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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfap2d

Z-value: 0.58

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Transcription factors associated with Tfap2d

Gene Symbol Gene ID Gene Info
Tfap2d
ENSRNOG00000011642 transcription factor AP-2 delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2drn6_v1_chr9_+_25304876_253048760.001.0e+00Click!

Activity profile of Tfap2d motif

Sorted Z-values of Tfap2d motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_54734385 21.93 ENSRNOT00000005023
Nr0b1
nuclear receptor subfamily 0, group B, member 1
chr10_+_86340940 20.65 ENSRNOT00000073486
Pnmt
phenylethanolamine-N-methyltransferase
chr3_-_160301552 20.45 ENSRNOT00000014498
Rims4
regulating synaptic membrane exocytosis 4
chr9_+_99998275 17.57 ENSRNOT00000074395
Gpc1
glypican 1
chr1_-_270472866 13.19 ENSRNOT00000015979
Sorcs1
sortilin-related VPS10 domain containing receptor 1
chr2_+_123791335 10.84 ENSRNOT00000077096
Adad1
adenosine deaminase domain containing 1
chr2_+_123790915 10.77 ENSRNOT00000023282
Adad1
adenosine deaminase domain containing 1
chr5_+_147714163 10.20 ENSRNOT00000012663
Marcksl1
MARCKS-like 1
chr3_+_111545007 10.16 ENSRNOT00000007247
Itpka
inositol-trisphosphate 3-kinase A
chrX_+_127562660 9.78 ENSRNOT00000029031
ENSRNOT00000010367
Gria3
glutamate ionotropic receptor AMPA type subunit 3
chr19_-_11669578 9.11 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr4_+_70903253 8.32 ENSRNOT00000019720
Ephb6
Eph receptor B6
chr16_-_59366824 8.21 ENSRNOT00000015062
RGD1304810
similar to 6430573F11Rik protein
chr10_-_98018014 8.12 ENSRNOT00000005367
Fam20a
FAM20A, golgi associated secretory pathway pseudokinase
chr16_-_21274688 7.63 ENSRNOT00000027953
Tssk6
testis-specific serine kinase 6
chr15_+_344685 7.31 ENSRNOT00000065542
ENSRNOT00000066928
Kcnma1
potassium calcium-activated channel subfamily M alpha 1
chr16_+_26906716 6.43 ENSRNOT00000064297
Cpe
carboxypeptidase E
chr1_+_263186235 5.69 ENSRNOT00000021876
Cnnm1
cyclin and CBS domain divalent metal cation transport mediator 1
chr7_+_116745061 5.41 ENSRNOT00000076174
Rhpn1
rhophilin, Rho GTPase binding protein 1
chr9_-_66845403 5.40 ENSRNOT00000041546
Ica1l
islet cell autoantigen 1-like
chr20_+_13680716 5.32 ENSRNOT00000029458
LOC103694876
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
chr6_+_107485249 5.16 ENSRNOT00000080859
Acot1
acyl-CoA thioesterase 1
chr2_+_165486910 5.12 ENSRNOT00000012982
LOC100362176
hypothetical protein LOC100362176
chr10_+_13836128 5.09 ENSRNOT00000012720
Pgp
phosphoglycolate phosphatase
chr3_+_152143811 5.02 ENSRNOT00000026578
LOC100911109
sperm-associated antigen 4 protein-like
chr8_+_61659445 4.94 ENSRNOT00000023831
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr8_-_69807826 4.90 ENSRNOT00000014071
Dis3l
DIS3-like exosome 3'-5' exoribonuclease
chr1_+_143036218 4.90 ENSRNOT00000025797
Pde8a
phosphodiesterase 8A
chr16_+_4469468 4.85 ENSRNOT00000021164
Wnt5a
wingless-type MMTV integration site family, member 5A
chr19_+_25095089 4.67 ENSRNOT00000041717
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
chr1_-_141349881 4.51 ENSRNOT00000021109
Rhcg
Rh family, C glycoprotein
chr3_+_176087700 4.32 ENSRNOT00000073679
Mrgbp
MRG domain binding protein
chr3_-_141305471 4.27 ENSRNOT00000016915
Nkx2-4
NK2 homeobox 4
chr16_-_55002322 4.24 ENSRNOT00000036092
Zdhhc2
zinc finger, DHHC-type containing 2
chr1_+_101554642 4.20 ENSRNOT00000028474
Bcat2
branched chain amino acid transaminase 2
chr15_+_344360 4.18 ENSRNOT00000077671
Kcnma1
potassium calcium-activated channel subfamily M alpha 1
chr17_+_11953552 4.15 ENSRNOT00000090782
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr2_-_186245163 4.04 ENSRNOT00000089339
Dclk2
doublecortin-like kinase 2
chr19_-_55300403 4.03 ENSRNOT00000018591
Rnf166
ring finger protein 166
chr10_-_16752205 3.86 ENSRNOT00000079462
Crebrf
CREB3 regulatory factor
chr5_+_127404450 3.77 ENSRNOT00000017575
Lrp8
LDL receptor related protein 8
chr1_-_220480132 3.73 ENSRNOT00000027421
Cnih2
cornichon family AMPA receptor auxiliary protein 2
chr3_-_12029877 3.70 ENSRNOT00000022327
Slc2a8
solute carrier family 2 member 8
chr1_+_5448958 3.68 ENSRNOT00000061930
Epm2a
epilepsy, progressive myoclonus type 2A
chr6_+_93740586 3.68 ENSRNOT00000011466
Dact1
dishevelled-binding antagonist of beta-catenin 1
chr4_-_113610243 3.62 ENSRNOT00000008813
Hk2
hexokinase 2
chr8_+_115179893 3.59 ENSRNOT00000017469
Rrp9
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr19_+_34139997 3.57 ENSRNOT00000017867
Arhgap10
Rho GTPase activating protein 10
chr14_+_96300596 3.41 ENSRNOT00000071967
LOC302228
similar to Spindlin-like protein 2 (SPIN-2)
chr16_+_61954590 3.36 ENSRNOT00000017883
Rbpms
RNA binding protein with multiple splicing
chr5_-_156689258 3.25 ENSRNOT00000065497
Pink1
PTEN induced putative kinase 1
chr11_+_87549059 3.01 ENSRNOT00000002567
Ccdc74a
coiled-coil domain containing 74A
chr1_+_72580424 2.97 ENSRNOT00000022977
Ube2s
ubiquitin-conjugating enzyme E2S
chr4_+_157511642 2.93 ENSRNOT00000065846
Pianp
PILR alpha associated neural protein
chr3_-_11317049 2.89 ENSRNOT00000030558
Swi5
SWI5 homologous recombination repair protein
chr10_+_86711240 2.86 ENSRNOT00000012812
Msl1
male specific lethal 1 homolog
chrX_+_63343724 2.71 ENSRNOT00000076530
ENSRNOT00000008558
Klhl15
kelch-like family member 15
chr19_-_25134055 2.68 ENSRNOT00000007519
Misp3
MISP family member 3
chr4_+_145580799 2.66 ENSRNOT00000013727
Vhl
von Hippel-Lindau tumor suppressor
chr3_-_15433252 2.58 ENSRNOT00000008817
Lhx6
LIM homeobox 6
chrX_+_63343546 2.57 ENSRNOT00000076315
Klhl15
kelch-like family member 15
chr18_-_18079560 2.51 ENSRNOT00000072093
AABR07031533.1

chr10_-_68142864 2.44 ENSRNOT00000004609
Myo1d
myosin ID
chr3_+_175924522 2.40 ENSRNOT00000086626
NEWGENE_1308612
MRG/MORF4L binding protein
chr6_+_137243185 2.35 ENSRNOT00000030879
Zbtb42
zinc finger and BTB domain containing 42
chr2_+_195684210 2.28 ENSRNOT00000028316
mrpl9
mitochondrial ribosomal protein L9
chr9_+_66716969 2.24 ENSRNOT00000031261
Fam117b
family with sequence similarity 117, member B
chr6_+_107596782 2.24 ENSRNOT00000076882
Dnal1
dynein, axonemal, light chain 1
chr20_-_6960481 2.20 ENSRNOT00000093172
Mtch1
mitochondrial carrier 1
chr14_-_11198194 2.19 ENSRNOT00000003083
Enoph1
enolase-phosphatase 1
chr2_-_186245342 2.19 ENSRNOT00000057062
ENSRNOT00000022292
Dclk2
doublecortin-like kinase 2
chr16_-_81756654 2.11 ENSRNOT00000026653
Cul4a
cullin 4A
chr19_+_24747178 2.03 ENSRNOT00000038879
ENSRNOT00000079106
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
chr19_-_25801526 2.00 ENSRNOT00000003884
Nacc1
nucleus accumbens associated 1
chr1_-_164590562 1.97 ENSRNOT00000024157
Tpbgl
trophoblast glycoprotein-like
chr10_+_91830654 1.95 ENSRNOT00000005176
Wnt3
wingless-type MMTV integration site family, member 3
chr8_+_53678777 1.93 ENSRNOT00000045944
Drd2
dopamine receptor D2
chr1_-_80515694 1.90 ENSRNOT00000075144
Clasrp
CLK4-associating serine/arginine rich protein
chr3_+_79678201 1.81 ENSRNOT00000087604
ENSRNOT00000079709
Mtch2
mitochondrial carrier 2
chr13_+_51795867 1.80 ENSRNOT00000006747
Ube2t
ubiquitin-conjugating enzyme E2T
chr17_+_36334147 1.78 ENSRNOT00000050261
E2f3
E2F transcription factor 3
chr10_-_14061703 1.76 ENSRNOT00000017917
Gfer
growth factor, augmenter of liver regeneration
chr8_-_60830448 1.75 ENSRNOT00000022419
Tspan3
tetraspanin 3
chr11_-_34598102 1.73 ENSRNOT00000068743
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr12_+_50090464 1.71 ENSRNOT00000032193
Sez6l
seizure related 6 homolog like
chr6_+_137824213 1.70 ENSRNOT00000056880
Pacs2
phosphofurin acidic cluster sorting protein 2
chr5_-_156689415 1.69 ENSRNOT00000083474
Pink1
PTEN induced putative kinase 1
chr1_-_226501920 1.65 ENSRNOT00000050716
Lrrc10b
leucine rich repeat containing 10B
chr11_-_34598275 1.64 ENSRNOT00000077233
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr10_-_85222861 1.61 ENSRNOT00000031045
Npepps
aminopeptidase puromycin sensitive
chr9_+_53906073 1.60 ENSRNOT00000017813
Nab1
Ngfi-A binding protein 1
chr1_+_214317965 1.60 ENSRNOT00000078754
Tmem80
transmembrane protein 80
chr14_-_12387102 1.57 ENSRNOT00000038872
Bmp3
bone morphogenetic protein 3
chr3_+_152933771 1.45 ENSRNOT00000027539
RGD1307752
similar to RIKEN cDNA 1110008F13
chr16_-_62483137 1.45 ENSRNOT00000020683
Purg
purine-rich element binding protein G
chr5_+_148193710 1.42 ENSRNOT00000088568
Adgrb2
adhesion G protein-coupled receptor B2
chr3_-_175644988 1.31 ENSRNOT00000084452
Cables2
Cdk5 and Abl enzyme substrate 2
chr12_+_15890170 1.29 ENSRNOT00000001654
Gna12
G protein subunit alpha 12
chr1_+_214317682 1.27 ENSRNOT00000032904
Tmem80
transmembrane protein 80
chr4_-_145147397 1.26 ENSRNOT00000010347
Lhfpl4
lipoma HMGIC fusion partner-like 4
chr10_+_61403130 1.26 ENSRNOT00000092490
ENSRNOT00000077649
Ccdc92b
coiled-coil domain containing 92B
chr3_+_147772165 1.26 ENSRNOT00000008713
Tbc1d20
TBC1 domain family, member 20
chr12_-_17486157 1.22 ENSRNOT00000001745
Get4
golgi to ER traffic protein 4
chr6_-_98566523 1.15 ENSRNOT00000077715
Ppp2r5e
protein phosphatase 2 regulatory subunit B', epsilon
chr8_+_116154913 1.12 ENSRNOT00000081242
Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr11_-_57993548 1.03 ENSRNOT00000002957
Nectin3
nectin cell adhesion molecule 3
chr4_-_58250798 0.88 ENSRNOT00000048436
Klf14
Kruppel-like factor 14
chr8_+_116154736 0.88 ENSRNOT00000021218
Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr2_+_52302170 0.88 ENSRNOT00000081157
Paip1
poly(A) binding protein interacting protein 1
chr1_+_198690794 0.80 ENSRNOT00000023999
Zfp771
zinc finger protein 771
chr8_+_128087345 0.69 ENSRNOT00000019777
Acvr2b
activin A receptor type 2B
chr13_+_97702097 0.68 ENSRNOT00000057787
LOC103689999
saccharopine dehydrogenase-like oxidoreductase
chr10_-_59360661 0.61 ENSRNOT00000036942
Cyb5d2
cytochrome b5 domain containing 2
chr7_-_139394166 0.58 ENSRNOT00000082429
Vdr
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr1_+_84470829 0.54 ENSRNOT00000025472
Ttc9b
tetratricopeptide repeat domain 9B
chr11_-_44292884 0.53 ENSRNOT00000084060
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr14_+_10854682 0.49 ENSRNOT00000091367
ENSRNOT00000003072
ENSRNOT00000033489
Sec31a
SEC31 homolog A, COPII coat complex component
chr1_-_214408549 0.47 ENSRNOT00000074016
Cend1
cell cycle exit and neuronal differentiation 1
chr1_+_1784078 0.40 ENSRNOT00000020098
Lats1
large tumor suppressor kinase 1
chr12_+_31934343 0.35 ENSRNOT00000011181
Tmem132d
transmembrane protein 132D
chr7_-_70498992 0.26 ENSRNOT00000067774
ENSRNOT00000079327
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr19_+_21372163 0.25 ENSRNOT00000020329
Siah1
siah E3 ubiquitin protein ligase 1
chr6_+_28571351 0.21 ENSRNOT00000005389
Adcy3
adenylate cyclase 3
chr1_-_125967756 0.18 ENSRNOT00000031488
Fam189a1
family with sequence similarity 189, member A1
chr1_-_112947399 0.11 ENSRNOT00000093306
ENSRNOT00000093259
Gabra5
gamma-aminobutyric acid type A receptor alpha 5 subunit
chr3_-_171342646 0.06 ENSRNOT00000071853
Pmepa1
prostate transmembrane protein, androgen induced 1
chr9_+_15068399 0.00 ENSRNOT00000064229
ENSRNOT00000087107
Foxp4
forkhead box P4

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2d

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
3.8 11.5 GO:0060082 eye blink reflex(GO:0060082)
3.4 20.6 GO:0042414 epinephrine metabolic process(GO:0042414)
2.1 8.3 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.7 6.8 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
1.6 8.1 GO:0044691 tooth eruption(GO:0044691)
1.5 4.5 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.4 8.6 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
1.4 4.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
1.4 21.9 GO:0030238 male sex determination(GO:0030238)
1.3 3.9 GO:1902211 regulation of prolactin signaling pathway(GO:1902211)
1.3 6.4 GO:2000173 insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
1.3 5.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
1.2 3.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.2 4.8 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
1.1 5.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
1.0 4.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.9 3.7 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.9 2.7 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.8 7.6 GO:0035092 sperm chromatin condensation(GO:0035092)
0.8 8.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.8 4.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.5 3.8 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.5 10.2 GO:0006020 inositol metabolic process(GO:0006020)
0.5 3.7 GO:0046959 habituation(GO:0046959)
0.5 4.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 20.4 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.4 5.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.4 1.3 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.4 9.8 GO:0060992 response to fungicide(GO:0060992)
0.4 6.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 2.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.3 4.9 GO:0016075 rRNA catabolic process(GO:0016075)
0.3 2.9 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.2 GO:1904378 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.3 2.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.3 1.8 GO:0035701 hematopoietic stem cell migration(GO:0035701) hematopoietic stem cell homeostasis(GO:0061484)
0.3 1.8 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.2 1.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 10.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 2.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 2.0 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.2 0.2 GO:0008355 olfactory learning(GO:0008355)
0.2 0.6 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.2 3.9 GO:0007141 male meiosis I(GO:0007141)
0.2 4.9 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.2 27.2 GO:0007286 spermatid development(GO:0007286)
0.2 0.5 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.1 0.4 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1 3.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 2.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 1.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 0.7 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.1 2.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 5.1 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.9 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 2.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 2.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.2 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 3.6 GO:0006364 rRNA processing(GO:0006364) rRNA metabolic process(GO:0016072)
0.0 1.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 2.9 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 21.9 GO:0042788 polysomal ribosome(GO:0042788)
1.1 11.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
1.0 2.9 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.7 2.9 GO:0072487 MSL complex(GO:0072487)
0.7 9.8 GO:0043083 synaptic cleft(GO:0043083)
0.5 4.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.5 4.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 2.0 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.5 9.8 GO:0043196 varicosity(GO:0043196)
0.4 3.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.4 4.9 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 6.4 GO:0031045 dense core granule(GO:0031045)
0.4 3.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.4 20.4 GO:0048786 presynaptic active zone(GO:0048786)
0.4 3.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 1.2 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3 6.7 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.3 2.7 GO:0030891 VCB complex(GO:0030891)
0.2 5.3 GO:0090544 BAF-type complex(GO:0090544)
0.2 2.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 7.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 17.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.6 GO:0001651 dense fibrillar component(GO:0001651)
0.1 2.9 GO:0005685 U1 snRNP(GO:0005685)
0.1 3.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.4 GO:0030673 axolemma(GO:0030673)
0.1 3.7 GO:0005844 polysome(GO:0005844)
0.1 2.9 GO:0035869 ciliary transition zone(GO:0035869)
0.1 5.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 5.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.0 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 6.7 GO:0043197 dendritic spine(GO:0043197)
0.0 5.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 8.3 GO:0005874 microtubule(GO:0005874)
0.0 3.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 21.9 GO:0050682 AF-2 domain binding(GO:0050682)
3.5 17.6 GO:0070052 collagen V binding(GO:0070052)
2.9 11.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
2.1 8.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
2.0 9.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.8 21.6 GO:0004000 adenosine deaminase activity(GO:0004000)
1.6 4.9 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.5 9.1 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.4 4.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.2 3.7 GO:2001070 starch binding(GO:2001070)
1.2 4.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
1.1 10.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.8 5.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.8 3.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.8 3.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.6 3.6 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.6 1.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.6 6.4 GO:0050897 cobalt ion binding(GO:0050897)
0.6 3.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.5 4.9 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.4 5.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.4 1.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.4 3.6 GO:0034511 U3 snoRNA binding(GO:0034511)
0.3 3.7 GO:0005536 glucose binding(GO:0005536)
0.3 4.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 20.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 1.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 4.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 4.9 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.2 2.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 4.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.6 GO:0038181 bile acid receptor activity(GO:0038181)
0.1 4.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 21.5 GO:0044325 ion channel binding(GO:0044325)
0.1 3.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 4.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 2.0 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 2.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.7 GO:0005080 protein kinase C binding(GO:0005080)
0.1 2.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0008494 translation activator activity(GO:0008494)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 7.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 4.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 7.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 5.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 5.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
1.3 21.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.5 7.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.4 11.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 12.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 4.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.9 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 2.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.7 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 20.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.8 17.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.5 9.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 4.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 6.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 4.9 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 4.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 16.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 6.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 3.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.7 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 3.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.3 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 1.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.6 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 1.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production