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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Scrt2

Z-value: 1.05

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Transcription factors associated with Scrt2

Gene Symbol Gene ID Gene Info
Scrt2
ENSRNOG00000005148 scratch family transcriptional repressor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Scrt2rn6_v1_chr3_+_147585947_1475859470.574.5e-29Click!

Activity profile of Scrt2 motif

Sorted Z-values of Scrt2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_49676540 59.92 ENSRNOT00000022032
ENSRNOT00000082205
Fxyd6
FXYD domain-containing ion transport regulator 6
chr2_-_119537837 53.94 ENSRNOT00000015200
Pex5l
peroxisomal biogenesis factor 5-like
chr14_-_43143973 53.21 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr2_+_121165137 47.48 ENSRNOT00000016236
Sox2
SRY box 2
chr9_-_85243001 46.52 ENSRNOT00000020219
Scg2
secretogranin II
chr18_-_6782996 42.93 ENSRNOT00000090320
Aqp4
aquaporin 4
chr18_-_6782757 42.77 ENSRNOT00000068150
Aqp4
aquaporin 4
chr1_-_93949187 41.76 ENSRNOT00000018956
Zfp536
zinc finger protein 536
chr10_+_58332588 38.46 ENSRNOT00000081954
Wscd1
WSC domain containing 1
chrX_+_17171605 37.77 ENSRNOT00000048236
Nudt10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr7_+_121408829 35.36 ENSRNOT00000023434
Mgat3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr14_-_78308933 35.31 ENSRNOT00000065334
Crmp1
collapsin response mediator protein 1
chr4_-_150829913 35.09 ENSRNOT00000041571
Cacna1c
calcium voltage-gated channel subunit alpha1 C
chr3_-_143063983 35.06 ENSRNOT00000006329
Napb
NSF attachment protein beta
chr10_+_91710495 33.21 ENSRNOT00000033276
Rprml
reprimo-like
chr4_-_150829741 33.18 ENSRNOT00000051846
ENSRNOT00000052017
Cacna1c
calcium voltage-gated channel subunit alpha1 C
chr8_+_64481172 33.14 ENSRNOT00000015332
Pkm
pyruvate kinase, muscle
chr20_+_37876650 30.80 ENSRNOT00000001054
Gja1
gap junction protein, alpha 1
chr1_-_199624783 26.87 ENSRNOT00000026908
Cox6a2
cytochrome c oxidase subunit 6A2
chr1_+_106896790 26.23 ENSRNOT00000042952
ENSRNOT00000064193
Ano5
anoctamin 5
chr2_-_9504134 26.18 ENSRNOT00000076996
Adgrv1
adhesion G protein-coupled receptor V1
chr4_-_83972540 25.34 ENSRNOT00000036951
Tril
TLR4 interactor with leucine-rich repeats
chr2_+_28049217 24.23 ENSRNOT00000022144
Enc1
ectodermal-neural cortex 1
chr20_-_47306318 22.69 ENSRNOT00000075151
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_+_4440876 22.47 ENSRNOT00000049325
ENSRNOT00000076529
ENSRNOT00000076748
Pdgfd
platelet derived growth factor D
chr15_+_67555835 22.43 ENSRNOT00000045882
Pcdh17
protocadherin 17
chr1_+_266953139 21.20 ENSRNOT00000054696
Neurl1
neuralized E3 ubiquitin protein ligase 1
chr12_-_44381289 20.59 ENSRNOT00000001493
Nos1
nitric oxide synthase 1
chr15_+_33544312 20.44 ENSRNOT00000020409
Bcl2l2
Bcl2-like 2
chr11_-_88972176 20.14 ENSRNOT00000002498
Pkp2
plakophilin 2
chrX_-_140303686 18.54 ENSRNOT00000033219
Gpr101
G protein-coupled receptor 101
chr12_+_2534212 18.19 ENSRNOT00000001399
Ctxn1
cortexin 1
chr13_-_42263024 17.60 ENSRNOT00000004741
Lypd1
Ly6/Plaur domain containing 1
chr20_+_5050327 16.73 ENSRNOT00000083353
Ddah2
dimethylarginine dimethylaminohydrolase 2
chr18_+_39172028 16.37 ENSRNOT00000086651
Kcnn2
potassium calcium-activated channel subfamily N member 2
chrX_-_23649466 15.84 ENSRNOT00000059431
Shroom2
shroom family member 2
chr2_-_142885604 14.44 ENSRNOT00000031487
Frem2
Fras1 related extracellular matrix protein 2
chr7_-_59514939 12.88 ENSRNOT00000085579
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr10_-_40764185 12.76 ENSRNOT00000017486
Sparc
secreted protein acidic and cysteine rich
chr4_+_34962339 12.74 ENSRNOT00000086248
AABR07059778.1

chr5_+_28480023 12.41 ENSRNOT00000075067
ENSRNOT00000093754
LOC100912373
uncharacterized LOC100912373
chr7_+_94130852 11.87 ENSRNOT00000011485
Mal2
mal, T-cell differentiation protein 2
chr10_+_11912543 11.11 ENSRNOT00000045192
Zfp597
zinc finger protein 597
chr16_+_8128689 11.08 ENSRNOT00000065618
Galnt15
polypeptide N-acetylgalactosaminyltransferase 15
chrX_+_134742356 11.03 ENSRNOT00000005267
ENSRNOT00000082363
Ocrl
OCRL, inositol polyphosphate-5-phosphatase
chr1_-_54748763 10.24 ENSRNOT00000074549
LOC100911027
protein MAL2-like
chr2_-_227160379 10.10 ENSRNOT00000066581
Usp53
ubiquitin specific peptidase 53
chrX_-_70978714 9.73 ENSRNOT00000076336
Slc7a3
solute carrier family 7 member 3
chr1_-_167911961 9.36 ENSRNOT00000025097
Olr59
olfactory receptor 59
chr3_+_100768637 9.19 ENSRNOT00000083542
Bdnf
brain-derived neurotrophic factor
chr1_-_15301998 9.01 ENSRNOT00000016400
Slc35d3
solute carrier family 35, member D3
chr7_+_12974169 8.84 ENSRNOT00000010555
C2cd4c
C2 calcium-dependent domain containing 4C
chr4_+_158243086 7.48 ENSRNOT00000032112
Ano2
anoctamin 2
chr13_+_50873605 7.47 ENSRNOT00000004382
Fmod
fibromodulin
chr2_-_210874304 7.18 ENSRNOT00000088657
Ampd2
adenosine monophosphate deaminase 2
chr18_+_65285318 6.78 ENSRNOT00000020431
Tcf4
transcription factor 4
chr12_+_38345456 6.70 ENSRNOT00000001685
Clip1
CAP-GLY domain containing linker protein 1
chr10_-_15211325 6.53 ENSRNOT00000027083
Rhot2
ras homolog family member T2
chr2_-_188413219 6.19 ENSRNOT00000065065
Fdps
farnesyl diphosphate synthase
chr15_-_28406046 5.75 ENSRNOT00000015418
Zfp219
zinc finger protein 219
chrX_+_53360839 5.54 ENSRNOT00000091467
ENSRNOT00000034372
ENSRNOT00000081061
Dmd
dystrophin
chr18_-_79258570 5.51 ENSRNOT00000022401
Galr1
galanin receptor 1
chr13_+_101698096 5.21 ENSRNOT00000089309
Aida
axin interactor, dorsalization associated
chr8_-_28208466 5.18 ENSRNOT00000012247
Jam3
junctional adhesion molecule 3
chr1_+_66004349 4.85 ENSRNOT00000042276
ENSRNOT00000052029
Vom2r34
vomeronasal 2 receptor, 34
chr7_+_5593735 4.45 ENSRNOT00000042179
Olr917
olfactory receptor 917
chr7_+_59349745 4.44 ENSRNOT00000085334
Ptprb
protein tyrosine phosphatase, receptor type, B
chr1_+_171592797 3.82 ENSRNOT00000026607
Syt9
synaptotagmin 9
chr1_+_193335645 3.76 ENSRNOT00000019640
Lcmt1
leucine carboxyl methyltransferase 1
chrX_-_124576133 3.62 ENSRNOT00000041904
Rhox3
reproductive homeobox on X chromosome 3
chr10_+_74886985 3.38 ENSRNOT00000009943
Mtmr4
myotubularin related protein 4
chr1_-_188101566 3.38 ENSRNOT00000092435
Syt17
synaptotagmin 17
chr1_+_53220397 3.14 ENSRNOT00000089989
AABR07001573.1

chr10_+_55555089 2.91 ENSRNOT00000006597
Slc25a35
solute carrier family 25, member 35
chr1_+_78820262 2.76 ENSRNOT00000022441
Gng8
G protein subunit gamma 8
chrX_-_70978952 2.76 ENSRNOT00000076910
Slc7a3
solute carrier family 7 member 3
chr1_-_79690434 2.75 ENSRNOT00000057986
ENSRNOT00000057988
LOC102557319
carcinoembryonic antigen-related cell adhesion molecule 3-like
chr1_-_253185533 2.57 ENSRNOT00000067822
Pank1
pantothenate kinase 1
chr3_-_9262628 2.57 ENSRNOT00000013286
Aif1l
allograft inflammatory factor 1-like
chr5_-_78183122 1.73 ENSRNOT00000002083
ENSRNOT00000067076
Fkbp15
FK506 binding protein 15
chr19_-_25261911 1.51 ENSRNOT00000045180
ENSRNOT00000009806
Cc2d1a
coiled-coil and C2 domain containing 1A
chr10_-_43895376 1.36 ENSRNOT00000031811
Olr1413
olfactory receptor 1413
chr2_-_211638788 1.28 ENSRNOT00000027666
Stxbp3
syntaxin binding protein 3
chr20_+_31102476 1.25 ENSRNOT00000078719
Lrrc20
leucine rich repeat containing 20
chr7_-_90318221 1.22 ENSRNOT00000050774
Trps1
transcriptional repressor GATA binding 1
chr3_-_11277757 1.21 ENSRNOT00000015792
Uck1
uridine-cytidine kinase 1
chr11_+_46108470 1.02 ENSRNOT00000073467
Adgrg7
adhesion G protein-coupled receptor G7
chr9_+_19451630 0.80 ENSRNOT00000065048
Enpp4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr8_-_22874637 0.70 ENSRNOT00000064551
ENSRNOT00000090424
Dock6
dedicator of cytokinesis 6
chr19_+_25123724 0.50 ENSRNOT00000007407
LOC686013
hypothetical protein LOC686013
chr7_-_24667301 0.33 ENSRNOT00000009154
Tmem263
transmembrane protein 263
chrX_-_123867149 0.30 ENSRNOT00000089754
Rhox3
reproductive homeobox on X chromosome 3
chr7_+_122157201 0.23 ENSRNOT00000025193
Adsl
adenylosuccinate lyase
chr5_+_13379772 0.14 ENSRNOT00000010032
Npbwr1
neuropeptides B/W receptor 1
chr12_+_22153983 0.00 ENSRNOT00000080775
ENSRNOT00000001894
Pcolce
procollagen C-endopeptidase enhancer

Network of associatons between targets according to the STRING database.

First level regulatory network of Scrt2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
21.4 85.7 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
11.9 47.5 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
11.4 68.3 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
10.3 30.8 GO:0010643 cell communication by chemical coupling(GO:0010643)
9.4 37.8 GO:0071543 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
8.8 35.3 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
8.8 35.1 GO:0035494 SNARE complex disassembly(GO:0035494)
7.7 53.9 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) positive regulation of corticotropin secretion(GO:0051461)
7.5 22.5 GO:2000437 regulation of monocyte extravasation(GO:2000437)
6.6 46.3 GO:0048496 maintenance of organ identity(GO:0048496)
6.2 62.4 GO:0007412 axon target recognition(GO:0007412)
6.1 24.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
5.1 20.6 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
4.6 41.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.8 22.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
3.3 33.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
3.1 9.4 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
3.1 46.5 GO:0048245 eosinophil chemotaxis(GO:0048245)
2.8 5.5 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
2.7 16.4 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
2.5 12.5 GO:1903401 L-lysine transmembrane transport(GO:1903401)
2.5 22.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
2.2 22.4 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
2.2 26.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.9 35.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
1.9 16.7 GO:0006527 arginine catabolic process(GO:0006527)
1.8 5.5 GO:0021627 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
1.7 20.4 GO:0060011 Sertoli cell proliferation(GO:0060011)
1.6 21.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
1.3 6.7 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
1.2 6.0 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384)
1.2 7.2 GO:0032264 IMP salvage(GO:0032264)
1.1 15.8 GO:0045217 cell-cell junction maintenance(GO:0045217)
1.0 59.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.9 16.7 GO:0005513 detection of calcium ion(GO:0005513)
0.8 25.3 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.8 9.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.8 12.8 GO:0009629 response to gravity(GO:0009629)
0.7 18.5 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.6 17.6 GO:1903831 acetylcholine receptor signaling pathway(GO:0095500) negative regulation of protein localization to plasma membrane(GO:1903077) signal transduction involved in cellular response to ammonium ion(GO:1903831) negative regulation of protein localization to cell periphery(GO:1904376) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.6 12.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.6 5.2 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.5 6.8 GO:1900746 regulation of vascular endothelial growth factor signaling pathway(GO:1900746)
0.5 5.2 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
0.4 11.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.4 10.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.3 3.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 6.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.3 2.8 GO:0043584 nose development(GO:0043584)
0.3 1.2 GO:0044211 CTP salvage(GO:0044211)
0.3 3.8 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.3 1.3 GO:0022615 protein to membrane docking(GO:0022615)
0.2 7.5 GO:0030199 collagen fibril organization(GO:0030199)
0.1 2.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 7.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 13.9 GO:0006821 chloride transport(GO:0006821)
0.1 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 1.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 4.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048)
0.0 14.4 GO:0007507 heart development(GO:0007507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 35.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
5.7 68.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
5.1 25.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
4.9 53.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
4.4 26.2 GO:0002142 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
3.2 12.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
3.1 50.3 GO:0031045 dense core granule(GO:0031045)
2.9 20.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
2.4 85.7 GO:0046930 pore complex(GO:0046930)
1.7 26.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.6 30.8 GO:0005916 fascia adherens(GO:0005916)
1.1 20.6 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.1 51.1 GO:0031941 filamentous actin(GO:0031941)
1.0 53.2 GO:1904115 axon cytoplasm(GO:1904115)
0.9 20.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.8 6.7 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.8 21.2 GO:0097440 apical dendrite(GO:0097440)
0.6 5.2 GO:0033010 paranodal junction(GO:0033010)
0.6 9.2 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.3 GO:0070820 tertiary granule(GO:0070820)
0.4 16.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 11.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 24.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 5.5 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 47.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.3 6.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 33.1 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.1 14.4 GO:0005604 basement membrane(GO:0005604)
0.1 112.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 22.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.7 GO:0030426 growth cone(GO:0030426)
0.0 7.5 GO:0044431 Golgi apparatus part(GO:0044431)
0.0 1.5 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.3 53.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
11.7 35.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
11.4 68.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
10.8 53.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
9.4 37.8 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
8.3 33.1 GO:0004743 pyruvate kinase activity(GO:0004743)
6.2 30.8 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
6.1 85.7 GO:0015250 water channel activity(GO:0015250)
5.6 16.7 GO:0016403 dimethylargininase activity(GO:0016403)
5.2 41.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
4.1 20.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
3.0 47.5 GO:0035198 miRNA binding(GO:0035198)
2.3 16.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
2.3 6.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.1 12.5 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
1.8 22.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.8 7.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.8 35.3 GO:0031005 filamin binding(GO:0031005)
1.7 33.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
1.6 44.3 GO:0042056 chemoattractant activity(GO:0042056)
1.5 20.1 GO:0045294 alpha-catenin binding(GO:0045294)
1.4 11.0 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
1.3 59.9 GO:0017080 sodium channel regulator activity(GO:0017080)
1.3 20.4 GO:0051400 BH domain binding(GO:0051400)
1.3 17.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
1.2 18.5 GO:0004935 adrenergic receptor activity(GO:0004935)
1.2 6.0 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.1 9.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.1 22.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
1.0 12.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
1.0 25.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.9 26.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 35.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.7 5.5 GO:0004966 galanin receptor activity(GO:0004966)
0.6 2.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.6 12.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.6 38.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.5 3.8 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.5 21.2 GO:0045182 translation regulator activity(GO:0045182)
0.4 31.7 GO:0017022 myosin binding(GO:0017022)
0.4 32.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.3 6.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.2 GO:0004849 uridine kinase activity(GO:0004849)
0.2 12.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 15.8 GO:0008013 beta-catenin binding(GO:0008013)
0.2 11.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 7.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 26.2 GO:0003779 actin binding(GO:0003779)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 5.2 GO:0005178 integrin binding(GO:0005178)
0.1 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 7.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 9.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 53.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.7 30.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7 35.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 22.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 5.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 6.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 9.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 7.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 20.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 6.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 14.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 12.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 85.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
3.4 30.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
2.0 35.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.6 35.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
1.1 33.5 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.8 3.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.6 11.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.5 7.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 12.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 22.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 6.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 6.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 22.5 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 5.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.8 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 8.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 5.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 6.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 6.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 5.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis