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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tead1

Z-value: 1.28

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Transcription factors associated with Tead1

Gene Symbol Gene ID Gene Info
Tead1
ENSRNOG00000015488 TEA domain transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tead1rn6_v1_chr1_+_177569618_1775696180.681.3e-44Click!

Activity profile of Tead1 motif

Sorted Z-values of Tead1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_21854763 45.18 ENSRNOT00000089196
ENSRNOT00000020528
Ctgf
connective tissue growth factor
chr1_+_214203861 39.80 ENSRNOT00000023219
Rassf7
Ras association domain family member 7
chr11_+_64522130 39.41 ENSRNOT00000004315
Upk1b
uroplakin 1B
chr18_+_57286322 39.15 ENSRNOT00000026174
Sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr16_+_47368768 38.24 ENSRNOT00000017966
Wwc2
WW and C2 domain containing 2
chr13_-_108841482 36.78 ENSRNOT00000004632
ENSRNOT00000086775
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr10_-_88874528 32.42 ENSRNOT00000026783
Ptrf
polymerase I and transcript release factor
chr20_-_3605638 32.11 ENSRNOT00000074460
Sfta2
surfactant associated 2
chr6_+_109617596 30.97 ENSRNOT00000085031
ENSRNOT00000089972
ENSRNOT00000082402
Flvcr2
feline leukemia virus subgroup C cellular receptor family, member 2
chr10_+_84182118 30.24 ENSRNOT00000011027
Hoxb3
homeo box B3
chr1_-_252550394 29.88 ENSRNOT00000083468
Acta2
actin, alpha 2, smooth muscle, aorta
chr6_+_109617355 27.28 ENSRNOT00000011599
Flvcr2
feline leukemia virus subgroup C cellular receptor family, member 2
chr9_-_55256340 26.69 ENSRNOT00000028907
Sdpr
serum deprivation response
chr11_-_60679555 26.25 ENSRNOT00000059735
Ccdc80
coiled-coil domain containing 80
chr11_-_77703255 25.65 ENSRNOT00000083319
Cldn16
claudin 16
chr4_-_64981384 24.60 ENSRNOT00000017338
Creb3l2
cAMP responsive element binding protein 3-like 2
chr10_+_15672382 24.15 ENSRNOT00000027965
Rhbdf1
rhomboid 5 homolog 1
chr13_+_52662996 23.91 ENSRNOT00000047682
Tnnt2
troponin T2, cardiac type
chr17_-_10004321 23.63 ENSRNOT00000042394
Fgfr4
fibroblast growth factor receptor 4
chr3_+_79860179 22.46 ENSRNOT00000081160
ENSRNOT00000068444
Rapsn
receptor-associated protein of the synapse
chr15_-_33218456 22.43 ENSRNOT00000017753
Ajuba
ajuba LIM protein
chr7_-_143016040 22.22 ENSRNOT00000029697
Krt80
keratin 80
chr3_+_80362858 21.85 ENSRNOT00000021353
ENSRNOT00000086242
Lrp4
LDL receptor related protein 4
chr4_+_44597123 20.26 ENSRNOT00000078250
Cav1
caveolin 1
chr2_-_251532312 19.90 ENSRNOT00000019501
Cyr61
cysteine-rich, angiogenic inducer, 61
chr5_-_158439078 19.81 ENSRNOT00000025517
Klhdc7a
kelch domain containing 7A
chr8_+_111210811 19.46 ENSRNOT00000011347
Amotl2
angiomotin like 2
chr9_-_52238564 19.01 ENSRNOT00000005073
Col5a2
collagen type V alpha 2 chain
chr4_-_71763679 18.95 ENSRNOT00000024037
Epha1
Eph receptor A1
chr18_-_28454756 18.45 ENSRNOT00000040091
Spata24
spermatogenesis associated 24
chr13_-_86671515 18.34 ENSRNOT00000082869
AABR07021704.1

chr19_-_55367353 17.41 ENSRNOT00000091139
Piezo1
piezo-type mechanosensitive ion channel component 1
chr3_+_152857592 16.84 ENSRNOT00000027445
Myl9
myosin light chain 9
chr10_+_57322331 16.69 ENSRNOT00000041493
Kif1c
kinesin family member 1C
chr1_-_18058055 16.56 ENSRNOT00000020988
Ptprk
protein tyrosine phosphatase, receptor type, K
chr9_-_119332967 15.83 ENSRNOT00000021048
Myl12a
myosin light chain 12A
chr4_+_181286455 15.82 ENSRNOT00000083633
Ppfibp1
PPFIA binding protein 1
chr13_+_112031594 15.79 ENSRNOT00000008440
Lamb3
laminin subunit beta 3
chr1_-_219682287 15.79 ENSRNOT00000026092
Rhod
ras homolog family member D
chr1_-_131460473 15.45 ENSRNOT00000084336
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_-_122721496 14.65 ENSRNOT00000079697
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr8_-_61595032 13.61 ENSRNOT00000023428
Snx33
sorting nexin 33
chr4_+_157125998 13.44 ENSRNOT00000078349
C1r
complement C1r
chr4_+_120672152 13.26 ENSRNOT00000077231
Mgll
monoglyceride lipase
chr1_+_101517714 13.22 ENSRNOT00000028423
Plekha4
pleckstrin homology domain containing A4
chr1_-_261371508 12.94 ENSRNOT00000019978
Avpi1
arginine vasopressin-induced 1
chrX_+_77119911 12.49 ENSRNOT00000080141
Atp7a
ATPase copper transporting alpha
chr9_+_15166118 11.43 ENSRNOT00000020432
Mdfi
MyoD family inhibitor
chr10_-_85636902 10.98 ENSRNOT00000017241
Pcgf2
polycomb group ring finger 2
chr1_-_216703534 10.52 ENSRNOT00000027972
Phlda2
pleckstrin homology-like domain, family A, member 2
chr19_-_37938857 10.11 ENSRNOT00000026730
Slc12a4
solute carrier family 12 member 4
chr19_+_43163562 10.03 ENSRNOT00000048900
Clec18a
C-type lectin domain family 18, member A
chr19_-_11341863 9.49 ENSRNOT00000025694
Mt4
metallothionein 4
chr2_-_116002561 9.43 ENSRNOT00000012924
Prkci
protein kinase C, iota
chr13_+_73929136 9.39 ENSRNOT00000005425
Nphs2
nephrosis 2, idiopathic, steroid-resistant
chr7_-_67345295 8.78 ENSRNOT00000087045
ENSRNOT00000005829
Avpr1a
arginine vasopressin receptor 1A
chr20_-_27757149 8.55 ENSRNOT00000088287
Dse
dermatan sulfate epimerase
chr19_+_43163129 8.11 ENSRNOT00000073721
Clec18a
C-type lectin domain family 18, member A
chr5_+_75392790 8.07 ENSRNOT00000048457
Musk
muscle associated receptor tyrosine kinase
chr7_+_116745061 7.46 ENSRNOT00000076174
Rhpn1
rhophilin, Rho GTPase binding protein 1
chr10_+_74413989 7.29 ENSRNOT00000036098
Ska2
spindle and kinetochore associated complex subunit 2
chr5_+_164796185 6.96 ENSRNOT00000010779
Nppb
natriuretic peptide B
chr10_-_56000225 6.80 ENSRNOT00000013439
Tmem88
transmembrane protein 88
chr10_-_70646495 6.51 ENSRNOT00000071218
Gas2l2
growth arrest-specific 2 like 2
chr5_+_28850950 6.41 ENSRNOT00000009759
Tmem64
transmembrane protein 64
chr18_-_55771730 6.31 ENSRNOT00000026426
Smim3
small integral membrane protein 3
chr5_+_138300107 5.43 ENSRNOT00000047151
Cldn19
claudin 19
chr13_+_68709243 5.13 ENSRNOT00000066419
Ivns1abp
influenza virus NS1A binding protein
chr2_+_198231291 5.08 ENSRNOT00000078288
ENSRNOT00000046739
Otud7b
OTU deubiquitinase 7B
chr10_+_104523996 4.61 ENSRNOT00000065339
ENSRNOT00000086747
Itgb4
integrin subunit beta 4
chr7_-_117070936 4.19 ENSRNOT00000048446
Fam83h
family with sequence similarity 83, member H
chr4_-_40036563 3.69 ENSRNOT00000084531
Tmem168
transmembrane protein 168
chr12_-_16126953 3.68 ENSRNOT00000001682
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_-_55681930 3.49 ENSRNOT00000065744
Colca2
colorectal cancer associated 2
chrX_-_14783792 2.92 ENSRNOT00000087609
LOC691895
similar to ferritin, heavy polypeptide-like 17
chr20_+_46428124 2.86 ENSRNOT00000000327
Foxo3
forkhead box O3
chr10_-_62699723 2.85 ENSRNOT00000086706
Coro6
coronin 6
chr3_+_93648343 2.08 ENSRNOT00000091164
AABR07053136.1

chr5_+_169475270 1.97 ENSRNOT00000014625
Icmt
isoprenylcysteine carboxyl methyltransferase
chr8_-_66893083 1.81 ENSRNOT00000037028
ENSRNOT00000091755
Kif23
kinesin family member 23
chr15_+_52265557 1.75 ENSRNOT00000015969
Nudt18
nudix hydrolase 18
chr8_-_73194837 1.46 ENSRNOT00000024885
ENSRNOT00000081450
ENSRNOT00000064613
Tln2
talin 2
chr13_+_26172243 1.25 ENSRNOT00000003840
Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr1_-_217720414 0.91 ENSRNOT00000078810
Ppfia1
PTPRF interacting protein alpha 1
chr1_+_99729704 0.45 ENSRNOT00000037867
Klk9
kallikrein related-peptidase 9
chr5_+_59080765 0.36 ENSRNOT00000021888
ENSRNOT00000064419
Rgp1
RGP1 homolog, RAB6A GEF complex partner 1
chr17_+_86408151 0.35 ENSRNOT00000022734
Otud1
OTU deubiquitinase 1
chr1_+_46835971 0.22 ENSRNOT00000066798
Synj2
synaptojanin 2
chr19_+_54766589 0.10 ENSRNOT00000025894
Banp
Btg3 associated nuclear protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 60.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
9.0 45.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
8.0 23.9 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
7.6 30.2 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
7.5 29.9 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
6.8 20.3 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) regulation of inward rectifier potassium channel activity(GO:1901979) positive regulation of gap junction assembly(GO:1903598) receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
6.0 29.9 GO:0090131 glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
5.9 23.6 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
5.8 58.3 GO:0015886 heme transport(GO:0015886)
5.1 15.4 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
4.8 19.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
3.6 39.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
3.3 19.9 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
3.3 13.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
3.1 12.5 GO:0051542 negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
2.9 8.8 GO:0045819 cellular response to water deprivation(GO:0042631) positive regulation of glycogen catabolic process(GO:0045819)
2.8 8.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
2.5 17.4 GO:0033634 positive regulation of integrin activation(GO:0033625) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.3 9.4 GO:0072313 metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
2.2 22.5 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
1.9 36.8 GO:0001946 lymphangiogenesis(GO:0001946)
1.8 25.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.8 10.5 GO:0060721 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
1.7 5.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.6 6.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.5 13.6 GO:0036089 cleavage furrow formation(GO:0036089) macropinocytosis(GO:0044351)
1.3 9.4 GO:0034351 negative regulation of glial cell apoptotic process(GO:0034351)
1.2 3.7 GO:0007386 compartment pattern specification(GO:0007386)
1.2 16.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
1.0 7.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.6 1.8 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.6 11.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.6 1.7 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.5 4.6 GO:0061450 nail development(GO:0035878) trophoblast cell migration(GO:0061450)
0.5 32.7 GO:0070527 platelet aggregation(GO:0070527)
0.5 2.9 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.5 16.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 5.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.4 1.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.4 14.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.4 15.8 GO:0035987 endodermal cell differentiation(GO:0035987)
0.3 24.1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.3 44.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 24.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.3 49.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.2 2.9 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 1.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 2.0 GO:0018410 C-terminal protein amino acid modification(GO:0018410) S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 12.9 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 4.2 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 11.0 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.1 13.4 GO:0031638 zymogen activation(GO:0031638)
0.1 8.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 6.8 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 17.5 GO:0016055 Wnt signaling pathway(GO:0016055)
0.1 5.1 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.1 39.4 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 9.5 GO:0006875 cellular metal ion homeostasis(GO:0006875)
0.0 9.2 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.4 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:0046855 inositol phosphate dephosphorylation(GO:0046855) intracellular distribution of mitochondria(GO:0048312)
0.0 10.2 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 29.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
6.0 23.9 GO:1990584 cardiac Troponin complex(GO:1990584)
4.8 19.0 GO:0005588 collagen type V trimer(GO:0005588)
2.3 20.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.8 21.9 GO:0016600 flotillin complex(GO:0016600)
1.8 15.8 GO:0005610 laminin-5 complex(GO:0005610)
1.6 11.0 GO:0001739 sex chromatin(GO:0001739)
1.5 22.5 GO:0099634 postsynaptic specialization membrane(GO:0099634)
1.5 29.6 GO:0016460 myosin II complex(GO:0016460)
1.3 26.2 GO:0005614 interstitial matrix(GO:0005614)
1.0 22.2 GO:0030057 desmosome(GO:0030057)
1.0 17.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.9 9.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.8 45.2 GO:0005801 cis-Golgi network(GO:0005801)
0.7 13.3 GO:0043196 varicosity(GO:0043196)
0.5 9.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.5 7.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.5 1.8 GO:0097149 centralspindlin complex(GO:0097149)
0.4 12.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.4 48.0 GO:0005923 bicellular tight junction(GO:0005923)
0.3 4.6 GO:0030056 hemidesmosome(GO:0030056)
0.3 26.7 GO:0005901 caveola(GO:0005901)
0.3 39.2 GO:0055037 recycling endosome(GO:0055037)
0.3 16.7 GO:0005871 kinesin complex(GO:0005871)
0.3 19.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 16.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 37.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 46.4 GO:0005911 cell-cell junction(GO:0005911)
0.1 8.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 46.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 19.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.2 GO:0045095 keratin filament(GO:0045095)
0.1 10.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 79.7 GO:0005856 cytoskeleton(GO:0005856)
0.1 13.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 16.6 GO:0005925 focal adhesion(GO:0005925)
0.0 2.5 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 28.0 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 58.3 GO:0015232 heme transporter activity(GO:0015232)
6.0 23.9 GO:0030172 troponin C binding(GO:0030172)
3.2 19.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
3.0 23.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.9 8.8 GO:0031893 vasopressin receptor binding(GO:0031893)
2.8 8.5 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
2.5 12.5 GO:0032767 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
2.5 22.5 GO:0043495 protein anchor(GO:0043495)
2.4 69.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.9 17.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.8 20.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
1.7 22.4 GO:0045294 alpha-catenin binding(GO:0045294)
1.5 24.6 GO:0035497 cAMP response element binding(GO:0035497)
1.5 16.8 GO:0032036 myosin heavy chain binding(GO:0032036)
1.3 6.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.3 15.4 GO:0045295 gamma-catenin binding(GO:0045295)
1.3 21.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.0 13.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.0 15.4 GO:0001972 retinoic acid binding(GO:0001972)
0.9 26.2 GO:0001968 fibronectin binding(GO:0001968)
0.9 11.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.8 4.2 GO:1990254 keratin filament binding(GO:1990254)
0.8 18.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.6 1.7 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.5 5.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.5 38.2 GO:0032947 protein complex scaffold(GO:0032947)
0.5 26.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.5 9.4 GO:0004697 protein kinase C activity(GO:0004697)
0.4 30.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 19.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 7.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 23.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 2.0 GO:0051998 cAMP response element binding protein binding(GO:0008140) carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.3 15.8 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 18.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 38.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.9 GO:0008199 ferric iron binding(GO:0008199)
0.1 14.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 15.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 49.2 GO:0005198 structural molecule activity(GO:0005198)
0.1 3.7 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 2.9 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 15.8 GO:0003924 GTPase activity(GO:0003924)
0.1 15.8 GO:0045296 cadherin binding(GO:0045296)
0.0 10.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 16.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 7.5 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 2.9 GO:0051015 actin filament binding(GO:0051015)
0.0 1.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 20.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.9 19.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.9 45.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.9 20.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.8 19.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.6 18.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.4 19.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.4 16.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 14.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.3 17.7 PID FGF PATHWAY FGF signaling pathway
0.3 50.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 28.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.3 16.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 15.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 2.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 1.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 33.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.7 46.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
1.7 23.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.6 45.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.5 32.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
1.2 40.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.9 19.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.7 20.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.4 19.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 20.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.3 3.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 12.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 15.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 8.5 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 1.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 7.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME KINESINS Genes involved in Kinesins
0.0 8.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases