00000093356
myotilin
chr1_+_263554453 20.24 ENSRNOT00000070861
ATP binding cassette subfamily C member 2
chr9_+_37727942 19.98 ENSRNOT00000016511
ENSRNOT00000074276
myotilin-like
chr3_-_10371240 19.88 ENSRNOT00000012075
argininosuccinate synthase 1
chr10_+_40247436 19.74 ENSRNOT00000079830
glutathione peroxidase 3
chr1_-_80689171 18.89 ENSRNOT00000045574
basal cell adhesion molecule (Lutheran blood group)
chr2_+_189423559 18.24 ENSRNOT00000029076
tropomyosin 3
chr19_-_24875137 17.52 ENSRNOT00000006152
adhesion G protein-coupled receptor E5
chr2_+_256964860 17.46 ENSRNOT00000073547
interferon-induced protein 44-like
chr3_-_80012750 16.68 ENSRNOT00000018154
nuclear receptor subfamily 1, group H, member 3
chr10_-_94576512 16.65 ENSRNOT00000035474
intercellular adhesion molecule 2
chrX_-_32095867 16.56 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr12_+_38828444 16.15 ENSRNOT00000001809
4-hydroxyphenylpyruvate dioxygenase
chr13_+_78805347 15.81 ENSRNOT00000003748
serpin family C member 1
chr2_-_200762492 15.73 ENSRNOT00000056172
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_-_80331626 15.60 ENSRNOT00000022577

chr1_+_189359853 15.08 ENSRNOT00000055083
acyl-CoA synthetase medium-chain family member 1
chrM_+_10160 14.75 ENSRNOT00000042928
mitochondrially encoded NADH dehydrogenase 4
chr8_+_115151627 14.60 ENSRNOT00000064252
abhydrolase domain containing 14b
chr12_+_25264400 14.31 ENSRNOT00000087656
GTF2I repeat domain containing 1
chr10_+_55626741 14.30 ENSRNOT00000008492
aurora kinase B
chr10_-_70337532 14.18 ENSRNOT00000055963
schlafen family member 13
chr4_-_10517832 14.08 ENSRNOT00000039953
ENSRNOT00000083964
gamma-secretase activating protein
chr5_-_137321121 13.83 ENSRNOT00000027414
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr12_+_25264192 13.65 ENSRNOT00000079392
GTF2I repeat domain containing 1
chrX_+_77230180 13.31 ENSRNOT00000085879
toll-like receptor 13
chr9_-_113598477 13.27 ENSRNOT00000035606
ENSRNOT00000084884
ralA binding protein 1
chr4_-_120840111 12.67 ENSRNOT00000022231
minichromosome maintenance complex component 2
chr17_-_10004321 12.64 ENSRNOT00000042394
fibroblast growth factor receptor 4
chr14_+_84447885 12.60 ENSRNOT00000009150
GATS protein-like 3
chr8_+_128044084 12.47 ENSRNOT00000019106
xylulokinase
chr16_+_20109200 12.31 ENSRNOT00000079784
Janus kinase 3
chr10_-_40419054 12.18 ENSRNOT00000039040
coiled-coil domain containing 69
chr2_+_125752130 11.98 ENSRNOT00000038703
FAT atypical cadherin 4
chr8_-_21831668 11.96 ENSRNOT00000027897
collagen type V alpha 3 chain
chr10_-_47775055 11.95 ENSRNOT00000057864
mitogen-activated protein kinase 7-like
chr11_+_83855753 11.63 ENSRNOT00000030686
similar to 60S ribosomal protein L12
chr13_-_91981432 10.96 ENSRNOT00000004637

chr1_+_214005791 10.86 ENSRNOT00000071831
EF-hand calcium-binding domain-containing protein 4A-like
chr16_+_83358116 10.61 ENSRNOT00000031109
RAB20, member RAS oncogene family
chr1_+_141821916 10.55 ENSRNOT00000071574
enoyl-CoA hydratase, short chain 1
chr2_+_260884337 10.54 ENSRNOT00000032808
crystallin zeta
chr4_-_157433467 10.51 ENSRNOT00000028965
lymphocyte activating 3
chr17_+_44556039 10.50 ENSRNOT00000086540
protease, serine 16
chrX_+_71174699 10.47 ENSRNOT00000076957
ENSRNOT00000090192
ENSRNOT00000040334
mediator complex subunit 12
chr10_-_49007089 10.45 ENSRNOT00000073706
mitogen-activated protein kinase 7
chr7_-_80796670 10.06 ENSRNOT00000010539
actin-binding Rho activating protein
chr1_+_101554642 10.00 ENSRNOT00000028474
branched chain amino acid transaminase 2
chr10_-_109909646 9.98 ENSRNOT00000074362
ENSRNOT00000088907
dicarbonyl and L-xylulose reductase
chr11_+_84399417 9.96 ENSRNOT00000048306
ENSRNOT00000091595
ATP binding cassette subfamily C member 5
chr4_+_179481263 9.93 ENSRNOT00000021284
electron transfer flavoprotein regulatory factor 1
chr2_-_100249811 9.91 ENSRNOT00000086760
hepatocyte nuclear factor 4, gamma
chr1_+_81499821 9.88 ENSRNOT00000027100
Ly6/Plaur domain containing 3
chr7_+_120067379 9.87 ENSRNOT00000011270
CDC42 effector protein 1
chr3_-_12502859 9.77 ENSRNOT00000022814
zinc finger and BTB domain containing 43
chr1_-_80609836 9.67 ENSRNOT00000091647
ENSRNOT00000046169
apolipoprotein C1
chr9_+_16529579 9.67 ENSRNOT00000067894
pre T-cell antigen receptor alpha
chr8_+_76754492 9.60 ENSRNOT00000085727
myosin IE
chr3_-_57957346 9.53 ENSRNOT00000036728
solute carrier family 25 member 12
chr16_-_47535358 9.43 ENSRNOT00000040731
claudin 22
chr8_+_103459161 9.43 ENSRNOT00000074047
procollagen C-endopeptidase enhancer 2
chr10_-_86930947 9.42 ENSRNOT00000081440
topoisomerase (DNA) II alpha
chr1_-_212579057 9.40 ENSRNOT00000025446
enoyl-CoA hydratase, mitochondrial-like
chr5_+_128190708 9.37 ENSRNOT00000012492
origin recognition complex, subunit 1
chr15_-_27819376 9.30 ENSRNOT00000067400
RIKEN cDNA A930018M24 gene
chr19_+_46455761 9.30 ENSRNOT00000034012
ENSRNOT00000093392
nudix hydrolase 7
chr4_-_98995590 9.25 ENSRNOT00000008698
threonine synthase-like 2
chr16_-_21017163 9.20 ENSRNOT00000027661
myocyte enhancer factor 2B
chr7_+_11490852 9.14 ENSRNOT00000044484
cAMP responsive element binding protein 3-like 3
chr7_+_141666111 9.11 ENSRNOT00000083250

chr16_+_20020444 8.99 ENSRNOT00000024827
6-phosphogluconolactonase
chr7_-_120077612 8.87 ENSRNOT00000011750
galectin 2
chr4_-_151428894 8.79 ENSRNOT00000010556
adiponectin receptor 2
chr15_-_29548400 8.52 ENSRNOT00000078176

chr1_+_189514553 8.47 ENSRNOT00000020039
acyl-CoA synthetase medium-chain family member 3
chr1_+_221735517 8.46 ENSRNOT00000028628
ENSRNOT00000044866
splicing factor 1
chr19_-_10884047 8.39 ENSRNOT00000088196
ENSRNOT00000063791
copine 2
chr7_-_130151880 8.32 ENSRNOT00000088623
plexin B2
chr20_-_4935887 8.30 ENSRNOT00000064734
RT1 class I, locus CE4
chr1_-_77893509 7.97 ENSRNOT00000015059
glioma tumor suppressor candidate region gene 1
chr7_+_120176530 7.94 ENSRNOT00000087548
TRIO and F-actin binding protein
chr1_-_166939541 7.92 ENSRNOT00000079675
folate receptor 1
chr12_-_19294888 7.92 ENSRNOT00000001815
zinc finger protein 3
chr13_-_86451002 7.85 ENSRNOT00000043004
ENSRNOT00000027996
PBX homeobox 1
chr8_+_71914867 7.67 ENSRNOT00000023372
death-associated protein kinase 2
chr1_-_263885169 7.60 ENSRNOT00000030782
conserved helix-loop-helix ubiquitous kinase
chr5_+_107712579 7.59 ENSRNOT00000090739
methylthioadenosine phosphorylase
chr20_-_3813673 7.59 ENSRNOT00000081085
ring finger protein 1
chr1_-_216920625 7.53 ENSRNOT00000028119
oxysterol binding protein-like 5
chr3_+_132052612 7.53 ENSRNOT00000030148

chr9_-_53118613 7.50 ENSRNOT00000065581
ORMDL sphingolipid biosynthesis regulator 1
chr1_-_85317968 7.48 ENSRNOT00000026891
glia maturation factor, gamma
chr1_+_88078350 7.46 ENSRNOT00000048677
RAS guanyl releasing protein 4
chr12_-_48365784 7.43 ENSRNOT00000077317
D-amino-acid oxidase
chr3_-_110556808 7.41 ENSRNOT00000092158
ENSRNOT00000045362
similar to hypothetical protein
chr1_+_99599620 7.26 ENSRNOT00000024690
cytosolic thiouridylase subunit 1
chr5_-_173611202 7.24 ENSRNOT00000047854
agrin
chr6_+_26566494 7.24 ENSRNOT00000079292
general transcription factor IIIC subunit 2
chr5_+_151343493 7.01 ENSRNOT00000077807
WAS protein family, member 2
chr12_+_47239663 6.96 ENSRNOT00000077871
unc-119 lipid binding chaperone B
chr11_-_65845418 6.96 ENSRNOT00000091057
follistatin-like 1
chr15_-_24199341 6.92 ENSRNOT00000015553
DLG associated protein 5
chr19_-_43848937 6.85 ENSRNOT00000044844
lactate dehydrogenase D
chr16_+_69046514 6.84 ENSRNOT00000092344
RAB11 family interacting protein 1
chr7_+_117763783 6.78 ENSRNOT00000021208
major facilitator superfamily domain containing 3
chr5_+_159735008 6.63 ENSRNOT00000064310
REM2 and RAB-like small GTPase 1
chr5_+_169506138 6.62 ENSRNOT00000014904
ribosomal protein L22
chr10_+_37215937 6.60 ENSRNOT00000006567
secretion associated, Ras related GTPase 1B
chr16_+_7758996 6.60 ENSRNOT00000061063
biotinidase
chr8_-_21453190 6.58 ENSRNOT00000078192
zinc finger protein 26
chr20_+_2057878 6.50 ENSRNOT00000051480
RT1 class I, locus M6, gene 1
chr8_-_61919874 6.41 ENSRNOT00000064830
similar to human chromosome 15 open reading frame 39
chr20_+_31096214 6.40 ENSRNOT00000000676
leucine rich repeat containing 20
chr10_-_45514878 6.34 ENSRNOT00000036940
IBA57 homolog, iron-sulfur cluster assembly
chr1_+_101397828 6.32 ENSRNOT00000028189
potassium voltage-gated channel subfamily A member 7
chr3_+_55910177 6.32 ENSRNOT00000009969
kelch-like family member 41
chr3_+_170996193 6.28 ENSRNOT00000008959
SPO11, initiator of meiotic double stranded breaks
chr12_+_29012852 6.28 ENSRNOT00000002006
general transcription factor II-I repeat domain-containing protein 1-like
chr17_+_57040023 6.22 ENSRNOT00000020204
cAMP responsive element modulator
chr4_+_57378069 6.15 ENSRNOT00000080173
ENSRNOT00000011851
nuclear respiratory factor 1
chr3_-_153321352 6.14 ENSRNOT00000064824
RB transcriptional corepressor like 1
chr6_+_6908684 6.07 ENSRNOT00000079095
metastasis associated 1 family, member 3
chr20_+_49319307 6.03 ENSRNOT00000057078
autophagy related 5
chr8_+_75625174 6.02 ENSRNOT00000013742
interactor of little elongation complex ELL subunit 2
chr10_+_89352835 5.99 ENSRNOT00000028060
ribosomal protein L27
chr4_+_180062799 5.99 ENSRNOT00000021623
Ras association domain family member 8
chr12_+_29012695 5.97 ENSRNOT00000085696
general transcription factor II-I repeat domain-containing protein 1-like
chr5_+_159734838 5.95 ENSRNOT00000079905
REM2 and RAB-like small GTPase 1
chr10_-_67478848 5.94 ENSRNOT00000005325
transcription elongation factor, mitochondrial
chr3_-_119405453 5.92 ENSRNOT00000090355
signal peptide peptidase-like 2A
chr7_+_38819771 5.90 ENSRNOT00000006109
lumican
chr16_-_47537476 5.87 ENSRNOT00000050279
claudin 24
chr14_+_84282073 5.79 ENSRNOT00000078271
SEC14-like lipid binding 4
chr4_+_100277391 5.79 ENSRNOT00000086820
ENSRNOT00000084281
ENSRNOT00000017927
gamma-glutamyl carboxylase
chr6_-_91456696 5.68 ENSRNOT00000005577
ribosomal protein S29
chr16_+_70778913 5.63 ENSRNOT00000019281
hook microtubule-tethering protein 3
chr20_-_27308069 5.59 ENSRNOT00000056047
solute carrier family 25 member 16
chr12_+_25305823 5.54 ENSRNOT00000002010
GTF2I repeat domain containing 1
chr5_+_152613255 5.52 ENSRNOT00000037097
platelet-activating factor acetylhydrolase 2
chr10_-_59883839 5.43 ENSRNOT00000093579
aspartoacylase
chr19_-_26243223 5.42 ENSRNOT00000037766
zinc finger protein 791
chr5_-_136023511 5.38 ENSRNOT00000081747
ribosomal protein S8
chr6_+_123361864 5.37 ENSRNOT00000057577

chr19_+_52664322 5.36 ENSRNOT00000082754
cysteine-rich secretory protein LCCL domain containing 2
chr7_+_23854846 5.33 ENSRNOT00000037290
BPI fold containing family C
chr4_+_147692028 5.32 ENSRNOT00000014207
cullin-associated and neddylation-dissociated 2 (putative)
chr11_-_87924816 5.32 ENSRNOT00000031819
serpin family D member 1
chr17_-_78812111 5.30 ENSRNOT00000021506
DNA cross-link repair 1C
chr3_+_66673071 5.30 ENSRNOT00000034769
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chrX_-_123486814 5.28 ENSRNOT00000016993
similar to hypothetical protein FLJ22965
chr10_-_56506446 5.22 ENSRNOT00000021357
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr1_-_87174530 5.22 ENSRNOT00000089578
potassium two pore domain channel subfamily K member 6
chr5_+_58144705 5.18 ENSRNOT00000019886
galactose-1-phosphate uridylyltransferase
chr7_+_121361415 5.13 ENSRNOT00000067904
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr1_+_190555177 5.07 ENSRNOT00000021514
ubiquinol cytochrome c reductase core protein 2
chr3_+_145764932 5.05 ENSRNOT00000075257

chr5_+_173256834 5.03 ENSRNOT00000089936
cyclin L2
chr13_+_50196042 5.03 ENSRNOT00000090858
zinc finger CCCH-type containing 11A
chr5_-_61130026 5.00 ENSRNOT00000060149
solute carrier family 25, member 51
chr8_-_116993193 5.00 ENSRNOT00000026327
dystroglycan 1
chr9_-_4945352 4.85 ENSRNOT00000082530
sulfotransferase family 1C member 3
chr16_-_20562399 4.82 ENSRNOT00000031692
leucine rich repeat containing 25
chr20_+_2057689 4.82 ENSRNOT00000086007
RT1 class I, locus M6, gene 1
chr14_+_44524753 4.78 ENSRNOT00000076245
ribosomal protein L9
chr19_+_42066351 4.75 ENSRNOT00000066733
dihydroorotate dehydrogenase (quinone)
chr2_+_52397175 4.72 ENSRNOT00000082614
C-C motif chemokine ligand 28
chr5_+_173256637 4.71 ENSRNOT00000025531
cyclin L2
chr1_-_101514974 4.68 ENSRNOT00000044788
protein phosphatase 1, regulatory subunit 15A
chr2_+_93656946 4.66 ENSRNOT00000013905
zinc finger AN1-type containing 1
chr9_+_95274707 4.63 ENSRNOT00000045163
UDP glucuronosyltransferase family 1 member A5
chr8_+_118926478 4.63 ENSRNOT00000028426
coiled-coil domain containing 12
chr7_+_144899534 4.63 ENSRNOT00000065270
coatomer protein complex, subunit zeta 1
chr12_+_30165694 4.62 ENSRNOT00000001211
argininosuccinate lyase
chr10_-_37215899 4.59 ENSRNOT00000006356
SEC24 homolog A, COPII coat complex component
chr17_+_45188248 4.56 ENSRNOT00000091609
zinc finger and SCAN domain containing 26
chr8_+_129240528 4.55 ENSRNOT00000083427
ribosomal protein L14
chr3_-_112320762 4.51 ENSRNOT00000081074
ENSRNOT00000078893
ENSRNOT00000089857
zinc finger protein 106
chr3_+_66673246 4.47 ENSRNOT00000081338
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr11_-_68197772 4.45 ENSRNOT00000003060
ENSRNOT00000081875
Hspb associated protein 1
chr19_-_19727081 4.43 ENSRNOT00000020700
adenylate cyclase 7
chr14_-_114649173 4.41 ENSRNOT00000083528
spectrin, beta, non-erythrocytic 1
chr4_-_163528220 4.39 ENSRNOT00000090813
killer cell lectin-like receptor family I member 1
chr10_-_56300077 4.38 ENSRNOT00000064401
tumor necrosis factor superfamily member 12
chr10_-_110431792 4.36 ENSRNOT00000054922
hypothetical protein LOC619574

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 24.5 GO:0000053 argininosuccinate metabolic process(GO:0000053)
7.5 22.5 GO:0042732 D-xylose metabolic process(GO:0042732)
7.2 21.7 GO:0070268 cuticle development(GO:0042335) cornification(GO:0070268)
7.0 28.1 GO:0015811 L-cystine transport(GO:0015811)
5.5 22.1 GO:0010958 regulation of amino acid import(GO:0010958)
5.5 16.6 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
5.1 20.2 GO:0050787 detoxification of mercury ion(GO:0050787)
4.8 33.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
4.5 22.6 GO:1904970 brush border assembly(GO:1904970)
4.3 42.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
4.2 16.7 GO:0048550 negative regulation of pinocytosis(GO:0048550)
4.2 29.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
4.1 12.3 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
4.0 12.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
4.0 15.8 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
3.6 14.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
3.5 21.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
3.3 10.0 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
3.2 12.6 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
3.1 9.3 GO:0034034 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
2.8 19.7 GO:0002238 response to molecule of fungal origin(GO:0002238)
2.7 16.2 GO:0006572 tyrosine catabolic process(GO:0006572)
2.6 7.9 GO:0060974 cell migration involved in heart formation(GO:0060974)
2.6 15.7 GO:0034757 negative regulation of iron ion transport(GO:0034757)
2.6 7.7 GO:2000424 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
2.5 7.6 GO:0010034 response to acetate(GO:0010034)
2.5 7.6 GO:0070638 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
2.5 7.5 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
2.5 7.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
2.4 9.7 GO:0010916 regulation of phosphatidylcholine catabolic process(GO:0010899) regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
2.4 7.2 GO:0045887 positive regulation of synaptic growth at neuromuscular junction(GO:0045887) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) regulation of protein geranylgeranylation(GO:2000539) positive regulation of protein geranylgeranylation(GO:2000541)
2.4 9.5 GO:0089712 malate-aspartate shuttle(GO:0043490) L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712)
2.2 11.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
2.2 21.6 GO:0015697 quaternary ammonium group transport(GO:0015697)
2.1 10.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
1.9 9.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.9 9.3 GO:0006566 threonine metabolic process(GO:0006566) short-chain fatty acid biosynthetic process(GO:0051790)
1.8 5.5 GO:0009644 response to high light intensity(GO:0009644)
1.8 12.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.8 5.3 GO:0010265 SCF complex assembly(GO:0010265)
1.8 10.6 GO:0090383 phagosome acidification(GO:0090383)
1.7 10.5 GO:0071499 cellular response to laminar fluid shear stress(GO:0071499)
1.7 5.2 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
1.6 9.6 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
1.6 9.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
1.6 4.7 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
1.5 5.9 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
1.5 7.3 GO:0034227 tRNA thio-modification(GO:0034227)
1.4 5.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.4 4.3 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.4 4.1 GO:0046078 pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
1.3 10.5 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245)
1.3 5.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.3 6.3 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
1.3 6.3 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
1.2 7.5 GO:0006041 glucosamine metabolic process(GO:0006041)
1.2 6.0 GO:0034334 adherens junction maintenance(GO:0034334)
1.2 4.7 GO:1903576 response to L-arginine(GO:1903576)
1.2 4.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
1.2 3.5 GO:0044375 regulation of peroxisome size(GO:0044375)
1.2 14.1 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.2 16.2 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
1.1 6.8 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.1 3.4 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.1 26.4 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
1.1 4.4 GO:1902994 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
1.1 11.8 GO:0070244 negative regulation of thymocyte apoptotic process(GO:0070244)
1.1 2.1 GO:0052564 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
1.1 3.2 GO:1901143 insulin catabolic process(GO:1901143)
1.1 4.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
1.1 10.5 GO:0042178 xenobiotic catabolic process(GO:0042178)
1.0 4.1 GO:0046061 dATP catabolic process(GO:0046061)
1.0 6.0 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
1.0 1.9 GO:0070340 detection of diacyl bacterial lipopeptide(GO:0042496) detection of bacterial lipopeptide(GO:0070340)
0.9 2.8 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.9 3.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.9 8.8 GO:0061042 adiponectin-activated signaling pathway(GO:0033211) vascular wound healing(GO:0061042)
0.8 6.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.8 4.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.8 9.7 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.7 6.0 GO:1904044 response to aldosterone(GO:1904044)
0.7 5.2 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.7 24.5 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.7 14.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.7 5.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.7 2.1 GO:0097167 circadian regulation of translation(GO:0097167) response to sodium phosphate(GO:1904383) response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
0.7 9.6 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.7 3.4 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.7 2.7 GO:0030043 actin filament fragmentation(GO:0030043)
0.7 5.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.7 5.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.6 3.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.6 13.9 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.6 7.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.6 3.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.6 4.4 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.6 5.6 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.6 3.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.6 3.7 GO:0015722 canalicular bile acid transport(GO:0015722)
0.6 4.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.6 1.8 GO:0008592 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751)
0.6 2.4 GO:0019046 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.6 2.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.6 8.5 GO:0030575 male sex determination(GO:0030238) nuclear body organization(GO:0030575)
0.6 1.7 GO:0033986 response to methanol(GO:0033986)
0.5 7.5 GO:0051014 actin filament severing(GO:0051014)
0.5 4.6 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.5 7.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.5 3.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 5.0 GO:0071679 cytoskeletal anchoring at plasma membrane(GO:0007016) commissural neuron axon guidance(GO:0071679)
0.4 4.0 GO:0016559 peroxisome fission(GO:0016559) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.4 3.6 GO:0060613 fat pad development(GO:0060613)
0.4 2.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 19.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 13.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.4 9.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.4 9.0 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.4 2.0 GO:0070827 chromatin maintenance(GO:0070827)
0.4 1.9 GO:1904798 regulation of core promoter binding(GO:1904796) positive regulation of core promoter binding(GO:1904798)
0.4 4.1 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.4 13.8 GO:0045026 plasma membrane fusion(GO:0045026)
0.4 5.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.4 1.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
0.4 1.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.4 7.0 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.3 22.4 GO:0043462 regulation of ATPase activity(GO:0043462)
0.3 2.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 3.4 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.3 6.1 GO:0051593 response to folic acid(GO:0051593)
0.3 2.0 GO:0030222 eosinophil differentiation(GO:0030222)
0.3 3.7 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.3 10.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 19.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 4.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 6.9 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 5.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 5.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.3 12.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.3 1.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.3 24.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.3 3.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.3 7.5 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.3 1.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.3 1.7 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.3 1.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.3 4.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 9.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.3 3.9 GO:0032025 response to cobalt ion(GO:0032025)
0.3 13.3 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.3 0.8 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.3 2.4 GO:0007512 adult heart development(GO:0007512)
0.3 7.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 0.8 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.2 1.0 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.2 16.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 4.8 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.2 0.9 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 7.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 3.0 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.2 9.9 GO:0022904 respiratory electron transport chain(GO:0022904)
0.2 0.6 GO:0015965 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.2 3.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 0.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650) negative regulation of dendritic cell differentiation(GO:2001199)
0.2 31.2 GO:0010952 positive regulation of peptidase activity(GO:0010952)
0.2 6.6 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.2 11.2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 4.4 GO:0071361 cellular response to ethanol(GO:0071361)
0.2 2.0 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 6.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 1.8 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.8 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.2 3.7 GO:0032098 regulation of appetite(GO:0032098)
0.2 7.0 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 6.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 4.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 5.4 GO:0060325 face morphogenesis(GO:0060325)
0.2 0.9 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 3.4 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 25.0 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 7.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 3.3 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.1 4.6 GO:1901998 toxin transport(GO:1901998)
0.1 2.0 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 26.7 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 6.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 4.4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 1.9 GO:0031297 replication fork processing(GO:0031297)
0.1 2.9 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 1.5 GO:0019236 response to pheromone(GO:0019236)
0.1 1.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 1.6 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 2.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.5 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.9 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.1 1.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 1.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 2.9 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.4 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 1.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.3 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 1.8 GO:0006379 mRNA cleavage(GO:0006379)
0.1 1.4 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 9.9 GO:0030522 intracellular receptor signaling pathway(GO:0030522)
0.1 3.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.4 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 1.4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 3.9 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 2.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 5.4 GO:0042594 response to starvation(GO:0042594)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 7.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 6.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 3.5 GO:0015992 proton transport(GO:0015992)
0.0 2.7 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 6.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 4.2 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.8 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 3.7 GO:0016042 lipid catabolic process(GO:0016042)
0.0 1.5 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 7.6 GO:0006412 translation(GO:0006412)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.9 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.9 GO:0034968 histone lysine methylation(GO:0034968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 42.6 GO:0005859 muscle myosin complex(GO:0005859)
3.0 12.0 GO:0005588 collagen type V trimer(GO:0005588)
2.6 18.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.5 7.6 GO:0005760 gamma DNA polymerase complex(GO:0005760)
2.4 22.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
2.4 14.3 GO:0032133 chromosome passenger complex(GO:0032133)
2.4 9.4 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.9 7.5 GO:0035339 SPOTS complex(GO:0035339)
1.9 22.4 GO:0005861 troponin complex(GO:0005861)
1.6 20.2 GO:0046581 intercellular canaliculus(GO:0046581)
1.5 24.5 GO:0070852 cell body fiber(GO:0070852)
1.5 6.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.5 6.0 GO:0035363 histone locus body(GO:0035363)
1.4 14.0 GO:0032437 cuticular plate(GO:0032437)
1.3 9.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
1.3 3.9 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
1.2 3.7 GO:0046691 intracellular canaliculus(GO:0046691)
1.1 5.6 GO:0070695 FHF complex(GO:0070695)
1.1 16.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.1 7.6 GO:0001739 sex chromatin(GO:0001739)
0.9 4.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.8 5.9 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.8 2.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.8 7.0 GO:0031209 SCAR complex(GO:0031209)
0.8 21.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 5.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.7 5.0 GO:0016011 dystroglycan complex(GO:0016011)
0.7 6.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.6 1.9 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.6 1.9 GO:0035101 FACT complex(GO:0035101)
0.6 7.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 5.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.6 6.3 GO:0031143 pseudopodium(GO:0031143)
0.5 4.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.5 8.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 9.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.5 7.2 GO:0043083 synaptic cleft(GO:0043083)
0.5 2.9 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 1.0 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.5 5.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.4 7.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 8.8 GO:0000346 transcription export complex(GO:0000346)
0.4 6.1 GO:0008278 cohesin complex(GO:0008278)
0.4 22.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.4 26.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.4 4.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.4 29.1 GO:0005811 lipid particle(GO:0005811)
0.4 3.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 7.4 GO:0005686 U2 snRNP(GO:0005686)
0.4 18.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 4.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 1.4 GO:0070552 BRISC complex(GO:0070552)
0.3 5.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 4.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 3.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.3 7.8 GO:0001891 phagocytic cup(GO:0001891)
0.3 13.9 GO:0016592 mediator complex(GO:0016592)
0.3 22.4 GO:0045095 keratin filament(GO:0045095)
0.3 3.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 9.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.3 1.8 GO:0000243 commitment complex(GO:0000243)
0.3 30.9 GO:0072562 blood microparticle(GO:0072562)
0.3 13.3 GO:0016235 aggresome(GO:0016235)
0.3 6.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 25.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 3.0 GO:0016342 catenin complex(GO:0016342)
0.2 10.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 2.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.2 3.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.8 GO:0032806 holo TFIIH complex(GO:0005675) carboxy-terminal domain protein kinase complex(GO:0032806)
0.2 2.2 GO:0030891 VCB complex(GO:0030891)
0.2 9.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 3.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 62.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.8 GO:0019013 viral nucleocapsid(GO:0019013)
0.2 1.6 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 22.9 GO:0030018 Z disc(GO:0030018)
0.2 3.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.3 GO:0045120 pronucleus(GO:0045120)
0.2 3.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 2.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 3.6 GO:0000242 pericentriolar material(GO:0000242)
0.2 4.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 7.4 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.2 11.5 GO:0022627 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
0.2 1.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 1.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.4 GO:0042588 zymogen granule(GO:0042588)
0.1 21.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 6.6 GO:0030017 sarcomere(GO:0030017)
0.1 1.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 9.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.1 GO:0005638 lamin filament(GO:0005638)
0.1 11.7 GO:0005902 microvillus(GO:0005902)
0.1 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 11.2 GO:0016605 PML body(GO:0016605)
0.1 8.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 9.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 44.8 GO:0045177 apical part of cell(GO:0045177)
0.1 1.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 6.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 4.2 GO:0005844 polysome(GO:0005844)
0.1 6.7 GO:0005776 autophagosome(GO:0005776)
0.1 10.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 13.0 GO:0005681 spliceosomal complex(GO:0005681)
0.1 11.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 0.3 GO:0000814 ESCRT II complex(GO:0000814)
0.1 9.5 GO:0000922 spindle pole(GO:0000922)
0.1 0.3 GO:0097255 R2TP complex(GO:0097255)
0.1 208.1 GO:0070062 extracellular exosome(GO:0070062)
0.1 4.3 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 3.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 8.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 6.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.2 GO:0032040 small-subunit processome(GO:0032040)
0.1 5.1 GO:0001650 fibrillar center(GO:0001650)
0.1 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 8.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 6.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0033503 ubiquitin conjugating enzyme complex(GO:0031371) HULC complex(GO:0033503)
0.0 4.2 GO:0005925 focal adhesion(GO:0005925)
0.0 5.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0031201 SNARE complex(GO:0031201)
0.0 1.8 GO:0005770 late endosome(GO:0005770)
0.0 1.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 8.9 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0055037 recycling endosome(GO:0055037)
0.0 1.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
7.2 21.6 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
7.0 28.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
5.6 22.4 GO:0030899 troponin C binding(GO:0030172) calcium-dependent ATPase activity(GO:0030899)
5.6 16.7 GO:0032810 sterol response element binding(GO:0032810)
5.2 15.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
4.1 16.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
3.9 15.7 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
3.3 10.0 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
3.3 42.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
3.1 9.3 GO:0070905 serine binding(GO:0070905)
2.9 23.5 GO:0003996 acyl-CoA ligase activity(GO:0003996)
2.9 23.2 GO:0043199 sulfate binding(GO:0043199)
2.5 7.6 GO:0008384 IkappaB kinase activity(GO:0008384)
2.5 7.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
2.5 19.7 GO:0008430 selenium binding(GO:0008430)
2.3 9.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
2.3 22.6 GO:0032036 myosin heavy chain binding(GO:0032036)
2.2 6.6 GO:0047708 biotinidase activity(GO:0047708)
2.2 8.8 GO:0055100 adiponectin binding(GO:0055100)
2.1 10.5 GO:0070404 NADH binding(GO:0070404)
2.0 7.9 GO:0051870 methotrexate binding(GO:0051870)
2.0 5.9 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
1.9 9.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
1.9 7.6 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
1.8 5.4 GO:0019807 aspartoacylase activity(GO:0019807)
1.8 10.5 GO:0042289 MHC class II protein binding(GO:0042289)
1.6 12.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.5 21.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.5 6.0 GO:0019776 Atg8 ligase activity(GO:0019776)
1.4 4.1 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
1.3 10.6 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
1.3 5.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
1.2 4.8 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
1.2 4.7 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
1.2 4.6 GO:0016842 amidine-lyase activity(GO:0016842)
1.1 3.4 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
1.1 8.9 GO:0016936 galactoside binding(GO:0016936)
1.1 9.7 GO:0004859 phospholipase inhibitor activity(GO:0004859)
1.1 4.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
1.1 41.0 GO:0043236 laminin binding(GO:0043236)
1.0 19.9 GO:0015643 toxic substance binding(GO:0015643)
1.0 5.2 GO:0005534 galactose binding(GO:0005534)
1.0 5.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.9 7.6 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.9 31.2 GO:0016504 peptidase activator activity(GO:0016504)
0.9 13.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.9 16.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.9 5.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.9 12.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.9 14.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.8 3.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.8 5.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.8 4.5 GO:0001515 opioid peptide activity(GO:0001515)
0.7 4.4 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.7 16.6 GO:0004707 MAP kinase activity(GO:0004707)
0.7 2.0 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.7 20.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.6 5.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 1.9 GO:0042498 Toll-like receptor 2 binding(GO:0035663) diacyl lipopeptide binding(GO:0042498)
0.6 12.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 31.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.6 24.7 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.6 4.2 GO:0050692 DBD domain binding(GO:0050692)
0.6 9.6 GO:0035497 cAMP response element binding(GO:0035497)
0.6 11.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.6 1.8 GO:2001070 starch binding(GO:2001070)
0.6 16.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.6 7.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.6 3.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.6 3.9 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.5 3.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.5 18.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 24.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.5 3.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 4.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 14.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.4 2.2 GO:0005550 pheromone binding(GO:0005550)
0.4 12.0 GO:0043394 proteoglycan binding(GO:0043394)
0.4 14.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 3.4 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.4 22.6 GO:0000049 tRNA binding(GO:0000049)
0.4 3.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 12.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.4 7.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.4 3.6 GO:0019808 polyamine binding(GO:0019808)
0.3 1.0 GO:0070698 nodal binding(GO:0038100) type I activin receptor binding(GO:0070698)
0.3 2.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 41.3 GO:0008201 heparin binding(GO:0008201)
0.3 0.9 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.3 26.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 11.3 GO:0042605 peptide antigen binding(GO:0042605)
0.3 3.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 6.8 GO:0015295 solute:proton symporter activity(GO:0015295)
0.3 3.7 GO:0015250 water channel activity(GO:0015250)
0.3 8.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 1.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 7.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 3.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 2.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 9.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 2.1 GO:0003680 AT DNA binding(GO:0003680)
0.2 13.1 GO:0048029 monosaccharide binding(GO:0048029)
0.2 5.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 12.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 3.4 GO:0015288 porin activity(GO:0015288)
0.2 6.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.4 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 4.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 9.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 3.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 12.4 GO:0005178 integrin binding(GO:0005178)
0.2 21.9 GO:0051015 actin filament binding(GO:0051015)
0.1 4.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 20.0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 3.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 5.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 51.1 GO:0005525 GTP binding(GO:0005525)
0.1 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 5.9 GO:0005518 collagen binding(GO:0005518)
0.1 33.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 1.4 GO:0016805 dipeptidase activity(GO:0016805)
0.1 12.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 0.5 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 2.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 3.7 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 2.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 4.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 6.6 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 1.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 11.5 GO:0005267 potassium channel activity(GO:0005267)
0.1 2.6 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.1 6.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 0.6 GO:0015266 protein channel activity(GO:0015266)
0.1 2.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 3.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 10.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.8 GO:0017069 snRNA binding(GO:0017069)
0.1 0.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 4.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 5.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.3 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 7.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 20.2 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.0 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 2.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 11.4 GO:0003723 RNA binding(GO:0003723)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.7 5.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.5 21.2 PID AURORA A PATHWAY Aurora A signaling
0.4 13.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.4 7.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.4 16.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 9.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 13.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.4 16.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 2.0 PID IL5 PATHWAY IL5-mediated signaling events
0.3 10.5 ST GA12 PATHWAY G alpha 12 Pathway
0.3 10.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.3 8.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 5.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.3 11.9 PID ATR PATHWAY ATR signaling pathway
0.3 19.6 PID E2F PATHWAY E2F transcription factor network
0.2 12.0 NABA COLLAGENS Genes encoding collagen proteins
0.2 7.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 4.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 4.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 7.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 34.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 12.6 PID FGF PATHWAY FGF signaling pathway
0.2 2.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 1.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 6.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 10.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 3.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 23.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 10.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 10.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 5.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.9 ST GAQ PATHWAY G alpha q Pathway
0.1 2.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 5.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 4.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 21.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.6 60.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.3 15.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
1.3 50.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.2 12.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.0 15.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.0 5.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.9 34.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.9 12.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.9 9.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.8 7.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.8 12.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.8 10.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.7 10.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.7 43.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.7 14.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.6 7.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.6 10.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 10.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 5.1 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.5 13.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.5 5.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.4 6.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 7.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.4 5.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 5.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 10.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.4 37.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 7.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 16.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 6.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.3 8.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 3.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 15.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 9.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.3 7.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 4.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 18.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 2.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3 6.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 4.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 3.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 4.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 3.9 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.2 37.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 2.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 14.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 3.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 4.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 20.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 4.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 2.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 2.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 6.4 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2 4.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 3.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.3 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.9 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.9 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.1 6.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 21.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 12.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.5 REACTOME TRANSLATION Genes involved in Translation
0.1 14.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 2.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 4.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 3.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.9 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.7 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 5.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 1.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)