ISMARA results: Spi1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Spi1

Z-value: 3.16

Motif logo

Transcription factors associated with Spi1

Gene Symbol	Gene ID	Gene Info
Spi1 NCBI RGD Ensembl	ENSRNOG00000012172	Spi-1 proto-oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Spi1	rn6_v1_chr3_+_79918969_79918969	0.81	9.8e-77	Click!

Activity profile of Spi1 motif

Sorted Z-values of Spi1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_55173692 Show fit	158.39	ENSRNOT00000064785 ENSRNOT00000029878 ENSRNOT00000029865 ENSRNOT00000060292 ENSRNOT00000000814	Ptprc NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C
chr1_-_198662610 Show fit	121.84	ENSRNOT00000055012	Sept1 NCBI RGD Ensembl Show fit	septin 1
chr13_+_47602692 Show fit	110.09	ENSRNOT00000038822	Fcmr NCBI RGD Ensembl Show fit	Fc fragment of IgM receptor
chr7_+_119482272 Show fit	95.59	ENSRNOT00000009544	Ncf4 NCBI RGD Ensembl Show fit	neutrophil cytosolic factor 4
chr1_-_198577226 Show fit	90.23	ENSRNOT00000055013	Spn NCBI RGD Ensembl Show fit	sialophorin
chr10_-_70802782 Show fit	88.45	ENSRNOT00000045867	Ccl6 NCBI RGD Ensembl Show fit	chemokine (C-C motif) ligand 6
chr15_+_57221292 Show fit	86.39	ENSRNOT00000014502	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr4_-_170932618 Show fit	84.93	ENSRNOT00000007779	Arhgdib NCBI RGD Ensembl Show fit	Rho GDP dissociation inhibitor beta
chr1_+_198744050 Show fit	82.62	ENSRNOT00000024404	Itgal NCBI RGD Ensembl Show fit	integrin subunit alpha L
chr1_-_226791773 Show fit	77.74	ENSRNOT00000082482 ENSRNOT00000065376 ENSRNOT00000054812 ENSRNOT00000086669	LOC100911215 NCBI RGD Ensembl Show fit	T-cell surface glycoprotein CD5-like
chr7_-_119797098 Show fit	76.77	ENSRNOT00000009994	Rac2 NCBI RGD Ensembl Show fit	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr13_+_89774764 Show fit	74.39	ENSRNOT00000005619	Arhgap30 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 30
chr2_+_93792601 Show fit	71.82	ENSRNOT00000014701 ENSRNOT00000077311	Fabp4 NCBI RGD Ensembl Show fit	fatty acid binding protein 4
chr1_+_219403970 Show fit	65.85	ENSRNOT00000029607	Ptprcap NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C-associated protein
chr4_-_157263890 Show fit	65.79	ENSRNOT00000065416	Ptpn6 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 6
chr3_-_63568464 Show fit	64.98	ENSRNOT00000068494	AABR07052585.2 NCBI RGD Ensembl Show fit
chr2_-_190100276 Show fit	64.83	ENSRNOT00000015351	S100a9 NCBI RGD Ensembl Show fit	S100 calcium binding protein A9
chr16_-_19918644 Show fit	63.55	ENSRNOT00000083345 ENSRNOT00000023926	Plvap NCBI RGD Ensembl Show fit	plasmalemma vesicle associated protein
chr1_+_215628785 Show fit	63.37	ENSRNOT00000054864	Lsp1 NCBI RGD Ensembl Show fit	lymphocyte-specific protein 1
chr1_-_227441442 Show fit	63.18	ENSRNOT00000028433	Ms4a1 NCBI RGD Ensembl Show fit	membrane spanning 4-domains A1
chr20_+_4355175 Show fit	60.75	ENSRNOT00000000510	Gpsm3 NCBI RGD Ensembl Show fit	G-protein signaling modulator 3
chr1_-_199439210 Show fit	60.33	ENSRNOT00000026699	Pycard NCBI RGD Ensembl Show fit	PYD and CARD domain containing
chr10_+_83655460 Show fit	60.13	ENSRNOT00000008011	Gngt2 NCBI RGD Ensembl Show fit	G protein subunit gamma transducin 2
chr4_-_44136815 Show fit	60.01	ENSRNOT00000086810	Tfec NCBI RGD Ensembl Show fit	transcription factor EC
chr7_-_107392972 Show fit	59.74	ENSRNOT00000093425	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chr1_-_226887156 Show fit	59.48	ENSRNOT00000054809 ENSRNOT00000028347	Cd6 NCBI RGD Ensembl Show fit	Cd6 molecule
chr3_-_118959850 Show fit	59.40	ENSRNOT00000092750	Atp8b4 NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 8B4 (putative)
chr7_+_142776252 Show fit	59.38	ENSRNOT00000008673	Acvrl1 NCBI RGD Ensembl Show fit	activin A receptor like type 1
chr7_+_142776580 Show fit	59.11	ENSRNOT00000081047	Acvrl1 NCBI RGD Ensembl Show fit	activin A receptor like type 1
chr8_+_96551245 Show fit	58.96	ENSRNOT00000039850	Bcl2a1 NCBI RGD Ensembl Show fit	BCL2-related protein A1
chr1_+_201620642 Show fit	58.94	ENSRNOT00000093674	Dmbt1 NCBI RGD Ensembl Show fit	deleted in malignant brain tumors 1
chr20_+_30915213 Show fit	56.50	ENSRNOT00000000681	Prf1 NCBI RGD Ensembl Show fit	perforin 1
chr7_+_18440742 Show fit	56.32	ENSRNOT00000011513	Myo1f NCBI RGD Ensembl Show fit	myosin IF
chr13_-_50916982 Show fit	55.65	ENSRNOT00000004408	Btg2 NCBI RGD Ensembl Show fit	BTG anti-proliferation factor 2
chr3_-_110517163 Show fit	54.46	ENSRNOT00000078037	Plcb2 NCBI RGD Ensembl Show fit	phospholipase C, beta 2
chr13_+_51958834 Show fit	53.28	ENSRNOT00000007833	Ptpn7 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 7
chr10_+_106785077 Show fit	52.81	ENSRNOT00000075047	Tmc8 NCBI RGD Ensembl Show fit	transmembrane channel-like 8
chr5_+_154522119 Show fit	52.49	ENSRNOT00000072618	E2f2 NCBI RGD Ensembl Show fit	E2F transcription factor 2
chr1_-_222118459 Show fit	52.17	ENSRNOT00000067217	Ccdc88b NCBI RGD Ensembl Show fit	coiled-coil domain containing 88B
chr9_+_94745217 Show fit	51.45	ENSRNOT00000051338	Inpp5d NCBI RGD Ensembl Show fit	inositol polyphosphate-5-phosphatase D
chr5_+_154265097 Show fit	51.42	ENSRNOT00000012342	Cnr2 NCBI RGD Ensembl Show fit	cannabinoid receptor 2
chr4_+_158088505 Show fit	50.94	ENSRNOT00000026643	Vwf NCBI RGD Ensembl Show fit	von Willebrand factor
chr8_+_133029625 Show fit	50.75	ENSRNOT00000008809	Ccr3 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 3
chr7_-_107385528 Show fit	50.70	ENSRNOT00000093352	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chrX_+_134979646 Show fit	49.54	ENSRNOT00000006035	Sash3 NCBI RGD Ensembl Show fit	SAM and SH3 domain containing 3
chr12_-_20486276 Show fit	49.47	ENSRNOT00000074057	LOC680910 NCBI RGD Ensembl Show fit	similar to paired immunoglobin-like type 2 receptor beta
chr4_-_10329241 Show fit	49.33	ENSRNOT00000017232	Fgl2 NCBI RGD Ensembl Show fit	fibrinogen-like 2
chr2_+_183674522 Show fit	49.13	ENSRNOT00000014433	Tmem154 NCBI RGD Ensembl Show fit	transmembrane protein 154
chr7_+_119820537 Show fit	48.96	ENSRNOT00000077256 ENSRNOT00000056221	Cyth4 NCBI RGD Ensembl Show fit	cytohesin 4
chr1_+_81763614 Show fit	48.46	ENSRNOT00000027254	Cd79a NCBI RGD Ensembl Show fit	CD79a molecule
chr1_-_219438779 Show fit	48.31	ENSRNOT00000029237	Tbc1d10c NCBI RGD Ensembl Show fit	TBC1 domain family, member 10C
chr14_-_86146744 Show fit	48.22	ENSRNOT00000019335	Myl7 NCBI RGD Ensembl Show fit	myosin light chain 7
chr2_-_243224883 Show fit	48.18	ENSRNOT00000014139	Dapp1 NCBI RGD Ensembl Show fit	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
chr7_-_60341264 Show fit	48.13	ENSRNOT00000007747	Lyz2 NCBI RGD Ensembl Show fit	lysozyme 2
chr3_+_28627084 Show fit	47.84	ENSRNOT00000049884	Arhgap15 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 15
chr4_+_90990088 Show fit	47.81	ENSRNOT00000030320	Mmrn1 NCBI RGD Ensembl Show fit	multimerin 1
chr1_+_88875375 Show fit	46.74	ENSRNOT00000028284	Tyrobp NCBI RGD Ensembl Show fit	Tyro protein tyrosine kinase binding protein
chr3_-_6626284 Show fit	46.74	ENSRNOT00000012494	Fcnb NCBI RGD Ensembl Show fit	ficolin B
chr15_-_29443454 Show fit	46.10	ENSRNOT00000082167	AABR07017635.2 NCBI RGD Ensembl Show fit
chr7_+_145068286 Show fit	45.98	ENSRNOT00000088956 ENSRNOT00000065753	Nckap1l NCBI RGD Ensembl Show fit	NCK associated protein 1 like
chr3_+_171037957 Show fit	45.54	ENSRNOT00000008764	Rbm38 NCBI RGD Ensembl Show fit	RNA binding motif protein 38
chr7_-_29233392 Show fit	45.34	ENSRNOT00000064241	Spic NCBI RGD Ensembl Show fit	Spi-C transcription factor
chr15_-_54906203 Show fit	45.11	ENSRNOT00000020186	Cysltr2 NCBI RGD Ensembl Show fit	cysteinyl leukotriene receptor 2
chr2_+_88217188 Show fit	45.10	ENSRNOT00000014267	Car1 NCBI RGD Ensembl Show fit	carbonic anhydrase I
chr8_-_133002201 Show fit	44.81	ENSRNOT00000008772	Ccr1 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 1
chr14_+_91783514 Show fit	44.79	ENSRNOT00000080753	Ikzf1 NCBI RGD Ensembl Show fit	IKAROS family zinc finger 1
chr19_-_19727081 Show fit	44.32	ENSRNOT00000020700	Adcy7 NCBI RGD Ensembl Show fit	adenylate cyclase 7
chr5_-_151459037 Show fit	44.31	ENSRNOT00000064472 ENSRNOT00000087836	Sytl1 NCBI RGD Ensembl Show fit	synaptotagmin-like 1
chr14_-_23604834 Show fit	44.23	ENSRNOT00000002760	Stap1 NCBI RGD Ensembl Show fit	signal transducing adaptor family member 1
chr13_+_83996080 Show fit	44.22	ENSRNOT00000004403 ENSRNOT00000070958	Cd247 NCBI RGD Ensembl Show fit	Cd247 molecule
chr4_+_78320190 Show fit	44.03	ENSRNOT00000032742 ENSRNOT00000091359	Gimap4 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 4
chrX_+_78196300 Show fit	43.82	ENSRNOT00000048695	P2ry10 NCBI RGD Ensembl Show fit	purinergic receptor P2Y10
chr10_+_18996523 Show fit	43.52	ENSRNOT00000046135	Lcp2 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 2
chr6_+_24163026 Show fit	43.37	ENSRNOT00000061284	Lbh NCBI RGD Ensembl Show fit	limb bud and heart development
chr8_-_23148396 Show fit	43.36	ENSRNOT00000075237	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr14_-_18849258 Show fit	43.27	ENSRNOT00000033406	Pf4 NCBI RGD Ensembl Show fit	platelet factor 4
chr15_-_34603819 Show fit	43.06	ENSRNOT00000067539	Cma1 NCBI RGD Ensembl Show fit	chymase 1
chr2_+_143656793 Show fit	42.91	ENSRNOT00000084527 ENSRNOT00000017453	Postn NCBI RGD Ensembl Show fit	periostin
chr1_-_221015929 Show fit	42.87	ENSRNOT00000028137	Sipa1 NCBI RGD Ensembl Show fit	signal-induced proliferation-associated 1
chr2_+_189997129 Show fit	42.69	ENSRNOT00000015958	S100a4 NCBI RGD Ensembl Show fit	S100 calcium-binding protein A4
chr14_+_80195715 Show fit	42.65	ENSRNOT00000010784	Sh3tc1 NCBI RGD Ensembl Show fit	SH3 domain and tetratricopeptide repeats 1
chr17_+_28504623 Show fit	42.56	ENSRNOT00000021568	F13a1 NCBI RGD Ensembl Show fit	coagulation factor XIII A1 chain
chr19_+_38039564 Show fit	42.47	ENSRNOT00000087491	Nfatc3 NCBI RGD Ensembl Show fit	nuclear factor of activated T-cells 3
chr10_-_83655182 Show fit	42.18	ENSRNOT00000007897	Abi3 NCBI RGD Ensembl Show fit	ABI family, member 3
chr17_+_9639330 Show fit	42.01	ENSRNOT00000018232	Dok3 NCBI RGD Ensembl Show fit	docking protein 3
chr1_+_199555722 Show fit	41.77	ENSRNOT00000054983	Itgax NCBI RGD Ensembl Show fit	integrin subunit alpha X
chr9_-_14668297 Show fit	41.68	ENSRNOT00000042404	Treml2 NCBI RGD Ensembl Show fit	triggering receptor expressed on myeloid cells-like 2
chr10_+_47930633 Show fit	41.67	ENSRNOT00000003515	Grap NCBI RGD Ensembl Show fit	GRB2-related adaptor protein
chr4_-_113866674 Show fit	41.35	ENSRNOT00000010020	Dok1 NCBI RGD Ensembl Show fit	docking protein 1
chr16_-_9430743 Show fit	41.26	ENSRNOT00000043811	Wdfy4 NCBI RGD Ensembl Show fit	WDFY family member 4
chrX_+_65566047 Show fit	41.24	ENSRNOT00000092103	Heph NCBI RGD Ensembl Show fit	hephaestin
chr4_+_78371121 Show fit	41.17	ENSRNOT00000059157	Gimap1 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 1
chr3_+_119776925 Show fit	40.85	ENSRNOT00000018549	Dusp2 NCBI RGD Ensembl Show fit	dual specificity phosphatase 2
chr7_+_12782491 Show fit	40.38	ENSRNOT00000065093	Cnn2 NCBI RGD Ensembl Show fit	calponin 2
chr1_+_64074231 Show fit	40.03	ENSRNOT00000077327	Lilrb3l NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like
chr9_-_52238564 Show fit	40.02	ENSRNOT00000005073	Col5a2 NCBI RGD Ensembl Show fit	collagen type V alpha 2 chain
chr1_-_101236065 Show fit	39.61	ENSRNOT00000066834	Cd37 NCBI RGD Ensembl Show fit	CD37 molecule
chr8_-_49301125 Show fit	39.37	ENSRNOT00000091190	Cd3e NCBI RGD Ensembl Show fit	CD3e molecule
chr5_+_82587420 Show fit	39.23	ENSRNOT00000014020	Tlr4 NCBI RGD Ensembl Show fit	toll-like receptor 4
chr12_+_21678580 Show fit	39.16	ENSRNOT00000039797	LOC100910669 NCBI RGD Ensembl Show fit	paired immunoglobulin-like type 2 receptor alpha-like
chr7_+_116632506 Show fit	39.16	ENSRNOT00000009811	Gpihbp1 NCBI RGD Ensembl Show fit	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr11_-_66759402 Show fit	39.12	ENSRNOT00000003326	Hcls1 NCBI RGD Ensembl Show fit	hematopoietic cell specific Lyn substrate 1
chr11_+_64882288 Show fit	39.11	ENSRNOT00000077727	Pla1a NCBI RGD Ensembl Show fit	phospholipase A1 member A
chr3_+_16610086 Show fit	38.95	ENSRNOT00000046231	LOC100361009 NCBI RGD Ensembl Show fit	rCG64257-like
chr1_-_98521706 Show fit	38.86	ENSRNOT00000015941	Siglec10 NCBI RGD Ensembl Show fit	sialic acid binding Ig-like lectin 10
chr6_-_138508753 Show fit	38.47	ENSRNOT00000006888	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr1_+_198528635 Show fit	38.15	ENSRNOT00000022765	LOC308990 NCBI RGD Ensembl Show fit	hypothetical protein LOC308990
chr10_-_87067456 Show fit	38.07	ENSRNOT00000014163	Ccr7 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 7
chr10_-_103590607 Show fit	38.06	ENSRNOT00000034741	Cd300le NCBI RGD Ensembl Show fit	Cd300 molecule-like family member E
chrX_-_71169038 Show fit	38.03	ENSRNOT00000005343	Il2rg NCBI RGD Ensembl Show fit	interleukin 2 receptor subunit gamma
chr17_-_70548071 Show fit	37.82	ENSRNOT00000073144	Il2ra NCBI RGD Ensembl Show fit	interleukin 2 receptor subunit alpha
chr10_+_91254058 Show fit	37.60	ENSRNOT00000087218 ENSRNOT00000065373	Fmnl1 NCBI RGD Ensembl Show fit	formin-like 1
chr12_-_11265865 Show fit	37.52	ENSRNOT00000001315	Arpc1b NCBI RGD Ensembl Show fit	actin related protein 2/3 complex, subunit 1B
chr1_-_260254600 Show fit	37.36	ENSRNOT00000019014	Blnk NCBI RGD Ensembl Show fit	B-cell linker
chr5_+_149056078 Show fit	37.14	ENSRNOT00000083028	Laptm5 NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 5
chr3_-_159775643 Show fit	37.09	ENSRNOT00000010939	Jph2 NCBI RGD Ensembl Show fit	junctophilin 2
chr4_-_95970666 Show fit	36.93	ENSRNOT00000008826	Hpgds NCBI RGD Ensembl Show fit	hematopoietic prostaglandin D synthase
chr7_+_125288081 Show fit	36.91	ENSRNOT00000085216	Parvg NCBI RGD Ensembl Show fit	parvin, gamma
chr5_-_79222687 Show fit	36.91	ENSRNOT00000010516	Akna NCBI RGD Ensembl Show fit	AT-hook transcription factor
chr7_-_143837780 Show fit	36.87	ENSRNOT00000016642	Itgb7 NCBI RGD Ensembl Show fit	integrin subunit beta 7
chr9_+_91001828 Show fit	36.81	ENSRNOT00000080956	AABR07068214.1 NCBI RGD Ensembl Show fit
chr12_+_19714324 Show fit	36.76	ENSRNOT00000072303	RGD1559588 NCBI RGD Ensembl Show fit	similar to cell surface receptor FDFACT
chr19_-_10513349 Show fit	36.73	ENSRNOT00000061270	Adgrg5 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor G5
chr15_-_34479741 Show fit	36.69	ENSRNOT00000027759	Ripk3 NCBI RGD Ensembl Show fit	receptor-interacting serine-threonine kinase 3
chr9_-_55256340 Show fit	36.57	ENSRNOT00000028907	Sdpr NCBI RGD Ensembl Show fit	serum deprivation response
chr8_-_49308806 Show fit	36.57	ENSRNOT00000047291	Cd3e NCBI RGD Ensembl Show fit	CD3e molecule
chr10_-_56270640 Show fit	36.28	ENSRNOT00000056918	Cd68 NCBI RGD Ensembl Show fit	Cd68 molecule
chr11_+_84745904 Show fit	36.26	ENSRNOT00000002617	Klhl6 NCBI RGD Ensembl Show fit	kelch-like family member 6
chr10_-_104921866 Show fit	35.86	ENSRNOT00000077158	LOC100909671 NCBI RGD Ensembl Show fit	CMRF35-like molecule-like
chr8_-_33661049 Show fit	35.68	ENSRNOT00000068037	Fli1 NCBI RGD Ensembl Show fit	Fli-1 proto-oncogene, ETS transcription factor
chr7_-_107391184 Show fit	35.48	ENSRNOT00000056793	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chr13_-_90839411 Show fit	35.40	ENSRNOT00000010594	Slamf9 NCBI RGD Ensembl Show fit	SLAM family member 9
chr17_-_90149894 Show fit	35.27	ENSRNOT00000024272	Apbb1ip NCBI RGD Ensembl Show fit	amyloid beta precursor protein binding family B member 1 interacting protein
chr5_-_147761983 Show fit	35.27	ENSRNOT00000012936	Lck NCBI RGD Ensembl Show fit	LCK proto-oncogene, Src family tyrosine kinase
chr10_+_49000973 Show fit	35.13	ENSRNOT00000057880	LOC102553715 NCBI RGD Ensembl Show fit	microfibril-associated glycoprotein 4-like
chr17_+_43734461 Show fit	35.11	ENSRNOT00000072564	Hist1h1d NCBI RGD Ensembl Show fit	histone cluster 1, H1d
chr1_-_7064870 Show fit	34.90	ENSRNOT00000019983	Stx11 NCBI RGD Ensembl Show fit	syntaxin 11
chr3_+_149624712 Show fit	34.84	ENSRNOT00000018581	Bpifa1 NCBI RGD Ensembl Show fit	BPI fold containing family A, member 1
chrX_+_15155230 Show fit	34.83	ENSRNOT00000073289 ENSRNOT00000051439	Was NCBI RGD Ensembl Show fit	Wiskott-Aldrich syndrome
chr5_+_173640780 Show fit	34.74	ENSRNOT00000027476	Perm1 NCBI RGD Ensembl Show fit	PPARGC1 and ESRR induced regulator, muscle 1
chr10_+_94566928 Show fit	34.65	ENSRNOT00000078446	Prr29 NCBI RGD Ensembl Show fit	proline rich 29
chr15_-_34392066 Show fit	34.38	ENSRNOT00000027315	Tgm1 NCBI RGD Ensembl Show fit	transglutaminase 1
chr13_+_68949665 Show fit	34.33	ENSRNOT00000003320	Fam129a NCBI RGD Ensembl Show fit	family with sequence similarity 129, member A
chr18_+_86299463 Show fit	34.20	ENSRNOT00000058152	Cd226 NCBI RGD Ensembl Show fit	CD226 molecule
chr8_+_49282460 Show fit	34.17	ENSRNOT00000021488	Cd3d NCBI RGD Ensembl Show fit	CD3d molecule
chr1_-_88881460 Show fit	34.16	ENSRNOT00000028287	Hcst NCBI RGD Ensembl Show fit	hematopoietic cell signal transducer
chr10_-_70871066 Show fit	33.92	ENSRNOT00000015139	Ccl3 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 3
chr7_-_142300382 Show fit	33.66	ENSRNOT00000048262	Bin2 NCBI RGD Ensembl Show fit	bridging integrator 2
chr12_-_21362205 Show fit	33.46	ENSRNOT00000064787	LOC108348155 NCBI RGD Ensembl Show fit	paired immunoglobulin-like type 2 receptor beta-2
chr20_+_4363152 Show fit	33.35	ENSRNOT00000000508 ENSRNOT00000084841 ENSRNOT00000072848 ENSRNOT00000077561	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr4_+_163162211 Show fit	33.32	ENSRNOT00000082537	Clec1b NCBI RGD Ensembl Show fit	C-type lectin domain family 1, member B
chr12_-_21670269 Show fit	33.19	ENSRNOT00000074863	LOC100910801 NCBI RGD Ensembl Show fit	paired immunoglobulin-like type 2 receptor alpha-like
chr1_+_63759638 Show fit	32.94	ENSRNOT00000080799 ENSRNOT00000087669	Lilrb3a NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
chrX_+_65226748 Show fit	32.66	ENSRNOT00000076181	Msn NCBI RGD Ensembl Show fit	moesin
chr13_-_89306219 Show fit	32.57	ENSRNOT00000004183 ENSRNOT00000079247	Fcrla NCBI RGD Ensembl Show fit	Fc receptor-like A
chr2_-_45077219 Show fit	32.55	ENSRNOT00000014319	Gzmk NCBI RGD Ensembl Show fit	granzyme K
chr10_+_47765432 Show fit	32.45	ENSRNOT00000078231	LOC102553715 NCBI RGD Ensembl Show fit	microfibril-associated glycoprotein 4-like
chr14_+_3058993 Show fit	32.41	ENSRNOT00000002807	Gfi1 NCBI RGD Ensembl Show fit	growth factor independent 1 transcriptional repressor
chr19_-_55510460 Show fit	32.40	ENSRNOT00000019820	Cbfa2t3 NCBI RGD Ensembl Show fit	CBFA2/RUNX1 translocation partner 3
chr6_-_103470427 Show fit	32.30	ENSRNOT00000091560 ENSRNOT00000088795 ENSRNOT00000079824	Actn1 NCBI RGD Ensembl Show fit	actinin, alpha 1
chr1_+_227240383 Show fit	32.30	ENSRNOT00000074127	Ms4a6e NCBI RGD Ensembl Show fit	membrane spanning 4-domains A6E
chr1_-_104157855 Show fit	32.23	ENSRNOT00000019311	Csrp3 NCBI RGD Ensembl Show fit	cysteine and glycine rich protein 3
chr2_-_105047984 Show fit	32.17	ENSRNOT00000014970	Cpa3 NCBI RGD Ensembl Show fit	carboxypeptidase A3
chr1_+_252589785 Show fit	32.15	ENSRNOT00000025928	Fas NCBI RGD Ensembl Show fit	Fas cell surface death receptor
chr12_+_38160464 Show fit	32.10	ENSRNOT00000032249	Hcar2 NCBI RGD Ensembl Show fit	hydroxycarboxylic acid receptor 2
chr1_-_78195328 Show fit	31.98	ENSRNOT00000073034	C5ar1 NCBI RGD Ensembl Show fit	complement C5a receptor 1
chr13_+_90244681 Show fit	31.96	ENSRNOT00000078162	Cd84 NCBI RGD Ensembl Show fit	CD84 molecule
chr13_+_51022681 Show fit	31.87	ENSRNOT00000078599	Chi3l1 NCBI RGD Ensembl Show fit	chitinase 3 like 1
chr1_+_81779380 Show fit	31.70	ENSRNOT00000065865 ENSRNOT00000080143 ENSRNOT00000089592 ENSRNOT00000080840	Arhgef1 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 1
chrX_+_78259409 Show fit	31.63	ENSRNOT00000049779	RGD1560455 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA A630033H20 gene
chr6_+_139158334 Show fit	31.54	ENSRNOT00000089227	AABR07065673.1 NCBI RGD Ensembl Show fit
chr7_-_107616038 Show fit	31.12	ENSRNOT00000088752	Sla NCBI RGD Ensembl Show fit	src-like adaptor
chr13_+_50164563 Show fit	31.03	ENSRNOT00000029533	Lax1 NCBI RGD Ensembl Show fit	lymphocyte transmembrane adaptor 1
chr4_-_162025090 Show fit	30.95	ENSRNOT00000085887 ENSRNOT00000009904	Klrb1a NCBI RGD Ensembl Show fit	killer cell lectin-like receptor subfamily B, member 1A
chrX_-_105385852 Show fit	30.94	ENSRNOT00000086863	Btk NCBI RGD Ensembl Show fit	Bruton tyrosine kinase
chr7_+_70614617 Show fit	30.89	ENSRNOT00000035382	Arhgap9 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 9
chr5_+_149047681 Show fit	30.75	ENSRNOT00000015198	Laptm5 NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 5
chr9_-_16795887 Show fit	30.73	ENSRNOT00000071609	Cd79al NCBI RGD Ensembl Show fit	Cd79a molecule-like
chr15_+_57241968 Show fit	30.72	ENSRNOT00000082191	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr10_+_39109522 Show fit	30.69	ENSRNOT00000010968	Irf1 NCBI RGD Ensembl Show fit	interferon regulatory factor 1
chr1_-_191007503 Show fit	30.55	ENSRNOT00000023262	Igsf6 NCBI RGD Ensembl Show fit	immunoglobulin superfamily, member 6
chr13_+_89975267 Show fit	30.52	ENSRNOT00000006266 ENSRNOT00000000053	Cd244 NCBI RGD Ensembl Show fit	CD244 molecule
chr4_-_163049084 Show fit	30.45	ENSRNOT00000091644	Cd69 NCBI RGD Ensembl Show fit	Cd69 molecule
chr1_+_81230612 Show fit	30.30	ENSRNOT00000026489	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr5_-_59063592 Show fit	30.30	ENSRNOT00000022400	Tln1 NCBI RGD Ensembl Show fit	talin 1
chr10_+_104952237 Show fit	30.29	ENSRNOT00000085222	RGD1559482 NCBI RGD Ensembl Show fit	similar to immunoglobulin superfamily, member 7
chrX_+_1311121 Show fit	30.26	ENSRNOT00000038909	Cfp NCBI RGD Ensembl Show fit	complement factor properdin
chr7_+_58814805 Show fit	30.25	ENSRNOT00000005909	Tspan8 NCBI RGD Ensembl Show fit	tetraspanin 8
chr1_+_197999037 Show fit	30.20	ENSRNOT00000091065	Apobr NCBI RGD Ensembl Show fit	apolipoprotein B receptor
chr8_-_21995806 Show fit	30.13	ENSRNOT00000028034	S1pr2 NCBI RGD Ensembl Show fit	sphingosine-1-phosphate receptor 2
chr9_+_65614142 Show fit	30.10	ENSRNOT00000016613	Casp8 NCBI RGD Ensembl Show fit	caspase 8
chr1_+_81230989 Show fit	30.07	ENSRNOT00000077952	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr5_+_153507093 Show fit	30.04	ENSRNOT00000086650 ENSRNOT00000083645	Runx3 NCBI RGD Ensembl Show fit	runt-related transcription factor 3
chr18_+_55463308 Show fit	29.91	ENSRNOT00000073388	LOC100910979 NCBI RGD Ensembl Show fit	interferon-inducible GTPase 1-like
chr1_-_167347490 Show fit	29.85	ENSRNOT00000076499	Rhog NCBI RGD Ensembl Show fit	ras homolog family member G
chr3_-_142752325 Show fit	29.64	ENSRNOT00000006200	Thbd NCBI RGD Ensembl Show fit	thrombomodulin
chr3_-_44177689 Show fit	29.63	ENSRNOT00000006387	Cytip NCBI RGD Ensembl Show fit	cytohesin 1 interacting protein
chr3_-_14019204 Show fit	29.63	ENSRNOT00000072400 ENSRNOT00000092918	Traf1 NCBI RGD Ensembl Show fit	TNF receptor-associated factor 1
chr2_+_32820322 Show fit	29.58	ENSRNOT00000013768	Cd180 NCBI RGD Ensembl Show fit	CD180 molecule
chr15_-_108376221 Show fit	29.52	ENSRNOT00000034560	Gpr183 NCBI RGD Ensembl Show fit	G protein-coupled receptor 183

Network of associatons between targets according to the STRING database.

First level regulatory network of Spi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
52.8	158.4	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
40.6	121.8	GO:0007056	spindle assembly involved in female meiosis(GO:0007056)
30.9	92.7	GO:0001807	regulation of type IV hypersensitivity(GO:0001807)
30.7	30.7	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
28.3	84.9	GO:0071461	cellular response to redox state(GO:0071461)
24.9	99.8	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
24.1	96.2	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
22.4	67.2	GO:0072714	response to selenite ion(GO:0072714)
21.6	64.8	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
21.2	105.9	GO:0002580	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002580)
20.2	60.5	GO:0042222	interleukin-1 biosynthetic process(GO:0042222)
20.0	59.9	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
19.6	39.1	GO:0042531	regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
19.3	57.8	GO:2000449	regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
18.7	74.9	GO:0071307	cellular response to vitamin K(GO:0071307)
17.8	53.4	GO:0071661	granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
17.5	70.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
17.4	34.9	GO:0043316	cytotoxic T cell degranulation(GO:0043316)
16.5	98.7	GO:0061737	leukotriene signaling pathway(GO:0061737)
16.2	32.4	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
15.8	63.3	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
15.6	93.8	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
15.4	123.2	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
15.3	46.0	GO:2001187	actin polymerization-dependent cell motility(GO:0070358) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
15.0	15.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
15.0	60.0	GO:0002343	peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
14.7	44.2	GO:1903969	regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
14.5	58.2	GO:0033277	abortive mitotic cell cycle(GO:0033277)
14.5	58.2	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway(GO:0034137)
14.4	144.5	GO:0090500	endocardial cushion to mesenchymal transition(GO:0090500)
14.3	42.9	GO:0042631	cellular response to water deprivation(GO:0042631)
14.0	153.6	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
13.8	151.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
13.1	39.2	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
12.7	38.0	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
12.4	49.7	GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
12.3	172.1	GO:0001771	immunological synapse formation(GO:0001771)
12.1	24.2	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
12.0	23.9	GO:0072683	T cell extravasation(GO:0072683)
11.9	131.1	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
11.9	59.6	GO:0036337	Fas signaling pathway(GO:0036337)
11.9	35.7	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
11.8	59.0	GO:0090131	mesenchyme migration(GO:0090131)
11.7	11.7	GO:0002777	antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780)
11.6	23.3	GO:0006808	regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740)
11.4	11.4	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
11.2	44.9	GO:0010710	regulation of collagen catabolic process(GO:0010710)
11.0	44.1	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
11.0	33.0	GO:1904760	myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
11.0	76.8	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
10.9	21.8	GO:2000537	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
10.8	10.8	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
10.7	32.2	GO:1903919	regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
10.7	118.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
10.4	62.7	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
10.4	31.1	GO:0038158	granulocyte colony-stimulating factor signaling pathway(GO:0038158)
10.1	91.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
10.0	40.0	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
9.9	19.9	GO:0002339	B cell selection(GO:0002339)
9.9	49.6	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
9.8	29.5	GO:0061470	T follicular helper cell differentiation(GO:0061470)
9.6	9.6	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
9.5	28.6	GO:0030200	proteoglycan catabolic process(GO:0030167) heparan sulfate proteoglycan catabolic process(GO:0030200)
9.5	18.9	GO:0038145	macrophage colony-stimulating factor signaling pathway(GO:0038145)
9.2	36.9	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
9.1	9.1	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
9.1	127.3	GO:0051764	actin crosslink formation(GO:0051764)
9.1	27.2	GO:1903238	positive regulation of leukocyte tethering or rolling(GO:1903238)
9.0	27.1	GO:2000328	regulation of T-helper 17 cell lineage commitment(GO:2000328)
8.9	26.6	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
8.8	35.3	GO:0046645	positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
8.8	26.4	GO:0002215	defense response to nematode(GO:0002215)
8.7	52.5	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
8.6	17.2	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
8.5	25.6	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
8.5	25.6	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
8.0	40.0	GO:0001757	somite specification(GO:0001757)
8.0	32.0	GO:0032661	regulation of interleukin-18 production(GO:0032661) negative regulation of interleukin-18 production(GO:0032701)
7.9	15.9	GO:0072249	metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
7.9	7.9	GO:1990108	protein linear deubiquitination(GO:1990108)
7.7	69.7	GO:0038171	cannabinoid signaling pathway(GO:0038171)
7.6	30.6	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
7.6	30.4	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
7.6	15.2	GO:2000401	regulation of lymphocyte migration(GO:2000401)
7.5	29.9	GO:0010957	negative regulation of vitamin D biosynthetic process(GO:0010957) regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
7.4	36.9	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
7.4	14.7	GO:0003430	growth plate cartilage chondrocyte growth(GO:0003430)
7.3	22.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
7.2	43.4	GO:1904674	positive regulation of somatic stem cell population maintenance(GO:1904674)
7.2	21.5	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
7.0	35.2	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
7.0	21.1	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
7.0	34.8	GO:0050828	regulation of liquid surface tension(GO:0050828)
7.0	13.9	GO:0070602	regulation of centromeric sister chromatid cohesion(GO:0070602)
6.9	27.8	GO:0023021	termination of signal transduction(GO:0023021)
6.9	110.9	GO:0002283	neutrophil activation involved in immune response(GO:0002283)
6.9	20.6	GO:0021569	rhombomere 3 development(GO:0021569) rhombomere 4 development(GO:0021570)
6.9	20.6	GO:0045799	positive regulation of chromatin assembly or disassembly(GO:0045799)
6.8	75.2	GO:0042119	neutrophil activation(GO:0042119)
6.8	20.3	GO:1990705	cholangiocyte proliferation(GO:1990705)
6.7	20.2	GO:0006407	rRNA export from nucleus(GO:0006407)
6.7	13.5	GO:0072144	glomerular mesangial cell development(GO:0072144)
6.7	47.0	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
6.5	45.4	GO:0097084	vascular smooth muscle cell development(GO:0097084)
6.4	147.2	GO:0071285	cellular response to lithium ion(GO:0071285)
6.3	19.0	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
6.3	38.0	GO:0032831	regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
6.3	6.3	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
6.3	25.3	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
6.3	18.9	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
6.3	12.5	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
6.2	12.4	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
6.1	79.1	GO:0033623	regulation of integrin activation(GO:0033623)
6.1	18.2	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
5.9	5.9	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
5.8	23.2	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
5.8	86.4	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
5.7	17.2	GO:1902304	positive regulation of potassium ion export(GO:1902304)
5.7	11.4	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
5.7	108.3	GO:0042832	defense response to protozoan(GO:0042832)
5.7	22.7	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
5.5	11.1	GO:0003186	tricuspid valve morphogenesis(GO:0003186)
5.5	22.0	GO:0032826	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
5.5	5.5	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
5.4	16.2	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
5.4	26.9	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
5.4	58.9	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
5.3	32.1	GO:0033031	neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031)
5.3	63.8	GO:0001878	response to yeast(GO:0001878)
5.3	16.0	GO:0046833	positive regulation of RNA export from nucleus(GO:0046833)
5.3	21.3	GO:1903758	regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
5.3	37.1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
5.2	15.6	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
5.1	51.5	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
5.1	56.1	GO:0060546	negative regulation of necroptotic process(GO:0060546)
5.1	25.3	GO:1903519	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
5.0	10.0	GO:0070839	divalent metal ion export(GO:0070839)
5.0	14.9	GO:1905073	occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
5.0	34.8	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
5.0	19.8	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
4.9	14.6	GO:0044209	AMP salvage(GO:0044209)
4.8	14.4	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
4.7	14.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
4.7	14.1	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
4.7	93.6	GO:0001833	inner cell mass cell proliferation(GO:0001833)
4.7	18.6	GO:0071440	regulation of histone H3-K14 acetylation(GO:0071440)
4.6	13.9	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
4.6	37.1	GO:0032494	response to peptidoglycan(GO:0032494)
4.6	27.6	GO:0050917	sensory perception of umami taste(GO:0050917)
4.6	9.2	GO:0035772	interleukin-13-mediated signaling pathway(GO:0035772)
4.6	22.8	GO:0001574	ganglioside biosynthetic process(GO:0001574)
4.5	22.7	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
4.5	9.1	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
4.5	22.5	GO:0071603	endothelial cell-cell adhesion(GO:0071603)
4.5	13.5	GO:1902730	positive regulation of proteoglycan biosynthetic process(GO:1902730)
4.5	13.4	GO:1904976	cellular response to bleomycin(GO:1904976)
4.5	44.6	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
4.4	13.3	GO:0042494	detection of bacterial lipoprotein(GO:0042494)
4.4	44.4	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
4.4	13.2	GO:2000620	positive regulation of histone H4-K16 acetylation(GO:2000620)
4.4	30.8	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
4.4	26.4	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
4.4	35.1	GO:0016584	nucleosome positioning(GO:0016584)
4.4	30.5	GO:0033622	integrin activation(GO:0033622)
4.4	69.7	GO:0032460	negative regulation of protein oligomerization(GO:0032460)
4.4	13.1	GO:0032819	positive regulation of natural killer cell proliferation(GO:0032819)
4.3	8.7	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
4.3	12.9	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
4.3	12.9	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
4.3	68.4	GO:0050765	negative regulation of phagocytosis(GO:0050765)
4.3	34.2	GO:0045059	positive thymic T cell selection(GO:0045059)
4.3	21.4	GO:0097527	necroptotic signaling pathway(GO:0097527)
4.2	127.4	GO:0048247	lymphocyte chemotaxis(GO:0048247)
4.2	12.7	GO:0070814	hydrogen sulfide biosynthetic process(GO:0070814)
4.2	46.3	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
4.2	16.6	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
4.1	37.1	GO:0070417	cellular response to cold(GO:0070417)
4.1	41.2	GO:1900017	positive regulation of cytokine production involved in inflammatory response(GO:1900017)
4.1	12.2	GO:1903544	response to butyrate(GO:1903544)
4.1	40.6	GO:0035855	megakaryocyte development(GO:0035855)
4.0	20.1	GO:0060454	positive regulation of gastric acid secretion(GO:0060454)
4.0	12.0	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419)
4.0	8.0	GO:1904580	regulation of intracellular mRNA localization(GO:1904580)
3.9	7.9	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.9	98.0	GO:1900027	regulation of ruffle assembly(GO:1900027)
3.9	38.9	GO:1901841	regulation of high voltage-gated calcium channel activity(GO:1901841)
3.9	46.5	GO:0001867	complement activation, lectin pathway(GO:0001867)
3.9	15.5	GO:0051136	regulation of NK T cell differentiation(GO:0051136)
3.8	19.2	GO:0002317	plasma cell differentiation(GO:0002317)
3.8	3.8	GO:0097694	establishment of RNA localization to telomere(GO:0097694)
3.8	15.2	GO:0090367	negative regulation of mRNA modification(GO:0090367)
3.8	52.6	GO:0030220	platelet formation(GO:0030220)
3.7	112.3	GO:0050853	B cell receptor signaling pathway(GO:0050853)
3.7	7.5	GO:1903691	positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
3.7	44.7	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
3.7	11.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
3.7	29.3	GO:0019388	galactose catabolic process(GO:0019388)
3.6	3.6	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
3.6	7.3	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
3.6	43.6	GO:0072678	T cell migration(GO:0072678)
3.6	32.4	GO:1903715	regulation of aerobic respiration(GO:1903715)
3.6	32.2	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
3.5	17.6	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
3.5	14.1	GO:1900086	cell differentiation involved in salivary gland development(GO:0060689) regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
3.4	20.6	GO:0003383	apical constriction(GO:0003383)
3.4	27.4	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
3.4	23.9	GO:0071409	cellular response to cycloheximide(GO:0071409)
3.4	6.8	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
3.4	23.6	GO:0002517	T cell tolerance induction(GO:0002517)
3.4	47.2	GO:0034501	protein localization to kinetochore(GO:0034501)
3.4	6.7	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
3.4	16.8	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
3.3	9.9	GO:1904170	regulation of bleb assembly(GO:1904170)
3.3	13.1	GO:0071802	negative regulation of podosome assembly(GO:0071802)
3.3	3.3	GO:0033083	regulation of immature T cell proliferation(GO:0033083)
3.3	13.0	GO:0061511	centriole elongation(GO:0061511)
3.3	29.3	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
3.2	16.2	GO:1904401	cellular response to Thyroid stimulating hormone(GO:1904401)
3.2	22.7	GO:1990785	response to water-immersion restraint stress(GO:1990785)
3.2	6.5	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
3.1	6.3	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087)
3.1	12.6	GO:0038129	ERBB3 signaling pathway(GO:0038129)
3.1	18.7	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
3.1	12.4	GO:0006685	sphingomyelin catabolic process(GO:0006685)
3.1	6.2	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
3.1	6.2	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
3.0	9.1	GO:1903903	regulation of toll-like receptor 3 signaling pathway(GO:0034139) regulation of establishment of T cell polarity(GO:1903903)
3.0	27.2	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
3.0	18.1	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
3.0	51.1	GO:0048242	epinephrine secretion(GO:0048242)
3.0	9.0	GO:0036066	protein O-linked fucosylation(GO:0036066)
3.0	20.9	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
2.9	20.6	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
2.9	35.1	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
2.9	5.8	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
2.9	11.6	GO:0006272	leading strand elongation(GO:0006272)
2.9	23.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
2.9	14.4	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
2.9	5.7	GO:0009608	response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
2.8	2.8	GO:0090135	actin filament branching(GO:0090135)
2.8	17.0	GO:0008228	opsonization(GO:0008228)
2.8	8.5	GO:0021649	vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
2.8	19.7	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
2.8	8.4	GO:0060279	positive regulation of ovulation(GO:0060279)
2.8	24.9	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
2.7	19.2	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
2.7	8.2	GO:0045408	regulation of interleukin-6 biosynthetic process(GO:0045408)
2.7	27.1	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
2.7	13.5	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
2.7	43.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
2.7	8.0	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
2.7	10.7	GO:0002035	brain renin-angiotensin system(GO:0002035)
2.7	34.7	GO:0072606	interleukin-8 secretion(GO:0072606)
2.7	23.9	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
2.6	13.2	GO:0030916	otic vesicle formation(GO:0030916)
2.6	13.2	GO:0048539	bone marrow development(GO:0048539)
2.6	7.8	GO:0061188	negative regulation of chromatin silencing at rDNA(GO:0061188)
2.6	20.7	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
2.6	33.4	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
2.6	18.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
2.6	20.4	GO:0002360	T cell lineage commitment(GO:0002360)
2.6	17.9	GO:0051694	pointed-end actin filament capping(GO:0051694)
2.5	22.9	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235)
2.5	20.3	GO:0048680	positive regulation of axon regeneration(GO:0048680)
2.5	30.4	GO:0006265	DNA topological change(GO:0006265)
2.5	7.6	GO:0010070	zygote asymmetric cell division(GO:0010070)
2.5	12.6	GO:0035166	post-embryonic hemopoiesis(GO:0035166)
2.5	22.6	GO:0051014	actin filament severing(GO:0051014)
2.5	5.0	GO:0099550	trans-synaptic signaling by trans-synaptic complex(GO:0099545) trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
2.5	5.0	GO:0080144	amino acid homeostasis(GO:0080144)
2.5	5.0	GO:0098886	modification of dendritic spine(GO:0098886)
2.5	27.2	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
2.5	61.3	GO:0071800	podosome assembly(GO:0071800)
2.4	12.1	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
2.4	12.0	GO:2000435	regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
2.4	19.3	GO:0097327	response to antineoplastic agent(GO:0097327)
2.4	28.9	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
2.4	7.2	GO:2001280	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
2.4	62.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
2.4	9.6	GO:0045061	thymic T cell selection(GO:0045061)
2.4	7.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
2.4	7.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
2.4	4.7	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
2.3	58.1	GO:0019835	cytolysis(GO:0019835)
2.3	6.9	GO:1902303	negative regulation of potassium ion export(GO:1902303)
2.3	6.9	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
2.3	6.8	GO:0032484	Ral protein signal transduction(GO:0032484)
2.3	6.8	GO:0086048	membrane depolarization during bundle of His cell action potential(GO:0086048)
2.3	15.8	GO:0090527	actin filament reorganization(GO:0090527)
2.3	22.5	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
2.2	55.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
2.2	15.4	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
2.2	22.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
2.2	8.8	GO:0035617	stress granule disassembly(GO:0035617)
2.2	4.3	GO:0090290	positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289) positive regulation of osteoclast proliferation(GO:0090290)
2.1	10.7	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
2.1	10.6	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
2.1	52.9	GO:0032011	ARF protein signal transduction(GO:0032011)
2.1	12.7	GO:0015860	purine nucleoside transmembrane transport(GO:0015860)
2.1	10.6	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
2.1	16.8	GO:0002446	neutrophil mediated immunity(GO:0002446)
2.1	4.2	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
2.1	21.0	GO:0007252	I-kappaB phosphorylation(GO:0007252)
2.1	21.0	GO:0090070	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
2.1	12.5	GO:0038203	TORC2 signaling(GO:0038203)
2.1	29.1	GO:0015671	oxygen transport(GO:0015671)
2.1	6.2	GO:0061009	common bile duct development(GO:0061009)
2.0	38.3	GO:0031581	hemidesmosome assembly(GO:0031581)
2.0	14.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
2.0	8.0	GO:0089700	protein kinase D signaling(GO:0089700)
2.0	16.1	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.0	30.0	GO:0030168	platelet activation(GO:0030168)
2.0	7.9	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
2.0	3.9	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
2.0	13.7	GO:0072347	response to anesthetic(GO:0072347)
2.0	5.9	GO:0006116	NADH oxidation(GO:0006116)
2.0	7.8	GO:0007296	vitellogenesis(GO:0007296)
1.9	5.8	GO:0097298	regulation of nucleus size(GO:0097298)
1.9	3.9	GO:0032298	positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
1.9	3.9	GO:0072592	oxygen metabolic process(GO:0072592)
1.9	15.3	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
1.9	5.7	GO:1990022	RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
1.9	7.5	GO:0035814	negative regulation of renal sodium excretion(GO:0035814)
1.9	15.0	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.9	37.6	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
1.9	20.6	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
1.9	7.5	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
1.9	7.5	GO:0006741	NADP biosynthetic process(GO:0006741)
1.8	20.2	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
1.8	5.5	GO:0046016	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) positive regulation of transcription by glucose(GO:0046016)
1.8	20.1	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
1.8	1.8	GO:0097374	sensory neuron axon guidance(GO:0097374)
1.8	5.5	GO:0072697	protein localization to cell cortex(GO:0072697)
1.8	3.6	GO:0006701	progesterone biosynthetic process(GO:0006701)
1.8	7.3	GO:0045903	positive regulation of translational fidelity(GO:0045903)
1.8	7.3	GO:0003360	brainstem development(GO:0003360)
1.8	21.8	GO:0002717	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
1.8	14.5	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
1.8	19.9	GO:0060347	heart trabecula formation(GO:0060347)
1.8	25.3	GO:0050869	negative regulation of B cell activation(GO:0050869)
1.8	10.8	GO:0046208	spermine catabolic process(GO:0046208)
1.8	23.2	GO:0034720	histone H3-K4 demethylation(GO:0034720)
1.8	23.1	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
1.8	19.5	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
1.8	8.8	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
1.8	5.3	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
1.8	10.5	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
1.7	6.9	GO:0051643	endoplasmic reticulum localization(GO:0051643)
1.7	18.9	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
1.7	13.7	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
1.7	13.6	GO:0043249	erythrocyte maturation(GO:0043249)
1.7	3.4	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.7	5.0	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) negative regulation of hair follicle development(GO:0051799)
1.7	5.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.6	19.7	GO:0050912	detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
1.6	4.9	GO:0032258	CVT pathway(GO:0032258)
1.6	3.3	GO:0014908	myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
1.6	30.8	GO:0007567	parturition(GO:0007567)
1.6	27.2	GO:0019532	oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
1.6	71.8	GO:0050852	T cell receptor signaling pathway(GO:0050852)
1.6	9.4	GO:0014894	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.6	4.7	GO:0034138	toll-like receptor 3 signaling pathway(GO:0034138)
1.6	18.7	GO:0016601	Rac protein signal transduction(GO:0016601)
1.5	9.2	GO:1903412	response to bile acid(GO:1903412)
1.5	19.7	GO:0007076	mitotic chromosome condensation(GO:0007076)
1.5	16.6	GO:0061298	retina vasculature development in camera-type eye(GO:0061298)
1.5	9.1	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
1.5	13.6	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
1.5	27.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
1.5	10.5	GO:0060056	mammary gland involution(GO:0060056)
1.5	4.4	GO:1902416	positive regulation of mRNA binding(GO:1902416)
1.5	181.7	GO:0007265	Ras protein signal transduction(GO:0007265)
1.5	10.2	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
1.5	13.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
1.5	171.6	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
1.5	8.7	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
1.5	4.4	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.5	1.5	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
1.4	4.3	GO:0032472	Golgi calcium ion transport(GO:0032472)
1.4	9.9	GO:0007021	tubulin complex assembly(GO:0007021)
1.4	38.3	GO:0035458	cellular response to interferon-beta(GO:0035458)
1.4	32.4	GO:0014850	response to muscle activity(GO:0014850)
1.4	56.3	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
1.4	49.0	GO:0070527	platelet aggregation(GO:0070527)
1.4	7.0	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
1.4	5.6	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
1.4	9.7	GO:1904386	response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
1.4	8.3	GO:0035162	embryonic hemopoiesis(GO:0035162)
1.4	5.5	GO:0002159	desmosome assembly(GO:0002159)
1.4	13.7	GO:0014029	neural crest formation(GO:0014029)
1.4	6.8	GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
1.4	9.5	GO:0002755	MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
1.3	14.8	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
1.3	5.4	GO:0006172	ADP biosynthetic process(GO:0006172)
1.3	30.6	GO:0071353	cellular response to interleukin-4(GO:0071353)
1.3	11.9	GO:0050706	regulation of interleukin-1 beta secretion(GO:0050706)
1.3	5.3	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
1.3	3.9	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
1.3	23.7	GO:0097421	liver regeneration(GO:0097421)
1.3	10.5	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
1.3	7.8	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.3	5.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
1.3	5.2	GO:0043654	recognition of apoptotic cell(GO:0043654)
1.3	2.6	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
1.3	5.2	GO:0051299	centrosome separation(GO:0051299)
1.3	5.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.3	32.2	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
1.3	3.9	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
1.3	1.3	GO:0045900	negative regulation of translational elongation(GO:0045900)
1.3	11.5	GO:0043983	histone H4-K12 acetylation(GO:0043983)
1.3	5.1	GO:0060468	prevention of polyspermy(GO:0060468)
1.3	16.4	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.3	11.4	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
1.3	8.8	GO:0035886	vascular smooth muscle cell differentiation(GO:0035886)
1.3	8.8	GO:0043476	endosome to melanosome transport(GO:0035646) pigment accumulation(GO:0043476) cellular pigment accumulation(GO:0043482) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
1.2	1.2	GO:0002158	osteoclast proliferation(GO:0002158)
1.2	11.1	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
1.2	17.3	GO:0060216	definitive hemopoiesis(GO:0060216)
1.2	12.2	GO:0035563	positive regulation of chromatin binding(GO:0035563)
1.2	3.6	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
1.2	9.6	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
1.2	1.2	GO:1990646	cellular response to prolactin(GO:1990646)
1.2	3.6	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
1.2	9.5	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
1.2	4.7	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.2	4.7	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
1.2	366.8	GO:0043547	positive regulation of GTPase activity(GO:0043547)
1.2	3.5	GO:0038096	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.2	4.6	GO:0002188	translation reinitiation(GO:0002188)
1.1	61.8	GO:0002181	cytoplasmic translation(GO:0002181)
1.1	5.7	GO:0032202	telomere assembly(GO:0032202)
1.1	46.4	GO:0007596	blood coagulation(GO:0007596)
1.1	5.6	GO:0060024	rhythmic synaptic transmission(GO:0060024)
1.1	3.4	GO:0006167	AMP biosynthetic process(GO:0006167)
1.1	46.8	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
1.1	6.6	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.1	6.6	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.1	13.1	GO:0035066	positive regulation of histone acetylation(GO:0035066)
1.1	31.6	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
1.1	6.5	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
1.1	24.8	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
1.1	4.3	GO:0070370	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.1	5.3	GO:0001946	lymphangiogenesis(GO:0001946)
1.0	4.2	GO:1901525	negative regulation of macromitophagy(GO:1901525)
1.0	3.1	GO:1904779	regulation of protein localization to centrosome(GO:1904779)
1.0	6.2	GO:1902866	regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
1.0	8.1	GO:0045793	positive regulation of cell size(GO:0045793)
1.0	3.0	GO:0043970	histone H3-K9 acetylation(GO:0043970)
1.0	13.1	GO:0032611	interleukin-1 beta production(GO:0032611)
1.0	4.0	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.0	33.9	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.0	6.9	GO:2000210	positive regulation of anoikis(GO:2000210)
1.0	19.5	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
1.0	40.9	GO:0006182	cGMP biosynthetic process(GO:0006182)
1.0	27.2	GO:0000028	ribosomal small subunit assembly(GO:0000028)
1.0	2.9	GO:0032380	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
1.0	6.7	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.0	2.9	GO:0015938	coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
1.0	5.7	GO:0071918	urea transmembrane transport(GO:0071918)
1.0	5.7	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
1.0	3.8	GO:0034214	protein hexamerization(GO:0034214)
0.9	8.5	GO:0032760	positive regulation of tumor necrosis factor production(GO:0032760) positive regulation of tumor necrosis factor superfamily cytokine production(GO:1903557)
0.9	3.8	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.9	6.5	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.9	4.6	GO:2000819	regulation of nucleotide-excision repair(GO:2000819)
0.9	12.9	GO:0032274	gonadotropin secretion(GO:0032274)
0.9	5.5	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.9	2.8	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.9	87.9	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
0.9	5.4	GO:0048563	post-embryonic organ morphogenesis(GO:0048563)
0.9	15.4	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.9	7.2	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.9	33.0	GO:0051092	positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.9	71.9	GO:0042113	B cell activation(GO:0042113)
0.9	10.6	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.9	5.3	GO:0043416	regulation of skeletal muscle tissue regeneration(GO:0043416)
0.9	1.8	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.9	2.6	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.9	13.1	GO:0031952	regulation of protein autophosphorylation(GO:0031952)
0.9	81.1	GO:0051607	defense response to virus(GO:0051607)
0.9	15.7	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.9	40.4	GO:0016525	negative regulation of angiogenesis(GO:0016525)
0.9	5.1	GO:0042908	xenobiotic transport(GO:0042908)
0.8	13.6	GO:0006691	leukotriene metabolic process(GO:0006691)
0.8	8.4	GO:0044247	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.8	3.3	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.8	9.9	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.8	9.9	GO:0050868	negative regulation of T cell activation(GO:0050868)
0.8	10.7	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.8	6.6	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.8	4.1	GO:1904749	regulation of protein localization to nucleolus(GO:1904749)
0.8	5.6	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.8	5.5	GO:0036260	7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.8	19.5	GO:0071593	lymphocyte aggregation(GO:0071593)
0.8	3.1	GO:0015889	cobalamin transport(GO:0015889)
0.8	2.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.8	6.1	GO:0098734	macromolecule depalmitoylation(GO:0098734)
0.8	4.6	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.8	4.5	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.8	1.5	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.7	3.7	GO:0015780	nucleotide-sugar transport(GO:0015780)
0.7	12.6	GO:0072520	seminiferous tubule development(GO:0072520)
0.7	2.2	GO:0033386	geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.7	1.5	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.7	7.1	GO:0015825	L-serine transport(GO:0015825)
0.7	6.4	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.7	19.8	GO:0030199	collagen fibril organization(GO:0030199)
0.7	2.8	GO:0002101	tRNA wobble cytosine modification(GO:0002101)
0.7	9.0	GO:0048485	sympathetic nervous system development(GO:0048485)
0.7	1.4	GO:0060126	somatotropin secreting cell differentiation(GO:0060126)
0.7	2.1	GO:0046333	octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.7	1.4	GO:0071454	cellular response to anoxia(GO:0071454) cellular response to sodium arsenite(GO:1903936)
0.7	10.2	GO:0010470	regulation of gastrulation(GO:0010470)
0.7	14.3	GO:0032675	regulation of interleukin-6 production(GO:0032675)
0.7	3.3	GO:0071169	establishment of protein localization to chromatin(GO:0071169)
0.7	6.7	GO:0030259	lipid glycosylation(GO:0030259)
0.7	3.3	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.7	4.6	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.6	10.4	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.6	4.5	GO:0032836	glomerular basement membrane development(GO:0032836)
0.6	2.6	GO:1902606	regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.6	5.7	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.6	5.0	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.6	6.9	GO:0036065	fucosylation(GO:0036065)
0.6	2.5	GO:0033227	dsRNA transport(GO:0033227)
0.6	3.7	GO:0019184	nonribosomal peptide biosynthetic process(GO:0019184)
0.6	3.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.6	8.5	GO:0042407	cristae formation(GO:0042407)
0.6	1.2	GO:0086100	endothelin receptor signaling pathway(GO:0086100)
0.6	17.1	GO:0030239	myofibril assembly(GO:0030239)
0.6	2.9	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.6	1.2	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.6	2.9	GO:0070933	histone H4 deacetylation(GO:0070933)
0.6	9.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.6	2.8	GO:0032790	ribosome disassembly(GO:0032790)
0.6	4.5	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6	3.3	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.6	1.1	GO:2000567	memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.6	6.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.5	1.6	GO:1900108	sequestering of BMP in extracellular matrix(GO:0035582) negative regulation of nodal signaling pathway(GO:1900108)
0.5	4.3	GO:0031294	lymphocyte costimulation(GO:0031294)
0.5	3.2	GO:0051418	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.5	1.1	GO:2000313	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5	10.5	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.5	6.8	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.5	2.1	GO:0046070	dGTP metabolic process(GO:0046070)
0.5	2.1	GO:0015879	carnitine transport(GO:0015879)
0.5	13.0	GO:1902117	positive regulation of organelle assembly(GO:1902117)
0.5	4.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.5	6.6	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.5	1.0	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.5	13.9	GO:0060976	coronary vasculature development(GO:0060976)
0.5	11.4	GO:0070207	protein homotrimerization(GO:0070207)
0.5	4.4	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.5	7.9	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.5	4.4	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.5	1.0	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.5	6.7	GO:0033077	T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.5	2.4	GO:0070230	positive regulation of lymphocyte apoptotic process(GO:0070230)
0.5	0.9	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.5	9.9	GO:0050873	brown fat cell differentiation(GO:0050873)
0.5	18.7	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.5	2.8	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.5	5.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.4	2.7	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.4	3.1	GO:0060343	trabecula formation(GO:0060343) bone trabecula formation(GO:0060346)
0.4	4.4	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.4	2.2	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585)
0.4	19.7	GO:0030218	erythrocyte differentiation(GO:0030218)
0.4	21.4	GO:0045727	positive regulation of translation(GO:0045727)
0.4	10.0	GO:0050715	positive regulation of cytokine secretion(GO:0050715)
0.4	1.7	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.4	7.0	GO:0070206	protein trimerization(GO:0070206)
0.4	13.2	GO:0009409	response to cold(GO:0009409)
0.4	18.9	GO:0018108	peptidyl-tyrosine phosphorylation(GO:0018108)
0.4	1.2	GO:0090249	cell motility involved in somitogenic axis elongation(GO:0090247) regulation of cell motility involved in somitogenic axis elongation(GO:0090249)
0.4	2.8	GO:0046549	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.4	24.8	GO:0002250	adaptive immune response(GO:0002250)
0.4	21.6	GO:0019882	antigen processing and presentation(GO:0019882)
0.4	11.9	GO:0097502	mannosylation(GO:0097502)
0.4	1.1	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.4	3.4	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.4	2.6	GO:0006705	mineralocorticoid biosynthetic process(GO:0006705)
0.4	2.1	GO:0006621	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.4	4.6	GO:0051154	negative regulation of striated muscle cell differentiation(GO:0051154)
0.3	2.8	GO:0044804	nucleophagy(GO:0044804)
0.3	3.4	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.3	6.0	GO:0006491	N-glycan processing(GO:0006491)
0.3	5.7	GO:0002115	store-operated calcium entry(GO:0002115)
0.3	3.9	GO:0006353	DNA-templated transcription, termination(GO:0006353)
0.3	3.2	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3	1.2	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093)
0.3	2.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.3	8.8	GO:0032508	DNA duplex unwinding(GO:0032508)
0.3	6.0	GO:0030488	tRNA methylation(GO:0030488)
0.3	4.2	GO:0010761	fibroblast migration(GO:0010761)
0.3	1.8	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.3	13.1	GO:0001824	blastocyst development(GO:0001824)
0.3	23.9	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3	2.3	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3	2.8	GO:2001240	negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.3	2.5	GO:0018298	protein-chromophore linkage(GO:0018298)
0.3	6.6	GO:0019433	triglyceride catabolic process(GO:0019433)
0.3	7.4	GO:0060479	lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.3	4.8	GO:0006953	acute-phase response(GO:0006953)
0.3	1.8	GO:0035372	protein localization to microtubule(GO:0035372)
0.3	7.1	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)
0.3	4.0	GO:0051205	protein insertion into membrane(GO:0051205)
0.3	1.3	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.3	6.0	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.2	3.0	GO:1901222	regulation of NIK/NF-kappaB signaling(GO:1901222)
0.2	5.4	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.2	2.2	GO:2000505	regulation of energy homeostasis(GO:2000505)
0.2	2.4	GO:0006895	Golgi to endosome transport(GO:0006895)
0.2	8.5	GO:0006284	base-excision repair(GO:0006284)
0.2	1.2	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.2	7.8	GO:0031047	gene silencing by RNA(GO:0031047)
0.2	3.9	GO:0006450	regulation of translational fidelity(GO:0006450)
0.2	0.5	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.2	1.4	GO:0015074	DNA integration(GO:0015074)
0.2	2.5	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.2	32.9	GO:0006898	receptor-mediated endocytosis(GO:0006898)
0.2	5.5	GO:0034605	cellular response to heat(GO:0034605)
0.2	0.6	GO:1901620	regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.2	2.7	GO:0000470	maturation of LSU-rRNA(GO:0000470)
0.2	5.2	GO:0006414	translational elongation(GO:0006414)
0.2	4.7	GO:0046626	regulation of insulin receptor signaling pathway(GO:0046626)
0.2	36.1	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.2	0.6	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.2	2.6	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.2	0.8	GO:0061157	mRNA destabilization(GO:0061157)
0.2	3.7	GO:0007099	centriole replication(GO:0007099)
0.2	4.8	GO:0070374	positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.2	0.6	GO:0060816	random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2	0.9	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.2	3.3	GO:0097503	sialylation(GO:0097503)
0.2	5.9	GO:0030217	T cell differentiation(GO:0030217)
0.2	1.9	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.2	5.8	GO:0001541	ovarian follicle development(GO:0001541)
0.2	3.0	GO:0000186	activation of MAPKK activity(GO:0000186)
0.2	3.5	GO:0045739	positive regulation of DNA repair(GO:0045739)
0.2	4.5	GO:0050909	sensory perception of taste(GO:0050909)
0.2	1.6	GO:0051601	exocyst localization(GO:0051601)
0.2	5.0	GO:0007569	cell aging(GO:0007569)
0.1	3.1	GO:0043487	regulation of RNA stability(GO:0043487)
0.1	1.2	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.1	0.4	GO:0042374	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1	0.3	GO:0042762	regulation of sulfur metabolic process(GO:0042762)
0.1	0.5	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.1	0.2	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.1	0.8	GO:0050729	positive regulation of inflammatory response(GO:0050729)
0.1	1.2	GO:0016081	synaptic vesicle docking(GO:0016081)
0.1	0.4	GO:0009838	abscission(GO:0009838) negative regulation of cytokinesis(GO:0032466)
0.1	1.3	GO:0046037	GMP metabolic process(GO:0046037)
0.1	4.7	GO:0010212	response to ionizing radiation(GO:0010212)
0.1	2.1	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1	0.4	GO:0006911	phagocytosis, engulfment(GO:0006911)
0.0	1.1	GO:0009408	response to heat(GO:0009408)
0.0	1.0	GO:0051412	response to corticosterone(GO:0051412)
0.0	0.2	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.2	GO:1900363	regulation of mRNA polyadenylation(GO:1900363)
0.0	0.1	GO:0014744	positive regulation of muscle adaptation(GO:0014744)
0.0	0.4	GO:0033146	regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0	0.5	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.2	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0	0.3	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.4	GO:0045807	positive regulation of endocytosis(GO:0045807)
0.0	0.1	GO:0008105	asymmetric protein localization(GO:0008105)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
27.5	220.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
21.8	43.5	GO:0036398	TCR signalosome(GO:0036398)
19.8	59.5	GO:0044214	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
18.3	36.7	GO:0097342	ripoptosome(GO:0097342)
18.2	54.5	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
15.9	79.4	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
14.0	42.0	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
13.2	132.2	GO:0043020	NADPH oxidase complex(GO:0043020)
12.3	184.0	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
12.1	48.5	GO:0019815	B cell receptor complex(GO:0019815)
12.1	60.3	GO:0072558	NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
10.5	42.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
10.2	82.0	GO:0042101	T cell receptor complex(GO:0042101)
10.0	40.0	GO:0005588	collagen type V trimer(GO:0005588)
9.5	28.6	GO:0071438	invadopodium membrane(GO:0071438)
9.5	28.5	GO:0005943	phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
9.4	56.5	GO:0031904	endosome lumen(GO:0031904)
9.3	288.0	GO:0008305	integrin complex(GO:0008305)
9.2	18.4	GO:0072557	IPAF inflammasome complex(GO:0072557)
8.9	53.6	GO:0005608	laminin-3 complex(GO:0005608)
8.5	50.9	GO:0033093	Weibel-Palade body(GO:0033093)
8.5	16.9	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
8.1	32.3	GO:0030485	smooth muscle contractile fiber(GO:0030485)
7.5	112.5	GO:0072687	meiotic spindle(GO:0072687)
7.3	29.2	GO:0044299	C-fiber(GO:0044299)
7.3	29.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
6.6	72.7	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
6.6	26.3	GO:0031092	platelet alpha granule membrane(GO:0031092)
6.4	19.2	GO:0097651	phosphatidylinositol 3-kinase complex, class I(GO:0097651)
6.3	18.9	GO:1990682	CSF1-CSF1R complex(GO:1990682)
6.2	168.3	GO:0001891	phagocytic cup(GO:0001891)
6.0	53.8	GO:0032009	early phagosome(GO:0032009)
5.6	106.4	GO:0042589	zymogen granule membrane(GO:0042589)
5.5	38.7	GO:0000137	Golgi cis cisterna(GO:0000137)
5.4	48.6	GO:0031209	SCAR complex(GO:0031209)
5.0	15.0	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
4.7	14.1	GO:0070110	interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
4.3	13.0	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
4.3	34.6	GO:0097443	sorting endosome(GO:0097443)
4.3	13.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
4.2	33.4	GO:0043219	lateral loop(GO:0043219)
4.1	12.4	GO:0097453	mesaxon(GO:0097453) ensheathing process(GO:1990015)
3.9	27.4	GO:0030870	Mre11 complex(GO:0030870)
3.8	110.7	GO:0001772	immunological synapse(GO:0001772)
3.8	11.4	GO:0034457	Mpp10 complex(GO:0034457)
3.7	54.8	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
3.6	14.3	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
3.5	60.3	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
3.5	63.7	GO:0031091	platelet alpha granule(GO:0031091)
3.5	945.3	GO:0009897	external side of plasma membrane(GO:0009897)
3.5	14.0	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
3.3	79.8	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
3.3	13.2	GO:0031436	BRCA1-BARD1 complex(GO:0031436)
3.2	12.7	GO:0097149	centralspindlin complex(GO:0097149)
3.1	55.3	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
3.0	158.1	GO:0031672	A band(GO:0031672)
3.0	72.3	GO:0005605	basal lamina(GO:0005605)
2.9	8.7	GO:0061673	mitotic spindle astral microtubule(GO:0061673)
2.9	20.0	GO:0005826	actomyosin contractile ring(GO:0005826)
2.8	8.5	GO:0044609	DBIRD complex(GO:0044609)
2.8	13.9	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
2.8	8.4	GO:0043511	inhibin complex(GO:0043511)
2.8	5.5	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
2.7	19.1	GO:0090543	Flemming body(GO:0090543)
2.7	13.6	GO:0071797	LUBAC complex(GO:0071797)
2.7	10.8	GO:1990584	cardiac Troponin complex(GO:1990584)
2.6	33.9	GO:0005885	Arp2/3 protein complex(GO:0005885)
2.6	23.4	GO:0097433	dense body(GO:0097433)
2.5	12.7	GO:0031262	Ndc80 complex(GO:0031262)
2.5	50.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
2.5	22.3	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
2.4	78.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
2.4	270.5	GO:0005884	actin filament(GO:0005884)
2.4	7.2	GO:0002944	cyclin K-CDK12 complex(GO:0002944)
2.3	15.9	GO:0031527	filopodium membrane(GO:0031527)
2.3	38.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
2.2	24.6	GO:0042555	MCM complex(GO:0042555)
2.2	8.8	GO:0060053	neurofilament cytoskeleton(GO:0060053)
2.2	15.2	GO:0097452	GAIT complex(GO:0097452)
2.1	197.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
2.1	14.9	GO:0031415	NatA complex(GO:0031415)
2.1	23.4	GO:0042613	MHC class II protein complex(GO:0042613)
2.1	10.6	GO:0044530	supraspliceosomal complex(GO:0044530)
2.1	23.0	GO:0097542	ciliary tip(GO:0097542)
2.1	150.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
2.1	78.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
2.1	35.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
2.0	175.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.0	16.1	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
1.9	7.8	GO:0032059	bleb(GO:0032059)
1.9	32.8	GO:0005721	pericentric heterochromatin(GO:0005721)
1.9	7.7	GO:0072487	MSL complex(GO:0072487)
1.9	7.5	GO:0033503	HULC complex(GO:0033503)
1.8	22.0	GO:0008278	cohesin complex(GO:0008278)
1.8	7.2	GO:0000444	MIS12/MIND type complex(GO:0000444)
1.8	17.9	GO:0044615	nuclear pore nuclear basket(GO:0044615)
1.8	5.3	GO:0044326	dendritic spine neck(GO:0044326)
1.7	6.8	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
1.7	37.0	GO:0002080	acrosomal membrane(GO:0002080)
1.7	8.3	GO:0034455	t-UTP complex(GO:0034455)
1.7	5.0	GO:0097444	spine apparatus(GO:0097444)
1.7	19.8	GO:0005687	U4 snRNP(GO:0005687)
1.6	42.4	GO:0002102	podosome(GO:0002102)
1.6	16.2	GO:0031258	lamellipodium membrane(GO:0031258)
1.6	14.5	GO:0032982	myosin filament(GO:0032982)
1.6	11.0	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.6	6.3	GO:1990005	granular vesicle(GO:1990005)
1.6	14.1	GO:0005915	zonula adherens(GO:0005915)
1.6	9.3	GO:1990111	spermatoproteasome complex(GO:1990111)
1.5	12.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
1.5	15.1	GO:0005641	nuclear envelope lumen(GO:0005641)
1.5	18.0	GO:0043202	lysosomal lumen(GO:0043202)
1.4	70.6	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.4	10.0	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
1.4	28.6	GO:0000930	gamma-tubulin complex(GO:0000930)
1.4	2.8	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
1.4	22.5	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
1.4	42.1	GO:0046930	pore complex(GO:0046930)
1.4	15.2	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
1.4	16.4	GO:0031616	spindle pole centrosome(GO:0031616)
1.4	13.6	GO:0042588	zymogen granule(GO:0042588)
1.3	17.5	GO:0031932	TORC2 complex(GO:0031932)
1.3	8.0	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
1.3	8.0	GO:0045180	basal cortex(GO:0045180)
1.3	13.1	GO:0042587	glycogen granule(GO:0042587)
1.3	24.8	GO:0030014	CCR4-NOT complex(GO:0030014)
1.3	11.5	GO:0005828	kinetochore microtubule(GO:0005828)
1.3	33.2	GO:0035371	microtubule plus-end(GO:0035371)
1.3	3.8	GO:0048269	methionine adenosyltransferase complex(GO:0048269)
1.2	6.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
1.2	8.6	GO:0000796	condensin complex(GO:0000796)
1.2	3.6	GO:0070557	PCNA-p21 complex(GO:0070557)
1.2	5.9	GO:0090568	nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571)
1.2	105.1	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
1.1	84.8	GO:0005604	basement membrane(GO:0005604)
1.1	5.7	GO:0097413	Lewy body(GO:0097413)
1.1	4.6	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
1.1	126.9	GO:0030027	lamellipodium(GO:0030027)
1.1	152.6	GO:0001650	fibrillar center(GO:0001650)
1.1	11.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.1	47.8	GO:0032587	ruffle membrane(GO:0032587)
1.1	5.6	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
1.1	6.7	GO:0008290	F-actin capping protein complex(GO:0008290)
1.1	57.0	GO:0017053	transcriptional repressor complex(GO:0017053)
1.1	104.2	GO:0016605	PML body(GO:0016605)
1.1	5.4	GO:0032426	stereocilium tip(GO:0032426)
1.1	10.7	GO:0035631	CD40 receptor complex(GO:0035631)
1.1	22.1	GO:0005771	multivesicular body(GO:0005771)
1.0	28.3	GO:0000788	nuclear nucleosome(GO:0000788)
1.0	4.2	GO:0070938	contractile ring(GO:0070938)
1.0	5.0	GO:0044294	dendritic growth cone(GO:0044294)
1.0	26.5	GO:0016459	myosin complex(GO:0016459)
1.0	15.6	GO:0019013	viral nucleocapsid(GO:0019013)
1.0	36.7	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
1.0	3.8	GO:0061689	tricellular tight junction(GO:0061689)
1.0	6.7	GO:0030057	desmosome(GO:0030057)
1.0	7.6	GO:0097431	mitotic spindle pole(GO:0097431)
0.9	226.7	GO:0005925	focal adhesion(GO:0005925)
0.9	7.6	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.9	20.7	GO:0005640	nuclear outer membrane(GO:0005640)
0.9	66.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.9	5.5	GO:0016589	NURF complex(GO:0016589)
0.9	11.8	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.9	22.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.9	15.9	GO:0035145	exon-exon junction complex(GO:0035145)
0.9	3.5	GO:0070552	BRISC complex(GO:0070552)
0.9	18.0	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.8	6.7	GO:0010369	chromocenter(GO:0010369)
0.8	3.1	GO:0000938	GARP complex(GO:0000938) EARP complex(GO:1990745)
0.7	42.7	GO:0005901	caveola(GO:0005901)
0.7	4.2	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.7	3.4	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.7	2.7	GO:0070545	PeBoW complex(GO:0070545)
0.7	3.3	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.7	6.6	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.6	1.3	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.6	1.9	GO:0044292	dendrite terminus(GO:0044292)
0.6	46.5	GO:0072562	blood microparticle(GO:0072562)
0.6	10.8	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.6	1.8	GO:0042382	paraspeckles(GO:0042382)
0.6	8.9	GO:0030061	mitochondrial crista(GO:0030061)
0.6	46.0	GO:0000790	nuclear chromatin(GO:0000790)
0.6	8.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.6	2.8	GO:0043293	apoptosome(GO:0043293)
0.6	8.4	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.5	173.4	GO:0005667	transcription factor complex(GO:0005667)
0.5	5.8	GO:0035253	ciliary rootlet(GO:0035253)
0.5	161.2	GO:0009986	cell surface(GO:0009986)
0.5	3.2	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.5	1.6	GO:0098833	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.5	166.9	GO:0031012	extracellular matrix(GO:0031012)
0.5	23.7	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.5	18.3	GO:0043198	dendritic shaft(GO:0043198)
0.5	31.3	GO:0005811	lipid particle(GO:0005811)
0.5	484.3	GO:0005615	extracellular space(GO:0005615)
0.5	10.5	GO:0097546	ciliary base(GO:0097546)
0.5	3.5	GO:0061617	MICOS complex(GO:0061617)
0.5	2.3	GO:0005827	polar microtubule(GO:0005827)
0.5	2.3	GO:1990130	Iml1 complex(GO:1990130)
0.5	4.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.4	3.1	GO:0005677	chromatin silencing complex(GO:0005677)
0.4	2.6	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.4	1.7	GO:1990909	Wnt signalosome(GO:1990909)
0.4	1.3	GO:1902560	GMP reductase complex(GO:1902560)
0.4	1.6	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.4	2.8	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.4	5.1	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.4	1.2	GO:0097422	tubular endosome(GO:0097422)
0.4	2.7	GO:0000812	Swr1 complex(GO:0000812)
0.4	11.4	GO:0045171	intercellular bridge(GO:0045171)
0.4	47.4	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4	4.4	GO:0045120	pronucleus(GO:0045120)
0.4	9.2	GO:0060170	ciliary membrane(GO:0060170)
0.3	8.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.3	18.7	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.3	20.5	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.3	4.3	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3	6.5	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.3	13.0	GO:0005913	cell-cell adherens junction(GO:0005913)
0.3	3.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.3	8.9	GO:0016592	mediator complex(GO:0016592)
0.3	1.1	GO:0070876	SOSS complex(GO:0070876)
0.3	40.5	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	1.2	GO:0031501	mannosyltransferase complex(GO:0031501)
0.2	2.9	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.2	1.8	GO:0005861	troponin complex(GO:0005861)
0.2	1.8	GO:0016282	eukaryotic 43S preinitiation complex(GO:0016282)
0.2	5.9	GO:0031594	neuromuscular junction(GO:0031594)
0.2	0.6	GO:0071942	XPC complex(GO:0071942)
0.2	3.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.2	2.4	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.2	2.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.2	2.7	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2	3.0	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	1.5	GO:0097346	INO80-type complex(GO:0097346)
0.1	1.0	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1	1.4	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	8.2	GO:0030017	sarcomere(GO:0030017)
0.1	3.7	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.1	1.9	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.5	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1	0.3	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	1.5	GO:0000791	euchromatin(GO:0000791)
0.1	124.4	GO:0005654	nucleoplasm(GO:0005654)
0.1	0.2	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	3.3	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0	0.3	GO:0000145	exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
23.7	213.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
23.0	46.0	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
21.6	129.6	GO:0098821	BMP receptor activity(GO:0098821)
21.1	63.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
19.7	98.7	GO:0004974	leukotriene receptor activity(GO:0004974)
19.2	57.7	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
17.4	69.7	GO:0004949	cannabinoid receptor activity(GO:0004949)
16.4	98.2	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
15.5	154.7	GO:0019957	C-C chemokine binding(GO:0019957)
14.8	59.4	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
14.7	44.2	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
14.6	87.6	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
12.9	51.4	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
12.7	38.0	GO:0019976	interleukin-2 binding(GO:0019976)
12.5	62.3	GO:0070891	lipoteichoic acid binding(GO:0070891)
12.3	86.3	GO:0035375	zymogen binding(GO:0035375)
11.8	47.3	GO:0035877	death effector domain binding(GO:0035877)
11.5	287.6	GO:0042288	MHC class I protein binding(GO:0042288)
11.0	109.8	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
10.7	32.0	GO:0001847	opsonin receptor activity(GO:0001847)
10.6	74.4	GO:0005138	interleukin-6 receptor binding(GO:0005138)
10.6	31.7	GO:0001605	adrenomedullin receptor activity(GO:0001605)
10.4	31.1	GO:0051916	granulocyte colony-stimulating factor binding(GO:0051916)
10.3	51.3	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
10.0	49.8	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
9.8	39.2	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
9.7	29.1	GO:0031720	haptoglobin binding(GO:0031720)
9.5	47.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
9.4	47.1	GO:0019770	IgG receptor activity(GO:0019770)
8.8	35.3	GO:0042610	CD8 receptor binding(GO:0042610)
8.6	60.4	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
8.6	60.1	GO:0003924	GTPase activity(GO:0003924)
8.5	25.6	GO:0002114	interleukin-33 receptor activity(GO:0002114)
8.5	51.0	GO:0032558	adenyl deoxyribonucleotide binding(GO:0032558)
8.5	25.5	GO:0034211	GTP-dependent protein kinase activity(GO:0034211)
8.1	32.2	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
8.0	32.2	GO:0043120	tumor necrosis factor binding(GO:0043120)
7.6	22.8	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
7.5	74.8	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
7.4	22.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
7.4	59.1	GO:0019958	C-X-C chemokine binding(GO:0019958)
7.3	51.1	GO:0098634	protein binding involved in cell-matrix adhesion(GO:0098634)
7.3	94.6	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
7.2	21.5	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
7.0	28.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
6.9	27.5	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
6.9	41.2	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
6.7	20.2	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
6.6	99.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
6.6	26.3	GO:0042806	fucose binding(GO:0042806)
6.5	39.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
6.4	45.1	GO:0004064	arylesterase activity(GO:0004064)
6.2	24.8	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)
6.0	48.1	GO:0070087	chromo shadow domain binding(GO:0070087)
6.0	24.0	GO:0030345	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
5.9	35.5	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
5.9	35.1	GO:0070051	fibrinogen binding(GO:0070051)
5.7	45.5	GO:0030274	LIM domain binding(GO:0030274)
5.6	45.0	GO:0035197	siRNA binding(GO:0035197)
5.5	88.3	GO:0051400	BH domain binding(GO:0051400)
5.5	22.0	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
5.5	142.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
5.3	31.9	GO:0004568	chitinase activity(GO:0004568)
5.3	37.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
5.3	26.4	GO:0004614	phosphoglucomutase activity(GO:0004614)
5.2	25.9	GO:0001042	RNA polymerase I core binding(GO:0001042)
5.0	20.1	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
4.9	14.6	GO:0002060	purine nucleobase binding(GO:0002060)
4.8	14.3	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
4.7	28.5	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
4.7	51.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
4.6	31.9	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
4.5	22.5	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
4.4	13.2	GO:0045322	unmethylated CpG binding(GO:0045322)
4.3	17.4	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
4.3	17.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
4.2	8.4	GO:0008184	glycogen phosphorylase activity(GO:0008184)
4.2	16.8	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
4.0	28.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
4.0	32.0	GO:0016936	galactoside binding(GO:0016936)
4.0	75.1	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
3.9	7.9	GO:0035800	deubiquitinase activator activity(GO:0035800)
3.9	15.6	GO:0042289	MHC class II protein binding(GO:0042289)
3.9	19.4	GO:0032405	mismatch base pair DNA N-glycosylase activity(GO:0000700) MutLalpha complex binding(GO:0032405)
3.9	50.5	GO:0003796	lysozyme activity(GO:0003796)
3.8	3.8	GO:0070506	high-density lipoprotein particle receptor activity(GO:0070506)
3.8	26.5	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
3.8	45.4	GO:0015026	coreceptor activity(GO:0015026)
3.8	22.5	GO:0043237	laminin-1 binding(GO:0043237)
3.7	37.4	GO:0016502	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
3.7	26.1	GO:0048495	Roundabout binding(GO:0048495)
3.7	70.2	GO:0023026	MHC class II protein complex binding(GO:0023026)
3.6	10.9	GO:0008142	oxysterol binding(GO:0008142)
3.6	21.8	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
3.6	28.9	GO:0004630	phospholipase D activity(GO:0004630)
3.6	10.8	GO:0046592	polyamine oxidase activity(GO:0046592)
3.6	118.6	GO:0001784	phosphotyrosine binding(GO:0001784)
3.5	63.1	GO:0005522	profilin binding(GO:0005522)
3.5	24.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
3.5	24.2	GO:0035325	Toll-like receptor binding(GO:0035325)
3.4	86.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
3.4	64.4	GO:0003993	acid phosphatase activity(GO:0003993)
3.4	27.1	GO:0045545	syndecan binding(GO:0045545)
3.4	40.4	GO:0004950	chemokine receptor activity(GO:0004950)
3.3	140.6	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
3.3	9.9	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
3.2	9.7	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
3.2	9.6	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
3.2	22.4	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
3.2	79.8	GO:0004383	guanylate cyclase activity(GO:0004383)
3.2	50.5	GO:0017166	vinculin binding(GO:0017166)
3.1	18.9	GO:0046624	sphingolipid transporter activity(GO:0046624)
3.1	9.4	GO:0000253	3-keto sterol reductase activity(GO:0000253)
3.1	18.7	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
3.1	96.1	GO:0005158	insulin receptor binding(GO:0005158)
3.1	36.8	GO:0031432	titin binding(GO:0031432)
3.1	61.1	GO:0019865	immunoglobulin binding(GO:0019865)
3.0	12.2	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
3.0	66.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
3.0	30.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
3.0	14.9	GO:0010997	anaphase-promoting complex binding(GO:0010997)
2.9	8.8	GO:0051373	FATZ binding(GO:0051373)
2.9	23.3	GO:0051525	NFAT protein binding(GO:0051525)
2.9	14.4	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
2.8	25.5	GO:0043495	protein anchor(GO:0043495)
2.8	8.5	GO:0030626	U12 snRNA binding(GO:0030626)
2.8	14.1	GO:0046923	ER retention sequence binding(GO:0046923)
2.8	8.4	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
2.8	8.4	GO:0035198	miRNA binding(GO:0035198)
2.8	19.6	GO:0097157	pre-mRNA intronic binding(GO:0097157)
2.8	44.6	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
2.8	11.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
2.8	33.2	GO:1990405	protein antigen binding(GO:1990405)
2.7	41.2	GO:0043274	phospholipase binding(GO:0043274)
2.7	37.7	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
2.6	15.9	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
2.6	15.8	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
2.6	105.4	GO:0005044	scavenger receptor activity(GO:0005044)
2.5	12.4	GO:0032027	myosin light chain binding(GO:0032027)
2.5	44.6	GO:0031996	thioesterase binding(GO:0031996)
2.5	19.7	GO:0030368	interleukin-17 receptor activity(GO:0030368)
2.4	14.6	GO:0008420	CTD phosphatase activity(GO:0008420)
2.4	74.8	GO:1990841	promoter-specific chromatin binding(GO:1990841)
2.4	33.4	GO:0004697	protein kinase C activity(GO:0004697)
2.4	19.0	GO:0035184	histone threonine kinase activity(GO:0035184)
2.4	30.8	GO:0042043	neurexin family protein binding(GO:0042043)
2.3	41.5	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
2.3	6.8	GO:0033906	hyaluronoglucuronidase activity(GO:0033906)
2.3	11.3	GO:0005534	galactose binding(GO:0005534)
2.3	27.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
2.2	33.6	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
2.2	617.4	GO:0030695	GTPase regulator activity(GO:0030695)
2.2	6.7	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
2.2	8.9	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
2.2	8.8	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
2.2	8.7	GO:0035827	rubidium ion transmembrane transporter activity(GO:0035827)
2.1	21.5	GO:0045295	gamma-catenin binding(GO:0045295)
2.1	6.4	GO:0097363	protein O-GlcNAc transferase activity(GO:0097363)
2.1	19.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
2.1	4.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
2.0	8.1	GO:0071532	ankyrin repeat binding(GO:0071532)
2.0	138.2	GO:0019843	rRNA binding(GO:0019843)
2.0	18.2	GO:1990446	U1 snRNP binding(GO:1990446)
2.0	15.9	GO:0008131	primary amine oxidase activity(GO:0008131)
2.0	13.8	GO:0030957	Tat protein binding(GO:0030957)
2.0	57.0	GO:0003785	actin monomer binding(GO:0003785)
1.9	7.8	GO:0050700	CARD domain binding(GO:0050700)
1.9	15.2	GO:0008143	poly(A) binding(GO:0008143)
1.9	76.2	GO:0030544	Hsp70 protein binding(GO:0030544)
1.9	35.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
1.8	7.4	GO:0035497	cAMP response element binding(GO:0035497)
1.8	27.2	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
1.8	10.8	GO:0031013	troponin I binding(GO:0031013)
1.8	16.1	GO:0001727	lipid kinase activity(GO:0001727)
1.8	23.2	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453)
1.8	45.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
1.8	52.9	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.7	10.4	GO:1990226	histone methyltransferase binding(GO:1990226)
1.7	12.1	GO:0003896	DNA primase activity(GO:0003896)
1.7	13.7	GO:0005167	neurotrophin TRK receptor binding(GO:0005167) neurotrophin TRKB receptor binding(GO:0005169)
1.7	3.4	GO:0016842	amidine-lyase activity(GO:0016842)
1.7	8.5	GO:0050786	RAGE receptor binding(GO:0050786)
1.7	25.2	GO:0001618	virus receptor activity(GO:0001618)
1.7	1.7	GO:0048030	disaccharide binding(GO:0048030)
1.7	8.4	GO:0034711	inhibin binding(GO:0034711)
1.7	33.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
1.6	53.5	GO:0043425	bHLH transcription factor binding(GO:0043425)
1.6	8.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.6	16.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.6	120.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.6	56.9	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.6	18.9	GO:0005344	oxygen transporter activity(GO:0005344)
1.6	60.7	GO:1990782	protein tyrosine kinase binding(GO:1990782)
1.5	40.3	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
1.5	4.5	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
1.5	152.1	GO:0017124	SH3 domain binding(GO:0017124)
1.5	7.5	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
1.5	127.8	GO:0005178	integrin binding(GO:0005178)
1.5	24.0	GO:0008307	structural constituent of muscle(GO:0008307)
1.5	16.4	GO:0008046	axon guidance receptor activity(GO:0008046)
1.5	34.3	GO:0042169	SH2 domain binding(GO:0042169)
1.5	32.2	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
1.4	6.9	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
1.4	12.2	GO:0005000	vasopressin receptor activity(GO:0005000)
1.4	6.8	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.3	30.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.3	7.9	GO:0003708	retinoic acid receptor activity(GO:0003708)
1.3	10.5	GO:0005113	patched binding(GO:0005113)
1.3	7.9	GO:0004126	cytidine deaminase activity(GO:0004126)
1.3	13.0	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
1.3	5.1	GO:0032190	acrosin binding(GO:0032190)
1.3	6.3	GO:0008140	cAMP response element binding protein binding(GO:0008140)
1.2	15.0	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
1.2	1.2	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
1.2	15.8	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.2	51.9	GO:0005080	protein kinase C binding(GO:0005080)
1.2	20.2	GO:0043236	laminin binding(GO:0043236)
1.2	5.9	GO:0071253	connexin binding(GO:0071253)
1.2	5.9	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.2	16.5	GO:0001968	fibronectin binding(GO:0001968)
1.2	22.3	GO:0070577	lysine-acetylated histone binding(GO:0070577)
1.2	161.5	GO:0051015	actin filament binding(GO:0051015)
1.2	81.6	GO:0003725	double-stranded RNA binding(GO:0003725)
1.2	3.5	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.2	17.3	GO:0070888	E-box binding(GO:0070888)
1.1	6.9	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.1	2.3	GO:0030348	syntaxin-3 binding(GO:0030348)
1.1	2.3	GO:0019961	interferon binding(GO:0019961)
1.1	6.8	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.1	3.4	GO:0030158	protein xylosyltransferase activity(GO:0030158)
1.1	10.0	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
1.1	5.6	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
1.1	2.2	GO:0015616	DNA translocase activity(GO:0015616)
1.1	3.3	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.1	6.5	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.1	6.4	GO:0019238	cyclohydrolase activity(GO:0019238)
1.1	14.9	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
1.1	4.2	GO:0004967	glucagon receptor activity(GO:0004967)
1.0	6.3	GO:0051880	G-quadruplex DNA binding(GO:0051880)
1.0	8.2	GO:0001222	transcription corepressor binding(GO:0001222)
1.0	2.1	GO:0016715	dopamine beta-monooxygenase activity(GO:0004500) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
1.0	8.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
1.0	127.3	GO:0008201	heparin binding(GO:0008201)
1.0	8.1	GO:0017070	U6 snRNA binding(GO:0017070)
1.0	8.9	GO:0017049	GTP-Rho binding(GO:0017049)
1.0	7.9	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.0	6.9	GO:0000146	microfilament motor activity(GO:0000146)
1.0	10.7	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.0	356.7	GO:0005525	GTP binding(GO:0005525)
1.0	17.4	GO:0051010	microtubule plus-end binding(GO:0051010)
1.0	4.8	GO:0004920	interleukin-10 receptor activity(GO:0004920)
1.0	4.8	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.9	119.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9	7.5	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.9	206.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.9	2.8	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.9	2.8	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.9	20.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.9	15.1	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.9	3.5	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733)
0.9	6.2	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.9	2.6	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.9	35.1	GO:0005504	fatty acid binding(GO:0005504)
0.9	226.3	GO:0030246	carbohydrate binding(GO:0030246)
0.9	7.0	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.9	6.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.9	21.7	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.9	3.5	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.9	34.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.8	4.2	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.8	6.7	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.8	5.0	GO:0015189	L-lysine transmembrane transporter activity(GO:0015189)
0.8	10.6	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.8	231.6	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.8	8.0	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.8	3.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.8	7.5	GO:0070182	DNA polymerase binding(GO:0070182)
0.8	219.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.7	2.9	GO:0048156	tau protein binding(GO:0048156)
0.7	2.9	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.7	31.9	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.7	2.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.7	33.8	GO:0035064	methylated histone binding(GO:0035064)
0.7	24.6	GO:0003678	DNA helicase activity(GO:0003678)
0.7	2.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.7	3.3	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.7	21.8	GO:0022829	wide pore channel activity(GO:0022829)
0.6	30.6	GO:0046332	SMAD binding(GO:0046332)
0.6	1.3	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.6	7.5	GO:0003951	NAD+ kinase activity(GO:0003951)
0.6	62.3	GO:0001047	core promoter binding(GO:0001047)
0.6	16.2	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.6	3.7	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.6	3.0	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.6	39.4	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.6	7.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.6	1.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.6	39.2	GO:0016209	antioxidant activity(GO:0016209)
0.6	1.1	GO:0023023	MHC protein complex binding(GO:0023023)
0.5	1.6	GO:0016015	morphogen activity(GO:0016015)
0.5	8.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.5	11.9	GO:0000030	mannosyltransferase activity(GO:0000030)
0.5	17.5	GO:0032813	tumor necrosis factor receptor superfamily binding(GO:0032813)
0.5	21.8	GO:0019894	kinesin binding(GO:0019894)
0.5	1.5	GO:0070569	uridylyltransferase activity(GO:0070569)
0.5	3.9	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.5	3.9	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.5	12.4	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.5	1.4	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.5	16.5	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.5	1.4	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.5	4.1	GO:0001054	RNA polymerase I activity(GO:0001054)
0.4	5.8	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.4	1.8	GO:0031014	troponin T binding(GO:0031014)
0.4	2.2	GO:0004161	dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.4	3.1	GO:0031419	cobalamin binding(GO:0031419)
0.4	8.8	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.4	17.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.4	10.2	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.4	1.3	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.4	6.9	GO:0048365	Rac GTPase binding(GO:0048365)
0.4	5.9	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.4	7.8	GO:0042162	telomeric DNA binding(GO:0042162)
0.4	9.4	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.4	1.1	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.4	1.5	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4	106.5	GO:0003712	transcription cofactor activity(GO:0003712)
0.4	4.3	GO:0008179	adenylate cyclase binding(GO:0008179)
0.4	7.1	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4	7.4	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.3	3.6	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.3	4.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.3	2.6	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.3	8.3	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3	2.5	GO:0009881	photoreceptor activity(GO:0009881)
0.3	10.1	GO:0004521	endoribonuclease activity(GO:0004521)
0.3	3.6	GO:0017127	cholesterol transporter activity(GO:0017127)
0.3	0.8	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.3	1.8	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.2	1.2	GO:0004945	angiotensin type II receptor activity(GO:0004945) endothelin receptor activity(GO:0004962)
0.2	1.2	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.2	0.9	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2	2.3	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.2	1.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.2	4.0	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.2	3.3	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.2	2.7	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2	15.2	GO:0042393	histone binding(GO:0042393)
0.2	7.9	GO:0003684	damaged DNA binding(GO:0003684)
0.2	2.2	GO:0050072	m7G(5')pppN diphosphatase activity(GO:0050072)
0.2	0.4	GO:0070697	activin receptor binding(GO:0070697)
0.2	38.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	3.1	GO:0005112	Notch binding(GO:0005112)
0.2	8.1	GO:0005088	Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2	4.5	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.2	1.4	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	7.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.1	2.5	GO:0008198	ferrous iron binding(GO:0008198)
0.1	6.4	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.1	0.5	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	2.9	GO:0071949	FAD binding(GO:0071949)
0.1	0.6	GO:0008502	melatonin receptor activity(GO:0008502)
0.1	1.2	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	1.4	GO:0004532	exoribonuclease activity(GO:0004532)
0.1	1.1	GO:0001972	retinoic acid binding(GO:0001972)
0.1	0.9	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.1	1.1	GO:0004407	histone deacetylase activity(GO:0004407)
0.1	0.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.4	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.1	11.2	GO:0044212	transcription regulatory region DNA binding(GO:0044212)
0.0	0.9	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	2.9	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	1.0	GO:0008527	taste receptor activity(GO:0008527)
0.0	0.1	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.3	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	2.5	GO:0004497	monooxygenase activity(GO:0004497)
0.0	0.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
26.6	53.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
9.4	271.7	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
9.4	618.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
9.3	102.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
8.8	158.9	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
8.1	484.9	PID BCR 5PATHWAY	BCR signaling pathway
7.7	161.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
5.8	87.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
5.0	156.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
4.8	28.6	PID S1P S1P3 PATHWAY	S1P3 pathway
4.6	105.1	PID ENDOTHELIN PATHWAY	Endothelins
4.5	80.5	PID S1P S1P1 PATHWAY	S1P1 pathway
4.4	79.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
4.4	48.7	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
4.2	253.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
4.1	62.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
4.1	126.6	PID ALK1 PATHWAY	ALK1 signaling events
4.0	210.1	PID ILK PATHWAY	Integrin-linked kinase signaling
4.0	28.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
3.9	73.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
3.8	142.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
3.7	125.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
3.5	49.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
3.3	66.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
3.2	19.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
3.2	140.1	PID AURORA B PATHWAY	Aurora B signaling
3.0	60.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
2.9	26.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
2.9	64.6	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
2.8	22.3	PID CD40 PATHWAY	CD40/CD40L signaling
2.7	5.5	PID IL5 PATHWAY	IL5-mediated signaling events
2.7	66.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
2.6	39.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
2.4	191.9	PID CMYB PATHWAY	C-MYB transcription factor network
2.4	40.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
2.3	63.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
2.3	93.9	PID AP1 PATHWAY	AP-1 transcription factor network
2.3	57.8	PID RHOA PATHWAY	RhoA signaling pathway
2.3	52.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
2.3	453.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
2.2	94.3	PID RAC1 PATHWAY	RAC1 signaling pathway
2.2	8.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
2.1	18.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
2.1	10.4	ST GAQ PATHWAY	G alpha q Pathway
2.0	34.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
2.0	14.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
1.8	16.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.8	14.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.7	43.6	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
1.6	63.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.6	36.8	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
1.5	182.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.5	6.2	SIG CHEMOTAXIS	Genes related to chemotaxis
1.5	18.5	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
1.5	33.9	PID IL12 2PATHWAY	IL12-mediated signaling events
1.5	21.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
1.5	65.4	PID E2F PATHWAY	E2F transcription factor network
1.4	38.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
1.3	38.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.3	19.5	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
1.3	199.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.3	36.0	PID CONE PATHWAY	Visual signal transduction: Cones
1.3	6.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
1.3	22.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein
1.2	5.9	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
1.2	50.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.2	21.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
1.1	44.3	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.1	24.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
1.0	35.4	PID PLK1 PATHWAY	PLK1 signaling events
1.0	5.2	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
1.0	39.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
1.0	7.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.9	8.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.9	27.9	PID P53 REGULATION PATHWAY	p53 pathway
0.8	7.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.8	7.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.7	9.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.7	13.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.7	10.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.6	5.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.6	9.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.6	4.7	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.6	9.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.5	4.8	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.5	5.9	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.4	15.9	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.4	6.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	1.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.4	4.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.4	4.8	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.4	4.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.4	4.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	21.6	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.4	13.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	9.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.3	5.1	PID ARF6 PATHWAY	Arf6 signaling events
0.3	1.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	5.6	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	3.6	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	4.7	PID FGF PATHWAY	FGF signaling pathway
0.2	3.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	1.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	1.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	2.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	7.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
33.9	373.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
11.9	190.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
10.0	79.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
8.3	366.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
8.2	114.2	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
8.1	317.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
7.8	70.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
7.8	387.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
7.1	192.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
6.6	79.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
6.5	64.7	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
6.0	137.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
6.0	41.7	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
5.8	23.2	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
5.4	85.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
5.3	79.8	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
5.3	79.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
5.3	42.0	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
5.2	78.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
5.2	57.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
4.9	58.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
4.7	51.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
4.5	53.5	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
4.2	80.5	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
4.2	33.5	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
4.2	33.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
4.1	41.3	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
4.1	20.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
4.1	28.4	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
3.9	43.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
3.5	35.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
3.2	73.4	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
3.1	18.9	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
3.1	18.7	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
3.1	130.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
3.0	407.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.8	25.3	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
2.8	14.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
2.7	8.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
2.6	62.8	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
2.6	264.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.5	25.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
2.5	7.4	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
2.4	65.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
2.4	28.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
2.2	24.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
2.2	15.3	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
2.1	88.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
2.1	14.4	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
2.1	144.1	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
2.0	15.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
2.0	43.3	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
1.9	34.7	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
1.9	30.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
1.8	7.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.8	79.2	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
1.8	41.1	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
1.7	22.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.7	32.9	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.7	38.7	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.6	52.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.6	200.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
1.6	15.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.5	41.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.5	33.7	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
1.4	18.6	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
1.4	26.0	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.4	32.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.3	30.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
1.3	21.1	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
1.3	10.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
1.3	36.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
1.3	8.8	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.2	21.9	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.2	26.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
1.2	12.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
1.2	11.9	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
1.2	24.3	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.1	11.4	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
1.1	18.0	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
1.0	6.3	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
1.0	19.9	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
1.0	22.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.9	66.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.9	11.8	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.9	38.1	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.9	1.8	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.8	75.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.8	9.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8	41.0	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.8	22.0	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.8	14.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.8	59.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	8.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.7	38.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.7	31.6	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.7	56.2	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.7	9.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.7	7.6	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.7	14.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.7	5.4	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.6	7.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6	5.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.6	9.9	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.6	4.6	REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	Genes involved in E2F mediated regulation of DNA replication
0.5	5.4	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.5	9.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.4	7.2	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.4	6.3	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.4	20.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.4	7.0	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.4	12.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.4	9.3	REACTOME KINESINS	Genes involved in Kinesins
0.4	6.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.4	5.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.4	23.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.4	6.1	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3	6.5	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	6.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	4.8	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.3	5.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	5.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3	7.4	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.3	1.8	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3	2.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.3	3.1	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.3	7.8	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.2	4.0	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	1.9	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.2	6.3	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2	0.2	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.2	4.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.2	2.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.1	1.7	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.1	1.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	12.8	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.1	3.9	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	3.6	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	1.3	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1	0.5	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	1.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex

Results for Spi1

Z-value: 3.16

Motif logo

Transcription factors associated with Spi1

Activity-expression correlation:

Activity profile of Spi1 motif

Sorted Z-values of Spi1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: