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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pou3f4

Z-value: 0.76

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Transcription factors associated with Pou3f4

Gene Symbol Gene ID Gene Info
Pou3f4
ENSRNOG00000002784 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou3f4rn6_v1_chrX_+_82143789_821437890.638.6e-37Click!

Activity profile of Pou3f4 motif

Sorted Z-values of Pou3f4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_156552328 27.95 ENSRNOT00000055401
Dlg2
discs large MAGUK scaffold protein 2
chr15_-_71779033 26.86 ENSRNOT00000017765
Pcdh20
protocadherin 20
chr11_+_20474483 26.52 ENSRNOT00000082417
ENSRNOT00000002895
Ncam2
neural cell adhesion molecule 2
chr16_-_81880502 23.85 ENSRNOT00000079096
Mcf2l
MCF.2 cell line derived transforming sequence-like
chr1_+_151439409 23.22 ENSRNOT00000022060
ENSRNOT00000050639
Grm5
glutamate metabotropic receptor 5
chr7_+_133400485 23.05 ENSRNOT00000006219
Cntn1
contactin 1
chr12_-_29743705 21.49 ENSRNOT00000001185
Caln1
calneuron 1
chr11_+_42259761 21.44 ENSRNOT00000047310
Epha6
Eph receptor A6
chr5_+_145257714 21.39 ENSRNOT00000019214
Dlgap3
DLG associated protein 3
chr2_-_19808937 20.75 ENSRNOT00000044237
Atp6ap1l
ATPase H+ transporting accessory protein 1 like
chr3_-_26056818 20.08 ENSRNOT00000044209
Lrp1b
LDL receptor related protein 1B
chr7_-_93502571 19.67 ENSRNOT00000077033
ENSRNOT00000076080
Samd12
sterile alpha motif domain containing 12
chr4_-_135069970 16.83 ENSRNOT00000008221
Cntn3
contactin 3
chr1_-_93949187 16.79 ENSRNOT00000018956
Zfp536
zinc finger protein 536
chr9_-_45558993 16.56 ENSRNOT00000087866
ENSRNOT00000017714
Chst10
carbohydrate sulfotransferase 10
chr10_+_54155876 15.19 ENSRNOT00000072855
Gas7
growth arrest specific 7
chr20_-_25826658 15.16 ENSRNOT00000057950
ENSRNOT00000084660
Ctnna3
catenin alpha 3
chr10_+_74871523 13.09 ENSRNOT00000076995
ENSRNOT00000076026
ENSRNOT00000088581
ENSRNOT00000076701
Sept4
septin 4
chr7_-_124929025 12.77 ENSRNOT00000015447
Efcab6
EF-hand calcium binding domain 6
chr14_-_91989307 12.74 ENSRNOT00000057051
Ddc
dopa decarboxylase
chr19_-_11669578 12.44 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr7_+_121408829 12.21 ENSRNOT00000023434
Mgat3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr6_+_102215603 11.70 ENSRNOT00000014257
Plekhh1
pleckstrin homology, MyTH4 and FERM domain containing H1
chr18_+_30527705 11.52 ENSRNOT00000027168
Pcdhb14
protocadherin beta 14
chr6_+_29518416 10.92 ENSRNOT00000078660
AABR07063346.1

chr5_-_16799776 10.89 ENSRNOT00000011721
Plag1
PLAG1 zinc finger
chr13_-_47916185 10.71 ENSRNOT00000087793
Dyrk3
dual specificity tyrosine phosphorylation regulated kinase 3
chr5_-_153840178 10.46 ENSRNOT00000025075
Nipal3
NIPA-like domain containing 3
chr18_+_30398113 10.37 ENSRNOT00000027206
Pcdhb5
protocadherin beta 5
chr2_-_104461863 10.21 ENSRNOT00000016953
Crh
corticotropin releasing hormone
chr5_-_156689415 10.10 ENSRNOT00000083474
Pink1
PTEN induced putative kinase 1
chr15_-_80713153 9.97 ENSRNOT00000063800
Klhl1
kelch-like family member 1
chr6_+_7900972 9.56 ENSRNOT00000006953
ENSRNOT00000068030
Dync2li1
dynein cytoplasmic 2 light intermediate chain 1
chr14_-_55081551 8.96 ENSRNOT00000049245
Pcdh7
protocadherin 7
chr2_-_28003186 8.89 ENSRNOT00000048554
Hexb
hexosaminidase subunit beta
chr14_+_114152472 8.57 ENSRNOT00000042965
Rtn4
reticulon 4
chr3_-_107760550 8.44 ENSRNOT00000077091
ENSRNOT00000051638
Meis2
Meis homeobox 2
chr14_+_60764409 8.27 ENSRNOT00000005168
Lgi2
leucine-rich repeat LGI family, member 2
chr6_-_135251073 8.24 ENSRNOT00000088986
Mok
MOK protein kinase
chr4_-_145678066 8.20 ENSRNOT00000014103
Ghrl
ghrelin and obestatin prepropeptide
chr11_+_82194657 8.20 ENSRNOT00000002445
Etv5
ets variant 5
chr8_+_122076759 8.18 ENSRNOT00000012545
Clasp2
cytoplasmic linker associated protein 2
chr1_-_49844547 8.17 ENSRNOT00000086127
ENSRNOT00000077423
ENSRNOT00000089439
ENSRNOT00000090521
AABR07001519.1

chr2_+_22909569 8.13 ENSRNOT00000073871
Homer1
homer scaffolding protein 1
chr5_+_27326762 7.44 ENSRNOT00000066191
Runx1t1
RUNX1 translocation partner 1
chr5_+_57947716 7.44 ENSRNOT00000067657
Dnai1
dynein, axonemal, intermediate chain 1
chr1_+_217151166 7.38 ENSRNOT00000071484
Shank2
SH3 and multiple ankyrin repeat domains 2
chr20_+_25990304 7.28 ENSRNOT00000033980
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_8928534 7.15 ENSRNOT00000088509
ENSRNOT00000065300
Miga2
mitoguardin 2
chr2_+_12516702 7.07 ENSRNOT00000050072
Tmem161b
transmembrane protein 161B
chr1_+_236031988 6.98 ENSRNOT00000016164
Pcsk5
proprotein convertase subtilisin/kexin type 5
chr1_-_67094567 6.56 ENSRNOT00000073583
AABR07071871.1

chr18_+_61377051 6.46 ENSRNOT00000066659
Oacyl
O-acyltransferase like
chr6_+_44230985 6.30 ENSRNOT00000005858
Kidins220
kinase D-interacting substrate 220
chr8_+_82043403 6.06 ENSRNOT00000091789
Myo5a
myosin VA
chr5_-_57947183 5.56 ENSRNOT00000060642
Fam219a
family with sequence similarity 219, member A
chr2_-_259382765 5.23 ENSRNOT00000091407
St6galnac3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr7_-_117788550 4.76 ENSRNOT00000021775
MGC94207
similar to RIKEN cDNA C030006K11
chr19_+_39126589 4.71 ENSRNOT00000027561
Sntb2
syntrophin, beta 2
chr13_-_61003744 4.47 ENSRNOT00000005163
Rgs13
regulator of G-protein signaling 13
chr1_+_65781547 4.33 ENSRNOT00000026204
Zfp329
zinc finger protein 329
chr2_+_72006099 4.11 ENSRNOT00000034044
Cdh12
cadherin 12
chr2_-_149347796 4.07 ENSRNOT00000091020
P2ry14
purinergic receptor P2Y14
chr19_+_21541742 3.93 ENSRNOT00000021095
ENSRNOT00000042077
Abcc12
ATP binding cassette subfamily C member 12
chr9_-_66019065 3.80 ENSRNOT00000088729
Als2
ALS2, alsin Rho guanine nucleotide exchange factor
chr15_-_55424024 3.73 ENSRNOT00000077733
Nudt15
nudix hydrolase 15
chr10_-_87335823 3.72 ENSRNOT00000079297
Krt12
keratin 12
chr10_-_59888198 3.68 ENSRNOT00000093482
ENSRNOT00000049311
ENSRNOT00000093230
Aspa
aspartoacylase
chr7_+_9897983 3.67 ENSRNOT00000042498
LOC100910577
zinc finger protein 709-like
chr16_+_32457521 3.67 ENSRNOT00000083579
Clcn3
chloride voltage-gated channel 3
chr1_-_66321642 3.65 ENSRNOT00000074234
AABR07002093.1

chrM_+_5323 3.50 ENSRNOT00000050156
Mt-co1
mitochondrially encoded cytochrome c oxidase 1
chr11_-_62128044 3.44 ENSRNOT00000093141
Zbtb20
zinc finger and BTB domain containing 20
chr4_+_78735279 3.21 ENSRNOT00000011970
Malsu1
mitochondrial assembly of ribosomal large subunit 1
chr8_+_100260049 3.05 ENSRNOT00000011090
AABR07071101.1

chr15_+_18539210 3.04 ENSRNOT00000083212
Pdhb
pyruvate dehydrogenase (lipoamide) beta
chr1_-_251387002 2.99 ENSRNOT00000092063
Atad1
ATPase family, AAA domain containing 1
chr16_-_9658484 2.97 ENSRNOT00000065216
Mapk8
mitogen-activated protein kinase 8
chr6_+_36107672 2.96 ENSRNOT00000093003
Rdh14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr10_-_95431312 2.73 ENSRNOT00000085552
AABR07030603.2

chr1_+_61733805 2.64 ENSRNOT00000086029
LOC682206
similar to Zinc finger protein 208
chr5_+_64412895 2.59 ENSRNOT00000010561
Murc
muscle-related coiled-coil protein
chr3_+_72540538 2.56 ENSRNOT00000012379
Aplnr
apelin receptor
chr14_-_11546314 2.50 ENSRNOT00000090334
AABR07014355.1

chr2_-_147693082 2.38 ENSRNOT00000022507
Wwtr1
WW domain containing transcription regulator 1
chr3_-_50120392 2.30 ENSRNOT00000006175
Fign
fidgetin, microtubule severing factor
chr10_-_87300728 2.28 ENSRNOT00000036023
ENSRNOT00000081709
Krt10
keratin 10
chr18_-_38374 2.09 ENSRNOT00000036914
Vom2r75
vomeronasal 2 receptor, 75
chr19_-_41029206 2.06 ENSRNOT00000023383
Vac14
Vac14, PIKFYVE complex component
chr9_-_81879211 1.84 ENSRNOT00000085140
Rnf25
ring finger protein 25
chr5_+_116420690 1.83 ENSRNOT00000087089
Nfia
nuclear factor I/A
chr15_+_12827707 1.49 ENSRNOT00000012452
Fezf2
Fez family zinc finger 2
chr7_+_12840938 1.49 ENSRNOT00000039232
Polrmt
RNA polymerase mitochondrial
chrX_+_136466779 1.42 ENSRNOT00000093268
ENSRNOT00000068717
Arhgap36
Rho GTPase activating protein 36
chrX_+_88298266 1.41 ENSRNOT00000041508
AABR07039936.1

chr10_+_83476107 1.37 ENSRNOT00000075733
Phb
prohibitin
chr3_-_77389521 1.29 ENSRNOT00000043928
Olr657
olfactory receptor 657
chr6_-_103949275 1.27 ENSRNOT00000047825
AABR07065012.1

chr6_+_106052212 1.24 ENSRNOT00000010626
Sipa1l1
signal-induced proliferation-associated 1 like 1
chr2_-_219262901 1.18 ENSRNOT00000037068
Gpr88
G-protein coupled receptor 88
chr3_-_74701712 1.05 ENSRNOT00000041127
Olr541
olfactory receptor 541
chr9_-_32868371 0.99 ENSRNOT00000038369
LOC689725
similar to chromosome 9 open reading frame 79
chr4_-_165747201 0.96 ENSRNOT00000007435
Tas2r130
taste receptor, type 2, member 130
chr7_-_13108630 0.94 ENSRNOT00000087038
ENSRNOT00000080491
Giot1
gonadotropin inducible ovarian transcription factor 1
chr2_+_138194136 0.88 ENSRNOT00000014928
RGD1307595
similar to RIKEN cDNA 1700018B24
chr3_-_150960030 0.86 ENSRNOT00000024714
Ncoa6
nuclear receptor coactivator 6
chr8_+_13305152 0.85 ENSRNOT00000012940
Mre11a
MRE11 homolog A, double strand break repair nuclease
chr1_-_230079916 0.82 ENSRNOT00000091024
Olr358
olfactory receptor 358
chr7_-_97071968 0.81 ENSRNOT00000006596
Slc22a22
solute carrier family 22 (organic cation transporter), member 22
chr9_-_99821954 0.76 ENSRNOT00000090382
ENSRNOT00000022220
Otos
otospiralin
chr3_-_78886096 0.66 ENSRNOT00000008864
Olr729
olfactory receptor 729
chrX_+_157759624 0.53 ENSRNOT00000003192
LOC686087
similar to motile sperm domain containing 1
chr20_-_3440769 0.52 ENSRNOT00000084981
Ier3
immediate early response 3
chr2_-_170300408 0.41 ENSRNOT00000046681
Si
sucrase-isomaltase
chr7_-_140506925 0.41 ENSRNOT00000083354
Kmt2d
lysine methyltransferase 2D
chr13_-_90443157 0.40 ENSRNOT00000006862
Nhlh1
nescient helix loop helix 1
chrX_+_110670119 0.38 ENSRNOT00000014811
ENSRNOT00000089579
LOC680663
hypothetical protein LOC680663
chr9_+_19451630 0.37 ENSRNOT00000065048
Enpp4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr11_-_28979169 0.36 ENSRNOT00000061601
AABR07033580.1

chr5_+_63870432 0.35 ENSRNOT00000007641
Stx17
syntaxin 17
chr1_+_172728264 0.33 ENSRNOT00000075297
Olr267
olfactory receptor 267
chr1_-_88558696 0.26 ENSRNOT00000038642
AABR07002896.1

chr3_-_94418711 0.23 ENSRNOT00000089554
Hipk3
homeodomain interacting protein kinase 3
chr1_-_166988062 0.22 ENSRNOT00000039564
Lrtomt
leucine rich transmembrane and O-methyltransferase domain containing
chr1_-_101773508 0.19 ENSRNOT00000067430
Sult2b1
sulfotransferase family 2B member 1
chr8_+_19548488 0.10 ENSRNOT00000008605
Olr1148
olfactory receptor 1148
chr3_-_72808425 0.01 ENSRNOT00000048581
Olr441
olfactory receptor 441

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou3f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.2 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
4.6 18.4 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
3.2 12.7 GO:0052314 phytoalexin metabolic process(GO:0052314)
2.6 13.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
2.5 28.0 GO:0046710 GDP metabolic process(GO:0046710)
2.1 10.7 GO:0035617 stress granule disassembly(GO:0035617)
2.0 10.1 GO:1903384 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
1.9 15.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.9 16.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.6 8.2 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.5 6.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.4 9.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.3 8.9 GO:0007341 penetration of zona pellucida(GO:0007341)
1.2 8.6 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.2 7.0 GO:0002001 renin secretion into blood stream(GO:0002001)
1.1 3.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
1.0 3.0 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
1.0 28.0 GO:0007413 axonal fasciculation(GO:0007413)
0.9 3.7 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.8 8.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 10.5 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.7 3.7 GO:0042262 dGTP catabolic process(GO:0006203) DNA protection(GO:0042262)
0.7 24.3 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988)
0.7 21.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 12.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.6 7.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.6 7.4 GO:0098880 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.5 10.9 GO:0060736 prostate gland growth(GO:0060736)
0.5 3.8 GO:0051036 regulation of endosome size(GO:0051036)
0.5 8.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216) regulation of store-operated calcium entry(GO:2001256)
0.5 6.3 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.5 19.5 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.4 61.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 7.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.4 3.7 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.4 16.6 GO:0007616 long-term memory(GO:0007616)
0.4 4.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.4 23.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.3 1.4 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.3 2.4 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.3 5.2 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.3 12.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 10.0 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 3.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.2 GO:0061743 motor learning(GO:0061743)
0.2 7.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 3.0 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 3.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2 0.8 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.2 0.9 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.2 7.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 1.8 GO:0072189 ureter development(GO:0072189)
0.2 2.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.4 GO:0008542 visual learning(GO:0008542)
0.1 1.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 15.2 GO:0008360 regulation of cell shape(GO:0008360)
0.1 4.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.4 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.4 GO:0001555 oocyte growth(GO:0001555)
0.1 2.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 3.4 GO:0032760 positive regulation of tumor necrosis factor production(GO:0032760)
0.0 0.9 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.5 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 1.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.4 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.9 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.4 GO:0046130 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0 1.8 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
2.0 6.1 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.7 28.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.7 20.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.6 33.3 GO:0097449 astrocyte projection(GO:0097449)
1.3 13.1 GO:0031105 septin complex(GO:0031105) sperm annulus(GO:0097227)
1.3 21.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.2 7.4 GO:0036157 outer dynein arm(GO:0036157)
1.2 8.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.8 15.2 GO:0005916 fascia adherens(GO:0005916)
0.8 21.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 7.0 GO:1990635 proximal dendrite(GO:1990635)
0.5 10.2 GO:0043196 varicosity(GO:0043196)
0.5 8.9 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.5 7.4 GO:0005883 neurofilament(GO:0005883)
0.4 39.9 GO:0031225 anchored component of membrane(GO:0031225)
0.4 9.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 3.7 GO:0042581 specific granule(GO:0042581)
0.3 12.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 8.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 3.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.3 2.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.3 1.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 8.2 GO:0097546 ciliary base(GO:0097546)
0.2 10.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 23.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 3.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 8.1 GO:0043034 costamere(GO:0043034)
0.1 15.2 GO:0005884 actin filament(GO:0005884)
0.1 0.9 GO:0030870 Mre11 complex(GO:0030870)
0.1 3.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 2.3 GO:0001533 cornified envelope(GO:0001533)
0.1 5.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 46.6 GO:0030424 axon(GO:0030424)
0.0 21.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 6.3 GO:0005770 late endosome(GO:0005770)
0.0 36.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 3.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 10.9 GO:0016607 nuclear speck(GO:0016607)
0.0 1.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 4.7 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.9 GO:0035097 histone methyltransferase complex(GO:0035097)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 23.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
4.2 12.7 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
3.8 22.6 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
2.8 28.0 GO:0004385 guanylate kinase activity(GO:0004385)
2.4 9.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
2.1 16.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.1 8.2 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
1.8 8.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.7 15.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
1.6 8.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
1.2 3.7 GO:0035539 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
1.2 3.7 GO:0019807 aspartoacylase activity(GO:0019807)
1.2 3.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.0 5.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
1.0 20.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.0 10.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.0 23.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.9 18.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.8 3.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.7 10.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.6 21.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.6 7.4 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.5 2.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.5 1.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.4 3.0 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.4 8.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 6.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.3 4.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 5.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 12.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.3 10.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 16.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.2 23.1 GO:0001948 glycoprotein binding(GO:0001948)
0.2 3.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 3.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 7.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 57.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.4 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 11.6 GO:0051015 actin filament binding(GO:0051015)
0.1 6.3 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 1.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.8 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.1 1.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 4.8 GO:0003774 motor activity(GO:0003774)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 7.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 9.5 GO:0042277 peptide binding(GO:0042277)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 3.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 8.6 GO:0045296 cadherin binding(GO:0045296)
0.0 6.5 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups(GO:0016747)
0.0 8.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 10.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 7.1 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.7 23.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.6 21.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 23.1 PID NOTCH PATHWAY Notch signaling pathway
0.3 12.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 3.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 8.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 8.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.9 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.8 23.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.7 8.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.6 8.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 12.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.4 12.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.4 5.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 3.0 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.3 6.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.2 6.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 2.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 4.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 10.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 3.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 9.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 8.6 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.5 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases