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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfap2e

Z-value: 0.49

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Transcription factors associated with Tfap2e

Gene Symbol Gene ID Gene Info
Tfap2e
ENSRNOG00000027595 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2ern6_v1_chr5_-_144761787_144761787-0.123.0e-02Click!

Activity profile of Tfap2e motif

Sorted Z-values of Tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_100530183 26.27 ENSRNOT00000067754
Mybpc2
myosin binding protein C, fast-type
chr10_+_86340940 24.78 ENSRNOT00000073486
Pnmt
phenylethanolamine-N-methyltransferase
chr3_+_5709236 18.27 ENSRNOT00000061201
ENSRNOT00000070887
Dbh
dopamine beta-hydroxylase
chr10_-_98018014 11.84 ENSRNOT00000005367
Fam20a
FAM20A, golgi associated secretory pathway pseudokinase
chr18_-_55859333 10.11 ENSRNOT00000025989
Myoz3
myozenin 3
chr9_+_99998275 8.62 ENSRNOT00000074395
Gpc1
glypican 1
chr18_-_40716686 8.60 ENSRNOT00000000172
Cdo1
cysteine dioxygenase type 1
chr4_-_113610243 6.14 ENSRNOT00000008813
Hk2
hexokinase 2
chr7_-_77162148 5.93 ENSRNOT00000008350
Klf10
Kruppel-like factor 10
chr8_-_50531423 4.87 ENSRNOT00000090985
ENSRNOT00000074942
Apoc3
apolipoprotein C3
chrX_-_157095274 4.78 ENSRNOT00000084088
Abcd1
ATP binding cassette subfamily D member 1
chr17_-_35037076 4.13 ENSRNOT00000090946
Dusp22
dual specificity phosphatase 22
chr1_+_78933372 4.07 ENSRNOT00000029810
Ccdc8
coiled-coil domain containing 8
chr17_+_11953552 3.85 ENSRNOT00000090782
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr4_+_120133713 3.57 ENSRNOT00000017240
Gata2
GATA binding protein 2
chr10_-_85684138 3.08 ENSRNOT00000017989
Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
chr4_-_64831233 2.96 ENSRNOT00000079285
Dgki
diacylglycerol kinase, iota
chr7_-_140454268 2.72 ENSRNOT00000081468
Wnt10b
wingless-type MMTV integration site family, member 10B
chr8_+_53678777 2.71 ENSRNOT00000045944
Drd2
dopamine receptor D2
chr10_+_83231409 2.54 ENSRNOT00000006230
Spop
speckle type BTB/POZ protein
chr17_-_10208360 2.33 ENSRNOT00000087397
Unc5a
unc-5 netrin receptor A
chr10_+_105156632 2.29 ENSRNOT00000086288
Galr2
galanin receptor 2
chr10_+_105156822 1.81 ENSRNOT00000012523
Galr2
galanin receptor 2
chr8_+_22625874 1.78 ENSRNOT00000012269
Timm29
translocase of inner mitochondrial membrane 29
chr20_-_3793985 1.57 ENSRNOT00000049540
ENSRNOT00000086293
RT1-CE16
RT1 class I, locus CE16
chr1_+_173275336 1.51 ENSRNOT00000086302
AABR07004992.1

chr1_+_79911516 1.46 ENSRNOT00000019075
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr2_+_189169877 1.21 ENSRNOT00000028225
She
Src homology 2 domain containing E
chr19_-_11326139 1.12 ENSRNOT00000025669
Mt3
metallothionein 3
chr10_+_84031955 1.12 ENSRNOT00000009934
Hoxb13
homeo box B13
chr10_+_86582612 0.97 ENSRNOT00000048349
Gsdma
gasdermin A
chr1_+_87045796 0.92 ENSRNOT00000027620
Lgals7
galectin 7
chr14_+_81819415 0.90 ENSRNOT00000018515
ENSRNOT00000075863
ENSRNOT00000077060
Mxd4
Max dimerization protein 4
chr9_-_115382445 0.81 ENSRNOT00000091316
Ptprm
protein tyrosine phosphatase, receptor type, M
chrX_+_21696772 0.73 ENSRNOT00000043559
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
chr9_-_24451435 0.69 ENSRNOT00000060805
Defb49
defensin beta 49
chrX_-_73778595 0.52 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
Rlim
ring finger protein, LIM domain interacting
chr1_-_168471161 0.37 ENSRNOT00000055227
Olr94
olfactory receptor 94
chr8_+_108958046 0.28 ENSRNOT00000079618
ENSRNOT00000066917
Stag1
stromal antigen 1
chr20_-_1984737 0.19 ENSRNOT00000040232
ENSRNOT00000051634
ENSRNOT00000079445
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
chr19_-_25801526 0.17 ENSRNOT00000003884
Nacc1
nucleus accumbens associated 1
chr8_-_22625959 0.10 ENSRNOT00000012138
Yipf2
Yip1 domain family, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
4.1 24.8 GO:0042414 epinephrine metabolic process(GO:0042414)
2.9 8.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
2.9 8.6 GO:0042412 taurine biosynthetic process(GO:0042412)
2.6 26.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
2.4 11.8 GO:0044691 tooth eruption(GO:0044691)
1.6 4.9 GO:0010982 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) regulation of high-density lipoprotein particle clearance(GO:0010982)
1.5 6.1 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
1.2 3.6 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
1.0 4.1 GO:1902608 regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
1.0 3.8 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.8 4.8 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.7 2.7 GO:0042640 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) anagen(GO:0042640) regulation of anagen(GO:0051884)
0.7 2.7 GO:1900166 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) negative regulation of dopamine receptor signaling pathway(GO:0060160) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.4 2.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 1.1 GO:2000295 cadmium ion homeostasis(GO:0055073) regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214) regulation of hydrogen peroxide catabolic process(GO:2000295)
0.4 3.0 GO:0046959 habituation(GO:0046959)
0.3 2.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.2 4.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.2 1.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2 5.9 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.2 0.5 GO:0060816 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 4.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.3 GO:0034774 secretory granule lumen(GO:0034774)
2.2 26.3 GO:0005859 muscle myosin complex(GO:0005859)
1.3 24.8 GO:0043196 varicosity(GO:0043196)
0.8 4.1 GO:1990393 3M complex(GO:1990393)
0.8 4.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.3 4.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 3.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 10.1 GO:0030018 Z disc(GO:0030018)
0.1 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 6.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.7 GO:0060170 ciliary membrane(GO:0060170)
0.0 7.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
2.0 26.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
1.7 8.6 GO:0070052 collagen V binding(GO:0070052)
1.6 4.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.0 6.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.8 4.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 4.1 GO:0004966 galanin receptor activity(GO:0004966)
0.5 2.3 GO:0005042 netrin receptor activity(GO:0005042)
0.4 3.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 11.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 8.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 2.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.3 24.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 3.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 6.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:0030283 testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
0.1 1.1 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 4.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 5.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 2.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 3.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 9.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 11.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 43.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.7 26.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 4.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 8.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 4.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 8.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 6.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 3.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 3.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 3.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 4.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors