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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Relb

Z-value: 0.62

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Transcription factors associated with Relb

Gene Symbol Gene ID Gene Info
Relb
ENSRNOG00000033235 RELB proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Relbrn6_v1_chr1_-_80544825_805448250.591.6e-31Click!

Activity profile of Relb motif

Sorted Z-values of Relb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_20479999 26.10 ENSRNOT00000050573
AABR07051733.2

chr20_-_4863011 25.77 ENSRNOT00000079503
Ltb
lymphotoxin beta
chr20_-_4863198 25.61 ENSRNOT00000001108
Ltb
lymphotoxin beta
chr20_+_5184515 24.21 ENSRNOT00000089411
LOC103694381
lymphotoxin-beta
chr4_+_101882994 23.81 ENSRNOT00000087773
AABR07060963.1

chr20_-_1878126 22.98 ENSRNOT00000000995
Ubd
ubiquitin D
chr4_+_93888502 20.59 ENSRNOT00000090783
AABR07060792.1

chr11_+_85042348 13.28 ENSRNOT00000042220
AABR07034718.1

chr6_+_109562587 11.92 ENSRNOT00000011563
Batf
basic leucine zipper ATF-like transcription factor
chr3_+_2643610 10.88 ENSRNOT00000037169
Fut7
fucosyltransferase 7
chr13_+_47539231 10.70 ENSRNOT00000029694
Fcamr
Fc fragment of IgA and IgM receptor
chr1_-_80544825 9.24 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
Relb
RELB proto-oncogene, NF-kB subunit
chr1_-_89269930 8.84 ENSRNOT00000028532
Ffar2
free fatty acid receptor 2
chr17_+_56109549 8.48 ENSRNOT00000022190
Map3k8
mitogen-activated protein kinase kinase kinase 8
chr5_-_136002900 7.98 ENSRNOT00000025197
Plk3
polo-like kinase 3
chr5_+_168019058 7.93 ENSRNOT00000077202
Tnfrsf9
TNF receptor superfamily member 9
chr20_+_4852671 7.69 ENSRNOT00000001111
Lta
lymphotoxin alpha
chr3_-_105214989 7.03 ENSRNOT00000037895
Grem1
gremlin 1, DAN family BMP antagonist
chr20_+_4852496 6.67 ENSRNOT00000088936
Lta
lymphotoxin alpha
chr4_+_87293871 6.30 ENSRNOT00000090943
AABR07060628.1

chr20_-_49486550 5.82 ENSRNOT00000048270
ENSRNOT00000076541
Prdm1
PR/SET domain 1
chr1_-_3849080 4.76 ENSRNOT00000045301
RGD1560633
similar to ribosomal protein L27a
chr4_-_80313411 4.37 ENSRNOT00000041621
RGD1565415
similar to ribosomal protein L27a
chr1_+_93242050 4.31 ENSRNOT00000013741
RGD1562402
similar to 60S ribosomal protein L27a
chr11_-_82366505 4.08 ENSRNOT00000041326
RGD1559972
similar to ribosomal protein L27a
chr1_-_170579616 4.04 ENSRNOT00000076100
Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr6_-_99400822 3.63 ENSRNOT00000089594
Zbtb25
zinc finger and BTB domain containing 25
chr6_-_41039437 3.57 ENSRNOT00000005774
Trib2
tribbles pseudokinase 2
chr5_-_59025631 3.56 ENSRNOT00000049000
ENSRNOT00000022801
Tpm2
tropomyosin 2, beta
chr2_-_84437084 3.46 ENSRNOT00000077598
Ankrd33b
ankyrin repeat domain 33B
chr6_-_107678156 3.35 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr5_-_79570073 3.32 ENSRNOT00000011845
Tnfsf15
tumor necrosis factor superfamily member 15
chrX_+_156655960 3.32 ENSRNOT00000085723
Mecp2
methyl CpG binding protein 2
chr13_+_49870976 2.86 ENSRNOT00000090170
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr10_-_40296470 2.80 ENSRNOT00000086456
Tnip1
TNFAIP3 interacting protein 1
chr11_+_47243342 2.78 ENSRNOT00000041116
Nfkbiz
NFKB inhibitor zeta
chr5_-_165316652 2.71 ENSRNOT00000012726
LOC102552055
angiopoietin-related protein 7-like
chr2_-_84436912 2.59 ENSRNOT00000059565
Ankrd33b
ankyrin repeat domain 33B
chr2_+_140471690 2.58 ENSRNOT00000017379
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr3_+_77047466 1.85 ENSRNOT00000089424
Olr648
olfactory receptor 648
chrX_-_32355296 1.13 ENSRNOT00000081652
ENSRNOT00000065075
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr14_+_17210733 0.76 ENSRNOT00000003075
Cxcl10
C-X-C motif chemokine ligand 10
chr1_-_86948845 0.70 ENSRNOT00000027212
Nfkbib
NFKB inhibitor beta
chr3_+_111767161 0.32 ENSRNOT00000009430
Mapkbp1
mitogen activated protein kinase binding protein 1
chr6_-_76270457 0.31 ENSRNOT00000009894
Nfkbia
NFKB inhibitor alpha
chr5_+_25146949 0.31 ENSRNOT00000061370
Rad54b
RAD54 homolog B (S. cerevisiae)
chr18_-_36322320 0.21 ENSRNOT00000060260
Grxcr2
glutaredoxin and cysteine rich domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.4 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
3.5 24.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
2.9 23.0 GO:0070842 aggresome assembly(GO:0070842)
2.6 7.9 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
2.2 8.8 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
1.8 3.6 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.8 7.0 GO:1900158 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
1.6 4.9 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
1.1 3.3 GO:2000820 positive regulation of histone H3-K9 trimethylation(GO:1900114) negative regulation of dendrite extension(GO:1903860) negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
1.1 11.9 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.8 10.9 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.7 5.8 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
0.7 9.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.6 4.0 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.4 2.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 0.8 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.2 3.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.2 2.8 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.2 2.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 8.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 3.6 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 48.0 GO:0006955 immune response(GO:0006955)
0.0 1.1 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 9.1 GO:0006412 translation(GO:0006412)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 10.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.8 4.0 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 3.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.5 23.0 GO:0016235 aggresome(GO:0016235)
0.4 2.6 GO:0031415 NatA complex(GO:0031415)
0.2 3.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 10.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 2.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 9.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 96.7 GO:0005615 extracellular space(GO:0005615)
0.0 3.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.8 GO:0005795 Golgi stack(GO:0005795)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.1 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 51.4 GO:0043120 tumor necrosis factor binding(GO:0043120)
2.1 10.7 GO:0019862 IgA binding(GO:0019862)
1.8 10.9 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.4 7.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
1.2 23.0 GO:0070628 proteasome binding(GO:0070628)
1.0 41.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.7 3.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.4 7.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 2.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 8.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 2.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 8.0 GO:0002039 p53 binding(GO:0002039)
0.1 3.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 4.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 20.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.1 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 8.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 11.0 PID CD40 PATHWAY CD40/CD40L signaling
0.3 14.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.3 7.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 9.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 54.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 7.0 PID BMP PATHWAY BMP receptor signaling
0.1 8.0 PID P73PATHWAY p73 transcription factor network
0.1 2.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 5.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 1.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 3.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 8.8 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events