Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Rest

Z-value: 3.87

Motif logo

logo of

Transcription factors associated with Rest

Gene Symbol Gene ID Gene Info
Rest
ENSRNOG00000002074 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Restrn6_v1_chr14_-_33164141_33164141-0.622.5e-35Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_125428260 325.28 ENSRNOT00000028892
Chgb
chromogranin B
chr3_-_176816114 318.85 ENSRNOT00000079262
ENSRNOT00000018697
Stmn3
stathmin 3
chr10_-_20622600 314.21 ENSRNOT00000020554
Fbll1
fibrillarin-like 1
chr18_-_24182012 307.02 ENSRNOT00000023594
Syt4
synaptotagmin 4
chr12_+_41073824 287.52 ENSRNOT00000001844
Rph3a
rabphilin 3A
chr4_+_145238947 281.25 ENSRNOT00000067396
ENSRNOT00000091934
Cpne9
copine family member 9
chr6_+_126434226 263.75 ENSRNOT00000090857
Chga
chromogranin A
chr1_+_84470829 251.64 ENSRNOT00000025472
Ttc9b
tetratricopeptide repeat domain 9B
chr2_-_189096785 240.22 ENSRNOT00000028200
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
chr2_-_179704629 237.99 ENSRNOT00000083361
ENSRNOT00000077941
Gria2
glutamate ionotropic receptor AMPA type subunit 2
chr9_-_92291220 236.50 ENSRNOT00000093357
Dner
delta/notch-like EGF repeat containing
chr3_-_2534663 232.23 ENSRNOT00000049297
ENSRNOT00000044246
Grin1
glutamate ionotropic receptor NMDA type subunit 1
chr1_+_106998623 231.23 ENSRNOT00000022383
Slc17a6
solute carrier family 17 member 6
chr4_-_154043850 230.86 ENSRNOT00000018902
Iqsec3
IQ motif and Sec7 domain 3
chr1_-_143315633 229.21 ENSRNOT00000026030
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr3_-_2534375 217.58 ENSRNOT00000037725
Grin1
glutamate ionotropic receptor NMDA type subunit 1
chr17_+_89171250 216.90 ENSRNOT00000024901
Gad2
glutamate decarboxylase 2
chr6_-_92760018 211.05 ENSRNOT00000009560
Trim9
tripartite motif-containing 9
chr3_+_161433410 199.93 ENSRNOT00000024657
Slc12a5
solute carrier family 12 member 5
chr2_-_30127269 196.20 ENSRNOT00000023869
Cartpt
CART prepropeptide
chr10_+_90342051 192.11 ENSRNOT00000028487
Rundc3a
RUN domain containing 3A
chr20_+_5815837 190.31 ENSRNOT00000036999
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr5_-_172809353 175.32 ENSRNOT00000022246
Gabrd
gamma-aminobutyric acid type A receptor delta subunit
chr13_-_111765944 172.77 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr9_+_86874685 169.50 ENSRNOT00000041337
NEWGENE_1305560
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_+_151310598 167.92 ENSRNOT00000092194
Mmp24
matrix metallopeptidase 24
chr10_+_67862054 165.19 ENSRNOT00000031746
Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
chr3_-_5693147 163.42 ENSRNOT00000008660
Fam163b
family with sequence similarity 163, member B
chr1_+_105285419 161.26 ENSRNOT00000089693
Slc6a5
solute carrier family 6 member 5
chr9_+_77834091 159.34 ENSRNOT00000033459
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr5_+_145257714 158.58 ENSRNOT00000019214
Dlgap3
DLG associated protein 3
chr3_-_175479395 152.82 ENSRNOT00000077308
Hrh3
histamine receptor H3
chr5_+_29538380 148.84 ENSRNOT00000010845
Calb1
calbindin 1
chr1_+_42169501 147.74 ENSRNOT00000025477
ENSRNOT00000092791
Vip
vasoactive intestinal peptide
chr8_+_117620317 143.87 ENSRNOT00000084220
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr7_-_117587103 139.66 ENSRNOT00000035423
Scrt1
scratch family transcriptional repressor 1
chr10_-_64915148 138.05 ENSRNOT00000048543
Sez6
seizure related 6 homolog
chr12_+_45727112 134.15 ENSRNOT00000001507
Srrm4
serine/arginine repetitive matrix 4
chr1_+_43475589 133.88 ENSRNOT00000092034
ENSRNOT00000024682
Oprm1
opioid receptor, mu 1
chrX_+_156911345 131.48 ENSRNOT00000080945
L1cam
L1 cell adhesion molecule
chr17_+_43357888 126.54 ENSRNOT00000022329
Scgn
secretagogin, EF-hand calcium binding protein
chr6_-_108415093 124.45 ENSRNOT00000031650
Syndig1l
synapse differentiation inducing 1-like
chr6_+_147876557 124.36 ENSRNOT00000080090
Tmem196
transmembrane protein 196
chr17_-_10766253 123.50 ENSRNOT00000000117
Cplx2
complexin 2
chr8_+_64364741 121.75 ENSRNOT00000082840
Celf6
CUGBP, Elav-like family member 6
chr6_+_147876237 120.16 ENSRNOT00000056649
Tmem196
transmembrane protein 196
chr20_-_45815940 116.33 ENSRNOT00000073276
Gpr6
G protein-coupled receptor 6
chr6_-_137084739 113.04 ENSRNOT00000060943
Tmem179
transmembrane protein 179
chr10_-_40953651 108.91 ENSRNOT00000063889
Glra1
glycine receptor, alpha 1
chrX_+_1321315 105.55 ENSRNOT00000014250
Syn1
synapsin I
chr15_+_34167945 100.78 ENSRNOT00000032252
Carmil3
capping protein regulator and myosin 1 linker 3
chr16_-_37908173 97.67 ENSRNOT00000075026
Glra3
glycine receptor, alpha 3
chr3_+_3310954 92.34 ENSRNOT00000061773
Kcnt1
potassium sodium-activated channel subfamily T member 1
chr16_-_38063821 91.84 ENSRNOT00000077452
ENSRNOT00000089533
Glra3
glycine receptor, alpha 3
chr16_+_8497569 87.72 ENSRNOT00000027054
Ogdhl
oxoglutarate dehydrogenase-like
chr10_-_40953467 86.72 ENSRNOT00000092189
Glra1
glycine receptor, alpha 1
chr6_+_126040631 85.80 ENSRNOT00000008886
Slc24a4
solute carrier family 24 member 4
chr8_-_62248013 78.52 ENSRNOT00000080012
ENSRNOT00000089602
Scamp5
secretory carrier membrane protein 5
chr9_+_117795132 73.64 ENSRNOT00000086943
Akain1
A-kinase anchor inhibitor 1
chr1_-_215536980 67.85 ENSRNOT00000027344
Ifitm10
interferon induced transmembrane protein 10
chr6_+_137997335 67.57 ENSRNOT00000006872
Tmem121
transmembrane protein 121
chr7_-_117786872 65.63 ENSRNOT00000030517
Lrrc24
leucine rich repeat containing 24
chr3_-_80000091 60.52 ENSRNOT00000079394
Madd
MAP-kinase activating death domain
chr3_-_175479034 58.24 ENSRNOT00000086761
Hrh3
histamine receptor H3
chr8_-_21743338 57.63 ENSRNOT00000027829
Olfm2
olfactomedin 2
chr5_-_48194251 56.86 ENSRNOT00000081748
ENSRNOT00000065912
Ankrd6
ankyrin repeat domain 6
chr1_+_193187972 56.13 ENSRNOT00000090172
ENSRNOT00000065342
Slc5a11
solute carrier family 5 member 11
chr5_+_26493212 50.28 ENSRNOT00000061328
Triqk
triple QxxK/R motif containing
chr1_+_220322940 45.20 ENSRNOT00000074972
LOC108348085
beta-1,4-glucuronyltransferase 1
chr10_-_13075864 42.19 ENSRNOT00000005220
Paqr4
progestin and adipoQ receptor family member 4
chr10_+_61403130 34.65 ENSRNOT00000092490
ENSRNOT00000077649
Ccdc92b
coiled-coil domain containing 92B
chr17_-_23923792 33.17 ENSRNOT00000018739
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr1_+_164425475 30.23 ENSRNOT00000023386
Klhl35
kelch-like family member 35
chr1_-_215536770 29.09 ENSRNOT00000078030
Ifitm10
interferon induced transmembrane protein 10
chr8_-_68038533 28.02 ENSRNOT00000018756
Skor1
SKI family transcriptional corepressor 1
chr3_+_172385672 26.93 ENSRNOT00000090989
Gnas
GNAS complex locus
chr15_+_42653148 25.99 ENSRNOT00000022095
Clu
clusterin
chr7_-_58587787 21.28 ENSRNOT00000005814
Lgr5
leucine rich repeat containing G protein coupled receptor 5
chr8_+_130749838 20.75 ENSRNOT00000079273
Snrk
SNF related kinase
chr3_+_153580861 18.98 ENSRNOT00000080516
ENSRNOT00000012739
Src
SRC proto-oncogene, non-receptor tyrosine kinase
chr10_+_60231027 17.81 ENSRNOT00000085543
Olr1482
olfactory receptor 1482
chr3_+_100769839 17.13 ENSRNOT00000077703
Bdnf
brain-derived neurotrophic factor
chr17_+_8135251 16.15 ENSRNOT00000016982
Trpc7
transient receptor potential cation channel, subfamily C, member 7
chr10_-_14597969 14.11 ENSRNOT00000029674
Gnptg
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr1_-_225128740 11.90 ENSRNOT00000026897
Rom1
retinal outer segment membrane protein 1
chr5_-_64946580 5.44 ENSRNOT00000007290
Ppp3r2
protein phosphatase 3, regulatory subunit B, beta
chr1_+_85252103 5.12 ENSRNOT00000080740
Ifnl1
interferon, lambda 1
chr1_+_80256973 4.83 ENSRNOT00000024113
Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr1_-_85237775 4.06 ENSRNOT00000035328
Ifnl3
interferon, lambda 3
chr10_-_60006037 3.29 ENSRNOT00000065541
Olr1485
olfactory receptor 1485

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
153.7 615.0 GO:0021586 pons maturation(GO:0021586)
104.7 314.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
87.9 263.7 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
86.3 518.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
80.1 240.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
54.2 216.9 GO:0006538 glutamate catabolic process(GO:0006538)
49.7 546.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
49.0 196.2 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
44.6 133.9 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
37.2 148.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
35.2 211.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
32.9 131.5 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
31.9 318.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
28.8 143.9 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
25.7 231.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
23.7 236.5 GO:0007220 Notch receptor processing(GO:0007220)
22.2 199.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
20.2 60.5 GO:0036395 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276)
18.5 147.7 GO:0070459 prolactin secretion(GO:0070459)
17.5 192.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
12.9 167.9 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
12.7 190.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
12.4 460.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
11.5 229.2 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
10.3 238.0 GO:0060992 response to fungicide(GO:0060992)
9.6 230.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
9.5 123.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
9.4 281.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
9.0 26.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
8.7 26.0 GO:1902988 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
7.8 116.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
7.7 138.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
7.0 105.5 GO:0097091 synaptic vesicle clustering(GO:0097091)
5.7 56.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
5.3 21.3 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
5.2 57.6 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
4.8 255.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
4.7 19.0 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
3.9 187.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
3.4 78.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
2.9 87.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
2.9 85.8 GO:0097186 amelogenesis(GO:0097186)
2.5 73.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
2.4 4.8 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
2.3 139.7 GO:2001222 regulation of neuron migration(GO:2001222)
2.1 17.1 GO:0061193 taste bud development(GO:0061193)
1.8 56.1 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
1.7 175.3 GO:1902476 chloride transmembrane transport(GO:1902476)
1.3 5.1 GO:0042509 negative regulation of interleukin-13 production(GO:0032696) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.9 65.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 14.1 GO:0006622 protein targeting to lysosome(GO:0006622)
0.5 11.9 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.4 142.7 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.4 92.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 4.1 GO:0002385 mucosal immune response(GO:0002385)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
112.5 449.8 GO:0044307 dendritic branch(GO:0044307)
63.2 189.5 GO:0098982 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
55.1 165.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
39.3 314.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
26.3 289.7 GO:0042583 chromaffin granule(GO:0042583)
23.8 238.0 GO:0098839 postsynaptic density membrane(GO:0098839)
21.9 307.0 GO:0031045 dense core granule(GO:0031045)
20.6 123.5 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
17.5 87.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
16.5 643.4 GO:0060077 inhibitory synapse(GO:0060077)
16.4 229.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
13.6 190.3 GO:0032426 stereocilium tip(GO:0032426)
12.8 231.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
12.2 158.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
12.0 240.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
11.0 131.5 GO:0044294 dendritic growth cone(GO:0044294)
10.9 294.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
10.3 175.3 GO:1902711 GABA-A receptor complex(GO:1902711)
9.3 333.8 GO:0032590 dendrite membrane(GO:0032590)
7.2 217.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
6.3 393.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
5.3 138.0 GO:0097440 apical dendrite(GO:0097440)
2.3 288.7 GO:0008021 synaptic vesicle(GO:0008021)
1.9 126.5 GO:0030658 transport vesicle membrane(GO:0030658)
1.7 318.9 GO:0030426 growth cone(GO:0030426)
1.6 148.8 GO:0043195 terminal bouton(GO:0043195)
1.6 4.8 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
1.6 473.8 GO:0030141 secretory granule(GO:0030141)
1.2 92.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.0 236.5 GO:0005769 early endosome(GO:0005769)
1.0 211.1 GO:0043209 myelin sheath(GO:0043209)
1.0 11.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.6 19.0 GO:0002102 podosome(GO:0002102)
0.4 30.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 152.3 GO:0043025 neuronal cell body(GO:0043025)
0.4 324.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 139.7 GO:0016604 nuclear body(GO:0016604)
0.2 1059.5 GO:0016021 integral component of membrane(GO:0016021)
0.2 205.2 GO:0005615 extracellular space(GO:0005615)
0.2 255.3 GO:0005886 plasma membrane(GO:0005886)
0.2 14.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 200.8 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
90.0 449.8 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
79.3 238.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
65.2 195.6 GO:0030977 taurine binding(GO:0030977)
63.2 189.5 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
61.4 307.0 GO:0030348 syntaxin-3 binding(GO:0030348)
53.8 161.3 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
43.4 216.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
42.2 211.1 GO:0004969 histamine receptor activity(GO:0004969)
37.2 148.8 GO:0099510 calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
35.9 287.5 GO:0008430 selenium binding(GO:0008430)
29.2 87.7 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
27.4 192.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
26.8 133.9 GO:0004977 melanocortin receptor activity(GO:0004977)
24.2 314.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
16.7 199.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
15.4 231.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
14.1 240.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
12.3 85.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
11.6 116.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
9.9 236.5 GO:0005112 Notch binding(GO:0005112)
9.4 131.5 GO:0033691 sialic acid binding(GO:0033691)
8.9 230.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
7.0 175.3 GO:0004890 GABA-A receptor activity(GO:0004890)
6.5 196.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
5.6 56.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
5.2 165.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
4.7 14.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
4.5 158.6 GO:0001540 beta-amyloid binding(GO:0001540)
4.1 123.5 GO:0017075 syntaxin-1 binding(GO:0017075)
3.8 26.9 GO:0047391 mu-type opioid receptor binding(GO:0031852) alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
3.2 73.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
3.2 92.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
3.0 383.8 GO:0000149 SNARE binding(GO:0000149)
2.4 19.0 GO:0071253 connexin binding(GO:0071253)
2.1 17.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.7 105.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.6 26.0 GO:0051787 misfolded protein binding(GO:0051787)
1.4 60.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.4 167.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.2 323.7 GO:0008022 protein C-terminus binding(GO:0008022)
1.0 124.3 GO:0005179 hormone activity(GO:0005179)
0.9 16.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.6 134.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 28.0 GO:0046332 SMAD binding(GO:0046332)
0.3 169.4 GO:0005509 calcium ion binding(GO:0005509)
0.2 45.2 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.1 121.8 GO:0003723 RNA binding(GO:0003723)
0.0 20.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 33.2 GO:0016491 oxidoreductase activity(GO:0016491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 165.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
4.8 238.0 PID NCADHERIN PATHWAY N-cadherin signaling events
3.2 236.5 PID NOTCH PATHWAY Notch signaling pathway
2.5 131.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
2.1 19.0 ST STAT3 PATHWAY STAT3 Pathway
1.9 133.9 PID IL4 2PATHWAY IL4-mediated signaling events
1.6 56.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
1.1 60.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.7 167.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 17.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 95.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
38.2 687.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
26.4 105.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
20.0 240.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
13.8 385.1 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
9.2 165.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
9.0 161.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
8.3 216.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
7.9 236.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
7.3 174.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
6.0 167.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
5.4 150.5 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
5.3 211.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
4.8 517.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
4.5 133.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
1.3 16.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.9 211.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 26.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 8.5 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds