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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox15

Z-value: 0.32

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Transcription factors associated with Sox15

Gene Symbol Gene ID Gene Info
Sox15
ENSRNOG00000012155 SRY box 15

Activity profile of Sox15 motif

Sorted Z-values of Sox15 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_79406381 29.86 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
Mbp
myelin basic protein
chr5_+_49311030 17.89 ENSRNOT00000010850
Cnr1
cannabinoid receptor 1
chr3_+_35014538 15.53 ENSRNOT00000006341
Kif5c
kinesin family member 5C
chr16_-_39476025 14.99 ENSRNOT00000014312
Gpm6a
glycoprotein m6a
chr3_-_51643140 12.53 ENSRNOT00000006646
Scn3a
sodium voltage-gated channel alpha subunit 3
chr13_-_91872954 11.57 ENSRNOT00000004613
ENSRNOT00000079263
Cadm3
cell adhesion molecule 3
chr8_+_128824508 11.54 ENSRNOT00000025343
Mobp
myelin-associated oligodendrocyte basic protein
chr1_+_264059374 5.65 ENSRNOT00000075397
Scd2
stearoyl-Coenzyme A desaturase 2
chr12_-_8156151 5.29 ENSRNOT00000064721
Mtus2
microtubule associated tumor suppressor candidate 2
chr15_+_12827707 4.85 ENSRNOT00000012452
Fezf2
Fez family zinc finger 2
chr7_-_98098268 4.30 ENSRNOT00000010361
Fbxo32
F-box protein 32
chr8_-_87282156 4.12 ENSRNOT00000087874
Filip1
filamin A interacting protein 1
chr4_+_158088505 1.86 ENSRNOT00000026643
Vwf
von Willebrand factor
chr6_+_73358112 1.18 ENSRNOT00000041373
Arhgap5
Rho GTPase activating protein 5
chr18_-_58097316 1.16 ENSRNOT00000088527
AABR07032265.1

chr6_-_147172813 0.84 ENSRNOT00000066545
Itgb8
integrin subunit beta 8
chr7_-_36408588 0.54 ENSRNOT00000063946
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr13_-_95250235 0.48 ENSRNOT00000085648
Akt3
AKT serine/threonine kinase 3
chr14_+_11198896 0.39 ENSRNOT00000079767
Hnrnpdl
heterogeneous nuclear ribonucleoprotein D-like
chr1_+_185863043 0.18 ENSRNOT00000079072
Sox6
SRY box 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 29.9 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
6.0 17.9 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
3.9 15.5 GO:0098963 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
1.4 5.6 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.3 12.5 GO:0046684 response to pyrethroid(GO:0046684)
1.2 4.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.9 4.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.3 15.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 1.9 GO:0070417 cellular response to cold(GO:0070417)
0.2 11.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.8 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 1.2 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 29.9 GO:0033269 internode region of axon(GO:0033269)
1.0 15.5 GO:0035253 ciliary rootlet(GO:0035253)
0.6 12.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 15.0 GO:0044295 axonal growth cone(GO:0044295)
0.3 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 0.8 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 17.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 11.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 11.5 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 17.9 GO:0004949 cannabinoid receptor activity(GO:0004949)
3.5 41.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.6 15.5 GO:0034190 apolipoprotein receptor binding(GO:0034190)
1.4 5.6 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4 12.5 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 15.0 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 5.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 5.3 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 17.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 4.3 PID FOXO PATHWAY FoxO family signaling
0.0 0.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 17.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions