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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat6

Z-value: 0.84

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Transcription factors associated with Stat6

Gene Symbol Gene ID Gene Info
Stat6
ENSRNOG00000025023 signal transducer and activator of transcription 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Stat6rn6_v1_chr7_+_70950231_709502310.141.4e-02Click!

Activity profile of Stat6 motif

Sorted Z-values of Stat6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_63568464 30.76 ENSRNOT00000068494
AABR07052585.2

chr16_-_18766174 27.40 ENSRNOT00000084813
Sftpd
surfactant protein D
chr18_-_61057365 22.89 ENSRNOT00000042352
Alpk2
alpha-kinase 2
chr1_-_88066101 22.03 ENSRNOT00000079473
ENSRNOT00000027893
Ryr1
ryanodine receptor 1
chr6_+_56625650 21.90 ENSRNOT00000008803
Meox2
mesenchyme homeobox 2
chr1_-_198233588 18.22 ENSRNOT00000088473
Aldoa
aldolase, fructose-bisphosphate A
chr1_-_198233215 17.81 ENSRNOT00000087928
Aldoa
aldolase, fructose-bisphosphate A
chr4_-_148437961 17.52 ENSRNOT00000082907
Alox5
arachidonate 5-lipoxygenase
chr1_-_143392532 16.50 ENSRNOT00000026089
Fsd2
fibronectin type III and SPRY domain containing 2
chr2_+_199162745 16.40 ENSRNOT00000023488
Gja5
gap junction protein, alpha 5
chr8_-_108777717 16.33 ENSRNOT00000034188
Il20rb
interleukin 20 receptor subunit beta
chr17_-_15467320 14.61 ENSRNOT00000072490
ENSRNOT00000093561
Ogn
osteoglycin
chr7_-_60341264 14.09 ENSRNOT00000007747
Lyz2
lysozyme 2
chr7_-_33793565 13.37 ENSRNOT00000065354
AABR07056633.1

chr14_+_37113210 13.34 ENSRNOT00000089094
Sgcb
sarcoglycan, beta
chr15_+_83703791 12.78 ENSRNOT00000090637
Klf5
Kruppel-like factor 5
chr13_-_70667658 12.58 ENSRNOT00000092521
Lamc1
laminin subunit gamma 1
chrX_-_111887906 12.15 ENSRNOT00000085118
Tsc22d3
TSC22 domain family, member 3
chr18_-_6782757 11.80 ENSRNOT00000068150
Aqp4
aquaporin 4
chr8_-_114449956 10.68 ENSRNOT00000056414
Col6a6
collagen type VI alpha 6 chain
chr2_-_173836854 10.34 ENSRNOT00000074278
Wdr49
WD repeat domain 49
chr9_+_66335492 10.33 ENSRNOT00000037555
RGD1562029
similar to KIAA2012 protein
chr15_+_41937880 9.75 ENSRNOT00000032514
Kcnrg
potassium channel regulator
chr16_+_29674793 9.61 ENSRNOT00000059724
Anxa10
annexin A10
chr7_+_59326518 9.55 ENSRNOT00000085231
Ptprb
protein tyrosine phosphatase, receptor type, B
chr4_+_78354335 9.52 ENSRNOT00000059167
Gimap7
GTPase, IMAP family member 7
chr15_-_35417273 9.41 ENSRNOT00000083961
ENSRNOT00000041430
Gzmb
granzyme B
chr1_-_221281180 9.21 ENSRNOT00000028379
Cdc42ep2
CDC42 effector protein 2
chr2_-_98610368 9.09 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr18_+_30840868 8.97 ENSRNOT00000027026
Pcdhga5
protocadherin gamma subfamily A, 5
chr15_-_36114752 8.66 ENSRNOT00000045209
Gzmbl3
Granzyme B-like 3
chr4_-_58881045 8.62 ENSRNOT00000087241
Podxl
podocalyxin-like
chr1_+_127802978 8.62 ENSRNOT00000055877
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr13_+_47454591 8.47 ENSRNOT00000005791
LOC498222
similar to specifically androgen-regulated protein
chr1_-_195096460 8.37 ENSRNOT00000077253
Snrpn
small nuclear ribonucleoprotein polypeptide N
chr15_-_36472327 8.23 ENSRNOT00000032601
ENSRNOT00000059660
LOC102553861
granzyme-like protein 1-like
chr4_-_133951264 7.98 ENSRNOT00000090506
Pdzrn3
PDZ domain containing RING finger 3
chrX_+_68891227 7.72 ENSRNOT00000009635
Efnb1
ephrin B1
chr13_+_51022681 7.38 ENSRNOT00000078599
Chi3l1
chitinase 3 like 1
chr1_-_217844957 7.20 ENSRNOT00000090653
Ano1
anoctamin 1
chr9_+_111028824 6.98 ENSRNOT00000041418
ENSRNOT00000056457
Pam
peptidylglycine alpha-amidating monooxygenase
chr1_+_171793782 6.86 ENSRNOT00000081351
Olfml1
olfactomedin-like 1
chr8_-_114940163 6.71 ENSRNOT00000083303
ENSRNOT00000086232
Alas1
5'-aminolevulinate synthase 1
chr5_-_163231494 6.70 ENSRNOT00000085929
ENSRNOT00000022968
Tnfrsf8
TNF receptor superfamily member 8
chr7_-_70467915 6.65 ENSRNOT00000088995
Slc26a10
solute carrier family 26, member 10
chr7_+_97559841 6.38 ENSRNOT00000007326
Zhx2
zinc fingers and homeoboxes 2
chr19_-_22281778 6.37 ENSRNOT00000049624
Phkb
phosphorylase kinase regulatory subunit beta
chr3_+_139894331 6.24 ENSRNOT00000064695
Rin2
Ras and Rab interactor 2
chr5_+_139597731 5.85 ENSRNOT00000072427
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr18_+_30913842 5.84 ENSRNOT00000026947
Pcdhgc3
protocadherin gamma subfamily C, 3
chr15_+_4209703 5.80 ENSRNOT00000082236
Ppp3cb
protein phosphatase 3 catalytic subunit beta
chr5_-_166116516 5.56 ENSRNOT00000079919
ENSRNOT00000080888
Kif1b
kinesin family member 1B
chr1_+_282715344 5.55 ENSRNOT00000074399
LOC100910259
liver carboxylesterase-like
chr12_+_40553741 5.50 ENSRNOT00000057396
LOC100360238
rCG21419-like
chr1_+_198199622 5.46 ENSRNOT00000026688
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
chr20_+_5057701 5.40 ENSRNOT00000001119
Ly6g6c
lymphocyte antigen 6 complex, locus G6C
chr4_-_77706994 5.30 ENSRNOT00000038517
Zfp777
zinc finger protein 777
chr18_+_29506128 5.17 ENSRNOT00000003878
Slc35a4
solute carrier family 35, member A4
chr8_-_53816447 5.09 ENSRNOT00000011454
Ttc12
tetratricopeptide repeat domain 12
chr13_+_88265331 5.05 ENSRNOT00000031190
Ccdc190
coiled-coil domain containing 190
chrX_+_20351486 4.76 ENSRNOT00000093675
ENSRNOT00000047444
Wnk3
WNK lysine deficient protein kinase 3
chr8_-_129919120 4.66 ENSRNOT00000074423
Ulk4
unc-51 like kinase 4
chr4_-_10329241 4.53 ENSRNOT00000017232
Fgl2
fibrinogen-like 2
chr15_+_3938075 4.16 ENSRNOT00000065644
Camk2g
calcium/calmodulin-dependent protein kinase II gamma
chr1_+_128606770 4.15 ENSRNOT00000073355
Ttc23
tetratricopeptide repeat domain 23
chrX_+_20423401 4.08 ENSRNOT00000093162
Wnk3
WNK lysine deficient protein kinase 3
chr1_+_64114721 4.08 ENSRNOT00000080466
Tmc4
transmembrane channel-like 4
chr13_-_109580271 4.02 ENSRNOT00000088326
Flvcr1
feline leukemia virus subgroup C cellular receptor 1
chr19_+_43163129 4.01 ENSRNOT00000073721
Clec18a
C-type lectin domain family 18, member A
chr10_-_89130339 3.87 ENSRNOT00000027640
Ezh1
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr2_+_211337271 3.60 ENSRNOT00000045155
Cox6b1
cytochrome c oxidase subunit 6B1
chr18_+_30820321 3.52 ENSRNOT00000060472
Pcdhga3
protocadherin gamma subfamily A, 3
chr1_+_221710670 3.48 ENSRNOT00000064798
Map4k2
mitogen activated protein kinase kinase kinase kinase 2
chr3_-_91195981 3.24 ENSRNOT00000056935
RGD1309730
similar to RIKEN cDNA B230118H07
chr3_+_7109920 3.18 ENSRNOT00000084092
ENSRNOT00000013809
Ralgds
ral guanine nucleotide dissociation stimulator
chr15_-_12513931 3.07 ENSRNOT00000010103
Atxn7
ataxin 7
chr4_-_157266018 3.05 ENSRNOT00000019570
LOC100911713
protein C10-like
chr14_+_7618022 2.99 ENSRNOT00000088508
ENSRNOT00000002819
Slc10a6
solute carrier family 10 member 6
chr5_-_135561914 2.93 ENSRNOT00000023178
Mmachc
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr9_-_50762082 2.74 ENSRNOT00000015492
Mettl21c
methyltransferase like 21C
chr1_-_6970040 2.62 ENSRNOT00000016273
Utrn
utrophin
chr10_-_6870011 2.58 ENSRNOT00000003439
RGD1309748
similar to CG4768-PA
chr15_-_35166211 2.57 ENSRNOT00000059662
LOC691670
similar to natural killer cell protease 7
chr1_-_103323476 2.53 ENSRNOT00000019051
Mrgprx3
MAS related GPR family member X3
chr13_+_48790951 2.36 ENSRNOT00000090233
Elk4
ELK4, ETS transcription factor
chr13_+_27032048 2.23 ENSRNOT00000031789
Serpinb13
serpin family B member 13
chr17_+_47241017 2.21 ENSRNOT00000092193
Gpr141
G protein-coupled receptor 141
chr17_+_23116661 2.20 ENSRNOT00000067374
Nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr2_+_189629297 2.18 ENSRNOT00000049810
Dennd4b
DENN domain containing 4B
chr4_-_23119005 2.12 ENSRNOT00000048061
Steap4
STEAP4 metalloreductase
chr13_+_48790767 2.02 ENSRNOT00000087504
Elk4
ELK4, ETS transcription factor
chr19_-_38796 2.01 ENSRNOT00000077592
AABR07042565.1

chr1_-_172030164 1.96 ENSRNOT00000026807
Ovch2
ovochymase 2
chr7_+_143897014 1.94 ENSRNOT00000017314
Espl1
extra spindle pole bodies like 1, separase
chr14_+_107750162 1.87 ENSRNOT00000012767
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr7_-_143473697 1.82 ENSRNOT00000055336
ENSRNOT00000083027
Krt77
keratin 77
chr20_+_48881194 1.80 ENSRNOT00000000304
Rtn4ip1
reticulon 4 interacting protein 1
chr4_+_183896303 1.77 ENSRNOT00000055437
RGD1309621
similar to hypothetical protein FLJ10652
chr19_-_37725623 1.72 ENSRNOT00000024197
Gfod2
glucose-fructose oxidoreductase domain containing 2
chr2_+_149899836 1.71 ENSRNOT00000086481
RGD1560324
similar to hypothetical protein C130079G13
chr13_+_99387950 1.70 ENSRNOT00000004815
RGD1564463
similar to Mdes protein
chr14_-_28967980 1.68 ENSRNOT00000048175
Adgrl3
adhesion G protein-coupled receptor L3
chr11_+_61970976 1.67 ENSRNOT00000078921
Tigit
T cell immunoreceptor with Ig and ITIM domains
chr15_-_35195725 1.49 ENSRNOT00000044840
Gzmf
granzyme F
chr3_-_74906989 1.49 ENSRNOT00000071001
Olr545
olfactory receptor 545
chr10_+_106712127 1.48 ENSRNOT00000040629
Tnrc6c
trinucleotide repeat containing 6C
chr11_-_54344615 1.47 ENSRNOT00000090307
Myh15
myosin, heavy chain 15
chr8_-_49158971 1.44 ENSRNOT00000020573
Kmt2a
lysine methyltransferase 2A
chr1_-_193700673 1.42 ENSRNOT00000071314
Paip2l1
polyadenylate-binding protein-interacting protein 2-like 1
chr11_-_78341349 1.42 ENSRNOT00000068116
Tp63
tumor protein p63
chr20_+_7818289 1.39 ENSRNOT00000042539
Ppard
peroxisome proliferator-activated receptor delta
chr20_+_2057878 1.38 ENSRNOT00000051480
RT1-M6-1
RT1 class I, locus M6, gene 1
chr2_-_90568486 1.38 ENSRNOT00000059380
LOC100910852
uncharacterized LOC100910852
chr20_+_1764794 1.34 ENSRNOT00000075084
Olr1736
olfactory receptor 1736
chr13_+_90184569 1.33 ENSRNOT00000082393
Slamf1
signaling lymphocytic activation molecule family member 1
chr19_-_10581842 1.31 ENSRNOT00000021639
Polr2c
RNA polymerase II subunit C
chr3_-_118427851 1.29 ENSRNOT00000055995
Fam227b
family with sequence similarity 227, member B
chr10_-_56368360 1.29 ENSRNOT00000019674
Slc35g3
solute carrier family 35, member G3
chr13_-_91776397 1.26 ENSRNOT00000073147
Mptx1
mucosal pentraxin 1
chr20_+_2057689 1.22 ENSRNOT00000086007
RT1-M6-1
RT1 class I, locus M6, gene 1
chr9_+_20279938 1.20 ENSRNOT00000075612
Grcc10
gene rich cluster, C10 gene
chr8_-_55696601 1.18 ENSRNOT00000016127
RGD1562914
RGD1562914
chr11_-_78327282 1.18 ENSRNOT00000002636
Tp63
tumor protein p63
chr8_+_113939886 1.17 ENSRNOT00000079562
Aste1
asteroid homolog 1 (Drosophila)
chr1_+_260153645 1.11 ENSRNOT00000054717
Zfp518a
zinc finger protein 518A
chr1_-_124803363 1.06 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr8_-_36374673 1.04 ENSRNOT00000013763
Dcps
decapping enzyme, scavenger
chr4_+_1841955 1.02 ENSRNOT00000019271
Olr1096
olfactory receptor 1096
chr7_+_9262982 0.99 ENSRNOT00000047647
Olr1063
olfactory receptor 1063
chr1_-_149683357 0.96 ENSRNOT00000077975
Olr17
olfactory receptor 17
chr3_+_21698032 0.94 ENSRNOT00000013378
Rabgap1
RAB GTPase activating protein 1
chr8_+_43606676 0.90 ENSRNOT00000083262
Olr1319
olfactory receptor 1319
chr20_+_1736377 0.89 ENSRNOT00000047035
Olr1734
olfactory receptor 1734
chr11_+_60054408 0.88 ENSRNOT00000091756
Abhd10
abhydrolase domain containing 10
chr15_+_61826937 0.79 ENSRNOT00000084005
ENSRNOT00000079417
Elf1
E74-like factor 1
chr9_-_63291350 0.72 ENSRNOT00000058831
Hsfy2
heat shock transcription factor, Y linked 2
chr1_+_63184734 0.71 ENSRNOT00000078889
Vom1r110
vomeronasal 1 receptor 110
chr8_-_47094352 0.69 ENSRNOT00000048347
Grik4
glutamate ionotropic receptor kainate type subunit 4
chr13_-_47438360 0.69 ENSRNOT00000067445
Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr16_-_7412150 0.67 ENSRNOT00000047252
RGD1564325
similar to ribosomal protein S24
chr8_+_41235156 0.66 ENSRNOT00000071644
LOC100911958
olfactory receptor 147-like
chr15_-_36158195 0.64 ENSRNOT00000091636
Olr1288
olfactory receptor 1288
chr3_-_76718684 0.61 ENSRNOT00000050173
Olr631
olfactory receptor 631
chr5_+_135562034 0.61 ENSRNOT00000056967
Ccdc163
coiled-coil domain containing 163
chr8_+_45797315 0.58 ENSRNOT00000059997
AABR07070046.1

chr16_+_2634603 0.57 ENSRNOT00000019113
Hesx1
HESX homeobox 1
chr15_+_35685009 0.44 ENSRNOT00000085764
LOC100911127
olfactory receptor 144-like
chr11_+_80319177 0.43 ENSRNOT00000036777
Rtp2
receptor (chemosensory) transporter protein 2
chr15_+_34282936 0.42 ENSRNOT00000026364
Irf9
interferon regulatory factor 9
chr15_-_34392066 0.37 ENSRNOT00000027315
Tgm1
transglutaminase 1
chr1_+_218076116 0.35 ENSRNOT00000028374
Oraov1
oral cancer overexpressed 1
chr1_-_168710460 0.33 ENSRNOT00000047399
Olr114
olfactory receptor 114
chr1_+_88582641 0.33 ENSRNOT00000028187
Zfp382
zinc finger protein 382
chr20_+_1749716 0.32 ENSRNOT00000048856
Olr1735
olfactory receptor 1735
chr8_+_62317265 0.30 ENSRNOT00000083418
ENSRNOT00000091204
Fam219b
family with sequence similarity 219, member B
chr10_-_78993045 0.29 ENSRNOT00000043005
LOC100363469
ribosomal protein S24-like
chr14_+_76657311 0.26 ENSRNOT00000076730
Clnk
cytokine-dependent hematopoietic cell linker
chr19_-_10620671 0.23 ENSRNOT00000021842
Ccl17
C-C motif chemokine ligand 17
chr8_-_43235208 0.18 ENSRNOT00000060095
Olr1304
olfactory receptor 1304
chr7_-_5106708 0.16 ENSRNOT00000046001
Olr892
olfactory receptor 892
chr3_-_77893647 0.11 ENSRNOT00000080803
Olr678
olfactory receptor 678
chr1_-_170841363 0.10 ENSRNOT00000046171
Olr213
olfactory receptor 213
chr1_-_226606344 0.05 ENSRNOT00000028079
Tmem216
transmembrane protein 216
chrX_-_135419704 0.03 ENSRNOT00000044435
Zfp280c
zinc finger protein 280C

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 27.4 GO:0050828 regulation of liquid surface tension(GO:0050828)
5.5 16.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
5.4 16.3 GO:0001807 regulation of type IV hypersensitivity(GO:0001807)
4.4 17.5 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
4.4 21.9 GO:0001757 somite specification(GO:0001757)
3.1 22.0 GO:0071313 cellular response to caffeine(GO:0071313)
3.1 9.4 GO:0060545 positive regulation of necroptotic process(GO:0060545)
2.9 11.8 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
2.9 8.8 GO:2000682 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
2.6 36.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.2 6.7 GO:0032759 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
1.9 5.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
1.8 21.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
1.7 7.0 GO:0031179 peptide modification(GO:0031179)
1.3 4.0 GO:0097037 heme export(GO:0097037)
1.3 13.3 GO:0097084 vascular smooth muscle cell development(GO:0097084)
1.2 12.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
1.2 3.5 GO:0060988 lipid tube assembly(GO:0060988)
1.1 6.7 GO:0010045 response to nickel cation(GO:0010045) response to platinum ion(GO:0070541)
1.1 5.6 GO:0019520 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.8 7.2 GO:0015705 iodide transport(GO:0015705)
0.8 9.8 GO:1903817 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.7 5.2 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.7 9.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.7 12.6 GO:0070831 hemidesmosome assembly(GO:0031581) basement membrane assembly(GO:0070831)
0.6 2.6 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.5 1.4 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.5 14.1 GO:0019835 cytolysis(GO:0019835)
0.4 1.3 GO:0002277 leukocyte chemotaxis involved in inflammatory response(GO:0002232) myeloid dendritic cell activation involved in immune response(GO:0002277)
0.4 7.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.4 2.9 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.4 6.7 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.4 3.9 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.3 4.2 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.3 2.2 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.3 2.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 7.7 GO:0031295 T cell costimulation(GO:0031295)
0.3 0.9 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.3 3.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 2.1 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.3 4.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 16.0 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.2 1.5 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 3.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 10.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 4.4 GO:0070932 histone H3 deacetylation(GO:0070932)
0.2 4.5 GO:0007567 parturition(GO:0007567)
0.1 0.6 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.9 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 1.5 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 6.4 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 1.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 1.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.7 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 0.3 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 1.7 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 3.6 GO:0021762 substantia nigra development(GO:0021762)
0.1 5.4 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 10.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.4 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.7 GO:0042220 response to cocaine(GO:0042220)
0.0 0.4 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 1.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:0031338 regulation of vesicle fusion(GO:0031338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.6 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
2.4 22.0 GO:0030314 junctional membrane complex(GO:0030314)
2.3 14.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
2.2 13.3 GO:0016012 sarcoglycan complex(GO:0016012)
2.1 36.0 GO:0035686 sperm fibrous sheath(GO:0035686)
1.8 17.5 GO:0005641 nuclear envelope lumen(GO:0005641)
1.2 9.4 GO:0044194 cytolytic granule(GO:0044194)
1.0 5.8 GO:0005955 calcineurin complex(GO:0005955)
0.9 8.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.8 6.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.8 16.4 GO:0005922 connexon complex(GO:0005922)
0.7 27.4 GO:0005771 multivesicular body(GO:0005771)
0.7 8.4 GO:0005687 U4 snRNP(GO:0005687)
0.6 5.6 GO:0071821 FANCM-MHF complex(GO:0071821)
0.3 11.8 GO:0046930 pore complex(GO:0046930)
0.3 1.9 GO:0089701 U2AF(GO:0089701)
0.2 2.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 3.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 8.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 35.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 7.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 22.6 GO:0016607 nuclear speck(GO:0016607)
0.1 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 1.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 1.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.0 2.2 GO:0000922 spindle pole(GO:0000922)
0.0 1.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.5 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
5.5 22.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
5.4 16.3 GO:0042015 interleukin-20 binding(GO:0042015)
5.1 36.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
4.1 16.4 GO:0055077 gap junction hemi-channel activity(GO:0055077) gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
2.2 6.7 GO:0016748 succinyltransferase activity(GO:0016748)
1.8 7.2 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.7 7.0 GO:0016842 amidine-lyase activity(GO:0016842)
1.7 12.1 GO:0043426 MRF binding(GO:0043426)
1.5 9.2 GO:0001515 opioid peptide activity(GO:0001515)
1.5 5.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.4 12.6 GO:0043208 glycosphingolipid binding(GO:0043208)
1.2 7.4 GO:0004568 chitinase activity(GO:0004568)
1.1 27.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
1.1 14.1 GO:0003796 lysozyme activity(GO:0003796)
0.9 5.6 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.8 11.8 GO:0015250 water channel activity(GO:0015250)
0.8 6.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.7 8.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.6 3.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.6 3.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.6 1.7 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.6 3.9 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.5 6.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.5 21.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 6.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 4.0 GO:0015232 heme transporter activity(GO:0015232)
0.4 5.1 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 0.9 GO:0102390 mycophenolic acid acyl-glucuronide esterase activity(GO:0102390)
0.3 1.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.3 5.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 7.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.9 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 4.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 4.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 9.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 30.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 2.6 GO:0017166 vinculin binding(GO:0017166)
0.1 3.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 5.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.7 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 1.4 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 2.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 2.7 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 2.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 22.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 16.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 2.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 8.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 6.6 GO:0003924 GTPase activity(GO:0003924)
0.0 3.9 GO:0004672 protein kinase activity(GO:0004672)
0.0 1.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.7 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.6 22.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5 36.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 19.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 6.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 14.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 7.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 10.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 4.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 7.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 5.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 6.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 11.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 10.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 4.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 14.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
1.0 11.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.9 36.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.9 16.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.4 6.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 6.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 5.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 9.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 3.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 2.8 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 10.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 12.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 4.0 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 3.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway