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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat1

Z-value: 0.84

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Transcription factors associated with Stat1

Gene Symbol Gene ID Gene Info
Stat1
ENSRNOG00000014079 signal transducer and activator of transcription 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Stat1rn6_v1_chr9_-_54327958_543279580.612.3e-34Click!

Activity profile of Stat1 motif

Sorted Z-values of Stat1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_23148396 40.95 ENSRNOT00000075237
Acp5
acid phosphatase 5, tartrate resistant
chr1_-_98493978 40.89 ENSRNOT00000023942
Nkg7
natural killer cell granule protein 7
chr15_-_34392066 36.74 ENSRNOT00000027315
Tgm1
transglutaminase 1
chr3_-_72171078 36.48 ENSRNOT00000009817
Serping1
serpin family G member 1
chr19_+_54314865 27.91 ENSRNOT00000024069
Irf8
interferon regulatory factor 8
chr1_-_189181901 26.33 ENSRNOT00000092022
Gp2
glycoprotein 2
chr10_+_69412017 25.40 ENSRNOT00000009448
Ccl2
C-C motif chemokine ligand 2
chr1_-_176079125 25.25 ENSRNOT00000047044
RGD1566189
similar to ferritin light chain
chr10_-_56506446 24.44 ENSRNOT00000021357
Acap1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr8_+_127735258 22.58 ENSRNOT00000015888
Vill
villin-like
chr15_-_35417273 21.59 ENSRNOT00000083961
ENSRNOT00000041430
Gzmb
granzyme B
chr14_+_17195014 21.41 ENSRNOT00000031667
Cxcl11
C-X-C motif chemokine ligand 11
chr13_+_92103123 21.00 ENSRNOT00000004643
Olr1584
olfactory receptor 1584
chr7_-_139318455 20.99 ENSRNOT00000092029
Hdac7
histone deacetylase 7
chr9_+_10952374 20.57 ENSRNOT00000074993
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr14_-_23604834 20.28 ENSRNOT00000002760
Stap1
signal transducing adaptor family member 1
chr10_+_39109522 18.83 ENSRNOT00000010968
Irf1
interferon regulatory factor 1
chr3_-_160139947 18.79 ENSRNOT00000014151
Ada
adenosine deaminase
chr18_+_86299463 18.28 ENSRNOT00000058152
Cd226
CD226 molecule
chr15_-_36472327 17.84 ENSRNOT00000032601
ENSRNOT00000059660
LOC102553861
granzyme-like protein 1-like
chr20_-_3793985 17.35 ENSRNOT00000049540
ENSRNOT00000086293
RT1-CE16
RT1 class I, locus CE16
chr1_+_154131926 17.25 ENSRNOT00000035257
LOC102549852
ferritin light chain 1-like
chr2_+_225827504 16.89 ENSRNOT00000018343
Gclm
glutamate cysteine ligase, modifier subunit
chr18_-_31430973 16.87 ENSRNOT00000026065
Pcdh12
protocadherin 12
chr1_+_257157264 16.81 ENSRNOT00000067149
ENSRNOT00000079219
Plce1
phospholipase C, epsilon 1
chr7_+_16404755 16.69 ENSRNOT00000044977
LOC108349290
olfactory receptor 6C70-like
chr18_-_36285444 16.64 ENSRNOT00000087852
Prelid2
PRELI domain containing 2
chr1_-_78180216 16.09 ENSRNOT00000071576
C5ar2
complement component 5a receptor 2
chr2_+_199162745 16.08 ENSRNOT00000023488
Gja5
gap junction protein, alpha 5
chr11_+_68105369 15.79 ENSRNOT00000046888
Parp14
poly (ADP-ribose) polymerase family, member 14
chr14_-_19072677 15.68 ENSRNOT00000060548
LOC360919
similar to alpha-fetoprotein
chr8_-_48850671 15.64 ENSRNOT00000016580
Cxcr5
C-X-C motif chemokine receptor 5
chr20_-_3397039 15.60 ENSRNOT00000001084
ENSRNOT00000085259
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr15_+_34282936 15.04 ENSRNOT00000026364
Irf9
interferon regulatory factor 9
chr1_-_213921208 14.18 ENSRNOT00000044393
Ano9
anoctamin 9
chr2_+_30685840 14.16 ENSRNOT00000031385
Ccdc125
coiled-coil domain containing 125
chr7_+_1206648 14.08 ENSRNOT00000073689
Pros1
protein S (alpha)
chr6_-_76652757 13.73 ENSRNOT00000042177
LOC100359668
ferritin light chain 2
chr10_+_69476775 13.56 ENSRNOT00000031626
Ccl12
chemokine (C-C motif) ligand 12
chr5_+_133896141 13.45 ENSRNOT00000011434
Pdzk1ip1
PDZK1 interacting protein 1
chr10_+_84167331 12.91 ENSRNOT00000010965
Hoxb4
homeo box B4
chr8_+_116054465 12.70 ENSRNOT00000040056
Cish
cytokine inducible SH2-containing protein
chr17_-_15467320 12.45 ENSRNOT00000072490
ENSRNOT00000093561
Ogn
osteoglycin
chr5_-_153625869 12.26 ENSRNOT00000024464
Clic4
chloride intracellular channel 4
chrX_+_70461718 12.23 ENSRNOT00000078233
ENSRNOT00000003789
Kif4a
kinesin family member 4A
chr15_-_103927592 10.67 ENSRNOT00000031036
ENSRNOT00000013366
Abcc4
ATP binding cassette subfamily C member 4
chrX_+_77065397 10.62 ENSRNOT00000090007
Cox7b
cytochrome c oxidase subunit 7B
chr3_+_161519743 10.62 ENSRNOT00000055148
Cd40
CD40 molecule
chr19_+_15294248 10.50 ENSRNOT00000024622
Ces1f
carboxylesterase 1F
chr14_-_80973456 10.36 ENSRNOT00000013257
Hgfac
HGF activator
chr1_-_7480825 10.12 ENSRNOT00000048754
Phactr2
phosphatase and actin regulator 2
chr10_+_105393072 9.86 ENSRNOT00000013359
Ubald2
UBA-like domain containing 2
chrX_-_25590048 9.67 ENSRNOT00000004873
Mid1
midline 1
chrX_+_156854594 9.50 ENSRNOT00000083442
Renbp
renin binding protein
chr7_-_3342491 9.32 ENSRNOT00000081756
Rdh5
retinol dehydrogenase 5
chr8_-_82492243 9.29 ENSRNOT00000013852
Tmod3
tropomodulin 3
chr6_-_36940868 9.17 ENSRNOT00000006470
Gen1
GEN1 Holliday junction 5' flap endonuclease
chr7_-_70328148 9.02 ENSRNOT00000074645
Mettl21b
methyltransferase like 21B
chr7_-_3074359 8.95 ENSRNOT00000019738
Ikzf4
IKAROS family zinc finger 4
chr12_+_7081895 8.75 ENSRNOT00000047163
Hmgb1
high mobility group box 1
chr2_+_53109684 8.67 ENSRNOT00000086590
Selenop
selenoprotein P
chr7_-_137856485 8.57 ENSRNOT00000007003
LOC688906
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr3_-_52998650 8.52 ENSRNOT00000009988
RGD1560831
similar to 40S ribosomal protein S3
chr14_+_81488008 8.32 ENSRNOT00000018477
Tnip2
TNFAIP3 interacting protein 2
chr3_+_121632043 8.14 ENSRNOT00000024882
Polr1b
RNA polymerase I subunit B
chr8_+_133029625 8.14 ENSRNOT00000008809
Ccr3
C-C motif chemokine receptor 3
chr11_+_80255790 8.14 ENSRNOT00000002522
Bcl6
B-cell CLL/lymphoma 6
chr2_+_165601007 8.12 ENSRNOT00000013931
Smc4
structural maintenance of chromosomes 4
chr10_+_14240219 7.79 ENSRNOT00000020233
Igfals
insulin-like growth factor binding protein, acid labile subunit
chr7_+_143707237 7.70 ENSRNOT00000074212
Tns2
tensin 2
chr10_-_59883839 7.56 ENSRNOT00000093579
Aspa
aspartoacylase
chr11_+_31806618 7.14 ENSRNOT00000043410
ENSRNOT00000002769
Son
Son DNA binding protein
chr1_-_89042176 7.11 ENSRNOT00000080842
Kmt2b
lysine methyltransferase 2B
chr5_-_79874671 6.96 ENSRNOT00000084563
Tnc
tenascin C
chr8_-_116349896 6.80 ENSRNOT00000087306
Lsmem2
leucine-rich single-pass membrane protein 2
chr7_-_145174771 6.61 ENSRNOT00000055270
Glycam1
glycosylation dependent cell adhesion molecule 1
chr17_+_9596957 6.52 ENSRNOT00000017349
Fam193b
family with sequence similarity 193, member B
chr4_+_123118468 6.35 ENSRNOT00000010895
Tmem43
transmembrane protein 43
chr7_-_4293352 6.34 ENSRNOT00000047489
Olr984
olfactory receptor 984
chr7_+_3900228 6.28 ENSRNOT00000071350
Olr921
olfactory receptor 921
chr2_+_86996798 5.85 ENSRNOT00000070821
Zfp455
zinc finger protein 455
chr7_-_102298522 5.75 ENSRNOT00000006273
A1bg
alpha-1-B glycoprotein
chr8_+_49621568 5.70 ENSRNOT00000021949
Tmprss13
transmembrane protease, serine 13
chr1_-_37818879 5.58 ENSRNOT00000043747
LOC680200
similar to zinc finger protein 455
chr15_+_33004133 5.42 ENSRNOT00000013246
Oxa1l
OXA1L, mitochondrial inner membrane protein
chr10_-_95431312 5.38 ENSRNOT00000085552
AABR07030603.2

chr10_-_89338739 5.25 ENSRNOT00000073923
Ptges3l
prostaglandin E synthase 3 like
chr4_-_69211671 5.25 ENSRNOT00000017852
LOC286960
preprotrypsinogen IV
chr7_+_6096690 5.20 ENSRNOT00000051694
Olr1006
olfactory receptor 1006
chr2_-_140618405 5.17 ENSRNOT00000017736
Setd7
SET domain containing (lysine methyltransferase) 7
chr10_-_65805693 5.13 ENSRNOT00000012245
Tnfaip1
TNF alpha induced protein 1
chr9_+_42871950 4.96 ENSRNOT00000089673
Arid5a
AT-rich interaction domain 5A
chr2_+_211337271 4.79 ENSRNOT00000045155
Cox6b1
cytochrome c oxidase subunit 6B1
chr17_+_57075218 4.57 ENSRNOT00000089536
Crem
cAMP responsive element modulator
chr1_-_134870255 4.50 ENSRNOT00000055829
Chd2
chromodomain helicase DNA binding protein 2
chr20_+_4852671 4.50 ENSRNOT00000001111
Lta
lymphotoxin alpha
chr1_-_52894832 4.50 ENSRNOT00000016471
T
T brachyury transcription factor
chr3_-_161376119 4.37 ENSRNOT00000023521
Zfp335
zinc finger protein 335
chr19_-_10884047 4.27 ENSRNOT00000088196
ENSRNOT00000063791
Cpne2
copine 2
chr10_+_56605140 4.12 ENSRNOT00000024079
Phf23
PHD finger protein 23
chr9_+_15166118 3.85 ENSRNOT00000020432
Mdfi
MyoD family inhibitor
chr1_+_144239020 3.73 ENSRNOT00000032106
Adamtsl3
ADAMTS-like 3
chr15_+_34452116 3.71 ENSRNOT00000027647
Ltb4r
leukotriene B4 receptor
chr7_-_5818625 3.53 ENSRNOT00000051699
Olr886
olfactory receptor 886
chr7_-_16432738 3.44 ENSRNOT00000049493
Olr932
olfactory receptor 932
chr17_+_18358712 3.43 ENSRNOT00000001979
Nup153
nucleoporin 153
chr6_-_42616548 3.43 ENSRNOT00000081433
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr12_-_23727535 3.42 ENSRNOT00000085911
ENSRNOT00000001950
Dtx2
deltex E3 ubiquitin ligase 2
chr18_+_36829062 3.36 ENSRNOT00000025467
ENSRNOT00000086979
Tcerg1
transcription elongation regulator 1
chr7_-_70355619 3.18 ENSRNOT00000031272
Tspan31
tetraspanin 31
chr7_+_14037620 3.15 ENSRNOT00000009606
Syde1
synapse defective Rho GTPase homolog 1
chrX_-_143453612 3.13 ENSRNOT00000051319
Atp11c
ATPase phospholipid transporting 11C
chr13_+_47739526 3.05 ENSRNOT00000006246
Il10
interleukin 10
chr7_+_2718700 2.96 ENSRNOT00000050792
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr7_-_5168902 2.93 ENSRNOT00000090661
Olr894
olfactory receptor 894
chr20_+_4852496 2.92 ENSRNOT00000088936
Lta
lymphotoxin alpha
chr4_+_109477920 2.87 ENSRNOT00000008468
Reg3a
regenerating islet-derived 3 alpha
chrX_-_70461553 2.84 ENSRNOT00000076110
ENSRNOT00000003872
ENSRNOT00000076812
Pdzd11
PDZ domain containing 11
chr7_+_70328391 2.63 ENSRNOT00000075544
Mettl1
methyltransferase like 1
chr14_-_42560174 2.59 ENSRNOT00000003128
Tmem33
transmembrane protein 33
chr1_+_87790104 2.55 ENSRNOT00000074580
LOC103690114
zinc finger protein 383-like
chr13_+_90184569 2.52 ENSRNOT00000082393
Slamf1
signaling lymphocytic activation molecule family member 1
chr3_+_77072410 2.47 ENSRNOT00000078540
Olr649
olfactory receptor 649
chr3_-_74906989 2.44 ENSRNOT00000071001
Olr545
olfactory receptor 545
chr2_-_211001258 2.43 ENSRNOT00000037336
Atxn7l2
ataxin 7-like 2
chr2_+_86996497 2.41 ENSRNOT00000042058
Zfp455
zinc finger protein 455
chr10_+_10457320 2.40 ENSRNOT00000003832
Rbm25l1
RNA binding motif protein 25-like 1
chr7_+_117390285 2.17 ENSRNOT00000016464
Exosc4
exosome component 4
chr7_+_7461109 2.02 ENSRNOT00000074969
Olr1014
olfactory receptor 1014
chr5_+_164951789 1.96 ENSRNOT00000055658
ENSRNOT00000012193
Mad2l2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr2_-_232117134 1.90 ENSRNOT00000030798
Alpk1
alpha-kinase 1
chr7_+_5401508 1.85 ENSRNOT00000050898
Olr903
olfactory receptor 903
chr1_-_164441167 1.83 ENSRNOT00000023935
Rps3
ribosomal protein S3
chr11_-_82938357 1.73 ENSRNOT00000035945
Map3k13
mitogen-activated protein kinase kinase kinase 13
chr9_-_116222374 1.71 ENSRNOT00000090111
ENSRNOT00000067900
Arhgap28
Rho GTPase activating protein 28
chr19_-_25801526 1.62 ENSRNOT00000003884
Nacc1
nucleus accumbens associated 1
chr2_+_182006242 1.58 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr5_+_101526551 1.57 ENSRNOT00000015254
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr1_-_167093560 1.56 ENSRNOT00000027301
Il18bp
interleukin 18 binding protein
chr14_-_86387606 1.53 ENSRNOT00000089384
ENSRNOT00000006642
Ddx56
DEAD-box helicase 56
chr10_-_31052102 1.53 ENSRNOT00000007917
Thg1l
tRNA-histidine guanylyltransferase 1-like
chrX_+_159703578 1.51 ENSRNOT00000001162
Cd40lg
CD40 ligand
chr10_-_95262024 1.47 ENSRNOT00000066487
Bptf
bromodomain PHD finger transcription factor
chr7_-_3499697 1.46 ENSRNOT00000064311
Olr878
olfactory receptor 878
chr10_+_17542374 1.41 ENSRNOT00000064079
Fbxw11
F-box and WD repeat domain containing 11
chr1_+_157403595 1.31 ENSRNOT00000012781
Ccdc90b
coiled-coil domain containing 90B
chr7_-_5106708 1.16 ENSRNOT00000046001
Olr892
olfactory receptor 892
chr13_-_45068077 1.03 ENSRNOT00000004969
Mcm6
minichromosome maintenance complex component 6
chr7_+_11321057 0.90 ENSRNOT00000027737
Mrpl54
mitochondrial ribosomal protein L54
chr5_+_165415136 0.89 ENSRNOT00000016317
ENSRNOT00000079407
Masp2
mannan-binding lectin serine peptidase 2
chr2_+_189609800 0.78 ENSRNOT00000089016
Slc39a1
solute carrier family 39 member 1
chr10_+_89339029 0.75 ENSRNOT00000031208
Rundc1
RUN domain containing 1
chr5_-_151768123 0.54 ENSRNOT00000079380
Nudc
nuclear distribution C, dynein complex regulator
chr1_-_81412251 0.50 ENSRNOT00000026946
Pinlyp
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr3_-_111873974 0.37 ENSRNOT00000077546
AABR07053509.2

chr3_-_75168421 0.15 ENSRNOT00000072853
LOC103691842
olfactory receptor 10AG1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.4 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
7.2 21.6 GO:0060545 positive regulation of necroptotic process(GO:0060545)
6.8 40.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
6.8 20.3 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
6.6 26.3 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
6.3 18.8 GO:0070256 germinal center B cell differentiation(GO:0002314) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) inosine biosynthetic process(GO:0046103) regulation of adenosine receptor signaling pathway(GO:0060167) negative regulation of mucus secretion(GO:0070256)
6.1 18.3 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
5.4 16.1 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
5.4 16.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
4.7 14.2 GO:2001226 negative regulation of inorganic anion transmembrane transport(GO:1903796) negative regulation of chloride transport(GO:2001226)
4.2 16.9 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
3.8 18.8 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
2.9 8.8 GO:0002840 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) regulation of mismatch repair(GO:0032423) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) T-helper 1 cell activation(GO:0035711) positive regulation of glycogen catabolic process(GO:0045819) negative regulation of apoptotic cell clearance(GO:2000426)
2.7 37.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
2.6 39.6 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
2.6 10.5 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
2.4 9.5 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
2.3 7.0 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
2.1 21.0 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) negative regulation of NIK/NF-kappaB signaling(GO:1901223)
2.0 8.1 GO:0043380 regulation of mast cell cytokine production(GO:0032763) regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.8 12.9 GO:0048539 bone marrow development(GO:0048539)
1.8 5.4 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
1.7 12.2 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
1.7 12.1 GO:0033590 response to cobalamin(GO:0033590)
1.6 8.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.4 21.7 GO:0048245 eosinophil chemotaxis(GO:0048245)
1.4 4.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
1.3 21.4 GO:0010818 T cell chemotaxis(GO:0010818)
1.3 27.9 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
1.3 15.0 GO:0045351 type I interferon biosynthetic process(GO:0045351)
1.2 10.8 GO:0023035 CD40 signaling pathway(GO:0023035)
1.2 9.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.1 9.2 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
1.1 4.5 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) notochord formation(GO:0014028)
1.0 15.6 GO:0048535 lymph node development(GO:0048535)
0.9 12.3 GO:0001886 endothelial cell morphogenesis(GO:0001886) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.9 16.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.9 6.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.9 8.1 GO:0007000 nucleolus organization(GO:0007000)
0.9 9.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.9 4.4 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.8 20.6 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.7 15.7 GO:0042730 fibrinolysis(GO:0042730)
0.7 10.7 GO:0032310 prostaglandin secretion(GO:0032310)
0.7 2.6 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.6 2.6 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.6 3.7 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.6 1.8 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.5 5.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 8.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.5 3.0 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.5 2.0 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.5 2.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.4 7.1 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.4 3.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.4 7.6 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 2.2 GO:0045006 U4 snRNA 3'-end processing(GO:0034475) DNA deamination(GO:0045006) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.4 12.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 3.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 5.7 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 5.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.3 3.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.2 4.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 7.7 GO:0014850 response to muscle activity(GO:0014850)
0.2 12.5 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.2 16.8 GO:0032835 glomerulus development(GO:0032835)
0.2 3.8 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.2 1.6 GO:1900115 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2 5.0 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.1 1.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 1.7 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 18.3 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 4.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 6.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 9.3 GO:0007601 visual perception(GO:0007601)
0.1 1.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.5 GO:0007097 nuclear migration(GO:0007097)
0.0 47.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 12.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 13.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 3.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 1.5 GO:0001892 embryonic placenta development(GO:0001892)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 25.4 GO:0044299 C-fiber(GO:0044299)
2.7 21.6 GO:0044194 cytolytic granule(GO:0044194)
2.7 18.8 GO:0060205 cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
2.7 10.7 GO:0031088 platelet dense granule membrane(GO:0031088)
1.3 7.8 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
1.0 8.1 GO:0000796 condensin complex(GO:0000796)
0.9 10.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.8 16.1 GO:0005922 connexon complex(GO:0005922)
0.7 3.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.7 8.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 10.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.6 3.4 GO:0005642 annulate lamellae(GO:0005642)
0.5 64.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 2.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.4 2.0 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.4 7.0 GO:0005614 interstitial matrix(GO:0005614)
0.4 51.3 GO:0072562 blood microparticle(GO:0072562)
0.3 6.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 3.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 21.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 19.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 26.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 12.2 GO:0045171 intercellular bridge(GO:0045171)
0.2 12.3 GO:0034707 chloride channel complex(GO:0034707)
0.2 1.5 GO:0016589 NURF complex(GO:0016589)
0.2 2.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 11.5 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 1.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 9.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 10.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.0 GO:0042555 MCM complex(GO:0042555)
0.1 3.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.4 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 15.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 95.7 GO:0005615 extracellular space(GO:0005615)
0.1 5.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.7 GO:0005657 replication fork(GO:0005657)
0.0 11.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 9.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.8 GO:0005844 polysome(GO:0005844)
0.0 7.7 GO:0005925 focal adhesion(GO:0005925)
0.0 3.1 GO:0055037 recycling endosome(GO:0055037)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 6.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 9.0 GO:0016604 nuclear body(GO:0016604)
0.0 4.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 9.5 GO:0005730 nucleolus(GO:0005730)
0.0 1.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 62.5 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
6.5 39.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
5.4 16.1 GO:0001847 opsonin receptor activity(GO:0001847)
4.3 21.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
4.0 16.1 GO:0086075 gap junction hemi-channel activity(GO:0055077) gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
3.7 36.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
2.5 7.6 GO:0019807 aspartoacylase activity(GO:0019807)
2.2 40.9 GO:0003993 acid phosphatase activity(GO:0003993)
2.1 37.4 GO:0001848 complement binding(GO:0001848)
1.8 8.8 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
1.7 15.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
1.6 21.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.6 18.8 GO:0004000 adenosine deaminase activity(GO:0004000)
1.4 7.1 GO:0050733 RS domain binding(GO:0050733)
1.4 8.1 GO:0019957 C-C chemokine binding(GO:0019957)
1.1 8.7 GO:0008430 selenium binding(GO:0008430)
0.9 8.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.9 7.0 GO:0045545 syndecan binding(GO:0045545)
0.8 9.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 6.6 GO:0043199 sulfate binding(GO:0043199)
0.8 16.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.8 16.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.8 9.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.8 12.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.7 3.7 GO:0004974 leukotriene receptor activity(GO:0004974)
0.7 14.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.7 15.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 8.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.5 9.3 GO:0005523 tropomyosin binding(GO:0005523)
0.5 15.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 10.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 3.4 GO:0043495 protein anchor(GO:0043495)
0.4 9.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.4 1.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.4 3.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 20.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.4 1.8 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.3 10.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 1.6 GO:0048019 receptor antagonist activity(GO:0048019)
0.3 7.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 25.9 GO:0003823 antigen binding(GO:0003823)
0.3 7.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 56.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 5.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 8.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 2.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.2 8.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 6.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 27.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 5.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 3.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 8.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 12.3 GO:0005254 chloride channel activity(GO:0005254)
0.1 3.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 12.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 3.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 16.8 GO:0001047 core promoter binding(GO:0001047)
0.1 2.2 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 5.4 GO:0043022 ribosome binding(GO:0043022)
0.1 9.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.5 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 16.8 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.0 GO:0008199 ferric iron binding(GO:0008199)
0.1 7.1 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.1 6.0 GO:0005178 integrin binding(GO:0005178)
0.0 5.0 GO:0044212 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 12.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 47.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 6.0 GO:0019902 phosphatase binding(GO:0019902)
0.0 1.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.5 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 3.0 GO:0005125 cytokine activity(GO:0005125)
0.0 16.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 15.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 5.4 GO:0003779 actin binding(GO:0003779)
0.0 7.7 GO:0019900 kinase binding(GO:0019900)
0.0 2.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.6 GO:0008237 metallopeptidase activity(GO:0008237)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 15.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
1.4 66.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.9 21.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.7 29.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.7 18.8 PID IFNG PATHWAY IFN-gamma pathway
0.6 21.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.6 24.4 PID ARF6 PATHWAY Arf6 signaling events
0.5 16.8 PID RAS PATHWAY Regulation of Ras family activation
0.5 20.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.5 27.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 10.6 PID CD40 PATHWAY CD40/CD40L signaling
0.4 8.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 9.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.4 7.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 23.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 12.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 71.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 8.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 5.7 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.2 3.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.1 PID AURORA B PATHWAY Aurora B signaling
0.2 4.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.2 PID P53 REGULATION PATHWAY p53 pathway
0.1 17.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 2.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 10.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.5 32.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.4 70.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.2 18.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.0 61.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.9 16.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.9 12.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.8 8.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.7 30.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 40.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.6 16.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.6 12.7 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.5 21.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.4 12.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.4 7.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 21.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 8.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.3 3.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 7.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 8.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 10.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 2.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.4 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.1 3.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 3.4 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 1.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.0 REACTOME DNA REPAIR Genes involved in DNA Repair