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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx20

Z-value: 0.39

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Transcription factors associated with Tbx20

Gene Symbol Gene ID Gene Info
Tbx20
ENSRNOG00000016181 T-box 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx20rn6_v1_chr8_-_25904564_25904570-0.233.5e-05Click!

Activity profile of Tbx20 motif

Sorted Z-values of Tbx20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_86579694 10.38 ENSRNOT00000081209
AC119462.1

chr10_-_47997796 8.46 ENSRNOT00000078422
Slc5a10
solute carrier family 5 member 10
chr19_-_37907714 7.96 ENSRNOT00000026361
Ctrl
chymotrypsin-like
chr5_+_148661070 7.41 ENSRNOT00000056229
Nkain1
Sodium/potassium transporting ATPase interacting 1
chr15_-_42898150 7.00 ENSRNOT00000030036
Ptk2b
protein tyrosine kinase 2 beta
chr9_-_71852113 6.88 ENSRNOT00000083263
ENSRNOT00000072983
AABR07067896.1

chr5_-_161035368 5.49 ENSRNOT00000091640
AABR07050321.2

chr2_+_2694480 5.07 ENSRNOT00000083565
AABR07072671.1

chr6_+_107245820 4.93 ENSRNOT00000012757
Papln
papilin, proteoglycan-like sulfated glycoprotein
chr1_+_256745288 4.26 ENSRNOT00000022133
Cep55
centrosomal protein 55
chr1_-_245817809 3.30 ENSRNOT00000080607
AABR07006672.1

chr20_+_44803666 3.28 ENSRNOT00000057227
Rev3l
REV3 like, DNA directed polymerase zeta catalytic subunit
chr20_+_29897594 3.18 ENSRNOT00000057752
Vsir
V-set immunoregulatory receptor
chr6_+_21708487 2.50 ENSRNOT00000087358
AABR07063197.1

chr1_+_252944103 2.44 ENSRNOT00000025770
Ifit1
interferon-induced protein with tetratricopeptide repeats 1
chr1_-_102845083 2.38 ENSRNOT00000082289
Saa4
serum amyloid A4
chr17_-_89163113 2.38 ENSRNOT00000050445
LOC100360843
ribosomal protein S19-like
chr17_+_20619324 2.17 ENSRNOT00000079788
AABR07027235.1

chr1_+_78025995 2.16 ENSRNOT00000086396
Slc8a2
solute carrier family 8 member A2
chr20_+_6211420 1.99 ENSRNOT00000000624
Kctd20
potassium channel tetramerization domain containing 20
chr14_-_25585222 1.86 ENSRNOT00000042106
RGD1565048
similar to 60S ribosomal protein L9
chr7_+_61165640 1.85 ENSRNOT00000087955
Mdm1
Mdm1 nuclear protein
chr17_-_14717420 1.78 ENSRNOT00000071131
LOC100910978
extracellular matrix protein 2-like
chr15_+_51303909 1.51 ENSRNOT00000085237
ENSRNOT00000058663
Loxl2
lysyl oxidase-like 2
chr8_-_90984224 1.42 ENSRNOT00000044931
Lca5
LCA5, lebercilin
chr1_-_141655894 1.27 ENSRNOT00000082591
Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chrX_-_72370044 1.25 ENSRNOT00000004224
Hdac8
histone deacetylase 8
chr3_-_146812989 1.23 ENSRNOT00000011315
Nanp
N-acetylneuraminic acid phosphatase
chr4_-_170104933 1.15 ENSRNOT00000071597
Smco3
single-pass membrane protein with coiled-coil domains 3
chr4_-_170195107 1.12 ENSRNOT00000073808
LOC100912450
uncharacterized LOC100912450
chr17_-_15555919 1.09 ENSRNOT00000043852
Ecm2
extracellular matrix protein 2
chrX_+_68752597 0.94 ENSRNOT00000077039
Stard8
StAR-related lipid transfer domain containing 8
chr4_-_170813012 0.85 ENSRNOT00000073975
LOC108348150
single-pass membrane and coiled-coil domain-containing protein 3
chr11_-_80826505 0.81 ENSRNOT00000032383
Rtp1
receptor (chemosensory) transporter protein 1
chr16_+_19501193 0.78 ENSRNOT00000085328
Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
chr1_-_141655417 0.77 ENSRNOT00000068084
Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr10_-_44659707 0.48 ENSRNOT00000002064
RGD1559534
similar to Alpha enolase (2-phospho-D-glycerate hydro-lyase)
chr8_-_20173107 0.31 ENSRNOT00000045215
Olr1163
olfactory receptor 1163
chr19_+_22569999 0.30 ENSRNOT00000022573
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
chr4_+_1601652 0.23 ENSRNOT00000072284
LOC100912152
olfactory receptor 8B3-like
chr4_-_165832323 0.07 ENSRNOT00000007497
Tas2r114
taste receptor, type 2, member 114
chr20_+_3176107 0.07 ENSRNOT00000001036
RT1-S3
RT1 class Ib, locus S3

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.7 3.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 3.2 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.4 1.2 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.4 1.2 GO:0046380 N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380)
0.3 1.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.3 2.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 4.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 8.5 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 0.8 GO:1901523 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.1 2.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 2.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.3 GO:0042197 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.1 7.4 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 1.5 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 1.4 GO:0042073 intraciliary transport(GO:0042073)
0.0 2.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.1 GO:0032759 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.0 4.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.4 7.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 4.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 6.4 GO:0005604 basement membrane(GO:0005604)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0032398 MHC class Ib protein complex(GO:0032398)
0.0 1.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.8 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.8 8.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.6 2.9 GO:0070052 collagen V binding(GO:0070052)
0.3 2.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 1.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 0.8 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
0.2 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 7.4 GO:0051117 ATPase binding(GO:0051117)
0.0 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 8.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 2.0 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 2.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription