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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Srf

Z-value: 2.37

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Transcription factors associated with Srf

Gene Symbol Gene ID Gene Info
Srf
ENSRNOG00000018232 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Srfrn6_v1_chr9_+_16737642_167376420.717.1e-50Click!

Activity profile of Srf motif

Sorted Z-values of Srf motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_105512939 300.50 ENSRNOT00000011773
Actc1
actin, alpha, cardiac muscle 1
chr8_+_119030875 181.77 ENSRNOT00000028458
Myl3
myosin light chain 3
chr6_-_127248372 161.82 ENSRNOT00000085517
Asb2
ankyrin repeat and SOCS box-containing 2
chr5_+_164808323 159.99 ENSRNOT00000011005
Nppa
natriuretic peptide A
chr10_+_70262361 151.56 ENSRNOT00000064625
ENSRNOT00000076973
Unc45b
unc-45 myosin chaperone B
chrX_+_71342775 142.98 ENSRNOT00000004888
Itgb1bp2
integrin subunit beta 1 binding protein 2
chr14_-_86146744 133.80 ENSRNOT00000019335
Myl7
myosin light chain 7
chr10_+_53621375 120.01 ENSRNOT00000004147
Myh3
myosin heavy chain 3
chr2_+_104416972 98.28 ENSRNOT00000017125
Trim55
tripartite motif-containing 55
chr12_+_49761120 93.56 ENSRNOT00000070961
Myo18b
myosin XVIIIb
chr4_-_115239723 90.20 ENSRNOT00000042699
Actg2
actin, gamma 2, smooth muscle, enteric
chr16_-_10941414 84.53 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
Ldb3
LIM domain binding 3
chr1_-_25839198 83.03 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
Trdn
triadin
chr4_-_99125111 79.50 ENSRNOT00000009184
Smyd1
SET and MYND domain containing 1
chr1_-_215838209 78.47 ENSRNOT00000050760
Igf2
insulin-like growth factor 2
chr16_+_49266903 74.64 ENSRNOT00000014704
Slc25a4
solute carrier family 25 member 4
chr13_+_52662996 69.51 ENSRNOT00000047682
Tnnt2
troponin T2, cardiac type
chr8_-_87282156 58.56 ENSRNOT00000087874
Filip1
filamin A interacting protein 1
chr3_-_123607352 53.67 ENSRNOT00000051404
ENSRNOT00000028854
Adam33
ADAM metallopeptidase domain 33
chr10_-_89338739 53.62 ENSRNOT00000073923
Ptges3l
prostaglandin E synthase 3 like
chr9_-_119332967 53.19 ENSRNOT00000021048
Myl12a
myosin light chain 12A
chr15_-_3544685 49.90 ENSRNOT00000015179
ENSRNOT00000085126
Vcl
vinculin
chr3_+_152857592 46.48 ENSRNOT00000027445
Myl9
myosin light chain 9
chr1_-_198232344 41.69 ENSRNOT00000080988
Aldoa
aldolase, fructose-bisphosphate A
chr10_-_62699723 40.51 ENSRNOT00000086706
Coro6
coronin 6
chr7_-_117288018 39.41 ENSRNOT00000091285
Plec
plectin
chr2_-_198002625 36.95 ENSRNOT00000091888
BC028528
cDNA sequence BC028528
chr1_+_199664173 33.84 ENSRNOT00000054980
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr7_+_12782491 31.43 ENSRNOT00000065093
Cnn2
calponin 2
chr1_-_209641123 30.51 ENSRNOT00000021702
Ebf3
early B-cell factor 3
chr15_+_32763067 29.65 ENSRNOT00000011998
AABR07017902.1

chr9_+_16737642 28.87 ENSRNOT00000061430
Srf
serum response factor
chr10_+_18911938 28.53 ENSRNOT00000007408
Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr15_-_19876389 26.98 ENSRNOT00000012400
ENSRNOT00000086368
Fermt2
fermitin family member 2
chr4_-_166803127 26.68 ENSRNOT00000067909
RGD1306750
LOC362451
chr6_+_109300433 26.12 ENSRNOT00000010712
Fos
FBJ osteosarcoma oncogene
chr2_+_189423559 24.56 ENSRNOT00000029076
Tpm3
tropomyosin 3
chr9_+_45672157 24.47 ENSRNOT00000017882
Pdcl3
phosducin-like 3
chr13_-_91872954 22.61 ENSRNOT00000004613
ENSRNOT00000079263
Cadm3
cell adhesion molecule 3
chr3_-_46726946 22.28 ENSRNOT00000011030
ENSRNOT00000086576
Itgb6
integrin subunit beta 6
chr2_+_208749996 22.17 ENSRNOT00000086321
Chia
chitinase, acidic
chr10_+_36098051 21.38 ENSRNOT00000083971
Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr2_+_208750356 20.97 ENSRNOT00000041562
Chia
chitinase, acidic
chr1_+_46835971 19.31 ENSRNOT00000066798
Synj2
synaptojanin 2
chr1_-_175796040 18.66 ENSRNOT00000024060
Mrvi1
murine retrovirus integration site 1 homolog
chr10_-_88060561 18.55 ENSRNOT00000019133
Krt19
keratin 19
chr1_+_40816107 17.33 ENSRNOT00000060767
Akap12
A-kinase anchoring protein 12
chr14_-_7384876 16.26 ENSRNOT00000086694
Aff1
AF4/FMR2 family, member 1
chr10_+_13915214 15.82 ENSRNOT00000015092
Pkd1
polycystin 1, transient receptor potential channel interacting
chr15_-_2648551 15.77 ENSRNOT00000086864
Vdac2
voltage-dependent anion channel 2
chr3_+_80555196 15.70 ENSRNOT00000067318
Arhgap1
Rho GTPase activating protein 1
chr17_-_80577027 15.35 ENSRNOT00000057827
Rsu1
Ras suppressor protein 1
chr1_+_220826560 15.31 ENSRNOT00000027891
Fosl1
FOS like 1, AP-1 transcription factor subunit
chr7_-_54778848 14.36 ENSRNOT00000005399
Glipr1
GLI pathogenesis-related 1
chr6_+_76745981 13.30 ENSRNOT00000076784
Brms1l
breast cancer metastasis-suppressor 1-like
chr5_+_139385429 11.29 ENSRNOT00000078622
Scmh1
sex comb on midleg homolog 1 (Drosophila)
chr15_-_34693034 10.51 ENSRNOT00000083314
Mcpt8
mast cell protease 8
chr1_-_80221710 10.25 ENSRNOT00000091687
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
chr4_-_145329878 9.52 ENSRNOT00000011827
Tada3
transcriptional adaptor 3
chr3_-_161299024 9.47 ENSRNOT00000021216
Neurl2
neuralized E3 ubiquitin protein ligase 2
chr16_-_3765917 9.21 ENSRNOT00000088284
Duxbl1
double homeobox B-like 1
chr1_-_47502952 8.59 ENSRNOT00000025580
Tagap
T-cell activation RhoGTPase activating protein
chr2_+_35977828 8.45 ENSRNOT00000076712
LOC108348103
serine protease inhibitor Kazal-type 5-like
chr2_-_45077219 8.24 ENSRNOT00000014319
Gzmk
granzyme K
chrX_-_156440461 8.03 ENSRNOT00000083951
Rpl10
ribosomal protein L10
chr13_-_36022197 7.94 ENSRNOT00000091280
Cfap221
cilia and flagella associated protein 221
chr10_-_13814304 7.93 ENSRNOT00000012203
Dnase1l2
deoxyribonuclease 1 like 2
chr15_-_54906203 7.90 ENSRNOT00000020186
Cysltr2
cysteinyl leukotriene receptor 2
chr18_-_38329721 7.23 ENSRNOT00000080220
ENSRNOT00000060125
RGD1563060
similar to AVLV472
chr8_-_104593625 6.82 ENSRNOT00000016625
Zbtb38
zinc finger and BTB domain containing 38
chr3_+_138024508 6.70 ENSRNOT00000007794
Dstn
destrin, actin depolymerizing factor
chr3_-_167759273 6.25 ENSRNOT00000049457
AABR07054721.1

chr1_-_31262466 6.08 ENSRNOT00000029531
Mrpl36
mitochondrial ribosomal protein L36
chrX_-_102510007 5.71 ENSRNOT00000082854
AABR07040494.1

chr1_-_193700673 5.08 ENSRNOT00000071314
Paip2l1
polyadenylate-binding protein-interacting protein 2-like 1
chr19_-_11057254 3.83 ENSRNOT00000025559
Herpud1
homocysteine inducible ER protein with ubiquitin like domain 1
chr10_-_44026578 3.72 ENSRNOT00000050448
Olr1418
olfactory receptor 1418
chr1_-_189666440 3.58 ENSRNOT00000019167
Dcun1d3
defective in cullin neddylation 1 domain containing 3
chr1_+_79474809 3.32 ENSRNOT00000044927
Ceacam12
carcinoembryonic antigen-related cell adhesion molecule 12
chr1_-_72339395 3.24 ENSRNOT00000021772
Zfp580
zinc finger protein 580
chr13_+_80125391 3.23 ENSRNOT00000044190
Mir199a2
microRNA 199a-2
chr8_+_60709851 2.59 ENSRNOT00000021817
Rcn2
reticulocalbin 2
chr15_+_31642169 2.59 ENSRNOT00000072362
AABR07017833.1

chr8_+_48569328 2.49 ENSRNOT00000084030
Ccdc153
coiled-coil domain containing 153
chr11_-_89510871 2.37 ENSRNOT00000035247
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr8_+_117780891 2.33 ENSRNOT00000077236
Shisa5
shisa family member 5
chr1_+_87650207 2.14 ENSRNOT00000077161
Zfp84
zinc finger protein 84
chr4_-_106983279 2.10 ENSRNOT00000007700
AABR07061152.1

chr15_-_36417868 1.82 ENSRNOT00000028062
AABR07018028.1

chr15_+_32012543 1.70 ENSRNOT00000078174
AABR07017868.5

chr6_-_102047758 1.63 ENSRNOT00000012101
Atp6v1d
ATPase H+ transporting V1 subunit D
chr9_+_84689150 1.39 ENSRNOT00000072242
Kcne4
potassium voltage-gated channel subfamily E regulatory subunit 4
chr11_+_31539016 1.20 ENSRNOT00000072856
Ifnar2
interferon alpha and beta receptor subunit 2
chr3_+_159569363 1.17 ENSRNOT00000064159
Tox2
TOX high mobility group box family member 2
chr1_-_212991658 1.10 ENSRNOT00000091487
Olr298
olfactory receptor 298
chr6_+_94636222 1.07 ENSRNOT00000005846
Daam1
dishevelled associated activator of morphogenesis 1
chr9_+_119873170 0.20 ENSRNOT00000037587
Mettl4
methyltransferase like 4
chr4_-_176606382 0.18 ENSRNOT00000065576
Recql
RecQ like helicase
chr15_-_29443454 0.09 ENSRNOT00000082167
AABR07017635.2

chr8_+_41336340 0.01 ENSRNOT00000072049
Olr1225
olfactory receptor 1225

Network of associatons between targets according to the STRING database.

First level regulatory network of Srf

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
78.1 390.7 GO:0090131 mesenchyme migration(GO:0090131)
53.3 160.0 GO:1902304 positive regulation of potassium ion export(GO:1902304)
27.7 83.0 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
23.2 69.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
18.7 74.6 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
11.2 78.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
9.6 28.9 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
8.6 43.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
7.8 93.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
7.1 28.5 GO:1903413 cellular response to bile acid(GO:1903413)
5.3 15.8 GO:0072237 distal tubule morphogenesis(GO:0072156) metanephric proximal tubule development(GO:0072237)
5.2 181.8 GO:0002026 regulation of the force of heart contraction(GO:0002026)
4.8 33.8 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
4.5 22.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
3.8 15.3 GO:0007296 vitellogenesis(GO:0007296)
3.4 6.7 GO:0030043 actin filament fragmentation(GO:0030043)
3.3 26.1 GO:0001661 conditioned taste aversion(GO:0001661)
3.2 41.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
3.1 15.7 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
3.1 24.5 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
2.8 49.9 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
2.7 79.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
2.6 112.5 GO:0045214 sarcomere organization(GO:0045214)
2.6 120.0 GO:0003009 skeletal muscle contraction(GO:0003009)
2.2 151.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
2.1 161.8 GO:0045445 myoblast differentiation(GO:0045445)
2.1 39.4 GO:0031581 hemidesmosome assembly(GO:0031581)
2.0 99.7 GO:0070527 platelet aggregation(GO:0070527)
1.9 18.7 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
1.7 184.7 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
1.7 17.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.5 31.4 GO:0050765 negative regulation of phagocytosis(GO:0050765)
1.4 19.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
1.3 7.9 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.0 9.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.9 9.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.8 3.8 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.6 2.4 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.6 7.9 GO:0003334 keratinocyte development(GO:0003334)
0.3 15.8 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.3 8.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 15.4 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.3 7.9 GO:0044458 motile cilium assembly(GO:0044458)
0.3 2.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.2 10.2 GO:0051412 response to corticosterone(GO:0051412)
0.2 3.6 GO:0010225 response to UV-C(GO:0010225) protein neddylation(GO:0045116)
0.2 13.3 GO:0016575 histone deacetylation(GO:0016575)
0.1 8.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 24.6 GO:0006936 muscle contraction(GO:0006936)
0.1 11.3 GO:0006338 chromatin remodeling(GO:0006338)
0.1 3.2 GO:0010595 positive regulation of endothelial cell migration(GO:0010595)
0.1 2.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 6.8 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 1.6 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
27.7 83.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
20.2 161.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
17.4 69.5 GO:1990584 cardiac Troponin complex(GO:1990584)
14.0 210.2 GO:0032982 myosin filament(GO:0032982)
11.1 99.7 GO:0016460 myosin II complex(GO:0016460)
10.4 93.6 GO:0016461 unconventional myosin complex(GO:0016461)
9.8 68.4 GO:1990357 terminal web(GO:1990357)
7.4 357.3 GO:0031672 A band(GO:0031672)
5.7 160.0 GO:0042629 mast cell granule(GO:0042629)
5.2 26.1 GO:0035976 AP1 complex(GO:0035976)
4.4 374.5 GO:0042641 actomyosin(GO:0042641)
3.9 19.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
2.4 9.5 GO:0005927 muscle tendon junction(GO:0005927)
2.0 39.4 GO:0030056 hemidesmosome(GO:0030056)
2.0 15.7 GO:0097443 sorting endosome(GO:0097443)
1.9 227.5 GO:0030018 Z disc(GO:0030018)
1.3 3.8 GO:1990037 Lewy body core(GO:1990037)
0.8 22.3 GO:0008305 integrin complex(GO:0008305)
0.7 9.5 GO:0030914 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.7 13.3 GO:0070822 Sin3-type complex(GO:0070822)
0.6 2.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.5 90.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.5 11.3 GO:0010369 chromocenter(GO:0010369)
0.3 15.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.3 16.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.3 33.8 GO:0016363 nuclear matrix(GO:0016363)
0.3 28.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 8.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 15.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 6.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 6.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 24.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 8.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 30.0 GO:0005924 cell-substrate adherens junction(GO:0005924) cell-substrate junction(GO:0030055)
0.1 25.6 GO:0000790 nuclear chromatin(GO:0000790)
0.1 6.8 GO:0072562 blood microparticle(GO:0072562)
0.1 1.6 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.1 21.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 32.2 GO:0005615 extracellular space(GO:0005615)
0.0 11.8 GO:0005730 nucleolus(GO:0005730)
0.0 3.6 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.4 69.5 GO:0030172 troponin C binding(GO:0030172)
8.3 74.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
7.2 43.1 GO:0004568 chitinase activity(GO:0004568)
6.8 33.8 GO:0048495 Roundabout binding(GO:0048495)
6.4 160.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
6.1 181.8 GO:0003785 actin monomer binding(GO:0003785)
6.0 41.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
5.8 46.5 GO:0032036 myosin heavy chain binding(GO:0032036)
5.3 84.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
5.0 110.0 GO:0000146 microfilament motor activity(GO:0000146)
4.6 300.5 GO:0017022 myosin binding(GO:0017022)
4.1 78.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
3.8 49.9 GO:0045294 alpha-catenin binding(GO:0045294)
3.8 151.6 GO:0051879 Hsp90 protein binding(GO:0051879)
3.1 24.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
2.9 28.9 GO:0070878 primary miRNA binding(GO:0070878)
2.4 19.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
2.4 82.5 GO:0008307 structural constituent of muscle(GO:0008307)
1.6 7.9 GO:0004974 leukotriene receptor activity(GO:0004974)
1.4 165.3 GO:0005178 integrin binding(GO:0005178)
1.0 17.3 GO:0008179 adenylate cyclase binding(GO:0008179)
1.0 28.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
1.0 26.1 GO:0070412 R-SMAD binding(GO:0070412)
0.8 90.4 GO:0003774 motor activity(GO:0003774)
0.7 53.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.7 15.8 GO:0015288 porin activity(GO:0015288)
0.7 161.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.7 13.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.6 75.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 2.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.6 27.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 75.1 GO:0044325 ion channel binding(GO:0044325)
0.5 9.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 79.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 1.2 GO:0019961 interferon binding(GO:0019961)
0.4 6.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 35.2 GO:0051015 actin filament binding(GO:0051015)
0.3 39.4 GO:0005516 calmodulin binding(GO:0005516)
0.3 3.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 73.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 7.9 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.1 33.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 2.3 GO:0050699 WW domain binding(GO:0050699)
0.1 23.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.2 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 14.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 70.0 GO:0005524 ATP binding(GO:0005524)
0.0 1.6 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 1.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 17.9 GO:0042802 identical protein binding(GO:0042802)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 55.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
1.6 79.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.6 134.2 PID AP1 PATHWAY AP-1 transcription factor network
1.3 49.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
1.2 22.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
1.1 78.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
1.1 46.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.6 15.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.5 36.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.5 18.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 54.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 12.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.9 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.2 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 395.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
9.3 186.6 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
5.7 160.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
3.7 78.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.5 42.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
2.2 74.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
1.9 47.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
1.6 26.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.4 39.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 41.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 148.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 7.9 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.5 19.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 21.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 22.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 24.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 14.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 8.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 1.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling