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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rbpj

Z-value: 0.72

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Transcription factors associated with Rbpj

Gene Symbol Gene ID Gene Info
Rbpj
ENSRNOG00000007797 recombination signal binding protein for immunoglobulin kappa J region
Rbpj
ENSRNOG00000046327 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rbpjrn6_v1_chr14_-_59735450_59735450-0.123.2e-02Click!

Activity profile of Rbpj motif

Sorted Z-values of Rbpj motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_55822551 26.46 ENSRNOT00000082624
Lrp2
LDL receptor related protein 2
chr13_+_56598957 22.98 ENSRNOT00000016944
ENSRNOT00000080335
ENSRNOT00000089913
F13b
coagulation factor XIII B chain
chr5_-_78985990 20.22 ENSRNOT00000009248
Ambp
alpha-1-microglobulin/bikunin precursor
chr10_+_71159869 18.85 ENSRNOT00000075977
ENSRNOT00000047427
Hnf1b
HNF1 homeobox B
chr10_+_56662561 18.83 ENSRNOT00000025254
Asgr1
asialoglycoprotein receptor 1
chr16_-_81797815 18.03 ENSRNOT00000026666
Proz
protein Z, vitamin K-dependent plasma glycoprotein
chr1_+_191829555 18.01 ENSRNOT00000067138
Scnn1b
sodium channel epithelial 1 beta subunit
chr4_-_154855098 16.61 ENSRNOT00000041957
LOC297568
alpha-1-inhibitor III
chr4_+_57952982 15.37 ENSRNOT00000014465
Cpa1
carboxypeptidase A1
chr3_-_161212188 15.28 ENSRNOT00000065751
Wfdc3
WAP four-disulfide core domain 3
chr10_+_56662242 15.02 ENSRNOT00000086919
Asgr1
asialoglycoprotein receptor 1
chr2_-_236480502 15.01 ENSRNOT00000015020
Sgms2
sphingomyelin synthase 2
chr7_+_141237768 14.07 ENSRNOT00000091717
Aqp2
aquaporin 2
chr1_-_189181901 12.34 ENSRNOT00000092022
Gp2
glycoprotein 2
chr3_-_101465995 11.12 ENSRNOT00000080175
Bbox1
gamma-butyrobetaine hydroxylase 1
chr10_-_88036040 10.16 ENSRNOT00000018851
Krt13
keratin 13
chr7_+_116745061 9.27 ENSRNOT00000076174
Rhpn1
rhophilin, Rho GTPase binding protein 1
chr2_-_113616766 9.26 ENSRNOT00000016858
ENSRNOT00000074723
Tmem212
transmembrane protein 212
chrX_-_139079336 9.18 ENSRNOT00000047605
Usp26
ubiquitin specific peptidase 26
chr1_-_85220237 8.98 ENSRNOT00000026907
Sycn
syncollin
chr14_+_34727915 8.97 ENSRNOT00000085089
Kdr
kinase insert domain receptor
chr14_+_34727623 8.67 ENSRNOT00000071405
ENSRNOT00000090183
Kdr
kinase insert domain receptor
chr8_+_69971778 8.27 ENSRNOT00000058007
ENSRNOT00000037941
ENSRNOT00000050649
Megf11
multiple EGF-like-domains 11
chr1_-_226152524 7.94 ENSRNOT00000027756
Fads2
fatty acid desaturase 2
chrX_+_68891227 7.81 ENSRNOT00000009635
Efnb1
ephrin B1
chr8_+_119160731 7.44 ENSRNOT00000046745
Als2cl
ALS2 C-terminal like
chr11_-_74315248 7.31 ENSRNOT00000002346
Hes1
hes family bHLH transcription factor 1
chr17_-_55709740 7.03 ENSRNOT00000033359
RGD1562037
similar to OTTHUMP00000046255
chr2_-_233743866 6.91 ENSRNOT00000087062
Enpep
glutamyl aminopeptidase
chr3_+_45683993 6.76 ENSRNOT00000038983
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr9_+_119517101 6.67 ENSRNOT00000020476
Lpin2
lipin 2
chrX_-_112473822 6.61 ENSRNOT00000079180
Col4a6
collagen type IV alpha 6 chain
chr11_+_81972219 6.47 ENSRNOT00000002452
Dgkg
diacylglycerol kinase, gamma
chr16_-_74864816 6.40 ENSRNOT00000017164
Alg11
ALG11, alpha-1,2-mannosyltransferase
chrX_+_110894845 6.27 ENSRNOT00000080072
Tbc1d8b
TBC1 domain family member 8B
chr11_-_14160697 6.18 ENSRNOT00000081096
Hspa13
heat shock protein 70 family, member 13
chr16_+_49485256 6.17 ENSRNOT00000059317
RGD1564308
similar to LOC495042 protein
chr12_-_23661009 5.97 ENSRNOT00000059451
Upk3bl
uroplakin 3B-like
chr8_-_55171718 5.53 ENSRNOT00000080736
LOC689959
hypothetical protein LOC689959
chr2_-_178334900 5.45 ENSRNOT00000090152
Fnip2
folliculin interacting protein 2
chr4_+_109497962 5.41 ENSRNOT00000057869
Reg1a
regenerating family member 1 alpha
chr18_+_56379890 5.12 ENSRNOT00000078764
Pdgfrb
platelet derived growth factor receptor beta
chr19_+_43163129 5.09 ENSRNOT00000073721
Clec18a
C-type lectin domain family 18, member A
chr18_-_31071371 4.96 ENSRNOT00000060432
Diaph1
diaphanous-related formin 1
chr11_-_14160892 4.82 ENSRNOT00000091864
Hspa13
heat shock protein 70 family, member 13
chr12_-_47046022 4.80 ENSRNOT00000001539
Srsf9
serine and arginine rich splicing factor 9
chr10_-_55783489 4.54 ENSRNOT00000010415
Alox15b
arachidonate 15-lipoxygenase, type B
chr5_-_24255606 4.50 ENSRNOT00000037483
Plekhf2
pleckstrin homology and FYVE domain containing 2
chr19_+_43163562 4.49 ENSRNOT00000048900
Clec18a
C-type lectin domain family 18, member A
chr1_+_64506735 4.46 ENSRNOT00000086331
Nlrp12
NLR family, pyrin domain containing 12
chrX_-_73778595 4.33 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
Rlim
ring finger protein, LIM domain interacting
chr7_+_117055395 4.32 ENSRNOT00000091960
Mapk15
mitogen-activated protein kinase 15
chr6_+_34094306 4.24 ENSRNOT00000051970
Wdr35
WD repeat domain 35
chr16_-_19777414 3.86 ENSRNOT00000022898
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr1_-_216274930 3.85 ENSRNOT00000040850
Trpm5
transient receptor potential cation channel, subfamily M, member 5
chr10_-_85636902 3.79 ENSRNOT00000017241
Pcgf2
polycomb group ring finger 2
chr1_+_101213788 3.79 ENSRNOT00000090838
Tead2
TEA domain transcription factor 2
chr6_-_88917070 3.77 ENSRNOT00000000767
Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chrX_-_77061604 3.77 ENSRNOT00000083643
ENSRNOT00000089386
Magt1
magnesium transporter 1
chr18_-_37245809 3.70 ENSRNOT00000079585
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
chr5_+_82587420 3.70 ENSRNOT00000014020
Tlr4
toll-like receptor 4
chr16_+_78539489 3.53 ENSRNOT00000057897
Csmd1
CUB and Sushi multiple domains 1
chr1_+_216254979 3.50 ENSRNOT00000046669
Tssc4
tumor suppressing subtransferable candidate 4
chr1_+_101214593 3.48 ENSRNOT00000028086
Tead2
TEA domain transcription factor 2
chr19_+_37282018 3.36 ENSRNOT00000021723
Tmem208
transmembrane protein 208
chr9_+_81880177 3.32 ENSRNOT00000022839
Stk36
serine/threonine kinase 36
chr17_-_45154355 3.29 ENSRNOT00000084976
Zkscan4
zinc finger with KRAB and SCAN domains 4
chr7_+_117055623 3.27 ENSRNOT00000012461
Mapk15
mitogen-activated protein kinase 15
chr6_+_107169528 3.23 ENSRNOT00000012495
Psen1
presenilin 1
chr1_+_162342051 3.20 ENSRNOT00000016478
Alg8
ALG8, alpha-1,3-glucosyltransferase
chr1_+_185427736 3.17 ENSRNOT00000064706
Plekha7
pleckstrin homology domain containing A7
chr4_-_30380119 3.08 ENSRNOT00000036460
Pon2
paraoxonase 2
chr1_-_100671074 2.95 ENSRNOT00000027132
Myh14
myosin heavy chain 14
chr16_-_23991570 2.68 ENSRNOT00000044198
ENSRNOT00000018854
Nat2
Nat1
N-acetyltransferase 2
N-acetyltransferase 1
chr5_+_146383942 2.55 ENSRNOT00000078588
Csmd2
CUB and Sushi multiple domains 2
chr7_-_92882068 2.38 ENSRNOT00000037809
Ext1
exostosin glycosyltransferase 1
chrX_+_112020646 2.37 ENSRNOT00000079841
Mid2
midline 2
chr1_+_252894663 2.36 ENSRNOT00000054757
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
chr6_+_111534548 2.29 ENSRNOT00000087462
AABR07065139.1

chr17_-_22678253 2.24 ENSRNOT00000083122
LOC100362172
LRRGT00112-like
chr2_+_86951776 2.21 ENSRNOT00000087275
AABR07009105.1

chr12_-_38782010 2.20 ENSRNOT00000001813
Wdr66
WD repeat domain 66
chr19_+_61334168 2.09 ENSRNOT00000080465
Nrp1
neuropilin 1
chr1_+_277190964 2.07 ENSRNOT00000080511
Casp7
caspase 7
chr7_+_11582984 2.04 ENSRNOT00000026893
Gng7
G protein subunit gamma 7
chr7_+_11033317 2.01 ENSRNOT00000007498
Gna11
guanine nucleotide binding protein, alpha 11
chr10_-_17075139 1.96 ENSRNOT00000039398
Neurl1b
neuralized E3 ubiquitin protein ligase 1B
chr1_+_199412834 1.95 ENSRNOT00000031891
Fus
fused in sarcoma RNA binding protein
chr1_+_157573324 1.89 ENSRNOT00000092066
Rab30
RAB30, member RAS oncogene family
chr19_-_37281933 1.89 ENSRNOT00000059663
Lrrc29
leucine rich repeat containing 29
chr3_+_7279340 1.84 ENSRNOT00000017029
Ak8
adenylate kinase 8
chr8_-_104912959 1.80 ENSRNOT00000017363
Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr12_+_19314251 1.79 ENSRNOT00000001827
Ap4m1
adaptor-related protein complex 4, mu 1 subunit
chr1_+_79931156 1.52 ENSRNOT00000019814
ENSRNOT00000084985
Sympk
symplekin
chr8_+_61659445 1.42 ENSRNOT00000023831
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr1_+_261180007 1.41 ENSRNOT00000072181
Zdhhc16
zinc finger, DHHC-type containing 16
chr13_+_110257571 1.41 ENSRNOT00000005715
Ints7
integrator complex subunit 7
chr16_-_49484985 1.38 ENSRNOT00000016723
Ufsp2
UFM1-specific peptidase 2
chr2_-_188587498 1.28 ENSRNOT00000027878
Slc50a1
solute carrier family 50 member 1
chr3_-_3834186 1.27 ENSRNOT00000061669
Sdccag3
serologically defined colon cancer antigen 3
chr14_+_4125380 1.23 ENSRNOT00000002882
Zfp644
zinc finger protein 644
chr6_-_103470427 1.13 ENSRNOT00000091560
ENSRNOT00000088795
ENSRNOT00000079824
Actn1
actinin, alpha 1
chr2_-_181102918 1.12 ENSRNOT00000017190
Gucy1a3
guanylate cyclase 1 soluble subunit alpha 3
chr18_+_58325319 0.99 ENSRNOT00000065802
ENSRNOT00000077726
Napg
NSF attachment protein gamma
chr3_+_11587941 0.94 ENSRNOT00000071505
Dpm2
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chrX_-_105417323 0.93 ENSRNOT00000015494
Gla
galactosidase, alpha
chr6_-_124177404 0.92 ENSRNOT00000005369
Nrde2
NRDE-2, necessary for RNA interference, domain containing
chr5_+_154800226 0.91 ENSRNOT00000016046
Htr1d
5-hydroxytryptamine receptor 1D
chr16_+_8350326 0.87 ENSRNOT00000027071
Parg
poly (ADP-ribose) glycohydrolase
chr6_-_67085390 0.86 ENSRNOT00000083277
Nova1
NOVA alternative splicing regulator 1
chr11_-_87628502 0.84 ENSRNOT00000002568
Med15
mediator complex subunit 15
chrX_+_128493614 0.75 ENSRNOT00000044240
Stag2
stromal antigen 2
chr1_-_226630900 0.62 ENSRNOT00000028092
Tmem138
transmembrane protein 138
chr12_-_29919320 0.53 ENSRNOT00000038092
Tyw1
tRNA-yW synthesizing protein 1 homolog
chr10_+_55707164 0.44 ENSRNOT00000009757
Hes7
hes family bHLH transcription factor 7
chr10_-_15346236 0.38 ENSRNOT00000088104
ENSRNOT00000027430
Capn15
calpain 15
chr3_+_161212156 0.32 ENSRNOT00000020280
ENSRNOT00000083553
Dnttip1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr2_+_184600721 0.30 ENSRNOT00000075823
Gatb
glutamyl-tRNA amidotransferase subunit B
chr12_+_19328957 0.29 ENSRNOT00000033288
Cnpy4
canopy FGF signaling regulator 4
chr15_-_60766579 0.29 ENSRNOT00000079978
Akap11
A-kinase anchoring protein 11
chr1_+_87697005 0.28 ENSRNOT00000028158
Zfp84
zinc finger protein 84
chr8_+_117170620 0.26 ENSRNOT00000075271
LOC498675
hypothetical LOC498675
chr7_-_145174771 0.25 ENSRNOT00000055270
Glycam1
glycosylation dependent cell adhesion molecule 1
chr20_-_6500523 0.23 ENSRNOT00000000629
Cpne5
copine 5
chr17_+_76532611 0.20 ENSRNOT00000024099
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr7_+_123043503 0.16 ENSRNOT00000026258
ENSRNOT00000086355
Tef
TEF, PAR bZIP transcription factor
chr3_+_37599728 0.15 ENSRNOT00000090575
Rif1
replication timing regulatory factor 1
chrX_-_112328642 0.08 ENSRNOT00000083150
Psmd10
proteasome 26S subunit, non-ATPase 10
chr20_+_33174892 0.06 ENSRNOT00000045139
LOC100361475
transforming growth factor beta regulator 1-like
chr5_+_73496027 0.05 ENSRNOT00000022395
Actl7a
actin-like 7a
chr9_-_81880105 0.02 ENSRNOT00000022677
Rnf25
ring finger protein 25

Network of associatons between targets according to the STRING database.

First level regulatory network of Rbpj

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.8 GO:0061296 mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
4.7 14.1 GO:0042631 cellular response to water deprivation(GO:0042631)
3.1 12.3 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
2.9 17.6 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
2.4 7.3 GO:0021558 trochlear nerve development(GO:0021558) negative regulation of auditory receptor cell differentiation(GO:0045608)
2.1 15.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
2.0 20.2 GO:0018298 protein-chromophore linkage(GO:0018298)
1.9 26.5 GO:0045056 transcytosis(GO:0045056)
1.9 11.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
1.8 3.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.8 5.4 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
1.5 4.5 GO:0045751 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751)
1.4 4.3 GO:1900095 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
1.4 6.9 GO:0002003 angiotensin maturation(GO:0002003)
1.3 5.1 GO:0072277 cell migration involved in vasculogenesis(GO:0035441) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.1 3.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.0 2.1 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.9 4.5 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.8 10.2 GO:0043587 tongue morphogenesis(GO:0043587)
0.8 2.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.7 9.6 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.7 7.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.6 3.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.5 3.2 GO:1904796 synaptic vesicle targeting(GO:0016080) regulation of core promoter binding(GO:1904796)
0.5 18.0 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.5 2.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 7.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.4 4.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.4 2.1 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.4 7.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 1.1 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.4 7.6 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.4 18.0 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.4 5.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 6.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.3 8.3 GO:0010842 retina layer formation(GO:0010842)
0.3 7.8 GO:0031295 T cell costimulation(GO:0031295)
0.3 2.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.3 3.7 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.3 3.8 GO:0015693 magnesium ion transport(GO:0015693)
0.3 2.7 GO:0097068 response to thyroxine(GO:0097068)
0.3 1.3 GO:1901656 glycoside transport(GO:1901656)
0.2 0.9 GO:0019348 dolichol metabolic process(GO:0019348)
0.2 3.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 7.4 GO:0007032 endosome organization(GO:0007032)
0.2 2.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 4.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 0.9 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 2.0 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.4 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 2.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.9 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.1 3.5 GO:0001964 startle response(GO:0001964)
0.1 4.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 33.9 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 31.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 16.4 GO:0007596 blood coagulation(GO:0007596)
0.1 1.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.3 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.1 9.0 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.1 0.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.9 GO:0098543 detection of bacterium(GO:0016045) detection of other organism(GO:0098543)
0.1 9.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.9 GO:0016246 RNA interference(GO:0016246)
0.1 1.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 2.7 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.1 1.8 GO:0021591 ventricular system development(GO:0021591)
0.1 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 3.8 GO:0050909 sensory perception of taste(GO:0050909)
0.0 5.5 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.3 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 1.4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 3.8 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 1.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 2.4 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 1.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 1.9 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 1.9 GO:0007030 Golgi organization(GO:0007030)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.9 GO:0021510 spinal cord development(GO:0021510)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
2.5 19.7 GO:0097443 sorting endosome(GO:0097443)
2.4 7.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.8 6.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.8 18.0 GO:0034706 sodium channel complex(GO:0034706)
0.7 3.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.7 2.9 GO:0097513 myosin II filament(GO:0097513)
0.6 4.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.5 3.8 GO:0001739 sex chromatin(GO:0001739)
0.5 3.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.5 6.9 GO:0031983 vesicle lumen(GO:0031983)
0.5 5.1 GO:0043202 lysosomal lumen(GO:0043202)
0.4 14.1 GO:0046930 pore complex(GO:0046930)
0.4 4.3 GO:0005915 zonula adherens(GO:0005915)
0.4 25.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 0.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3 1.5 GO:0097165 nuclear stress granule(GO:0097165)
0.2 3.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 2.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.2 1.9 GO:0044327 dendritic spine head(GO:0044327)
0.2 20.2 GO:0072562 blood microparticle(GO:0072562)
0.2 16.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.9 GO:0042588 zymogen granule(GO:0042588)
0.1 10.2 GO:0045095 keratin filament(GO:0045095)
0.1 9.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 4.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.3 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1 1.4 GO:0032039 integrator complex(GO:0032039)
0.1 5.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.3 GO:0030904 retromer complex(GO:0030904)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 39.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 5.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 6.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 41.7 GO:0005576 extracellular region(GO:0005576)
0.0 2.0 GO:0005769 early endosome(GO:0005769)
0.0 5.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 26.5 GO:0042954 lipoprotein transporter activity(GO:0042954)
4.0 20.2 GO:0019862 IgA binding(GO:0019862)
3.1 24.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
3.0 15.0 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
2.8 14.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
2.1 6.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
2.0 18.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
2.0 7.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
1.1 3.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.0 3.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.9 3.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.9 2.7 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.8 9.6 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 5.5 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.7 2.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.6 7.3 GO:0008432 JUN kinase binding(GO:0008432)
0.6 15.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 3.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.5 1.8 GO:0004127 cytidylate kinase activity(GO:0004127)
0.4 33.9 GO:0038024 cargo receptor activity(GO:0038024)
0.4 6.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 7.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 1.0 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.3 3.8 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 0.9 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.3 6.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 4.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 2.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 5.0 GO:0005522 profilin binding(GO:0005522)
0.3 7.6 GO:0004707 MAP kinase activity(GO:0004707)
0.3 3.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 3.2 GO:0070097 delta-catenin binding(GO:0070097)
0.2 11.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 2.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 7.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 4.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 7.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 16.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 15.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 12.3 GO:0003823 antigen binding(GO:0003823)
0.1 0.9 GO:0016936 galactoside binding(GO:0016936)
0.1 14.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.8 GO:0005272 sodium channel activity(GO:0005272)
0.1 6.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.3 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.1 10.6 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.1 1.9 GO:0031489 myosin V binding(GO:0031489)
0.1 2.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0051378 serotonin binding(GO:0051378)
0.1 13.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.9 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.1 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 3.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 5.4 GO:0008083 growth factor activity(GO:0008083)
0.0 0.3 GO:0043199 sulfate binding(GO:0043199)
0.0 1.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.5 GO:0010181 FMN binding(GO:0010181)
0.0 4.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 19.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
1.1 26.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.5 5.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.3 18.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 11.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.2 7.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 2.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 9.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 3.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 3.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 7.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 30.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 9.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 8.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 23.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.8 18.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.6 19.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.1 13.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.8 26.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.8 7.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.7 25.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.5 6.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.4 15.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 3.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.4 10.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 3.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 7.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 2.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 4.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 4.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 6.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 6.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 2.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 3.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 11.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.0 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis