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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Prdm14

Z-value: 0.66

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Transcription factors associated with Prdm14

Gene Symbol Gene ID Gene Info
Prdm14
ENSRNOG00000021792 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prdm14rn6_v1_chr5_+_5710392_57103920.062.9e-01Click!

Activity profile of Prdm14 motif

Sorted Z-values of Prdm14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_148119857 48.07 ENSRNOT00000040325
LOC100361547
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr20_-_4542073 35.00 ENSRNOT00000000477
Cfb
complement factor B
chr13_+_78805347 32.70 ENSRNOT00000003748
Serpinc1
serpin family C member 1
chr9_+_95241609 26.88 ENSRNOT00000032634
ENSRNOT00000077416
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr2_-_210809306 19.68 ENSRNOT00000047139
Gstm1
glutathione S-transferase mu 1
chr1_-_102826965 16.69 ENSRNOT00000078692
Saa4
serum amyloid A4
chr3_+_92640752 16.07 ENSRNOT00000007604
Slc1a2
solute carrier family 1 member 2
chr3_-_138116664 12.78 ENSRNOT00000055602
Rrbp1
ribosome binding protein 1
chrX_-_138435391 12.06 ENSRNOT00000043258
Mbnl3
muscleblind-like splicing regulator 3
chr1_+_184301493 11.87 ENSRNOT00000078096
Insc
inscuteable homolog (Drosophila)
chr7_-_132343169 10.09 ENSRNOT00000021064
Abcd2
ATP binding cassette subfamily D member 2
chr4_-_50860756 8.96 ENSRNOT00000068404
Cadps2
calcium dependent secretion activator 2
chr13_+_100980574 8.87 ENSRNOT00000067005
ENSRNOT00000004649
Capn8
calpain 8
chr19_+_15339152 7.80 ENSRNOT00000060929
Ces1a
carboxylesterase 1A
chr4_+_100218661 5.83 ENSRNOT00000079415
Tmem150a
transmembrane protein 150A
chrX_-_14972675 5.11 ENSRNOT00000079664
Slc38a5
solute carrier family 38, member 5
chrX_-_14972389 4.86 ENSRNOT00000038068
Slc38a5
solute carrier family 38, member 5
chr8_-_53816447 4.73 ENSRNOT00000011454
Ttc12
tetratricopeptide repeat domain 12
chr15_-_45927804 4.33 ENSRNOT00000086271
Ints6
integrator complex subunit 6
chr20_-_28814636 4.28 ENSRNOT00000086030
Sept10
septin 10
chr10_-_65963932 3.56 ENSRNOT00000011726
Nlk
nemo like kinase
chr4_-_123713319 3.03 ENSRNOT00000012875
ENSRNOT00000086982
Slc6a6
solute carrier family 6 member 6
chr1_+_225129097 2.86 ENSRNOT00000026938
Eml3
echinoderm microtubule associated protein like 3
chr2_-_188645196 2.85 ENSRNOT00000083793
Efna3
ephrin A3
chr8_+_55202725 2.58 ENSRNOT00000029166
Alg9
ALG9, alpha-1,2-mannosyltransferase
chr1_+_79894450 1.82 ENSRNOT00000057963
Nanos2
nanos C2HC-type zinc finger 2
chr1_-_88111293 1.33 ENSRNOT00000077195
Spred3
sprouty-related, EVH1 domain containing 3
chr2_-_189573280 1.32 ENSRNOT00000022897
Rps27
ribosomal protein S27
chr2_-_35104963 1.28 ENSRNOT00000018058
Rgs7bp
regulator of G-protein signaling 7-binding protein
chr2_-_78427751 1.00 ENSRNOT00000077768
AC113901.1

chr4_+_78496043 0.97 ENSRNOT00000059136
Aoc1
amine oxidase, copper containing 1
chr2_+_1410934 0.97 ENSRNOT00000013625
ENSRNOT00000080222
Erap1
endoplasmic reticulum aminopeptidase 1
chr3_-_147481073 0.91 ENSRNOT00000084722
Fam110a
family with sequence similarity 110, member A
chr2_-_179704629 0.89 ENSRNOT00000083361
ENSRNOT00000077941
Gria2
glutamate ionotropic receptor AMPA type subunit 2
chr14_-_12995584 0.75 ENSRNOT00000035446
ENSRNOT00000077861
Fgf5
fibroblast growth factor 5
chr6_+_137164535 0.61 ENSRNOT00000018225
Inf2
inverted formin, FH2 and WH2 domain containing
chr7_-_116920507 0.58 ENSRNOT00000048363
Mroh6
maestro heat-like repeat family member 6
chr20_+_3582743 0.52 ENSRNOT00000001103
Gtf2h4
general transcription factor 2H subunit 4
chr11_-_43617633 0.49 ENSRNOT00000060874
Olr1557
olfactory receptor 1557
chr12_+_36871999 0.44 ENSRNOT00000001334
ENSRNOT00000084236
Ncor2
nuclear receptor co-repressor 2
chr18_-_69780922 0.37 ENSRNOT00000079093
Me2
malic enzyme 2
chr1_-_89509343 0.32 ENSRNOT00000028637
Fxyd3
FXYD domain-containing ion transport regulator 3
chr1_-_225128740 0.27 ENSRNOT00000026897
Rom1
retinal outer segment membrane protein 1
chr3_-_10694649 0.23 ENSRNOT00000037742
Gpr107
G protein-coupled receptor 107
chr12_+_7081895 0.19 ENSRNOT00000047163
Hmgb1
high mobility group box 1
chr3_-_2938663 0.09 ENSRNOT00000050294
LOC108348105
allergen Fel d 4-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 32.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
6.6 19.7 GO:0018916 nitrobenzene metabolic process(GO:0018916)
3.2 16.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
3.2 35.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
3.0 26.9 GO:0052697 xenobiotic glucuronidation(GO:0052697)
1.8 48.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.3 10.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
1.1 9.0 GO:1990504 dense core granule exocytosis(GO:1990504)
0.7 10.0 GO:0015816 glycine transport(GO:0015816)
0.4 11.9 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.4 12.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.3 1.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.3 16.7 GO:0006953 acute-phase response(GO:0006953)
0.2 4.3 GO:0016180 snRNA processing(GO:0016180)
0.1 5.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.0 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 3.0 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 2.6 GO:0097502 mannosylation(GO:0097502)
0.1 0.4 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.2 GO:0035711 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) regulation of mismatch repair(GO:0032423) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) T-helper 1 cell activation(GO:0035711) positive regulation of glycogen catabolic process(GO:0045819) negative regulation of apoptotic cell clearance(GO:2000426)
0.1 2.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 8.9 GO:0007586 digestion(GO:0007586)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 12.8 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:0060992 response to fungicide(GO:0060992)
0.0 0.7 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.4 GO:1902031 malate metabolic process(GO:0006108) regulation of NADP metabolic process(GO:1902031)
0.0 3.6 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.3 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 16.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.6 67.7 GO:0072562 blood microparticle(GO:0072562)
0.5 16.1 GO:0030673 axolemma(GO:0030673)
0.3 4.3 GO:0032039 integrator complex(GO:0032039)
0.2 0.5 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.1 10.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 9.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 12.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 19.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 11.9 GO:0045177 apical part of cell(GO:0045177)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.0 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
2.5 19.7 GO:0016151 nickel cation binding(GO:0016151)
1.6 48.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.0 3.0 GO:0030977 taurine binding(GO:0030977)
0.9 26.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.8 10.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.4 8.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 32.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.7 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.2 0.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 35.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 3.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 2.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 10.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 7.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.4 GO:0016922 Notch binding(GO:0005112) ligand-dependent nuclear receptor binding(GO:0016922)
0.0 25.6 GO:0003723 RNA binding(GO:0003723)
0.0 4.3 GO:0005525 GTP binding(GO:0005525)
0.0 2.9 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 35.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.8 32.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 23.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 35.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
2.2 32.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.4 26.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.7 19.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.5 10.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.5 29.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.7 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation